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Transcript
Waltz Round the Cycle Once a jolly pyruvate enters the matrix Of a mitochondrion, so they say A decarboxylating, complex dehydrogenase Converts it to acetyl co-enzyme A. Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle today A decarboxylating, complex dehydrogenase Turns pyruvate to acetyl CoA. Oxaloacetate looking for a partner Thinks “active acetate” looks OK; Condensing enzyme arranging a merger Makes a new citrate, and kicks out CoA. Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle today Condensing enzyme arranging a merger Makes a new citrate, and kicks out CoA. Along comes aconitase, a hydro-dehydratase, Gives isocitrate reversibly. Then its dehydrogenase gives NADH, Carbon dioxide and a-OG. Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle with me Then its dehydrogenase gives NADH, Carbon dioxide and a-OG. Off with the CO2. Another oxidation Just like the PDC previously. Succinyl CoA with a thiokinase Yields succinate and GTP Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle with me Succinyl CoA with a thiokinase Yields succinate and GTP Succinate’s oxidized by its dehydrogenase Reducing FAD, fiving fumarate; Fumarase makes malate; another dehydrogenase Generates oxaloacetate. Waltz round the cycle Waltz round the cycle Waltz round the TCA cycle today Fumarase makes malate; another dehydrogenase Generates oxaloacetate.
