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Sarah M. Assmann Curriculum vitae Education Williams College, Williamstown, MA, 1976-1980, magna cum laude, Highest Honors in Biology Stanford University, Stanford, CA, 1981-1986, PhD Biology Research Career 1986-1987, University of California, Riverside, postdoctoral scholar 1987-1991, Harvard University, Assistant Professor, Department of Organismic and Evolutionary Biology (OEB) 1991-1993, Harvard University, Associate Professor, OEB 1993-1997, Penn State University, Associate Professor of Biology 1997-2001, Penn State University, Professor of Biology 2001-present, Penn State University, Waller Professor of Biology Honors 2015 2013-present 2013 2009 2008-2009 2007 2001 to present 2001 1999-2000 1988-1990 1981-1983 Editorial Boards 2010 - present 1998 – 2014 1998 – 2001 1997 – 2000 1994 – 1997 Elected AAAS Member-At-Large, Biological Sciences Section Elected Member, North American Arabidopsis Steering Committee (NAASC) Penn State Eberly Fellow Elected Fellow, American Association for the Advancement of Science (AAAS) President (elected), American Society of Plant Biologists (ASPB) Fellow of ASPB Award Waller Endowed Chair, Penn State University Penn State Faculty Scholars Medal in Life and Health Sciences, NSF POWRE Award Recipient, McKnight Foundation Individual Research Project Award NSF Predoctoral Fellowship Editor (Deputy Editor since 2016), Biochemical Journal Co-editor, The Plant Cell Editorial Board, Plant and Cell Physiology Subject Editor, Plant, Cell, & Environment Monitoring Editor, Plant Physiology Conferences Organized 2017: North American Arabidopsis Steering Committee Workshop: “Emerging Genomic Technologies”. 2015: 20th Penn State Plant Biology Symposium: “Plant Stress-omics in a Changing Climate” 2009: Proteomics workshop and symposium: “Proteomic, redox, and metabolomic networks,” Univ. Florida, Gainesville, FL (with Dr. Sixue Chen) 2009: President’s Symposium, ASPB Annual Meeting. 2006: ASPB focus meeting, “The Biology of Transpiration”, Snowbird, UT 2006: 16th Penn State Plant Physiology Symposium: “RNA Biology: Novel Insights from Plant Systems” 1 2005: Keystone Symposium: “Plant Cell Signaling: In Vivo and Omics Approaches” Santa Fe, NM 2005-2006: Organizer, week-long Penn State plant science summer camp for 4th-8th graders, “Magical Life in the Muggle World.” Enrollment was 89 children in 2005; 100 children in 2006. Service to Federal Agencies (recent) 2014-present Member of BERAC (Biological and Environmental Research Advisory Committee) - provides scientific and technical advice to the Director of the Office of Science of the Department of Energy (DOE) 2012 – 2015 Panel Member, US-Israel Binational Research and Development Fund (BARD) 2012, 2014, 2015 Panel Member, NSF-Molecular and Cellular Biosciences (NSF-MCB) 2012 Panel Member, DOE Plant Biosystems (synthetic biology) Other Selected Service to the Profession 2014-present Member, ASPB Meetings and Events Advisory Board 2012 – 2015 Member, ASPB Board of Trustees 2007 – 2010 President-Elect, President, Immediate Past President of ASPB 2008-2010 Member, ASPB Public Affairs Committee 2007-2010 Member, ASPB Executive Committee 2006-2010 Member, ASPB Education Foundation Board of Directors 2003-2004 Panel Manager, USDA Developmental Processes in Crop Species Current Research Funding Charles E. Kaufman Foundation: Discovery and Characterization of Novel RNA Switch Chemistry and Biology via RNA Structure-seq. PI: Paul Babitzke, co-PIs Philip C. Bevilacqua and Sarah M. Assmann. 9/1/2016 to 8/31/2018. NSF-IOS 16-21027: EAGER: Plant Sensory Perception via Heme Modulation of K+ Channels. PI: Timothy Jegla, co-PI: Sarah M. Assmann. 3/15/2016 to 2/28/2018. NSF-IOS (Plant Genome) 13-39282: The In Vivo Rice RNA Structurome in Abiotic Stress Sensing and Response. PI: Philip C. Bevilacqua, co-PIs: Sarah M. Assmann, David Mathews (U. Rochester) 6/1/14 to 5/31/18. USDA-AFRI - 2014-67013-21599 Manipulating Heterotrimeric G-protein Signaling for Improved Agronomic Traits and Drought Resistance in Rice. PI: Sarah M. Assmann; coPI: Hong Ma, 11/15/13 to 11/14/16. NSF-MCB-14-12644. Collaborative Research: Redox Regulation of Protein Kinase Functions in Guard Cell Signaling. PI: Sixue Chen (U FL), Co-PIs Alice Harmon (U FL), Sarah M. Assmann, 08/01/14 to 07/31/16 (in no cost extension). NSF-MCB-11-57921 Collaborative Research: Metabolomic Characterization of Red Light and CO2 in Guard Cells and Mesophyll Cells. PI: Sixue Chen (U FL), Co-PI: Sarah M. Assmann. 5/15/2012 to 4/30/2016 (in no cost extension). 2 Selected Recent Publications RNA Structure-Function Relationships: Su Z, Ritchey L, Bevilacqua PC, Assmann SM. Genome-wide analysis of RNA secondary structure. Annu. Rev. Genetics, PMID 27648642. Ding Y, Kwok CK, Tang Y, Bevilacqua PC, Assmann, SM 2015. Genome-wide profiling of in vivo RNA structure at single-nucleotide resolution using structure-seq. Nat. Protoc. 10: 1050-1066. doi: 10.1038/nprot.2015.064 Tang Y, Bouvier E, Kwok CK, Ding Y, Nekrutenko A, Bevilacqua PC, Assmann SM. 2015. StructureFold: Genome-wide RNA secondary structure mapping and reconstruction in vivo. Bioinformatics. Apr 16. pii: btv213. Kwok CK, Tang Y, Assmann SM, Bevilacqua PC. 2015. The RNA structurome: transcriptome-wide structure probing with next-generation sequencing. Trends Biochem Sci. 40: 221-232. doi: 10.1016/j.tibs.2015.02.005. Ding Y, Tang Y, Kwok CK, Zhang, Y, Bevilacqua, PC, Assmann, SM. 2014. In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features. Nature 505: 696-700 doi: 10.1038/nature12756. Kwok, C.K., Ding, Y., Tang, Y., Assmann, S.M., Bevilacqua, P.C. 2013. Determination of in vivo RNA structure in low-abundance transcripts. Nat Commun. 4:2971. doi: 10.1038/ncomms3971. Mullen, MA, Assmann, SM, Bevilacqua, PC. 2012. Toward a digital gene response: RNA Gquadruplexes with fewer quartets fold with higher co-operativity. J. Am. Chem. Soc. 134: 812-815. doi: 10.1021/ja2096255. Li, J., Kinoshita, K., Pandey, S., Ng, C K-Y., Gygi, S.P., Shimazaki, K-I., and Assmann, S.M. 2002. Modulation of an RNA-binding protein by abscisic-acid-activated kinase. Nature, 418: 793797. Guard Cell Systems Biology and G-Protein Signaling: Assmann SM, Jegla T. 2016. Guard cell sensory systems: recent insights on stomatal reponses to light, abscisic acid, and CO2. Curr Opin Plant Biol. 33: 157-167. Ferrero-Serrano Á, Assmann SM 2016. The α-subunit of the rice heterotrimeric G protein, RGA1, regulates drought tolerance during the vegetative phase in the dwarf rice mutant d1. J. Exp. Bot. 67: 3433-3443. Chakravorty D, Gookin TE, Milner MJ, Yu Y, Assmann SM. 2015. Extra-large G proteins expand the repertoire of subunits in Arabidopsis heterotrimeric G protein signaling. Plant Physiol. 169:512529. doi: 10.1104/pp.15.00251 Yu Y, Assmann SM. 2015. The heterotrimeric G-protein β subunit, AGB1, plays multiple roles in the Arabidopsis salinity response. Plant Cell Environ. 38:2143-2156. Sun, Z., Jin, X., Albert, R., Assmann, S.M. 2014. Multi-level modeling of light-induced stomatal opening offers new insight into its regulation by drought. PLoS Comp. Biol. 10: e1003930 Gookin, T.E., Assmann, S.M. 2014. Significant reduction of BiFC non-specific assembly facilitates in planta assessment of heterotrimeric G-protein interactors. Plant J. 80: 553-567. 3 Jin X, Wang RS, Zhu M, Jeon BW, Albert R, Chen S, Assmann SM. 2013. Abscisic acid-responsive guard cell metabolomes of Arabidopsis wild-type and gpa1 G-protein mutants. Plant Cell 25: 4789-811. Assmann, SM. 2013. Natural variation in abiotic stress and climate change responses in Arabidopsis: implications for 21st century agriculture. International Journal of Plant Sciences. (cover) 174: 3-26. Li S, Pandey S, Gookin TE, Zhao Z, Wilson L, Assmann. SM. 2012. Gene-sharing networks reveal organizing principles of transcriptomes in Arabidopsis and other multicellular organisms. Plant Cell 24: 1362-1378. Wang, R., Pandey, S., Li, S. Gookin, T.E. Zhao, Z., Albert, R. and Assmann, S.M. 2011. Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells. BMC Genomics, 12:216. Pandey S, Wang RS, Wilson L, Li S, Zhao Z, Gookin TE, Assmann SM, Albert R. 2010. Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G-protein action. Mol Syst Biol. 10.1038/msb.2010.28 Zhao Z, Zhang W, Stanley BA, Assmann SM. 2008. Functional proteomics of Arabidopsis thaliana guard cells uncovers new stomatal signaling pathways. Plant Cell. 20: 3210-32226. Wang, X-Q., Ullah, H., Jones, A.M., and Assmann, S.M. 2001. G protein regulation of ion channels and abscisic acid signaling in Arabidopsis guard cells. Science, 292: 2070-2072. Li, J., Wang, X-Q, Watson, M.B. and Assmann, S.M. 2000. Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase. Science, 287: 300-303. Lee, Y.R. and Assmann, S.M. 1999. Arabidopsis thaliana “extra-large GTP-binding protein” (AtXLG1): a new class of G-protein. Plant Mol. Biol., 40: 55-64. 4