Download Bone scintigraphy

Bone scintigraphy
One of the most commonly performed nuclear medicine diagnostic procedure
Although the appearance of bones on plain x-rays depends on the skeletal mineral content,
radionuclide bone scanning provides physiologic information, depecting blood flow to bone
and bone metabolism or turnover
High sensitivity (low specificity), ability to survey the entire skeletal system
Radiopharmaceuticals:
P-32 orthophosphate - 1935
Fluorine-18, calcium-45, strontium-89 – early 1940’s
technetium –99m- diphosphonates since 1973
Standard bone scan (technetium –99m-MDP)
Mechanism of the technetium-99m-polyphosphonates uptake:
Three-phase bone scan Blood flow – major determinant of radiotracer uptake
Increase uptake in the actively bone forming mineralizing layer – radiotracer became
incorporated into the hydroxyapatite crystal matrix.
Extraosseous accumulation
Indication: diagnostic of metastatic disease, follow-up metastatic cancer therapy, primary
bone tumors, infectious disease, miscellaneous (pagets disease, fibrous dysplasia, metabolic
disease,