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The race for the prize: T-cell trafficking strategies for
optimal surveillance
by Minyi Lee, Judith N. Mandl, Ronald N. Germain, and Andrew J. Yates
Blood
Volume 120(7):1432-1438
August 16, 2012
©2012 by American Society of Hematology
A model of naive T-cell trafficking and surveillance.
Minyi Lee et al. Blood 2012;120:1432-1438
©2012 by American Society of Hematology
Conservative estimates of the efficiency of detection depend on antigen abundance, precursor
numbers, and LN transit time.
Minyi Lee et al. Blood 2012;120:1432-1438
©2012 by American Society of Hematology
Restricting egress from an infected LN. The rate-limiting step is recruitment into the correct LN;
thus rapid transit (A left-most region, B top curves) yields more efficient detection.
Minyi Lee et al. Blood 2012;120:1432-1438
©2012 by American Society of Hematology
Slow transit facilitates the detection of rare self-antigens.
Minyi Lee et al. Blood 2012;120:1432-1438
©2012 by American Society of Hematology
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