Download PLAN in BIOCHEMISTRY Spring Semester, 2016/2017 2

PLAN in BIOCHEMISTRY
Spring Semester, 2016/2017
2-nd course (4 semester), speciality «Dentistry»
(1 h. lecture, 3 h. practical work, 2h. self study)
Lecturer - professor Lukasheva Elena Vasiljevna
Weeks
Course of lectures
1 week
Lipid metabolism 1.
Lipid Chemistry. β-Oxidation of fatty acids in
(upper)
06.02-13.02 mitochondria and its association with the
oxidative phosphorylation of ADP.
Transformation of glycerol.
2 week
13.02-18.02
3 week
Lipid metabolism 2.
20.02-25.02 Сentral role of CoA in lipid metabolism.
Biosynthesis of fatty acids. Acetone bodies:
synthesis, function, diagnostic value. Lipid
peroxidation. Regulation and pathology of lipid
metabolism.
4 week
27.02-03.03
5 week
Metabolism of simple proteins 1.
06.03-11.03 General pathways of amino acid (AA)
metabolism. AA deamination and transamination.
The role of coenzymes in these processes.
Detoxification of ammonia in the organism. Urea
cycle.
6 week
13.03-18.03
7 week
Metabolism of simple proteins 2.
Decarboxylation of AA. Biogenic amines their
20.03-25.03 role in the organism. The concept of the AA
hydroxylation. Transferring of one-carbon
fragments. Phenylketonuria.
8 week
27.03-01.04
Laboratory works
I. Сhecking homework - quiz.
II. Seminar: Lipid Chemistry and
functions. Lipids in biological
membranes. Decomposition and
resynthesis of triacylglycerols in the
intestine. Bile acids.
I. Quiz
II. Seminar: Intracellular lipolysis and its
regulation.
III.
Laboratory
work
(LW):
Determination of lecithin concentration in
blood serum.
I. Quiz
II. Seminar Biosynthesis and biological
role of cholesterol. Biosynthesis of
phospholipids.
III. LW Determination of cholesterol
concentration in blood serum.
Colloquium: “Lipid metabolism”
I. Quiz
II. Seminar Significance of proteins for
the organism. The concept of biological
value of proteins. Digestion of proteins in
the gastrointestinal tract.
III. LW Determination of transaminases
in blood serum.
I. Quiz
II. Seminar The concept of the nitrogen
balance in the body. The fate of α-keto
acids.
III. LW Determination of urea in the
urine
I. Quiz
II. Seminar Specific metabolic pathways of
certain amino acids
III. LW Express-method for
determination of phenylalanine in blood
serum
I. Quiz
II. Seminar Heme: biosynthesis
and
degradation.
Pathology
of
heme
metabolism.
III. LW Determination of bilirubin
concentration in blood serum
9 week
Metabolism of conjugated proteins
I. Quiz
03.04-08.04 Nucleotides: biosynthesis and degradation. Role II. Seminar Features of nucleic acids
of xanthine oxidase. Pathology of nucleotide exchange.
exchange.
10 week
Colloquium: “Metabolism of simple,
11.04-15.04
conjugated proteins and nucleic acids”
11 week
Dental Biochemistry 1.
I. Quiz
17.04-22.04 Biochemistry of connective tissue.
II. Seminar Features of the connective
Collagen, non-collagenous proteins, specific
tissue. Extracellular matrix proteins in
proteins of bone. Markers of formation and
various types of connective tissue.
disintegration of connective tissue.
Proteoglycans: structure, function, biosynthesis
and decomposition. Organic substances in
mineralized tissues. Lipids, carbohydrates.
12 week
I. Quiz
24.04-29.04
II.
Seminar
Glycosaminoglycans:
classification;
structure
of
the
disaccharide units. Pathology associated
with impaired metabolism of connective
tissue.
13 week Dental Biochemistry 2.
01.05-06.05 Biochemistry of mineralized tissues. Formation
of extracellular matrix - the basis for the
deposition of minerals. Mineral components of
hard tissues - apatite, their types, structural
features. The role of osteoblasts, osteocytes and
osteoclasts in bone metabolism. Hormones,
vitamins, proteins, RANKL, osteoprotegerin in
the regulation of bone formation and resorption.
14 week
08.05-13.05
I. Quiz
II. Seminar Formation and remodeling of
bone tissues. Ion exchange processes in
crystal the lattice. Fluorine effect on the
structure and properties of hydroxyapatite.
Fluorosis.
I. Quiz
III. LW Determination of alkaline
phosphatase in blood serum
15 week Dental Biochemistry 3.
I. Quiz
15.05-20.05 Biochemistry of oral liquids.
II. Seminar Mixed saliva, the origin of its
The chemical composition of saliva. The organic mineral and organic components.
components of saliva, their biological role. The Regulation of saliva secretion. Mucins,
most important proteins and enzymes of mixed their functions.
saliva. The protective properties of saliva. Mineral III. LW Isolation and qualitative
components of mixed saliva. The micelles of
determination of glycoproteins in saliva.
calcium phosphate. Theories of caries. Plaque and
tartar, their role in the development of caries and
periodontitis. Gingival fluid.
16 week
Test: “Dental biochemistry”
22.05-27.05
17 week The integration of metabolic pathways.
Colloquium: “Dental biochemistry”
29.05-02.06 Pathology associated with impaired regulation of
metabolism. Diagnostic role of intermediate
metabolites in blood serum.