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Download UBAP2L is a novel BMI1-interacting protein.
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UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity by Marie-Eve Bordeleau, Romain Aucagne, Jalila Chagraoui, Simon Girard, Nadine Mayotte, Éric Bonneil, Pierre Thibault, Caroline Pabst, Anne Bergeron, Frédéric Barabé, Josée Hébert, Martin Sauvageau, Christel Boutonnet, Sylvain Meloche, and Guy Sauvageau Blood Volume 124(15):2362-2369 October 9, 2014 ©2014 by American Society of Hematology UBAP2L is a novel BMI1-interacting protein. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology Ubap2l is preferentially expressed in primitive HSCs and AML specimens with high stem cell frequency. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology shRNA-mediated Ubap2l downregulation results in reduced progenitor and HSC activity. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology Conditional Ubap2l deletion results in loss of HSC activity. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology Bmi1 rescues the long-term repopulation defect caused by Ubap2l knockdown. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology UBAP2L does not affect BMI1 and RNF2 protein levels, and p16Ink4a expression, and forms a distinct PcG complex with BMI1. Marie-Eve Bordeleau et al. Blood 2014;124:2362-2369 ©2014 by American Society of Hematology
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