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SUNDAY 20 August 2006
10.00
Bus departure (Bratislava - Stara Lesna)
16.00 - 17.30
Registration
17.30 - 19.00
Opening ceremony
19.00 - 23.30
Welcome reception
MONDAY 21 August 2006
8.10 - 9.00
8.15 (45min)
9.00 - 10.45
Keynote lecture
Chair: Zdena Bartosova
The WTSI Cancer Genome Project: understanding the targets
Andy Futreal, Wellcome Trust Sanger Institute, Hinxton, UK
Session Retroviruses in malignant transformation
Chair: Cestmir Altaner
9.00 (30min)
New insights into translational regulation of growth control genes: lessons derived from study of
retroviruses
Kathleen Boris-Lawrie, Department of Veterinary Sciences, The Ohio State University, USA
9.35 (30min)
Metabolic pathways involved in transformation induced by oncoviral Tax proteins
Richard Kettmann, Faculty of Agronomy, Gembloux, Belgium
10.10 (30min)
Cell defense against retroviruses
Jan Svoboda, Institute of Molecular Genetics, Prague, Czech Republic
10.45 - 11.15
Coffee break
11.15 - 13.00
Session Molecular pathogenesis of cancer
Chair: Jan Sedlak
11.15 (30min)
The mechanisms of inactivation of the wild-type allele in hereditary cancers such as FAP and
HNPCC
Karl Heinimann, University of Basel, Switzerland
11.50 (30min)
Cyclin-dependent kinase inhibitor p15INK4B in leukemia and normal hematopoiesis
Linda Wolff, National Cancer Institute, Bethesda, USA
12.25 (30min)
Leukemogenesis and c-Myb: story of a tightly regulated transcriptional regulator
Juraj Bies, National Cancer Institute, Bethesda, USA
13.00 - 14.00
Lunch
14.00 - 15.40
Session DNA damage and repair processes I.
14.00 (30min)
14.35 (30min)
Chair: Josef Jiricny
In search of damage: Structure – function studies of nucleotide excision repair proteins
Bennett Van Houten, Laboratory of Molecular Genetics, NIEHS, Research Triangle Park, NC, USA
Cellular responses to DNA damage: Molecular mechanisms and spatio-temporal organization in
living mammalian cells
Jiri Lukas, Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society,
Copenhagen, Denmark
15.10 (30min)
15.45 - 16.00
DNA double strand break repair and cancer predisposition: Lessons from human syndromes
Mark O’Driscoll, Genome Damage and Stability Centre, University of Sussex, East Sussex United Kingdom
Coffee break
16.00 - 17.30
Session DNA damage and repair processes II.
Chair: Bennett Van Houten
16.00 (30min)
Repair of oxidative DNA damage in the helicase mutants
Miroslav Pirsel, Cancer Research Institute of SAS, Bratislava, Slovakia
16.35 (15min)
Repair of oxidative DNA damage in human cancers
Barbara Tudek, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland
16.55 (15min)
DNA repair capacity in individuals exposed to styrene and patients with type 1 diabetes mellitus
Rudolf Stetina, Faculty of Military Health Sciences, Czech Republic
17.15 (15min)
Current aspects on stannous chloride genotoxicity
Cristina Pungartnik, Universidade Estadual de Santa Cruz, Bahia, Brasil
17.30 - 18.00 Sponsoring company lecture
Speaker and the title to be confirmed, Siemens, Division of Medical Instruments
19.00 - 22.00
Dinner
TUESDAY 22 August 2006
8.30 - 9.20
8.30 (45min)
9.20 - 11.00
Keynote lecture
Chair: Zdena Bartosova
Towards the therapy of tumours with microsatellite instability
Josef Jiricny, Institute of Molecular Cancer Research, University of Zürich, Switzerland
Session Cancer Genetics
Chair: Karl Heinimann
9.20 (30min)
Functional significance and clinical phenotype of non-truncating inherited mismatch repair gene
variants
Minna Nyström, Department of Biological and Environmental Sciences, University of Helsinki, Finland
9.55 (30min)
FAP and HBOC: two players in one playground
Vladimir Zajac, Cancer Research Institute of SAS, Bratislava, Slovakia
10.30 (30min)
Advances in molecular diagnostics of hereditary non-polyposis colorectal cancer in Slovakia
Zdena Bartosova, Cancer Research Institute of SAS, Bratislava, Slovakia
11.00 - 11.30
Coffee break
11.30 - 13.00
Session Tumor cell signaling and cell death
Chair: Josef Jiricny
11.30 (30min)
Cell adhesion in tumor invasion and metastasis
Gerhard Christofori, Institute of Biochemistry and Genetics, University of Basel, Switzerland
12.05 (30min)
Nemosis – prospective cell based cancer therapy
Jozef Bizik, Cancer Research Institute of SAS, Bratislava, Slovakia
12.40 (15min)
Preliminary study on VEGF signalling in astroglial cell line A172
Petra Knizetova, Institute of Pathology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
13.00 - 14.00
Lunch
14.00 - 15.45
Session Carcinogenesis/Anticarcinogenesis I.
Chair: Miroslav Pirsel
14.00 (30min)
From initial DNA damage to cancer: lessons from mouse models
Leonard Mullenders, Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands
14.35 (30min)
Cancer prevention by fruits and vegetables; not just a question of antioxidants
Andrew Collins, Department of Nutrition, University of Oslo, Blindern, Oslo, Norway
15.10 (30min)
Anticarcinogenic activity of dietary isothiocyanates
Yongping Bao, University of East Anglia, Norwich, UK
15.45 - 16.15
Coffee break
16.15 - 18.00
Session Carcinogenesis/Anticarcinogenesis II.
Chair: Minna Nyström
16.15 (30min)
Cellular response to oxidative DNA damage in Saccharomyces cerevisiae
Miroslav Chovanec, Cancer Research Institute of SAS, Bratislava, Slovakia
16.50 (30min)
Modulation of laryngeal cancer incidence and progression by gene polymorphism
Krzysztof Szyfter, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
17.25 (30min)
Prevention of hereditary colorectal cancer
Hansjakob Mueller, University of Basel, Basel, Switzerland
19.00 - 22.00
Poster viewing & Dinner
WEDNESDAY 23 August 2006
8.30 - 18.00
Social events
Alternative 1 - Hiking in High Tatras
Alternative 2 - Historical sightseeing tour
19.00 - 23.30
Invited speakers dinner
THURSDAY 24 August 2006
8.30 - 9.20
8.30 (45min)
9.20 - 10.50
Keynote lecture
Chair: Cestmir Altaner
Targeted therapy: from bench to bedside
Ivan Horak, Research and Development, Enzon Pharmaceuticals, Inc., New Jersey, USA
Session Tumor - tailored therapies
Chair: Ivan Horak
9.20 (30min)
Chemoprotective gene therapy
Geoffrey Margison, Paterson Institute for Cancer Research, Manchester, United Kingdom
9.55 (30min)
A possible role of dietary chemopreventive compounds in tumor therapy
Jan Sedlak, Cancer Research Institute of SAS, Bratislava, Slovakia
10.30 (15min)
Tumor regression by anti-sense therapy against Plk1 and Bcl-2
Martin Brendel, Universidade Estadual de Santa Cruz, Bahia, Brasil
10.50 - 11.10
Coffee break
11.10 - 12.25
Session Stem cells and cancer stem cells
Chair: Geoffrey Margison
11.10 (30min)
Normal and cancer stem cells: potential implication for cancer therapy
Cestmir Altaner, Cancer Research Institute of SAS, Bratislava, Slovakia
11.45 (15min)
Cell cycle and DNA – damage response in murine embryonic stem cells
Vladimir Divoky, Faculty of Medicine Palacky University, Olomouc, Czech Republic
12.05 (15min)
Retrovirus transduced human adipose tissue-derived mesenchymal stem cells exert strong
antitumor effect
Lucia Kucerova, Cancer Research Institute of SAS, Bratislava, Slovakia
12.25 - 13.00
Session Cancer proteomics
Chair: Jozef Bizik
12.25 (15min)
Mass spectrometry analyses of the serum proteome in molecular diagnostics of cancer
Piotr Widlak, Maria-Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
12.45 (15min)
Applied Biosystems solutions for oncomarkers screening and development “BIOiTRAQ and
MIDAS proteomic technology”
Zdeno Cervenak, Applied Biosystems
13.00 - 14.00
Lunch
14.00 - 16.00
Young scientists present
Chairs: Jiri Lukas & Josef Jiricny
14.00 (7min)
Modulation of human monocyte-derived dendritic cell maturation by BioBran
Jana Jakubikova, Cancer Research Institute of SAS, Bratislava, Slovakia
14.10 (7min)
Sialic acid expression evaluation as a marker of neoplastic transformation of thyroid gland
Pavol Janega, Comenius University, Medical Faculty Bratislava, Slovakia
14.20 (7min)
Evaluation of nitroreductase and acetyltransferase participation in N-nitrosodiethylamine
genotoxicity
Claudia Alessandra Fortes Aiub, Division of Genetics, Salzburg University Austria
14.30 (7min)
Stress-induced inactivation of transcription factor c-Myb through conjugation of SUMO-2/3
proteins
Marek Sramko, Cancer Research Institute of SAS, Bratislava, Slovakia
14.40 (7min)
Mutation screening of BRCA1, BRCA2 and CHEK2 in Slovak HBOC families
Sona Ciernikova, Cancer Research Institute of SAS, Bratislava, Slovakia
14.50 (7min)
Cyclin-dependent kinase 2 (CDK-2) expression in human melanocytic lesions as a potential
prognostic marker of melanoma
Łukasz Kuzbicki, Institute of General and Molecular Biology, Nicolaus Copernicus University, Torun, Poland
15.00 (7min)
The yeast Snm1/Pso2 protein and its possible interactions
Zuzana Dudasova, Cancer Research Institute of SAS, Bratislava, Slovakia
15.10 (7min)
APC gene mutations may clinically mimic Lynch syndrome
Michal Kovac, Cancer Research Institute of SAS, Bratislava, Slovakia
15.20 (7min)
Formalin-induced fluorescence and Melan - A of cells of human melanoma
Anna Sztramska, Institute of General and Molecular Biology, Nicolaus Copernicus University, Torun, Poland
15.30 (7min)
Isothiocyanate E-4IB-induced MAPK activation, delayed transition through cell cycle and G 2/Mlinked apoptosis
Juraj Bodo, Cancer Research Institute of SAS, Bratislava, Slovakia
15.40 (7min)
Molecular mechanisms of zinc-induced growth inhibition in colorectal cells
Hana Andelova, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic
15.50 (7min)
Development of SNP - based method for directed HNPCC mutation screening
Maria Bujalkova, Cancer Research Institute of SAS, Bratislava, Slovakia
16.00 - 16.30
Closing ceremony
17.00 - 18.00
European Social Fund Project Discussion Session
17.00 (60min)
20.00 - 23.30
Innovative education programme of young creative experts in cancer research (for ESF lecturers and
stipendiaries only)
Gala dinner
FRIDAY 25 August 2006
10.00
Bus Departure (Stara Lesna - Bratislava)