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From: The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels
Journal of Vision. 2008;8(1):10. doi:10.1167/8.1.10
Figure Legend:
Dark: The chromophore molecule, 11-cis-retinal, lies in the pocket formed by the seven trans-membrane helices of the
G-protein-coupled-receptor-protein rhodopsin (R). Both the G-protein transducin (Gα-GDP-Gβ-Gγ) and the tetrameric
effector enzyme phosphodiesterase (PDE6) are in their inactive states; and the intracellular concentration of cGMP is
relatively high. cGMP is thus able to bind to and open cyclic-nucleotide-gated (CNG) channels in the plasma membrane,
through which Ca2+ and Na+ ions flow into the cell. Activation: The absorption of a photon isomerizes the chromophore to
its all-trans form and triggers a conformational change of the rhodopsin into its activated state (R*). R* then activates
transducin
by catalyzing
GDP for GTP,
which causes
theand
separation
of activated
α-transducin
Date
of download:
5/3/2017 the exchange
TheofAssociation
for Research
in Vision
Ophthalmology
Copyright
© 2017. All(Gα*)
rights reserved.
from the trimer. Gα* in turn activates the phosphodiesterase enzyme (PDE6*) by exposing a site that catalyzes the