Download Synthetic oxygen carriers

Synthetic Oxygen Carriers
Mohamed Dorgham
Assisstent Lecturer in Anaesthesiology
Depatement Ain-Shams University.
Red Blood Cell Substitute
O2 Carriers
Lack
coagulation
Immune function
Nutrition
Plasma protiens
HB Solutions
PFC
HB Solutions
HB
Tetramer
Dimers
Monomers
1. Filtered by the kidney
2. NO scavenger
3. Increase plasma osmotic
pressure
4. High O2 affinity
1. Ultrastructural modification
2. Artificial Blood Cells
1. Ultrastructural modification
Monomers and Dimers
Cross linking
Conjugantion
Ultra purification
Polymerization
Microspheres
Tetramers
Recombinent
DNA
2. Artificial Blood Cells
Encapsulated Hb in cell like structure
Liposomes
=
Pseudoerythrocyte
Nanocapsules
Coated with
Phospholipid Bilayer
and
Cholesterol
Coated with
Polylactide
Immunsuppression
Decreased
phagocytic activity
Coagulopathy
RBC membrane
Free radicals
Artificial RBC
Adverse
Effects
Of Hb
Solutions
Neurotoxicity
NO inactivation
Nephrotoxicity
RBC membrane
Vasoconstriction
NO inactivation
Endothelins
Lab Interference
PFC
Synthetic organic liquid compounds
8-10 carbon atoms
H+ atoms
!st Generation
Halogens
Flourine
Bromine
Iodine
Fluosol 20%
•Stored Frozen
•Limited O2 carrying
capacity.
Allergic reaction
2nd Generation
Oxygent 90%
•Stored at 4’c
•High O2 Carrynig
capacity
1. Higher O2 Solubility
Coefficient.
• Resuscitation
•Preop Blood donation
•Periop hemodilution
•Organ preservation
2. V. low viscosity
•Sickle crisis
•Vascular diseases
•Synthetic vessels
(CPB,ECMO, HD)
•Alveolar recruitment
•Liquid ventilation
•Decompression sickness
•Septic shock
3. High Density
4. High N2 Solubility
5. Inactivate NO
Allergy
Especially 1st Gen
Increase
Liver
Enzymes
Adverse
Effects
Of PFC
•Acute Rt sided Failure
Pulmonary Plt microemboli
•Pulmonary Hage
•Pulmonary edema
Bleeding
Tendency
Decrease
Plt Count
•Early: Headache
•Late: Flu like symptoms
Thank You