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Transcript 
Catalysis
Chapter 11
MichaelisMenten
Enzyme
Kinetics
Enzymes lower activation energy
Transition state stabilization
The binding of substrate more tightly in the transition state
results in a higher rate of reaction
Figure 11.3
Serine Proteases
Serine Protease Reaction
Formation of an acyl-enzyme
intermediate
Figure 11.5
Transition State Intermediate
Chymotrypsin Structure
Chymotrypsin
Active Site
Chymotrypsin
Domains
Serine Protease Specificity
Figure 11.11
Specificity pocket of mutant chymotrypsin
Figure 11.12
N-terminal
alpha-beta
structure (blue)
Subtilisin Structure
Catalytic triad
(purple)
Central
structure
(yellow)
Peptide
(red)
C-terminal
structure
(green)
Figure 11.13
Subtilisin active site
Subtilisin active site
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