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Anna C. Nelson Dittrich Department of Biochemistry and Biophysics Texas A&M University College Station, TX 77843 Phone: (979) 845-2600 Email: [email protected] EDUCATION Texas A&M University, College Station, TX Ph.D. Biochemistry GPA: 3.90/4.00 2006 – 2012 Southwestern Oklahoma State University, Weatherford, OK B.S. Biology (minor chemistry) GPA: 3.92/4.00 2002 – 2006 RESEARCH INTERESTS Protein phosphorylation and signal transduction pathways, cell death regulation, comparative and evolutionary biology, evolution of conserved pathways, plant-pathogen and plant-insect interactions, evolution of herbivory and host specificity, natural variation in host-parasite interactions. RESEARCH POSITIONS University of Arizona – Department of Ecology and Evolutionary Biology Postdoctoral researcher (PI: Noah Whiteman) Main project: Evolutionary biochemistry of mustard oil detoxification in the Drosophilidae Other projects: Thermal ecology of plant-herbivore interactions 2012 – Present Texas A&M University – Department of Biochemistry and Biophysics 2006 – 2012 Ph.D. student (PI: Timothy Devarenne) Dissertation project: Investigation of a 3-phosphoinositide-dependent protein kinase-1 (PDK1) homologue in the moss Physcomitrella patens. Other projects: Characterization of a second PDK1 phosphorylation site in the cell-death suppressing protein kinase Adi3, identification of an Adi3 mutant that can specifically utilize bulky ATP analogues. Southwestern Oklahoma State University – Department of Chemistry and Physics 2005 – 2006 Undergraduate research assistant (PIs: William Kelly and Doris Benbrook) Project: Characterization of the apopotosis-inducing effects of SHet-A2, a heteroarotinoid anticancer drug, on mitochondria isolated from cancer cell lines. Southwestern Oklahoma State University – Department of Biological Sciences Undergraduate research assistant (PI: Muatasem Ubeidat) Project: Investigation of 5’-nucleotidase localization and activity in Dictyostelium discoideum. 2004 – 2006 Southwestern Oklahoma State University – Department of Biological Sciences 2004 – 2006 Undergraduate research assistant (PI: Peter Grant) Project: Collection and cataloging of mayfly species in all major waterways throughout Oklahoma. MENTORING Devarenne lab – Texas A&M University Mentor to undergraduate research assistant Three semesters mentoring an undergraduate researcher, Austin Rivera 2010 – 2012 1 Project: Interaction between 3-phosphoinositide-dependent protein kinase-1 (PDK1) and the receptor-like kinase BAK1 in Arabidopsis. Biochemistry Graduate Student Association – Texas A&M University 2007 – 2012 Active member and mentor to new graduate students Provide advice and assistance to one incoming biochemistry graduate student each year Participate in recruitment of new biochemistry graduate students each spring Assist first-year biochemistry graduate students with development of an original research proposal (ORP) that is presented at the end of their first year Ubeidat lab – Southwestern Oklahoma State University Mentor to undergraduate research assistants Provide advice and assistance to several new undergraduate researchers Project: Investigation of 5’-nucleotidase localization and activity in Dictyostelium discoideum. 2005 – 2006 TEACHING EXPERIENCE Department of Biochemistry and Biophysics – Texas A&M University Teaching Assistant for Donald Pettigrew – BICH 410 (Comprehensive biochemistry I) lecture 2011 Department of Biochemistry and Biophysics – Texas A&M University Teaching Assistant for Bryant Miles – BICH 411 (Comprehensive biochemistry II) lecture 2010 Department of Biochemistry and Biophysics – Texas A&M University Teaching Assistant for Bill Park – BICH 411 (Comprehensive biochemistry II) lecture 2009 Department of Biochemistry and Biophysics – Texas A&M University Teaching Assistant for Leisha Mullins – BICH 411 (Comprehensive biochemistry II) lecture 2008 Department of Biological Sciences – Southwestern Oklahoma State University Teaching Assistant for Muatasem Ubeidat – BIOL 3254 (Genetics) laboratory 2005 Department of Biological Sciences – Southwestern Oklahoma State University 2004 – 2005 Biology departmental tutor – BIOL 1004 (Biological Concepts), BIOL 1054 (Principles of Biology), BIOL 2204 (Introductory Zoology), BIOL 2404 (Introductory Botany), BIOL 3254 (Genetics), BIOL 3704 (Human Anatomy) AWARDS 2012: Postdoctoral Excellence in Research and Teaching (PERT) fellowship, University of Arizona Center for Insect Science 2012: John Mack Prescott graduate research and academic excellence award ($1000), Texas A&M Department of Biochemistry and Biophysics 2011: Travel grant award ($575), American Society of Plant Biologists 2011: Travel grant award ($600), Texas A&M Department of Biochemistry and Biophysics 2010: Teaching excellence award for 2009, Texas A&M Department of Biochemistry and Biophysics 2008: Third place, Biochemistry and Biophysics departmental research competition ($200) 2006: Molecular and Cellular Biology training program, Texas A&M Department of Biochemistry and Biophysics 2006: Graduate merit fellowship, Texas A&M University 2006: Hobart F. Landreth award for outstanding research, Southwestern Oklahoma State University 2006: INBRE summer research grant ($3000), Southwestern Oklahoma State University 2 2005: M.D. Jirous Foundation scholarship, Southwestern Oklahoma State University 2005: Otis King memorial scholarship, Southwestern Oklahoma State University 2005: Mary L. Miller field biology award, Southwestern Oklahoma State University ORGANIZATIONS AND ACTIVITIES Texas A&M Student Research Week judge 2012 American Society of Plant Biologists member 2011 – present QPR Suicide Prevention, certified gatekeeper 2011 – present Reviewed manuscripts: FEBS Lett, J Biol Chem, Plant Physiol Biochem Laboratory Management and Conflict Resolution workshop participant, Texas A&M University 2010-2012 2010 Biochemistry Original Research Proposal volunteer, Texas A&M University 2007 – 2012 Biochemistry graduate student recruiting volunteer, Texas A&M University 2007 – 2012 Biochemistry Graduate Association member, Texas A&M University 2006 – 2012 Molecular and Cellular Biology training program, Texas A&M University 2006 – 2007 National Honor Society member 2005 – 2006 Weatherford blood testing clinic volunteer, Southwestern Oklahoma State University 2004 – 2006 Biology Club member, Southwestern Oklahoma State University 2003 – 2006 PUBLICATIONS Nelson Dittrich AC, Devarenne TP (2012) Perspectives in PDK1 evolution: insights from photosynthetic and nonphotosynthetic organisms. Plant Signaling and Behavior in press, publication June 2012. Nelson Dittrich AC, Devarenne TP (2012) Characterization of a PDK1 homologue from the moss Physcomitrella patens. Plant Physiology 158: 1018-1033. Nelson Dittrich AC, Devarenne TP (2012) An ATP analog-sensitive version of the tomato cell death suppressor protein kinase Adi3 for use in substrate identification. Biochimica et Biophysica Acta Proteins and Proteomics 1824: 269-273. Le TC, Berlin KD, Benson SD, Eastman MA, Bell-Eunice G, Nelson AC, and Benbrook DM (2007) Heteroarotinoids with anti-cancer activity against ovarian cancer cells. Open Medicinal Chemistry Journal 1: 1123. MANUSCRIPTS IN PREPARATION Nelson Dittrich AC, Devarenne TP. Significance of a second major phosphorylation site on the tomato cell death suppressing protein kinase Adi3. Nelson A, Cifuentes-Rojas C, Shakirov EV, Nelson Dittrich AC, Shippen DE. AtPOT1b: a telomerase accessory factor important for the processing of TER2 in Arabidopsis thaliana. Nelson A, Renfrew K, Nelson Dittrich AC, Surovtseva Y, Shippen DE. POT1c: a novel component of the telomere capping complex and negative regulator of telomerase activity in Arabidopsis thaliana. 3 PRESENTATIONS 2012: “Regulation of plant cell death by conserved protein kinases.” Invited talk, SWOSU Biology departmental seminar series. February 2012, Southwestern Oklahoma State University (Weatherford, OK). 2011: “3-phosphoinositide dependent protein kinase-1 in the moss Physcomitrella patens.” August 2011, American Society of Plant Biologists annual meeting (Minneapolis, MN). 2008: “Activation of the protein kinase Adi3, a negative regulator of cell death in tomato, by the upstream kinase PDK1.” Biochemistry student research competition. February 2008, Texas A&M University (College Station, TX). 2006: “Mitochondrial effects of the anticancer compound SHetA2 on ovarian cancer.” INBRE summer research seminar. July 2006, University of Oklahoma Health Sciences Center (Oklahoma City, OK). 2006: “Importance of Dictyostelium discoideum 5’ nucleotidase.” Oklahoma Research Day for Regional Universities. Spring 2006, Oklahoma State Capitol Building (Oklahoma City, OK). 2005: “Dictyostelium discoideum 5’ nucleotidase activity and localization.” SWOSU Research Day. Spring 2005, Southwestern Oklahoma State University (Weatherford, OK). REFERENCES Noah Whiteman, University of Arizona Department of Ecology and Evolutionary Biology 1041 E. Lowell St., P.O. Box 210088 Tucson, AZ 84721 Phone: (520) 626-3950 E-mail: [email protected] Timothy Devarenne, Texas A&M University Department of Biochemistry and Biophysics 300 Olsen Blvd. College Station, TX 77840 Phone: (979) 862-6509 E-mail: [email protected] Bill Park, Texas A&M University Department of Biochemistry and Biophysics 300 Olsen Blvd. College Station, TX 77840 Phone: (979) 845-8868 E-mail: [email protected] Michael Polymenis, Texas A&M University Department of Biochemistry and Biophysics 300 Olsen Blvd. College Station, TX 77840 Phone: (979) 458-3259 E-mail: [email protected] 4