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Polytrauma induces increased expression of pyruvate kinase in neutrophils by Rudolf Oehler, Gertrude Weingartmann, Nicole Manhart, Ulrich Salzer, Michael Meissner, Werner Schlegel, Andreas Spittler, Michael Bergmann, Daniela Kandioler, Christiane Oismüller, Heidi M. Struse, and Erich Roth Blood Volume 95(3):1086-1092 February 1, 2000 ©2000 by American Society of Hematology Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Schematic representation of the relationship between glycolysis, pentose phosphate pathway, and formation of oxygen radicals by NADPH oxidase.The form of arrows indicates the specific enzyme activities in PMNs as determined previously by Fauth et al17: thic... Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Lactate production of PMNs from PT patients and healthy volunteers.PMNs were isolated from venous blood of healthy volunteers (nā=ā5) and PT patients (nā=ā5) between the second and fifth posttraumatic day. Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Influence of glucose breakdown on superoxide anion production in PMNs.Superoxide anion production was determined as SOD-inhibitable cytochrome c reduction. Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology Glucose-dependent respiratory burst activity in PMNs from PT patients and healthy volunteers.Superoxide anion production was determined as SOD-inhibitable cytochrome c reduction. Rudolf Oehler et al. Blood 2000;95:1086-1092 ©2000 by American Society of Hematology