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S2 Table. IPA biofunctions deregulated following 3-day BPA treatment in FRTL-5 cells
Categories
Diseases or
Functions
Annotation
Cell Cycle
cell cycle
progression
Cell Death and Survival cell death of tumor
cell lines
Cell Cycle
M phase of tumor
cell lines
Cell Death and Survival cell death
p-Value
Cell Cycle
M phase of
cervical cancer cell
lines
Cell Death and Survival necrosis
Cell Death and Survival apoptosis of
cervical cancer cell
lines
Cellular Development, proliferation of
Cellular Growth and
tumor cell lines
Proliferation
Cellular Growth and
proliferation of
Proliferation
cells
Cell Cycle, DNA
checkpoint control
Replication,
Recombination, and
Repair
DNA Replication,
metabolism of
Recombination, and
DNA
Repair
Lipid Metabolism,
metabolism of
Small Molecule
sterol
Biochemistry, Vitamin
and Mineral
Metabolism
Lipid Metabolism,
metabolism of
Small Molecule
cholesterol
Biochemistry, Vitamin
and Mineral
Metabolism
Organismal Survival
organismal death
Cell Cycle, Cellular
cytokinesis of
Movement
tumor cell lines
Cell Cycle,
entry into
Reproductive System
interphase of
Development and
oocytes
Function
Cell Death and Survival cell survival
Activation
z-score
1.68E-22
Predicted
Activation
State
Decreased
-2.133
Number
of
molecules
80
3.21E-14
Increased
2.25
84
5.94E-13
Decreased
-2.909
19
2.03E-11
Increased
2.515
133
5.86E-11
Decreased
-2.137
15
1.96E-10
1.44E-09
Increased
Increased
2.407
2.642
108
26
3.07E-09
Decreased
-5.284
72
8.49E-09
Decreased
-5.383
133
2.09E-08
Decreased
-2.158
15
4.01E-08
Decreased
-2.175
30
5.88E-08
Decreased
-2.565
15
2.47E-07
Decreased
-2.376
14
7.08E-07
3.36E-06
Increased
Decreased
4.143
-2.357
92
10
3.90E-06
Decreased
-2
4
3.95E-06
Decreased
-3.811
60
Cell Death and Survival
Lipid Metabolism,
Small Molecule
Biochemistry, Vitamin
and Mineral
Metabolism
Cellular Development,
Cellular Growth and
Proliferation
Cell Death and Survival
cell viability
steroid metabolism
3.51E-05
5.71E-05
Decreased
Decreased
-3.074
-2.723
54
18
proliferation of
hepatoma cell lines
1.48E-04
Decreased
-2.867
14
cell viability of
tumor cell lines
Cancer, Gastrointestinal growth of liver
Disease, Hepatic
tumor
System Disease,
Organismal Injury and
Abnormalities
Cancer, Gastrointestinal growth of
Disease, Hepatic
hepatocellular
System Disease,
carcinoma
Organismal Injury and
Abnormalities
Cancer, Organismal
head and neck
Injury and
cancer
Abnormalities
Cell Morphology,
repair of cells
Cellular Function and
Maintenance
Cell Death and Survival cell viability of
myeloma cell lines
Embryonic
death of embryo
Development,
Organismal Survival
Cellular Development, proliferation of
Cellular Growth and
carcinoma cell
Proliferation
lines
Infectious Disease
Viral Infection
Cell Morphology,
repair of tumor cell
Cellular Function and
lines
Maintenance
Tissue Morphology
quantity of tumor
cell lines
Cancer, Gastrointestinal growth of digestive
Disease, Organismal
organ tumor
Injury and
Abnormalities
Cell Cycle
aneuploidy
Infectious Disease,
infection of
Organismal Injury and
embryonic cell
Abnormalities
lines
infection of
Infectious Disease
epithelial cell lines
1.84E-04
Decreased
-3.401
35
3.37E-04
Decreased
-2.599
7
4.45E-04
Decreased
-2.217
5
1.09E-03
Increased
2.183
29
1.21E-03
Decreased
-2.818
8
1.50E-03
Decreased
-2.828
8
1.50E-03
Increased
3.293
11
2.21E-03
Decreased
-2.179
17
2.44E-03
2.48E-03
Decreased
Decreased
-3.828
-2.449
57
6
2.49E-03
Increased
2.241
10
3.02E-03
Decreased
-2.773
8
4.08E-03
9.10E-03
Increased
Decreased
2.4
-2.365
7
14
9.10E-03
Decreased
-2.365
14
Cancer, Organismal
Injury and
Abnormalities
Infectious Disease,
Renal and Urological
Disease
Cellular Development,
Cellular Growth and
Proliferation
growth of
carcinoma
9.52E-03
Decreased
-2.938
9
infection of kidney
cell lines
1.14E-02
Decreased
-2.273
14
proliferation of
breast cancer cell
lines
1.32E-02
Decreased
-2.89
18