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Principal Investigator: James S. Economou (Last, first, middle) PHS 398/2590 OTHER SUPPORT ECONOMOU, J.S. ACTIVE R01 CA 79976 (Economou) 01/01/03-01/31/08 NIH/NCI $1,308,809 Dendritic cell-based genetic immunotherapy for melanoma. Role: Principal Investigator 1.2 calendar months 1 R01 CA129816-01 (Economou) 07/01/07-06/30/12 NIH/NCI $1,250,000 PET imaging of MART TCR-engineered CD8 T cells immunotherapy in man. Role: Principal Investigator (with Antoni Ribas as Co-PI) 2.4 calendar months W M Keck Foundation (Economou) Genetic Engineering of the Human Immune System. Role: Principal Investigator 1.2 calendar months 07/01/07-06/30/10 $1,800,000 20061804 (Economou) 07/01/06-06/30/08 .60 calendar months Samuel Waxman Cancer Research Fund $600,000 The UCLA-Caltech-USC Children’s Hospital-UConn Engineered Immunity Consortium of TCR-Engineered Immunity Consortium of TCR-Engineered Lymphocytes for In Vivo Targeting and Treatment of Human Melanoma. Role: Principal Investigator K12 CA76905 (Economou) NIH/NCI Clinical Scientist Training in Cancer Gene Medicine. Role: Principal Investigator 07/01/97-6/30/08 $2,319,760 1.2 calendar months National Gene Vector Laboratories (Economou) NIH Treatment and biological imaging of patients with locally advanced or metastatic melanoma with lentiviral vector MART-1 TCR/HSV1-sr39tk (FUW-M1-TCR/sr39tk) engineered lymphocytes MART-1 pulsed dendritic cells, and interleukin-2 after a nonmyeloablative conditioning regimen (for construction of a clinical grade lentiviral vector). National Institutes of Health Rapid Access to Interventional Development RAID Project No. 176: “A Phase I/II Trial Testing Immunization with AFP Plasmid Prime and AFP Adenoviral Vector Boost in Patients with Hepatocellular Carcinoma.” Total Award: cost of GMP manufacture > $1 million (2003-2007) P30 CA016042 (Gasson) NIH/NCI UCLA-Jonsson Comprehensive Cancer Center Cancer Center Support Grant Role: Deputy Director PHS 398/2590 (Rev. 09/06) 12/1/02 -11/30/08 $3,067,154 Page _____ 2.4 calendar months Other Support Format Page Principal Investigator: James S. Economou (Last, first, middle) R01 CA104524 (Butterfield) 2007-2010 NIH/NCI $750,000 Title: AFP-based prime boost immunotherapy for hepatocellular cancer Role: Co-Principal Investigator .24 calendar months P50 CA 086306 (Herschman) 05/01/05- 04/30/10 NIH/NCI $1,274,299 Title: The UCLA Center for In Vivo Imaging in Cancer Biology. Project I. In vivo imaging of antigen-specific T cells in mice and humans. Role: Co-Investigator (with Ribas) .60 calendar months R01 CA 112358 (Liau) 04/01/06-06/30/11 NIH/NCI $1,000,000 Dendritic cell-based vaccine targeting MAA in malignant gliomas. Role: Co-Investigator .24 calendar months PENDING P01 CA132681 (Baltimore) NIH/NCI Stem Cell Engineered Tumor Immunity in Man Role: Principal Co-Investigator 04/01/08-03/30/12 $17,987,545 R01 NS054093 (Liau) 2007-2012 NIH/NCI $1,125,000 Adoptive transfer of allo CTL for immunotherapy of recurrent grade III gliomas. Role: Co-Investigator PHS 398/2590 (Rev. 09/06) Page _____ 2.4 calendar months .60 calendar months Other Support Format Page