Download Complexation

PHM 1213 Physical Pharmacy 1
Tutorial
Complexation
1. Describe the following terms:
a. Ligand
b. Chelate
c. Coordination bond
d. Coordination number
e. Complex ion
f. Counter ion
g. Coordination compound
2. Give one example and the corresponding structure, for each of the following geometrical
complexes:
a. Linear
b. Tetrahedral
c. Square planar
d. Octahedral
3. Give one example for each of the following:
a. Unidentate ligand
b. Bidentate ligand
c. Quadridentate ligand
d. Hexadentate ligand
4. Describe the bonding in Al(H2O)6 3+ ion. Explain the reason for the six coordination
bonds. Support your answer with relevant illustration.
5. Describe the bonding of a complex ion formed using a hexadentate ligand.
6. Give an example of a multi-dentate ligand that functions in the biological system.
7. Show the importance of geometrical isomerism in the activity of a particular drug. Give an
example.
8. EDTA is used to prevent blood from coagulating. Describe how it functions.
9. Compare the bonding in metal ion complexes and organic molecular complexes. Give
three examples of organic molecular complexes.
10. Inclusion compounds have great advantages in drug delivery. Answer the following with
the aid of a diagram, wherever possible.
a. What is an inclusion compound?
b. List the types of inclusion compounds.
c. Give an example of an inclusion compound.
d. What is a monomolecular inclusion compound?
e. What are the advantages of the formation of inclusion compound complexes from
the pharmaceutical viewpoint? Give three examples.
f. Why is there a need to prepare derivative of an inclusion compound?
Prepared by: Kausar Ahmad
Date: 25-Jan-04
Page 1 of 1