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Table S1. List of tumor invasion and metastasis (TIM) related transcripts archived in the QPCR profiling, and their location and types Symbol ADAMTS1 ALDH3A1 BIRC3 CASP8 CCNE2 CCR7 CD44 CD82 CDH1 CDH11 CDH6 COL4A2 CST7 CTGF CTSB CTSD CTSK CTSL CXCL12 CXCR4 DRG1 EREG FGFR4 FLT1 FLT4 HDAC1 HGF HMGB1 HRAS HTATIP2 ID1 IGFBP7 IL13RA2 IL1B ISG20 ITGA7 ITGB3 JAG1 KISS1 KLRC2 KRAS KYNU LTBP1 MAP2K4 MAP2K5 MAP2K7 MCAM Entrez Gene Name Location Type(s) ADAM metallopeptidase with thrombospondin type 1 motif, 1 aldehyde dehydrogenase 3 family, member A1 baculoviral IAP repeat containing 3 caspase 8, apoptosis-related cysteine peptidase cyclin E2 chemokine (C-C motif) receptor 7 CD44 molecule (Indian blood group) CD82 molecule cadherin 1, type 1, E-cadherin (epithelial) cadherin 11, type 2, OB-cadherin (osteoblast) cadherin 6, type 2, K-cadherin (fetal kidney) collagen, type IV, alpha 2 cystatin F (leukocystatin) connective tissue growth factor cathepsin B cathepsin D cathepsin K cathepsin L chemokine (C-X-C motif) ligand 12 chemokine (C-X-C motif) receptor 4 developmentally regulated GTP binding protein 1 epiregulin fibroblast growth factor receptor 4 fms-related tyrosine kinase 1 fms-related tyrosine kinase 4 histone deacetylase 1 hepatocyte growth factor (hepapoietin A; scatter factor) high mobility group box 1 Harvey rat sarcoma viral oncogene homolog HIV-1 Tat interactive protein 2, 30kDa inhibitor of DNA binding 1, dominant negative helix-loop-helix protein insulin-like growth factor binding protein 7 interleukin 13 receptor, alpha 2 interleukin 1, beta interferon stimulated exonuclease gene 20kDa integrin, alpha 7 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) jagged 1 KiSS-1 metastasis-suppressor killer cell lectin-like receptor subfamily C, member 2 Kirsten rat sarcoma viral oncogene homolog kynureninase latent transforming growth factor beta binding protein 1 mitogen-activated protein kinase kinase 4 mitogen-activated protein kinase kinase 5 mitogen-activated protein kinase kinase 7 melanoma cell adhesion molecule Extracellular Space Cytoplasm Cytoplasm Nucleus Nucleus Plasma Membrane Plasma Membrane Plasma Membrane Plasma Membrane Plasma Membrane Plasma Membrane Extracellular Space Extracellular Space Extracellular Space Cytoplasm Cytoplasm Cytoplasm Cytoplasm Extracellular Space Plasma Membrane Cytoplasm Extracellular Space Plasma Membrane Plasma Membrane Plasma Membrane Nucleus Extracellular Space Nucleus Plasma Membrane Nucleus Nucleus Extracellular Space Plasma Membrane Extracellular Space Nucleus Plasma Membrane Plasma Membrane Extracellular Space Cytoplasm Plasma Membrane Cytoplasm Cytoplasm Extracellular Space Cytoplasm Cytoplasm Cytoplasm Plasma Membrane peptidase enzyme enzyme peptidase other G-protein coupled receptor enzyme other other other other other other growth factor peptidase peptidase peptidase peptidase cytokine G-protein coupled receptor other growth factor kinase kinase transmembrane receptor transcription regulator growth factor transcription regulator enzyme transcription regulator transcription regulator transporter transmembrane receptor cytokine enzyme other transmembrane receptor growth factor other transmembrane receptor enzyme enzyme other kinase kinase kinase other Symbol MET METAP2 MGAT5 MMP1 MMP10 MMP11 MMP13 MMP14 MMP2 MMP3 MMP7 MMP9 MTA2 MTSS1 MYC NEDD9 NF2 NME1 NME2 NME4 NME5 PAX5 PDGFA PLAUR PTEN PTGS2 RUNX1 SERPINB2 SERPINB5 SERPINE1 SMAD2 SMAD4 SOX4 SPARC SPP1 SRC SYK TFF1 TGFB1 TIMP1 TIMP2 TIMP3 TIMP4 TNC TP53 VEGFA Entrez Gene Name Location Type(s) met proto-oncogene methionyl aminopeptidase 2 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase matrix metallopeptidase 1 (interstitial collagenase) matrix metallopeptidase 10 (stromelysin 2) matrix metallopeptidase 11 (stromelysin 3) matrix metallopeptidase 13 (collagenase 3) matrix metallopeptidase 14 (membrane-inserted) matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) matrix metallopeptidase 3 (stromelysin 1, progelatinase) matrix metallopeptidase 7 (matrilysin, uterine) matrix metallopeptidase 9 (gelatinase B,, 92kDa type IV collagenase) metastasis associated 1 family, member 2 metastasis suppressor 1 v-myc avian myelocytomatosis viral oncogene homolog neural precursor cell expressed, developmentally down-regulated 9 neurofibromin 2 (merlin) NME/NM23 nucleoside diphosphate kinase 1 NME/NM23 nucleoside diphosphate kinase 2 NME/NM23 nucleoside diphosphate kinase 4 NME/NM23 family member 5 paired box 5 platelet-derived growth factor alpha polypeptide plasminogen activator, urokinase receptor phosphatase and tensin homolog prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) runt-related transcription factor 1 serpin peptidase inhibitor, clade B (ovalbumin), member 2 serpin peptidase inhibitor, clade B (ovalbumin), member 5 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SMAD family member 2 SMAD family member 4 SRY (sex determining region Y)-box 4 secreted protein, acidic, cysteine-rich (osteonectin) secreted phosphoprotein 1 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog spleen tyrosine kinase trefoil factor 1 transforming growth factor, beta 1 TIMP metallopeptidase inhibitor 1 TIMP metallopeptidase inhibitor 2 TIMP metallopeptidase inhibitor 3 TIMP metallopeptidase inhibitor 4 tenascin C tumor protein p53 vascular endothelial growth factor A Plasma Membrane Cytoplasm Cytoplasm kinase peptidase enzyme Extracellular Space Extracellular Space Extracellular Space Extracellular Space Extracellular Space Extracellular Space peptidase peptidase peptidase peptidase peptidase peptidase Extracellular Space Extracellular Space Extracellular Space Nucleus Cytoplasm Nucleus Nucleus Plasma Membrane Cytoplasm Nucleus Cytoplasm Other Nucleus Extracellular Space Plasma Membrane Cytoplasm Cytoplasm peptidase peptidase peptidase transcription regulator other transcription regulator other other kinase kinase kinase kinase transcription regulator growth factor transmembrane receptor phosphatase enzyme Nucleus Extracellular Space Extracellular Space Extracellular Space transcription regulator other other other Nucleus Nucleus Nucleus Extracellular Space Extracellular Space Cytoplasm Cytoplasm Extracellular Space Extracellular Space Extracellular Space Extracellular Space Extracellular Space Extracellular Space Extracellular Space Nucleus Extracellular Space transcription regulator transcription regulator transcription regulator other cytokine kinase kinase other growth factor other other other other other transcription regulator growth factor
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