Download Search for gene information Set 1 Set 2 Set 3 Set 4 Set 5 ABCG2

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Search for gene information
Set 1
Set 2
Set 3
Set 4
Set 5
ABCG2
(BCRP)
422
ABCC11
(MRP8)
498
SLC31A1
(CTR1)
469
ABCC3
(MRP3)
504
ABCA3
(ABC3)
463
ABCC1
(MRP1)
326
SLC29A1
(ENT1)
359
ABCC4
(MRP4)
394
ABCB5
(ABCB5)
369
ABCB1
(MDR1)
413
MVP
(LRP)
247
SLC28A1
(CNT1)
272
ABCB4
(MRP4)
329
ABCC10
(MRP7)
288
SLC29A2
(ENT2)
357
ATP7B
(WND)
161
ABCC9
(SUR2)
210
ABCG1
(ABC8)
258
ABCC5
(MRP5)
205
ABCA2
(ABC2)
289
CFTR
(ABCC7)
100
GAPDH
(GAPDH)
103
ABCC6
(MRP6)
205
ABCC2
(MRP2)
102
SLC28A2
(CNT2)
119
Search for substrate information
Set 1
Set 2
Set 3
Set 4
Set 5
ABCG2
Anthracyclines,
camptothecin,
epirubicin,
mitoxantrone,
SN-38, topotecan
ABCC11
5'-Fluorouracil,
5'-fluoro-2'deoxyuridine
SLC31A1
Cisplatin,
carboplatin,
oxaliplatin
ABCC3
Cisplatin,
doxorubicin,
etoposide,
methotrexate,
vincristine
ABCA3
Doxorubicin,
Daunorubicin
ABCC1
Anthracyclines,
etoposide,
vincristine,
vinblastine,
paclitaxel
SLC29A1
Cladribine, araC,
fludarabine,
gemcitabine
ABCC4
Methotrexate,
nucleoside
analogues
ABCB5
Doxorubicin,
Camptothecin,
5-FU
ABCB1
Anthracyclines,
taxanes, vinca
alkaloids,
etoposide,
Imatinib
MVP
Cisplatin,
doxorubicin,
vincristine,
carboplatin,
melphalan
SLC28A1
AraC, gemcitabine,
5’-deoxy-5fluorouridine
ABCB4
Pacletaxel,
vinblastine
ABCC10
Docetexel,
paclitaxel
SLC29A2
Gemcitabine,
cladribine
Flutarabine
ATP7B
Cisplatin,
carboplatin
ABCC9
Etoposide
ABCG1
Anti-cancer agents
ABCC5
Doxorubicin,
methotrexate,
nucleotide
analogs, topotecan
ABCA2
Mitoxantrone,
Estramustine
CFTR
Doxorubicin,
vincristine,
colchicine
GAPDH
ABCC6
Doxorubicin,
etoposide, teniposide
ABCC2
Cisplatin, CPT-11,
doxorubicin,
etoposide,
methotrexate, SN38, vincristine,
vinblastine
SLC28A2
Cladribine, 5fluoro-2'deoxyuridine
Drug information
Group
Anthracenediones
Anthracylines
Antimetabolites
(Nucleoside
analogues)
Anticancer mechanisms
Topoisomerase 2 inhibition + intercalation
Topoisomerase 2 inhibition + intercalation
Inhibition of nucleotide metabolism
Camptothecins
Nitorogen mustard
Platinum analogues
Podophyllotoxins
Taxenes
Vinca alkaloids
Topoisomerase 1 inhibition
Crosslinking DNA
Crosslinking DNA
Topoisomerase 2 inhibition
Block microtubule disassembly
Block microtubule assembly
Drug (Brand)
Carboplatin (Paraplatin)
Cisplatin (Platinol)
Cladribine (Leustatin)
Cytarabine, Ara-C (Cytosar-U)
Daunorubicin,
Daunomycin,
(Cerubidine)
5’-deoxy-5-fluorouridine,
5’-DFUR, Doxifluridine
(Furtulon)
Docetaxel (Taxotere)
Doxorubicin (Adriamycin)
Epirubicin (Ellence)
Estramustine (Estracyt)
Etoposide, VP-16
(Eposin, Etopophos, Vepesid )
Drugs
Mitoxantrone
Doxorubicin, daunorubicin, epirubicin
Folic acid: methotrexate
Purine: cladribine, fludarabine
Pyrimidine: 5-FU, 5’-deoxy-5-fluorouridine, 5’-fluoro-2’-deoxyuridine, cytarabine,
gemcitabine,
Topotecan, irinotecan
Estramustine
Cisplatin, carboplatin, oxaliplatin
Etoposide, teniposide
Paclitaxel, docetaxel
Vinblastine, vincristine
Clinical applications
Ovary, lung , breast cancer, bladder, head and neck
Lung, breast, bladder, head and neck, ovary, germ cell
Hairy cell leukemia (HCL), CLL, non-Hodgkin’s lymphoma
AML, ALL, non-Hodgkin lymphoma
AML, ALL
Colorectal cancer
Breast, ovary, non-small cell lung cancer, prostate, stomach, head and neck, ovary, bladder
Breast, lymphomas, soft tissue sarcoma, ovary, lung cancers, thyroid, Wilms’ tumor, neuroblastoma
Breast, ovary, stomach, lung, and lymphomas
Prostate cancer
Lung, testis, lymphoma, stomach, glioblastoma multiforme
Fludarabine (Fludara)
5’-fluoro-2’-deoxyuridine,
FUdR, FdUrd, Floxuridine
(FUDF)
5’-Fluorouracil ,5-FU( Adrucil)
Gemcitabine (Gemzar)
Imatinib (Gleevec)
Irinotecan, metabolite SN-38
(Camptosar)
Melphalan (Alkeran)
Methotrexate, MTX
(Amethoperrin)
Mitoxantrone (Novantrone)
Oxaliplatin (Eloxatin)
Paclitaxel (Taxol)
Teniposide (VM-26, Vumon)
Topotecan (Hycamtin)
Vinblastine (Velban)
Vincristine (Oncovin)
AML (FLAG regimen = fludarabine + ara c + granulocyte colony-stimulating factor), CLL, non-Hodgkin’s lymphoma
Colorectal cancer
Colorectal cancer, breast, anus, gastroesophageal cancer, head and neck, hepatocellular cancer
Non-small cell lung cancer, pancreas, bladder, breast, ovarian, non-Hodgkin’s lymphoma, soft tissue sarcoma
CML, gastrointestinal stromal tumors (GISTs), Philadelphia chromosome positive ALL
Colorectal cancer (FOLFIRI = Flolinc acid + infusional 5-FU + irinotecan), gastroesophageal cancer, small cell and
non-small cell lung cancers
Multiple myeloma, ovarian, breast, occasionally malignant melanoma
Breast, head and neck, bone, AML, non-Hodgkin's lymphoma, bladder, choricarcinoma
Prostate, non-Hodgkin’s lymphoma, breast, AML
Colorectal cancer (FOLFOX = Folinic acid + 5-FU + Oxaliplatin), pancreas, gastroesophageal cancer
Lung, ovarian, breast cancer, head and neck, bladder, prostate, gastroesophageal cancer
ALL
Small cell lung cancer, ovarian cancer
Lymphomas, non-small cell lung cancer, breast, head and neck, testis, Kaposi’s sarcoma
Non-Hodgkin's lymphoma (CHOP = cyclphosphamide + hydroxydaunorubicin (doxorubicin) + oncovin +
prednisone), Hodgkin's lymphoma (MOPP = mechlorethamine + oncovin + procarbazine + prednisone; COPP =
cyclophosphamide + oncovin + prednisone), ALL, neuroblastoma, Wilms’ tumor, rhabdomyosarcoma
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