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Treatment-influenced associations of PML-RARα
mutations, FLT3 mutations, and additional chromosome
abnormalities in relapsed acute promyelocytic leukemia
by Robert E. Gallagher, Barry K. Moser, Janis Racevskis, Xavier Poiré, Clara D.
Bloomfield, Andrew J. Carroll, Rhett P. Ketterling, Diane Roulston, Esther SchachterTokarz, Da-cheng Zhou, I-Ming L. Chen, Richard Harvey, Greg Koval, Dorie A. Sher,
James H. Feusner, Martin S. Tallman, Richard A. Larson, Bayard L. Powell,
Frederick R. Appelbaum, Elisabeth Paietta, Cheryl L. Willman, and Wendy Stock
Blood
Volume 120(10):2098-2108
September 6, 2012
©2012 by American Society of Hematology
Mutation sites in the ligand binding domain of PML-RARα after relapse on protocol C9710
(ATRA/CT-arm). ▴ represents site of 17 missense mutations; and ▵, site of 2 deletion (Δ)
mutations. Δ207-208, ΔK207Y208/T207 indicates deletion of lysine and tyrosine co...
Robert E. Gallagher et al. Blood 2012;120:2098-2108
©2012 by American Society of Hematology
Qualitative and quantitative variations in FLT3 mutations from diagnosis to relapse: majority
stable; loss of minor subclones; unbiased relapse distribution of FLT3-ITD+ On-ATRA/Off-ATRA;
possible On-ATRA relapse bias of FLT3-D835+; and coincidence of FLT3-...
Robert E. Gallagher et al. Blood 2012;120:2098-2108
©2012 by American Society of Hematology
In patients with PRα/LBD+, coincident ACA occurred more frequently after relapse Off-ATRA in
patients with ACA at diagnosis.
Robert E. Gallagher et al. Blood 2012;120:2098-2108
©2012 by American Society of Hematology