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Supplementary Table S1. Information on the class and target(s) of the drugs investigated by
the PPTP.
Drug
Vincristine
Eribulin
Cyclophosphamide
NSC750854
PR-104
Alternative name(s)
leurocristine, oncovin
Halaven
Cytophosphane
N/A
N/A
Alisertib
Vyxeos
MLN8237
CPX-351
MK-8242
SCH-900242
Topotecan
RG7112
Ispinesib
Temozolomide
Hycamtin
RO5045337
SB-715992
Temodar, Temodal,
Temcad
N/A
N/A
CBL0137
SAR3419
Navitoclax
Bortezomib
Broad class
Anti-mitotic
Anti-mitotic
DNA alkylating agent
Antimetabolite (purine analog)
DNA alkylating agent (delivered as preprodrug)
Anti-mitotic
Cytarabine; antimetabolite (pyrimidine
analog), daunorubicin; DNA-intercalator
MDM2 inhibitor
Cellular target(s)
Tubulin
Tubulin
DNA (structure)
DNA (synthesis)
DNA (structure)
Topoisomerase inhibitor
MDM2 inhibitor
Anti-mitotic
DNA alkylating agent
Topoisomerase I
MDM2
Kinesin spindle protein
Purines
Curaxin
Antibody-drug conjugate (anti-mitotic drug
component)
BH3 mimetic
Proteasome inhibitor
DNA (indirectly inhibits FACT)
Ab; CD19, cytotoxin (the
maytansinoid DM4); tubulin
Bcl-2/Bcl-xl/Bcl-w
26S proteasome
Kinase inhibitor
SMAC mimetic
MDM2 inhibitor
Kinase inhibitor
BH3 mimetic
Immune suppressant
HDAC inhibitor
PLK1, PLK2 and PLK3
cIAP1, cIAP2, XIAP
MDM2
CDK1, CDK2, CDK5 and CDK9
Bcl-2
mTOR, in complex with FKBP12
Primarily HDAC1, modest
targeting of HDACs 2-11
Exportin-1 (XPO1)
Src, Abl, c-Kit
PDGF-R, VEGF-Rs, c-KIT, RET,
CD114, CD135
HSP90
DNA (structure)
Aurora kinase A
DNA (synthesis)
MDM2
Volasertib
Birinapant
Serdemetan
Dinaciclib
Venetoclax
Rapamycin
Quisinostat
ABT-263
PS-341, Velcade, Neomib,
Bortecad
BI6727
TL32711
JNJ-26854165
SCH-727965
ABT-199
Sirolimus
JNJ-26481585
Selinexor
Dasatinib
Sunitinib
KPT-330
BMS-354825, Sprycel
Sutent, SU11248
Nuclear export inhibitor
Kinase inhibitor
Kinase inhibitor
Alvespimycin
Cisplatin
HSP90 inhibitor
DNA alkylating agent
Aplidin
17-DMAG
Cisplatinum, platamin,
neoplatin, cismaplat
Plitidepsin
AZD8055
MLN4924
N/A
Pevonedistat
Kinase inhibitor
Nedd8 activating enzyme (NAE) inhibitor
Unknown, indirectly activates Rac1
GTPase and inhibits protein
phosphatases
mTOR
NAE
Talazoparib
PF-03084014
Lapatinib
Selumetinib
BMN-673
N/A
Tykerb, Tyverb
AZD-6244, ARRY-142886
PARP inhibitor
Gamma-secretase inhibitor
Kinase inhibitor
Kinase inhibitor
PARP1, PARP2
Gamma-secretase
HER2
MAPKK/MEK1, MAPKK2/MEK2
Cediranib
Mapatumumab
PG11047
BMS-754807
XL-147
MLN0128
PCI-32765
SCH-717454
Vorinostat
GSK690693
Sorafenib
AT13387
LCL161
Lenalidomide
RO-4929097
SGI1776
MK-2206
AZD1480
BAL101553
CAL101
AZD-2171
HGS-ETR1
N/A
N/A
SAR245408
INK-128
Ibrutinib
19D12
SAHA, Zolinza
N/A
Nexavar
N/A
N/A
Revlimid
N/A
N/A
N/A
N/A
N/A
Idelalisib, Zydelig,
GS-1101
N/A
N/A
Kinase inhibitor
Monoclonal antibody
Polyamine analog
Kinase inhibitor
Kinase inhibitor
Kinase inhibitor
Kinase inhibitor
Monoclonal antibody
HDAC inhibitor
Kinase inhibitor
Kinase inhibitor
HSP90 inhibitor
SMAC mimetic
Immune modulator
Gamma-secretase inhibitor
Kinase inhibitor
Kinase inhibitor
Kinase inhibitor
Anti-mitotic
Kinase inhibitor
VEGF1, VEGF2, VEGF3, c-KIT
TRAIL1-R1
Polyamine biosynthetic enzymes
IGF-1R, IR
PI3K-alpha, delta, gamma
mTOR
BTK
IGF-1R
HDACs
Akt1, Akt2, Akt3
VEGFR, PDGFR, Raf
HSP90
cIAP1, cIAP2, XIAP
E3 ubiquitin ligase
Gamma-secretase
Pim-1, Pim-2, Pim-3, Flt3
Akt1, Akt2, Akt3
JAK1, JAK2, JAK3 and Tyk2
Tubulin
PI3K-delta
Kinase inhibitor
RNA synthesis inhibitor
FAK
RNA polymerase I
VS-4718
CX-5461
Inducer of oxidative stress