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Phenotypically similar dilated cardiomyopathy (DCM) caused by defects in different genes: precise description by MOGE(S) nosology system. The figure
shows three different examples of DCM; although the clinical diagnosis is the same, the diseases are different. In the MOGE(S) notation, M describes the
morphofunctional phenotype (hypertrophic cardiomyopathy, DCM, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy) as defined
in current guidelines,1 eventually adding key markers such as atrioventricular block; O describes the organs affected in the given patient (eg, Heart,
Skeletal muscle, Auditory, ocular systems); G defines whether a cardiomyopathy is genetic or not and includes information on the pattern of inheritance
(autosomal dominant, autosomal recessive, X-linked, matrilineal)3; E is the precision diagnostic descriptor and specifies the cause and, in case of genetic
Source: DILATED CARDIOMYOPATHY, Hurst's The Heart, 14e
diseases, the disease gene(s) and the mutation(s); and S includes New York Heart Association functional class and American Heart Association stage.
Fuster V,by
Harrington
RA,
Narula J, Eapen ZJ. Hurst's The Heart, (see
14e; Chap.
2017 Available
at: http://mhmedical.com/ Accessed: May 03,
The practicalCitation:
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57).
2017
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