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International Journal of Current Medical And Applied Sciences volume 6, Issue: 3, May- 2015, PP: 163-166. International Journal of Current Medical And Applied Sciences. [IJCMAAS] Volume: 6, Issue: 3, May-2015, pp: 163-166. Case Report Subject: General Surgery Gaint Extra Luminal GIST Presenting as Huge Abdominal Mass: Case Report E. Rajya Lakshmi* , Jagadeesha B.V.C ** & Mahesh Kariyappa** *Post Graduate, **Professor, Department of General Surgery . Corresponding Email ID :[email protected] -------------------------------------------------------------------------------------------------------------------Abstract: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, but they represent less than 3% of all gastrointestinal tract malignancies. This is a detailed case study of a 65 year old female patient treated for a rare presentation, huge abdominal mass, for whom the diagnosis is confirmed only intraoperatively as GIST. We report this case and review the literature with a special focus on patho morphological evaluation and prognostic factors. To our knowledge this is the first report of giant GIST ( 30*27*25 cms) presenting as huge abdominal mass . Asymptomatic tumors diagnosed at a late stage, which is often the case, can be large on presentation. Prognosis for patients diagnosed with GIST depend on tumor size, mitotic rate, histopathologic subtype and tumor location. That is why early diagnosis and R0 resection, which is usually feasible and safe even in giant GISTs, are the key factors for further treatment and good prognosis. Key Words: Gastrointestinal stromal tumour; Gastric gastrointestinal stromal tumour; Gastrointestinal tract tumour. ------------------------------------------------------------------------------------------------------------------------------------------- Copyright @ 2015 Logic Publications, IJCMAAS,E-ISSN:2321-9335,P-ISSN:2321-9327.