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Copyright 1980 - 2007 V. Ventruto / A. Di Luccio
Genus database
9620
foetal maternal varicella-zoster syndrome
Eponyms:
Inheritance:
chickenpox foetal effects
varicella-zoster (VZV) embryopathy
no genetic
Semeiological Cutaneous-neuro-oculo-skeletal disorder. Focal cutaneous ulcerations/scarring/cicatrix/reduction, deformities,
other multiple defects including cataract, choroidoretinal changes. Foetal liver hyperechogenicities. Tendency
Synthesis:
to develop leukaemia, cervical carcinoma Detection of VZV DNA in foetal blood and amniotic fluid by PCR.
Diagnosis in the immediate newborn period through cultures for the offending agents, antibody titers,
placental evaluation. Small risk (about 2%) of teratogenic effects between 13 and 20 weeks gestation.
Group
Sub group
Signs:
DERMATOLOGICAL DISORDERS
cutis, dysplastic, not including ectodermal
dysplasia
cutis, scarring
LABORATORY DATA
gene, structural-functional anomalies
gene analysis-DNA analysis
VZV DNA, Varicella-Zoster virus DNA
NEOPLASTIC DISEASES
cancer, genetic features
tumour susceptibility
NEUROLOGICAL DISORDERS
brain anomalies
brain hypodeveloped, brain atrophy, brain
degeneration, encephalopathy, including
cerebral palsy
microcephaly, microcrania
ventriculomegaly, wide ventricles
mental retardation
mental retardation
neurological dysfunctions
seizures, convulsions, epilepsy
OCULAR DISORDERS
choroidoretinal defects
choroidoretinal dystrophy
retinal pigmentation changes, retinal flecks
corneal defects not including dystrophy
microphthalmos (anteposterior globe
diameter less than 20 mm, in adult),
anophthalmos
eye, motility defects
nystagmus
lens, defects
cataract, congenital
cataract, no isolated defect
cataract, unspecified type
OTHERS
inheritance
inheritance, no genetic
supergroups
cutaneous-oculo disorders
PRENATAL-NEONATAL MODIFIED DATA
extrafoetal membrane, changes
polyhydramnios
umbilical artery, single
foetal changes
bilateral foetal fluid collections in the head
birth length, decreased; low birth length
foetal maternal varicella-zoster syndrome
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Copyright 1980 - 2007 V. Ventruto / A. Di Luccio
Genus database
birth weight, low; foetal growth decreased,
intrauterine growth retardation, intrauterine
growth restriction, IUGR
foetal changes, induced by maternal infections
foetal changes, recognized by laboratory data
foetal changes, recognized by ultrasound
techniques
hydrops foetalis, foetal hydrops, including
foetal ascites
prenatal diagnosis
prenatal diagnosis, echographic
prenatal diagnosis, molecular
SKELETAL DISORDERS
fingers, defects
ectrodactyly, adactyly, oligodactyly
hand-foot, changes
club foot, talipes, pes equinovarus
hand, clenched
limb anomalies, limb defects
ectromelia; limbs, mutilations
Super group:
cutaneous-neurological disorders
cutaneous-ocular disorders
Super aggreg. FOETAL CHANGES
foetal changes, induced by maternal infections
Aggregations:
foetal changes, recognized by laboratory data
foetal changes, recognized by ultrasound techniques
FOETAL FLUID COLLECTIONS IN THE HEAD
bilateral foetal fluid collections in the head
NEOPLASTIC DISORDERS
tumour, susceptibility
OTHER
cataract, not isolated defect
Differential
diagnosis:
Bibliography
1410 amniotic bands sequence
4570 cataract-leg deformity syndrome
9490 foetal maternal herpes simplex virus 1
syndrome
B.D.Encyclopedia 2499 p.708
Prenat.Diagn.19,163-166,1999
Prenat.Diagn. 21,121-124,2001
Smith's Recognizable Patterns of Human Malformation. 6th Edition pag. 662-663
Peter S.Harper: Practical Genetic Counselling. 6th Ed. 2004 pag. 347
Annuario Orphanet-Italia delle Malattie Rare 2005, pag.322
Emery&Rimoin's: Principles and Practice of Medical Genetics. Church. Livingstone. p.906,2007
foetal maternal varicella-zoster syndrome
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