Download 2) Antibiotics that Inhibit Protein Synthesis - Collegium Medicum

Katedra i Zakład Farmakologii i Terapii
Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy UMK w Toruniu
Kierownik: dr hab. n. med. Grzegorz Grześk
ul. M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz,
tel. / Fax. (52 585-35-84), e-mail: [email protected]
Pharmacology and Toxicology
I.
Name of the unit offering the course: Pharamcology and Therapy.
Head of the unit: MD, PhD, EC. Grzegorz Grześk.
II.
III.
Faculty of Medicine, Medical Program, year 4th
IV.
Course coordinator: MD, Ph D, EC. Grzegorz Grześk.
V.
Form of classes (tutorials / seminars/ lectures): lectures, tutorials and seminars.
VI.
Form of crediting: Tutorials: TEST
Seminars: TEST
Lectures: TEST
Number of hours: tutorials – 30 hours, seminars - 15hours
VII.
VIII.
Aim of the course:

Understanding the mechanism of action of drugs, their use;

Understanding the mechanism and effects of drugs with particular emphasis on
therapeutic activities, adverse reaction (side effects), toxicity, teratogenic and
carcinogenic effects;

Assimilate the principles of reasonable therapy and evaluation of drug action, analysis
of the risks and benefis;

Understanding paths of drug dosing, pharmacokinetic basics and principles of drug
dosing.
IX.
Topics of lectures/ tutorials/ seminars
Seminars and tutorials:
A) Glucocorticoids and non-steroidal anti-inflammatory drugs (NSAIDs or NAIDs).
B) Calcium channel blockers:

Phenylalkylamine derivatives: Verapamil, Gallopamil, Tiapamil, Anipamil,
Levemopamil;

Benzodiazepine derivatives: Diltiazem,Clentiazem, Diclofurmine;

1,4 – Dihydropyridine derivatives: Nifedipine, Nicardipine, Nifludipine, Nimodipine,
Nitrendipine, Nisoldipine, Azidopine, Felodipine,
Isradipine;

Other: Flunarizine, Cinnarizine, Lidoflazine, Bepridil, Prenylamine.
C) Angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists AT1
and AT2.
D) Drugs for respiratory:

Drugs affecting respiration;

Drug for bronchial asthma;

Expectorants, mucolytics and expectorants drugs;
E) Drugs acting on the cardiovascular system:

Drugs affecting heart function;

Drugs affecting the vascular system;

Anti-atherosclerosis drugs;

Drugs affecting coagulation (drugs affecting the coagulation cascade), antiplatelet
drugs and fibrynolitic drugs;

Drugs affecting homeostasis;
F) Drugs acting on the urinary system:

Diuretic, Loop diuretic;

Drugs acting on proximal part of distal tubule;

Potassium-sparing drugs (potassium-sparing diuretics): Spironolactone, Triamterene
and Amiloride;

Osmotic diuretics (changing urine pH).
G) Drugs acting on the gastrointestinal tract/alimentary system:

Drugs that inhibit acid secretion;

Antacids are stomach acid neutralizers;

Drugs that protect the mucosa;

Emetics and antiemetic;

Drugs acting on the bowel motility;

Drugs acting on the bile ducts.
H) Drugs acting on the nervous system:

Topical anesthetic

Analgesics

Anesthetic drugs
I) Anxiolytic (also antipanic) and sedative drugs:

Benzodiazepines

Benzodiazepine antagonist

Buspirone

Barbituratem
J) Antipsychotics:
 Neuroleptics typical:

Phenothiazines


Butyrophenones
Thioxanthenes
 Neuroleptics atypical.
K) Drugs used in affective disorders:

Tricyclic antidepressants: Imipramine, Desipramine, Amitriptyline, Clomipramine;

Selective serotonin reuptake inhibitors (SSRI): Fluoxetine, Fluvoxamine, Paroxetine,
citalopram;

Serotonin-norepinephrine reuptake inhibitors (SNRIs): Duloxetine, Milnacipran,
Venlafaxine;


Monoamine oxidase inhibitors (MAOIs) - MAO-A and MAO-B:
First generation:
Non-selective irreversible - Iproniazid, Tranylcypromine, Phenelzine;
 Second generation:
Selective irreversible - Clorgyline, Deprenyl;
 Third generation
Selective reversibly.
L) Epilepsy drugs:
Medications Used to Treat Parkinson's Disease.
M) Basic principles of chemotherapy:

Cancer chemotherapy;

Antibacterial drugs.
1) β -Lactam Antibiotics;
2) Antibiotics that Inhibit Protein Synthesis;
3) Antimycobacterial:

Antivirals;

Antifungals
N) Cytokinez:

Interleukin;

Colony growth factors;

Erythropoietin;

Interferons.
O) Individual variability and drug interactions, drug poisoning.
P) TEST.
X.
XI.
Self study topics.
Booklist:
XII.
Detailed list of required practical skills and confirmation of completing
STUDENT COMPETENCY CARD
COURSE SYLLABUS: PHARMACOLOGY AND TOXICOLOGY
MEDICAL FACULTY – 4TH YEAR OF STUDY
Students name/surname: .........................................................................................................
Practical assessment
Elaboration of therapeutics
strategies- filling
prescriptions on medicines
and magistral preparation in
present disease entity.
Determination of
antiepileptic drugs
concentrations of. Analysis
of the results.
Elaboration of strategies for
drugs dosing in renal failure
and liver and chronic
circulatory failure.
Interactions elimination of
polipharmacotherapy.
Date of pass
Instructor’s
Confirmation
Remarks