Download Apoptosis in Development

Warm-Up (1/12)
On the piece of white paper from the back, answer
the following question.
Describe how a cell
differentiates during
development.
Name
Date
Period
2E.1c: Programmed cell death (apoptosis) plays a role in the normal
development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic
enzymes, which are important in intracellular digestion, the recycling of a
cell’s organic materials and programmed cell death (apoptosis).
Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.
Differentiation through Death
1.
Apoptosis =
programmed cell death used
for normal development.
2.
3.
Apoptosis: Cell Suicide
Lysosomes are
organelles filled
with acid and
enzymes which
digest cellular
waste.
Lysosome
nucleus
Apoptosis: Cell Suicide
receptor
LYSOSOME
ACTIVATOR
PROTEIN
apoptosis
signal
P
Lysosomes are
organelles filled
with acid and
enzymes which
digest cellular
waste.
2nd
messenger
Lysosome
TF
nucleus
Apoptosis: Cell Suicide
receptor
apoptosis
signal
P
Lysosomes are
organelles filled
with acid and
enzymes which
digest cellular
waste.
2nd
messenger
Lysosome
nucleus
Apoptosis: Cell Suicide
MR.
CELL
Lysosomes are
organelles filled
with acid and
enzymes which
digest cellular
waste.
Lysosome
nucleus
Differentiation through Death
1.
Cells that
are going
to die
2.
Apoptosis =
programmed cell death used
for normal development.
3.
Cells that
did die
Critical Thinking Question #1
Discuss this question with your partner and write or
represent it. I will call on three people to share their
partners’ answers.
Describe how apoptosis plays a role in
development.
Critical Thinking Question #2
The model below shows a cell with a receptor that is unactivated. Redraw this model and revise it to show how
signals from other cells can promote apoptosis.
2E.1c: Programmed cell death (apoptosis) plays a role in the normal
development and differentiation.
Illustrative example: Morphogenesis of fingers and toes
4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic
enzymes, which are important in intracellular digestion, the recycling of a
cell’s organic materials and programmed cell death (apoptosis).
Lysosomes carry out intracellular digestion in a variety of ways.
4A.3c: Environmental stimuli can affect gene expression in a mature cell.
Illustrative Example: Melanin Production
Environmental stimuli can affect
gene expression in a mature cell.
cell membrane
nucleus
melanin
RNA
UV damage
melanin gene
Illustrative Example: Melanin Production
Environmental stimuli can affect
gene expression in a mature cell.
cell membrane
nucleus
melanin
RNA
UV damage
melanin gene
Closure
On the piece of white paper from the
back, answer the following question:
How do processes occurring in
the nucleus affect the lysosome
when a cell undergoes
apoptosis?
Name
Date
Period
Scale
1 – 10