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Cardiovascular: Advanced Physiology and Advanced Physiology smaller course should know: Resting membrane and equilibrium potential Generation and propagation of action potential Anatomy of the heart: atria, ventricles, major arteries and veins, valves Rhythmic excitation, intrinsic autoregulation of cardiac pumping ECG/EKG Cardiac innervation and control by the sympathetic/parasympathetic nervous system Cardiac cycle: systole and diastole, relation between left ventricular pressure and volume Function of cardiac valves Cardiac output: determinants Physical characteristics of the systemic circulation (blood vessels): relationship between pressure and velocity of blood flow Distribution of blood within the circulatory system Arteries: blood pressure, pulse pressure, measurement of blood pressure Regulatory sites of cardiac/circulatory function in brain stem and their role in blood pressure control Determinants of blood flow Advanced Physiology should know: Regulation of capillary flow Veins: Interrelationships between pressure and flow, factors that regulate venous return to the heart Control of regional blood flow at rest and during exercise Function of the lymph system Respiration Advanced Physiology and Advanced Physiology smaller course should know: Anatomy of the respiratory passages Changes in lung dimensions: respiratory muscles, pleural pressure, lung volumes Dead space and alveolar ventilation Normoventilation Compliance Surfactant Gas exchange in alveoli: partial pressure, diffusion, factors affecting diffusion Pulmonary circulation Gas transport in blood, function of hemoglobin, oxyhemoglobin dissociation curve Advanced Physiology should know: Hypo- and hyperventilation Regulation of respiration: central and peripheral chemoreceptors Diving and altitude physiology Muscle Advanced Physiology should know: Skeletal, heart and smooth muscle cell organization, sarcomere Activation of skeletal muscle: action potential, calcium homeostasis Regulatory and contractile proteins Cross bridge cycling Twitch, summation, tetanus Force-length relationship Force-velocity relationship Muscle energy metabolism Substrate utilization Fatigue Cardiac contraction and smooth muscle contraction