Download 339. Relations of Food Habits and Skin Diseases: Eczema

11th International Conference on Public Communication of Science and Technology (PCST)
New Delhi, India, 6-9 December 2010
339. Relations of Food Habits and Skin Diseases: Eczema
Vinayakumar Sonavane, Nikita Vinayakumar Sonavane
[email protected]: [email protected]
Eczema is a broad clinical term that embraces number of pathological different conditions characterized by red,
papulovescicular; oozing and crusted lesions at early stage and with persistence eventuate into raised, scaling plaques.
Eczema has acute phase, which if untreated goes into chronic eruptions, histipathological features are same of all these
conditions but clinically we can classify into following categories as:
•
Atopic dermatitis
•
Allergic contact and irritant contact dermatitis
•
Dyshidrotic eczema
•
Nummular eczema
•
Lichen simplex chronicus
•
Asteatotic eczema
•
Seborrheic eczema
Thus primary lesions may include papules, erythematous macules and vesicles, which can coalesce to form
patches and plaques. In severe eczema secondary lesions from infection or excoriation marked by
weeping and crusting may predominate. Long standing dermatitis is often dry and is characterized by thickened,
scaling skin that is also called as linchenification of skin (Acanthosis).
Atopic eczema: It is cutaneous expression of atopic state. It is characterized by family history of asthma, hay
fever, or dermatitis in up to 70% of patients. It is usually polymorphous on body site sharply defined scaly plaques
with or without inflammation, which may be associated with hair loss. It is prevalent mostly in Norwegian children up
to 23%. There is clear genetic predisposition. If both parents are affected, then over 80% of their children manifest the
disease. When only one of the parents is affected, then 50% of children get disease. These patients display variety of
immunoregulatory abnormalities like increased IgE synthesis, increased specific IgE to foods, aeroallergens, bacteria
and bacterial products. The atopic eczema characterized by weeping inflammatory patches and crusted plaques that
occur on face, back of neck, extensor surfaces of extremities, groin. In adults pattern is usually seen as localized type.
Pruritus is predominant characteristic of atopic eczema. Usually findings are secondary to rubbing or
scratching. Present therapy approves treatment with anti-histaminic, anti-pruritic drugs, systemic steroids, local
steroids are freely advocated. It is very difficult to detect allergen in particular patient, because of which treating him
becomes difficult with present anti-eczematous treatment. Still it has not succeeded in curing atopic eczema definitely.
Contact dermatitis: It is an inflammatory process caused by exogenous agent or agent that directly or indirectly
injures skin. If the injury is caused by inherent characteristic of compound, it is called as allergic contact dermatitis.
Phytodermatitis or plant dermatitis examples are Rhus family plants, Ivy poison, Oak poison, Sumac etc. If irritating
agent causes the injury, it is called as Irritant contact dermatitis. Examples are acid contact of skin, silk cloths, and
foam leather footwear’s etc. So in ACD if offending agent is identified, confirmed and removed, irruption will resolve.
Identification of allergen is difficult. Treatment is based on application of topical medicaments and oral medications.
Common sensitizers like nickel Sulphate, potassium dichromate, thimerosal in ocular preparations, neomycin Sulphate,
fragrances, formaldehyde and rubber-curing agents are used. Systemic steroids are used freely to treat ACD. Treating
infection, use of topical glucocorticoids, cool moist compressors plays no role in treating disease entity. However all
these treatments have their limitations?
Nummular eczema: It is characterized by circular or oval eruption, consists of edematous papules that become
crusted and scaly predominantly seen over trunk, extensor surfaces of extremities or dorsum of hands and legs. It is
also known as Tinea Pedis. Treatment is like above mentioned, but still it has its limitations.
Lichen simplex chronicus: It represents end stage of pruritic and eczematous disorders. It consists of wellcircumscribed plaques with Linchenified or thickened skin due to chronic scratching or rubbing.
Treatment is to break chronic itching that mainly occurs at sleep. High potency topical glucocorticoids along
with antihistamines
(hydroxyzine, tricyclic antidepressants-doxepin etc.) are mainly used to treat this disorder. Still all these treatment has
its limitations.
Asteatotic eczema: It is known as xerotic eczema or winter eczema is mildly inflammatory dermatitis seen
over lower 1/3 of both legs. Fine cracks with or without erythema develop on anterior surfaces of lower extremities. It
responds to avoidance of irritants, rehydration of skin, and application of topical emollients. But it has its limitations.
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Stasis dermatitis: It develops on lower extremities secondary to venous incompetence and chronic edema.
Typically involves medial aspect of ankles. As dermatitis progresses, skin becomes progressively pigmented due to
chronic erythrocyte extravasations leading to cutaneous hemosiderin deposition. Chronic stasis dermatitis is associated
with fibrosis, known as brawny edema of the skin. It is complicated by infection and contact dermatitis. Severe stasis
dermatitis may cause stasis ulcers. Treatment has limitation and use of topical applications and compression stockings
with 30mm of Hg pressure are beneficial to certain extent. Also elevation of affected foot while sitting or in sleep helps
in decreasing edema. However it has also its limitations. Surgical intervention by plastic surgery is best treatment.
Seborrheic eczema: It is a chronic common disorder characterized by greasy scales overlying erythematous
patches or plaques. It is prominently seen on scalp and it also called as dandruff. It is also seen on eyebrows, eyelids,
labella, nasolabial fold or ears. Treatment is use of low potency glucocorticoids along with shampoo. But it has its
limitations; because it does not give easy feeling (sensation) to patients and patients repeatedly feels to scratch his
scalp.
Pathogenecity: In acute stage, there is formation of red, papulovescicular, oozing, crusted lesion. These lesions
are prone for super infection. And itching its characteristic worsens this disease process. As time lapses, lesion becomes
dry and skin starts becoming Hyper keratinized.
Eczema is a chronic granulomatous skin disorder (CGD) affects skin as well as lung, lymph nodes, liver, bones.
Chronic Granulomatous Disorder is characterized by impaired host defense against microorganisms. Immunoglobulin
levels may be elevated or normal. Delayed hypersensitivity is impaired. Leucocytosis with increase in proportion
of neutrophils is characteristic of CGD. Neutrophils do not kill those microorganisms generally found in the lesion,
but kills staphylococci, lactobacilli, pneumococci. Microbicidal defect is mainly due to decrease in Phagocytosis,
which eventually induce metabolic burst. So decrease in oxygen supply, H2O2 deficiency and bacterial & fungal
resistance to existent available drugs are main causes of this disease process. It can be revealed
by presence of microorganisms, fungi, biopsy, Leucocytosis, raised neutrophils count. Others like KOH
preparation, Tzanck smear, Diascopy, Patch test is useful in diagnosis of this entity. Thus decrease in oxygen
supply and decrease in hydrogen peroxide in subcutaneous tissue are main cause of decrease in Phagocytosis.
Staphylococcus aureus, certain gram- negative bacteria, fungi are predominant pathogens. As neutrophils fail to kill
all microorganisms and there is influx of polymorphonuclear leucocytes with abscess formation, which is a feature,
with central necrosis, surrounded by numerous plasma cells, lymphocytes, macrophages characterized by yellow
lipid material. Diagnosis can be done by increase in neutrophils count and presence of microorganisms.
Microbiological explanation: The main characteristic of acute eczematous lesion is accumulation of edema
fluid in epidermis (spongiosis). In urticaria edema is localized to perivascular spaces of superficial
epidermis. In spongiotic dermatitis edema seeps down to intracellular spaces of epidermis, splaying apart
keratinocytes located primarily in stratum spongiosum. Thus intracellular bridges become prominent giving spongy
appearance to epidermis. So mechanical shearing of intracellular spaces and cell membrane progressively
accumulates fluid in formation of intraepidermal vesicles. Therefore during earliest stages of spongiotic
dermatitis, there is superficial perivascular lymphocytic infiltrates associated with papillary dermal edema and
mast cell deregulations. Thus spongiotic dermatitis resulting from drugs (Sulpha drugs, Chlorpropamide,
Methyldopa, Ampicillin, Amoxycillin,
Oral
contraceptives, Penicillin, Tetracycline, Chloroquine,
Phenylbutazone, Proxyvon-group of drugs) will show lymphocytic infiltrates often containing eosinophils and
extends around superficial and deep vessels and as the time passes spongiotic dermatitis may subside
giving rise to progressive epidermal hyperplasia with hyperkeratosis and parakeratosis.
Facts as patients reciprocate to anti-eczematous treatment: As we think of eczematous skin disease, a picture of
person scratching his skin is usually seen. People never take this disease very seriously at least in India, unless it harms
their daily routine work. This confirms that attitude and approach of patients to get cure from this skin disease is very
minimal. The main cause of avoiding to take treatment for eczema is failure of any method of treating disease entity to
cure this chronic eczematous skin disease process. So this eczema is also called as neglected disease by society. This
is mainly because of failure of drugs to cure this disease process. The failure is mainly due to:
•
Drug resistance
•
Cutaneous atrophy
•
Incurable itching
•
Inability to enhance Phagocytosis
It means inability to kill all pathogens causing this disease. Also all these eczemas are tension related. Thus
present anti-eczematous drug fail to bring an end to pathogenecity of chronic eczematous skin
disease process. Basically staphylococcus aureus and certain gram-negative bacteria along with certain fungi are
strongly resistant
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11th International Conference on Public Communication of Science & Technology
to available allopathic anti-eczematous skin disease process. Now facts regarding my invented Yashoderm are given
underneath:
•
The process of mixture is meant for external use only.
•
The solvent in this process is universal solvent (water).
•
The process according to the claim wherein the reaction is carried out in solvent within skin layers is
inert
•
•
•
under reaction condition.
As per claim this reaction is carried out at any room (atmospheric) temperature.
The process according to the claim wherein reactants formed are nascent oxygen,
hydrogen peroxide along with excess of chlorine and excess of hydrochloric acid formed
plays major role in enhancing phagocytosis.
As per claim the composition of chemicals have good physical and chemical stability.
Goals or objects of my invention: •
First stop chronic itching.
•
Demolish Linchenified (Hyperkeratotic [Acanthosis]) and make the skin totally normal by
medication only and ultimately remove ugliness of skin.
•
It must be affordable to any patient.
•
To find ultimate remedy to cure any type of eczema.
•
Patient must get cured in shortest duration of period without inducing extra tension of regularity of
taking number of drugs to these patients.
•
Cures dandruff (Seborrheic eczema) most effectively.
The said process is only for external use and solvent used is water. The drug must be kept in non-humid place,
out of reach of children. The said process composition must be kept in dark tan glass bottle or thick black plastic
container with tight cover and drying agent (dehydrating agent) like silica gel rapped in polyethylene bag (synthetic
paper) or cotton bag is kept in a special socket made from inside of cap or cover having holes at its bottom to absorb
water molecules present in container.
Before bathing and / or at night before sleeping appropriate quantity of mixture (1 to 1.5 grams) is taken in
saucer or glass container. Never use stainless steel vessel, because drug reacts with the same and stainless steel vessel
will get spoiled (damaged). Then wet eczema skin with water, so drug must be applied on wet skin only. Then add
at least ten milliliters of water to drug taken in saucer. As we add water to drug, all active ingredients get dissolved
in water and what remains behind is residue of calcium hydroxide. So mix it with hand only and immediately apply
prepared liquid drug by hand only on eczema skin and rub area with ordinary stone or turf of coconut hair by applying
tolerable pressure for two minutes. This process of rubbing must be delicately done most seriously, because the active
ingredients of drug get percolated deep in to the skin and there by kills all microorganisms and fungi present in that
area causing this chronic eczematous skin disease process most effectively. Then wash skin with
fresh water. So simple is my procedure. Then immediately bathe yourself and you can use any soap for bathing; but
after bathing, not a single particle of drug should remain on skin. If it exists, wipe it under running water or clean
with wet cotton. All eczema patients must reduce use of soap unnecessarily quite often in a day, because
saprophytic bacteria present on skin that protects skin from exogenous agent like bacteria or fungi.
In the above described process, to get synergistic effect, one can give injection of triamcinolone acetonide
intramuscularly once in a month. This way the patient gets cured of their disease very fast. In the above-described
process reactants formed are utmost essential to enhance phagocytosis in eczema. These reactants get percolated in
dermal layers and stops itching, removes acanthotic skin, kills all microorganisms and fungi by its highly potent action
and by correcting leukocyte metabolic activity; ultimately cures chronic eczematous skin disease process. The excess
of active agent forms plays subordinate role in removing or abolishing linchenified skin of eczema and finally brings
an end to chronic eczematous skin disease process.
Psoriasis is very obstinate, obscure chronic skin disease seen in human beings. There are eight types of
psoriasis. They are as follows:
i.
Plaque psoriasis: It is most prevalent form of disorder characterized by raised inflamed scaly lesions.
Dead skin cells form scales while inflammation is result of increased blood supply to areas of rapid cell
production.
ii.
Pustular psoriasis: It is characterized by pustules on skin. It has three distinct phases as reddening of
skin, formation of pustules and scaling of skin.
iii.
Guttate psoriasis: It produces small red-drop like lesions accompanied by scaling. It can be triggered by
strep’s
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iv.
v.
vi.
vii.
viii.
10%
throat or upper respiratory infections, chicken pox, physical trauma, illness by anti-malarial drugs.
Inverse psoriasis: It mainly affects skin folds characterized by smooth red inflamed lesion without scaling
often irritated by rubbing or by sweat.
Erythrodermic psoriasis: It is characterized by inflammation all over body with swelling, pain and itching.
Scalp psoriasis: About half of psoriasis has scalp psoriasis characterized by heavy scaly
skin with itching irritated by sweat or irritation.
Nail psoriasis: It mainly affects toe nails. Nails become thick, pitted and often yellowish in color.
Psoriasis arthritis: it causes inflammation and swelling of finger’s joints, feet, knees, hips, elbows. About
of psoriatic patients develop psoriatic arthritis.
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Psoriatic patient must avoid following food articles.
Fruits: Mango, Banana, Chikoo, Papaya, Pine apples, Jackfruits
Diet: Strictly abandon non-vegetarian food products of any kind
Munching items: Abstain Nagali’s or Udid’s papad if they are made with papadkhar (a type of salt).
If one prepares Nagali’s and Udid’s papad without making use of papadkhar; it can be indulged. Rice papad is
allowed to indulge. Abstain Mango pickle but you can eat lime, chilly and myrobalan pickles. One can eat
potato chips, Sago papad, Chakali made out of Sago and potato mixture with chilly powder, garlic. Wheat’s
kurdai can be indulged. However any oil-fried products must have very limitations.
Habits: No habits are allowed. Patient must be non-habitant.
Oils: Groundnut oil or use of complete groundnut or crushed groundnut in vegetables or any food products
must be avoided. Person can use sunflower oil, soybean’s oil, safflower oil or palm oil for preparing food.
Masala: Garam Masala is not allowed. Person can prepare all foods in red chilly powder only. One can eat
green or red chilly.
Vegetables: brinjals, cluster beans, drumsticks, coriander leaves or coriander, ginger must be abstained.
Milk and its products: Any plain milk without cream must be indulged. Cream is abstained. Milk
sweets are allowed but curd, buttermilk, sugar added buttermilk, kadhi, shrikhand are not allowed.
Ice-cream prepared from custard powder, milk, sugar but without cream can be indulged. Ice-cream with
cream is not allowed.
Nuts: gram nut and its all food products must be avoided. We prepare pithle, dhokale, bhaji, potato wada
(one can eat potato but potato wada must be avoided), we soak gram nut, mung and math in water. Then we
tie the same in simple cotton cloth for one day. It germinates and then we prepare vegetable out of the same.
So math, mung can be indulged but gram nut must be avoided, we prepare wade’s vegetable, puranpoli,
shev, chivda, farsan, fafada, bundi’s ladu, mysore-pak cake, kate-shev, chana-batura.all these products are
made out of gram nut. So they must be avoided. Use of white udad nut must be restricted.
Salt: Never eat excess of salt. Whatever salt is added while preparing food can be indulged. Some people
have habit of eating excess of salt, which is not allowed.
Soap: Use of soap is not allowed. One must bathe with shikakai, utana or bajara’s floor. Psoriatic patients
must avoid washing clothes. Contact with any type of soap is not allowed. Women must use disposable napkins
when they are having periods (menses). Also men must shave without use of cream. Just apply Luke-warm
water over beard area and have shave. After-shave spray or liquid are not allowed. Alum or dettol can be used
to wipe bearded area.
Cosmetics: Scents, perfumes are not allowed. One can use face powder, talc powder, no nail polish.
Please no bleaching of face or facial procedures.
Dry fruits: Most of dry fruits must be avoided. Even dry coconut is not to be indulged. Cashew, clove,
cinnamon, almond, walnut, a date, a dried date, godambi, coriander nut must be absolutely avoided. Fennel, a
currant (dry grapes), charoli cab be indulged.
Bakery products: Toast, soft bread, ban can be indulged. No other bakery products are
allowed. Ordinary glucose, Marie biscuits can be indulged. Cream-biscuits are not allowed. All
cold-drinks can be indulged. Mixed-fruit jam can be indulged at times.
Miscellaneous: Magi noodles, Chinese noodles in red chilly can be indulged. One can make use of any
sauce, chatnies without crushed groundnut. Certain allopathic drugs are promptly avoided in these patients.
They are as follows:
a.
Avoided quinine group of drugs like Chloroquine, primaquine and
quinine. b.
Avoid Proxyvon group of drugs like spamoproxyvon and
butaproxyvon.
c.
Avoid Ibuprofen group of drugs like combiflam, anaflam etc.
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11th International Conference on Public Communication of Science & Technology
d.
Avoid chlorpromazine and other
sedatives. e.
Avoid all anti-arthritic
drugs.
f.
Avoid salicilates like disprin, lithium carbonate, iodides, nystatin, and anti-hypertensive
beta-blockers. g.
Avoid sulpha drugs.
All the above mentioned factors disable equilibrium of human body. In our body every organ has fixed Ph. The
whole body is maintained normally at equilibrium. If acidity of body increases, person is likely to get intracranial
haemorrhage, strokes, infarcts, ischemic heart diseases. If the basicity of body increases person’s immune response
goes down (ability to fight against different diseases) and atmospheric bacteria, fungi or viruses attack on body and
patient becomes sick due to infectious diseases. I have developed Suswasthya Churna that brings body to equilibrium
and person becomes normal. Its outstanding properties are given underneath:
i.
It is best drug against acidity (acid-peptic diseases {APD}), Chronic constipation, has ability to stop
most abnormal activities of our body.
ii.
Promptly helps in reducing weight by dissolving excess of accumulated body fat.
iii.
At puberty, there are hormonal changes and most of people become victim of acne and body heat.
My Suswasthya Churna corrects and cures acne by destroying harmful effects of changes that had
affected body due to hormonal changes at puberty.
iv.
v.
Suswasthya Churna affects human Psychology and most of these patient feels comfortable due to
loss of lethargy, uneasiness, easy fatigability. People indulging Suswasthya Churna will certainly feel
fresh, normal and tidy.
It has been experienced by regular follow-up study in more than one thousand cases that, it has no
side- effects at all and helps in curing all chronic skin disorders, chronic APD, chronic constipation, UTI.
It has also been found beneficial in people suffering from chronic arthritis. I recommend its use by every
person suffering with chronic disorders. It does not have any side effects and it is always helpful in some
ways to distorted body.