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THE CONFERENCE'S SCIENTIFIC PROGRAM: Top leading scientists in the field of cancer research from Israel, Germany, France, Spain, Italy, UK and the USA were invited to present their latest data. The meeting will also present cutting edge cancer research technologies including genetically engineered mice, ex-vivo tissue manipulation, novel imaging technologies, including molecule-targeted imaging and new techniques in the field of cancer-stem-cell research. The lectures will link innate and adaptive immunoregulatory mechanisms with carcinogenesis and cancer treatment by focusing on relevant basic research, preclinical, translational and clinical issues. Ten lectures will be selected from submitted abstracts. INVITED SPEAKERS (in alphabetical order) – PRELIMINARY PROGRAM: Augustin Hellmut, DKFZ German Cancer Research Center, Heidelberg, Germany Angiopoietin-2: Critical regulator of inflammation and hepatic homeostasis Axelrod Jonathan, Hadassah Hebrew University Hospital, Jerusalem, Israel TBD Balmain Allan, UCSF, California, USA Genetic analysis of the opposing roles of inflammation in cancer Bartenschlager Ralf, University Hospital Heidelberg, Heidelberg, Germany Hepatitis C virus-induced alterations promoting HCC development Ben-Neriah Yinon, The Hebrew University of Jerusalem, Israel Inflammatory control of colorectal cancer progression Ben-Porath Ittai, The Hebrew University of Jerusalem, Jerusalem, Israel Dynamics of generation and elimination of senescent cells in vivo Breuhahn Kai, University Hospital Heidelberg, Heidelberg, Germany Single-strand nucleic acid-binding proteins in hepatocarcinogenesis - regulation and effector mechanisms Buendia Marie Annick, INSERM U785, Villejuif, France Hepatitis B and liver carcinogenesis: pending issues and controversies Fehse Boris, Hamburg University, Hamburg, Germany RGB marking for clonality assessment in liver regeneration and cancer Feldman Marc, University of Oxford, London, UK TBD Geiger Tamar, Tel-Aviv University, Tel-Aviv, Israel Deep proteomic analysis of breast cancer Gil Jesus, Imperial College London, London, UK Non-cell-autonomous senescence Karin Michael, UC San Diego, La Jolla, California, USA TBD Kühnel Florian, MHH Hannover Medical School, Hannover, Germany Breaking tolerance: virus infections in tumors and tumor-directed immune responses Levanon Erez, Bar Ilan University, Ramat-Gan, Israel RNA editing, as a mechanism for somatic mutations induced by inflammation Levy Carmit, Tel-Aviv University, Tel-Aviv, Israel The three M's: Melanoma, MITF and microRNA Malek Nisar, University Hospital, Tübingen, Germany The role of ubiquitin ligases in the pathogenesis of liver cancer Mandelboim Ofer, The Hebrew University of Jerusalem, Jerusalem, Israel Control of innate immune responses by miRNAs Mantovani Alberto, University of Milan, Milan, Italy Targeting cancer-related inflammation Peled Amnon, Hadassah Hebrew University Hospital, Jerusalem, Israel Inflammation-induced hepatocellular carcinoma is dependent on the chemokine receptor CCR5 Pikarsky Eli, The Hebrew University of Jerusalem, Jerusalem, Israel Inflammatory signaling pathways in inflammation induced liver cancer Rose-John Stefan, Christian-Albrechts-University of Kiel, Kiel, Germany Pro-and anti-inflammatory properties of cytokines: A matter of cleavage Sass Gabriele, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany Induction of heme oxygenase 1 interferes with progression to fibrosis and cancer Schrader Jorg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany Inflammation-induced extracellular matrix alteration in liver cancer Shaul Yosef, Weizmann Institute of Science, Rehovot, Israel Study of intrinsically disordered proteins in designing a new approach in cancer therapy Singer Stephan, University Hospital Heidelberg, Heidelberg, Germany A nuclear core component regulates p53 target genes Thorgeirsson Snorri S., National Institute of Health (NIH), Bethesda, Maryland, USA Cancer and Stem Cells: A Fatal Attraction Wagner Erwin F., The Spanish National Cancer Research Center (CNIO), Madrid, Spain Inflammation and cancer: Functions of AP-1 (Fos/Jun) Wege Henning, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany Transformation of telomerase-immortalized human hepatocytes – early steps of hepatocarcinogenesis Zender Lars, MHH Hannover Medical School, Hannover and HZI Helmholtz Center, Braunschweig, Germany Senescence surveillance in hepatocellular carcinoma