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MEDMYST 12 MISSION ONE: College ______ Name______________________Class_________ Date 1. In the Body Defender challenge, what two body parts make up the first line of defense against pathogens? _______________________ and ______________________________ 2. What is the name of the proteins made by B cells that can bind to a specific pathogen? An___________________________________ 3. In the Infect-O-Rama challenge, what are the ways in which viruses can be spread? 1. Hand—Direct Contact 4._____________________________ 2. _________________________ 5. _____________________________ 3. _________________________ 6. _____________________________ 4. Which two of the above modes of transmission from above are used by most germs? f__________________ and w_____________________ 5. In the Koch’s Concepts challenge, why is it necessary to wash the orange before infecting it with the fungus? To remove _____________________________________________ 6. Who worked out the four-step procedure scientists use to determine if a specific germ causes a particular disease? Dr. R__________________ K_____________________________ 7. In the Germ Blaster challenge, which types of infectious agents can be killed by antibiotics? B______________________, F____________________ and P___________________ 8. Which pathogen has no treatment? (If you catch it—you die.) P____________________________ 9. In the Enemy Agents challenge, you meet up with six different infectious agents. Name them. B______________________ P________________________ P________________ V______________________ F________________________ H________________ 10. Which type of infectious agent are a tapeworm, a roundworm, and a hookworm? H_________________________ MISSION TWO: Cholera 1. In the Arora II spacecraft, you learn of an outbreak of disease in Prokaryon. What type of disease is it? D_________________________________ 2. Before arriving in Prokaryon, Eureka helps you review the Germ Theory first proposed by Louis Pasteur. According to this theory, what are germs and what do they do? Germs are___________________________________________________________ 3. Eureka also shows you information on Joseph Lister, a surgeon who believed in the Germ Theory and therefore insisted that doctors do what 2 things? _______________________________ and ________________________________________ 4. In reviewing the infectious agents, you learn there are six types. What are they. B____________________ P________________________ P_____________________ V____________________ F________________________ H_____________________ 5. In the animation of bacteria, you learn that they are categorized according to shape--rod, sphere, or spiral. What are the three different shapes called? B____________________ S________________________ C____________________ 6. Upon arriving in Prokaryon, Sirius shows you a graph of diarrhea cases that indicates an epidemic. What is an epidemic? ________________________________________________________________________ 7. In the lab, Beta shows you what the wiggling menace looks like. What is the name of the wiggling menace? V___________________________ C___________________________ 8. After looking at the fecal slides, Beta shows you an animation on cholera. Describe the type of stool (poo) found in cases of cholera. ______________________________________________________________________________ 9. In what body part does V. cholera colonize or grow? ______________________________________________________________________________ 10. What is the treatment for cholera? ______________________________________________________________________________ 11. What ends up being the source of contamination? The tomatoes or the lake water? ______________________________________________ 12. At the end, Beta and Sirius say that the epidemic can be stopped if the refugees do what two things? ____________________________________________ and ______________________________ Name _______________________________________ Period_____ Mission 3: Smallpox . When Dr. Xu is talking to Beta and Delta, she tells them that she thinks that a patient has smallpox. You then learn that smallpox is contagious. What does contagious mean? __________________________________________________________________________ 2. When searching the apartment with Delta, you find out that smallpox was eradicated in the 20th century, but that smallpox could be used a weapon for what kind of terrorism? __________________________________________ ________________. 3. When searching the apartment with Delta, you find a Traveler’s Alert that tells you, that to avoid getting monkeypox, you should limit your contact with what 2 animals? 4. ______________________________ and _________________________ In the lab you see an interactive model of a virus. What is the part of the virus called that contains instructions to make other virus? ___________________________________________________ 5. In the lab, you see an interactive movie on viral reproduction. The process by which the virus obtains a new coating from the host cell’s membrane is it called replication, docking, or release? _____________________________________________________ 6. In the lab, you look at the viruses in Jeremy’s blisters with Beta. His blisters look similar to those a person would get from what disease? _________________. 7.When Alpha is in the lab he says that Dr. Xu has prevented anyone fromentering or leaving the hospital. What is this called when doctors isolate a patient? _____________________________________________ 8. After the dissection of the robospider, information is released which tells you who created the first vaccine. Who was it? ____________________________________________ 9. In the information that is released from the robospider, you learn that a pathogen from mild disease can protect someone against smallpox. What is the name of this mild disease? _________________________________________________ 10. After making the smallpox vaccine, you dip a special needle into the vaccine to vaccinate someone. What is the name of this special needle? __________________________________________________________________________ Mission 4: Malaria 1. In the game Vectorama, record one of the matches you make and list the disease the vector transmits. Disease ________________ transmitted by _________________________ 2. How many people die each year from malaria? _____________________________________ 3. Who discovered that a mosquito carried a parasite that caused disease ? ______________________________________________________________ 4. Is it the male of female mosquito that bites? _____________________________________ 5. In Plasmodia Invaders, the malaria parasite invades the liver and then destroys red blood cells. If too many red blood cells are destroyed, the patient can get a condition called ______________ _______. 6. In Immune System Defenders, what are the special chemicals called that white blood cells make that recognize and attack a specific pathogen? _____ ___________________ 7. “Phagocyte” means ________ ________ 9. What do anti-malarial drugs do to fight the disease? _______________________________________________________ 10. What did Eureka do to the guards in order to escape? ______________________________________________________ Mission 5: Diseases from Animals 1. List the four "Category A" pathogens that are zoonotic (spread from animals to humans). _____________ ________________ __________________ ___________________ 2. What did the Japanese use to spread plague infected fleas over China before World War II? _____________________________________________________________________________ 3. From where did the terrorist get the anthrax bacteria? PICK ONE career MedMyst Reloaded Microbiologist According to UtahFutures.org, how much does a biologist get paid in Utah? ________________ Disease Defenders What is step 1 of formulating a hypothesis? ______________________________________ What is step 2 of formulating a hypothesis? ______________________________________ What is step 3 of formulating a hypothesis? ______________________________________ What independent variable is being tested? ______________________________________ What is the dependent variable? ______________________________________ Why do you have to put on PPE before filtering the rabies fluid? ____________________ Is the hypothesis supported or rejected ______________________________________ Animal Alert What is encephalitis? _______________________________________________________ Patient samples were analyzed for what pathogens? ______________________________________ What type of pathogen is causing the encephalitis? ______________________________________ What specific pathogen does Dr. Adel Ratu think is causing the encephalitis? _________________ What is on a viral microarray? ______________________________________ The unknown viruses nucleic acid showed a ______% match to ____________________. What technique is used to confirm the microarray results? ______________________________ What were the results of the sequencing? ______________________________________ Serology was used to search the patient’s blood samples for _______________ to Nipah virus. What is the identity of the unknown virus? ______________________________________ What activity disrupted the fruit bats habitat that led to the outbreak? ______________________ MedMyst Reloaded Veterinarian According to UtahFutures.org, how much does a veterinarian get paid in Utah? ________________ Disease Defenders _____________________should always be worn in the necropsy suite. What is the vet’s hypothesis? ______________________________________ Which brain tissue sample serves as the positive control sample? ________________________________ Which brain tissue sample serves as the negative control sample? ______________________________ Which two brain tissue samples look very similar under the microscope after staining? ______________ Was the vet’s hypothesis supported or rejected by the results? ________________________________ The brain tissue staining confirmed that ___________________________________________________ Animal Alert What is encephalitis? ______________________________________ What is personal protective equipment? ______________________________________ What clinical signs do the sick pigs have? ______________________________________ What disease does the vet suspect the pigs have? ______________________________________ What is a quarantine? ______________________________________ What virus has infected the pigs? ______________________________________ What three things do pathogens cycle between in a disease transmission cycle? ____________________ _________________________ _______________________ A ______________ is where a pathogen normally lives. It is a constant source of a pathogen and is required for a pathogen to survive. What is a disease vehicle? _________________________________ ______ are the reservoir, ______ are the vector, ______ are the vehicle, and ______ are the host in the Yara virus transmission cycle. What activity disrupted the fruit bats habitat and led to the outbreak? ___________________________ MedMyst Reloaded Epidemiologist According to UtahFutures.org, how much does a medical scientist get paid in Utah? ________________ Disease Defenders A scientist who specializes in tracking outbreaks of disease is in the field of ________? What exposure and outcome are being investigated? Exposure= ______________________________________ Outcome= ______________________________________ Who are the cases in the outbreak simulation? ______________________________________ Who are the controls in the outbreak simulation? ______________________________________ What animal is hypothesized to be the source of the rabies? ___________________________________ You analyze the results of the questionnaire by putting them into a ________. The exposure odds ratio measures if there is an association between the ________ and the ________. Animal Alert What is encephalitis? ______________________________________ How do you determine if there is an outbreak occurring? ______________________________________ Who are the controls in the case-control study? ______________________________________ What pathogen is the cause of the encephalitis? ______________________________________ What do all the encephalitis cases in the North Village have in common? __________________ What is the source of Yara virus in the North, West, and East Village? _____________________ Who are affected with encephalitis in the South Village? _______________________________ What is the source of Yara virus in the South Village? __________________________________ What animal is the link between pigs, mangoes, and people? ___________________________ What activity disrupted the fruit bats habitat that led to the outbreak? ___________________ Name__________________________________ CSI: webadventures.rice.edu 1. What is DNA? ________________________________________________________________ 2. Which part of a cell contains DNA? _________________________________________________ 3. WHAT is CODIS? ________________________________________________________________ 4. How many markers are in a DNA profile? ____________________________________________ 5. What is toxicology? _____________________________________________________________ _____________________________________________________________________________ 6. What is usually collected by a medical examiner and sent to a tox lab after a person dies? _____________________________________________________________________________ 7. Which test reveals if a drug like heroin is in a body? ________________________________ 8. Toxicologist tend to have which personality types? ____________________ or ____________ 9. What is Rigor Mortis? __________________________________________________________ 10. What is Liver Mortis? ____________________________________________________________ 11. What is Algor Mortis? ____________________________________________________________ 12. What poison was in the dog food? _________________________________________________ 13. Bonus: Solve case Two: Who killed poor Mr. Williams? _________________________________________ 14. Bonus: Solve Case Three: Who Killed Freebird? ___________________________________________