Download Spherical Nucleic Acids: from Self

Spherical Nucleic Acids: from Self-assembly to Cancer Imaging
Presented by: Dr. Suchetan Pal
Center for Molecular Imaging and Nanotechnology (CMINT)
Memorial Sloan Kettering Cancer Center
New York, USA
ABSTRACT:
Spherical Nucleic Acids (SNAs) and DNA nanotechnology, two emerging and overlapping fields
dealing with artificial nucleic acid based nanostructures, have gained lot of attention in the field of
bio-detection, drug and gene delivery and self-assembly into higher order structures.1 In this talk
I will share a few of my results in the fields of spherical nucleic acids and DNA nanotechnology.
In the first part of the talk, I will discuss about self-assembly, dynamic modulation of selfassembled SNAs.2 In the second part of the presentation, I will present the results on how the
SNA based nanoparticles are utilized in high resolution imaging of expression of cancer related
antigens in vivo and the optimization of a new generation of ultra-bright nanoprobes using DNA
molecules for cancer imaging.
References:
1.
(a) Cutler, J. I.; Auyeung, E.; Mirkin, C. A., Spherical Nucleic Acids. Journal of the
American Chemical Society 2012, 134 (3), 1376-1391; (b) Jones, M. R.; Seeman, N. C.; Mirkin,
C. A., Programmable materials and the nature of the DNA bond. Science 2015, 347 (6224).
2.
(a) Pal, S.; Deng, Z.; Wang, H.; Zou, S.; Liu, Y.; Yan, H., DNA Directed Self-Assembly of
Anisotropic Plasmonic Nanostructures. Journal of the American Chemical Society 2011, 133 (44),
17606-17609; (b) Pal, S.; Zhang, Y.; Kumar, S. K.; Gang, O., Dynamic tuning of DNA-nanoparticle
superlattices by molecular intercalation of double helix. Journal of the American Chemical Society
2015, 137 (12), 4030-4033; (c) Zhang, Y.; Pal, S.; Srinivasan, B.; Vo, T.; Kumar, S.; Gang, O.,
Selective transformations between nanoparticle superlattices via the reprogramming of DNAmediated interactions. Nature materials 2015, 14 (8), 840-847.