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INDICATIONS Supplementation with SINERGA is indicated in children and adults, in susceptible individuals or in the course of Respiratory Infections (RI) and Recurrent Respiratory Infections (RRI), characterized by immunological virginity, functional immaturity of the whole body's defense system, system depressant action carried out by the viral infections on the immune system, partial deficiency of IgA (immunoglobulin A) and IgG (immunoglobulin G), ), damage caused by the viruses to the airway epithelial cells predisposing the bacterial adhesion adhesion. RI and RRI are characterized by the following clinical signs: fever and redness of all the mucous membranes of the respiratory tract, rhinitis,, sinusitis, pharyngotonsillitis, otitis, laryngitis, tracheobronchitis, obstructive ructive bronchitis and asthmatiform bronchitis, bronchial pneumonia. COMPOSITION (substances with a physiological effect) effect Palmitoylethanolamide Active lactic typed yeasts Kluyver B0399 (Kluyveromyces F.M. B0399) Colostrum Phenylethylamine HOW TO USE Pediatric age (3-12 years old) 1 liquid-dispersible sachet a day Adults (age > 12 years old) 2 liquid-dispersible sachets a day The assumption of the contents of the liquid-dispersible liquid sachets must be made preferably on an empty stomach, at least 15 minutes before meals, preferably in the morning or evening (for once daily dosing it is preferable to take the contents of the sachet in the morning).Supplementation with SINERGA in susceptible individuals or in the course of Respiratory Infections I (RI) and Recurrent Respiratory Infections (RR RRI), is recommended for 10 consecutive days per month, to be repeated for at least 4 consecutive months months. Supplementation with SINERGA is also indicated in conjunction with a possible antibiotic treatment. METHOD OF ASSUMPTION Pour the contents of the sachet into a glass (preferably plastic), add the thickness of two inches of water water, mix thoroughly and swallow. PACKS Box of 20 liquid-dispersible sachets of 3 g. WARNINGS To be used under medical supervision. Store product in a cool (T <25 ° C), dry place and protected from light light. The expiry date refers to the product closed and properly stored. Keep out of reach of children under 3 years old. Do not exceed the recommended daily dose. SINERGA is not intended as a substitute for a varied diet diet. It is advisable not to use the product during pregnancy and breastfeeding. MAIN ACTIVITIES of the physiological effect substances present in SINERGA Kluyveromyces F.M. B0399 is an homofermenting lactic YEAST (by fermentation only L-lactic acid is produced) with a strong bioregulator activity of the intestinal flora and modulator of the immune system with production of IgA and IgG IgG. The main features of Kluyveromyces FM B0399 are: Action of modulation of the immune system with production of IgA and IgG Production of high quantities of acid L-lactic L without the production of other substances potentially harmful to the body,, typical of heterofermenting lactobacilli (ex. CO2, ethyl alcohol, acetaldehyde ehyde, acetic acid etc.) It overcomes undamaged the gastric barrier due to the presence of chitin in the cell wall and has a strong vitality even at pH 3-3,5 It has the highest capacity for colonization of the intestine compared to the most common used probiotics (increase CFU/g 103→106 with 1-20 millions daily dosage) Highly resistant to most common ANTIBIOTICS used in RI and RRI Innate resistance to bacteriophages Palmitoylethanolamide or PEA is a natural endogenous compound belonging to the class of fatty acid amides, which is involved in some physiological mechanisms of protection that the body triggers in response to various types of tissue damage, such as the activation of inflammatory tissue reactivity and of the nociceptive airways. Its physiological activity has been recently defined as "Autacoids utacoids Local Injury Antagonism" (Levi Montalcini et al., 1996),, that is its involvement in the protection systems of the body, body not only inflammatory in nature. Palmitoylethanolamide supplementation exerts an a antagonist physiological action of a local nature against inflammation, modulating the reactivity of mast cells, often over-expressed over during RI and RRI,, which is expressed through the release of macromolecules with high potential pro inflammatory, halogen and itching (eg. cytokines, vasoactive amines, proteolytic enzymes,, bradykinin, histamine). In susceptible individuals ndividuals or in the course of Respiratory Infections and Recurrent Respiratory Infections, Palmitoylethanolamide almitoylethanolamide supplementation is useful to counter physiologically the deficit of its endogenous production that may occur. Colostrum is the milk produced by cows during the 48 hours after delivery, which contains numerous immune and growth factors, and other minor components. Colostrum supplementation helps lps bringing to the body all the immune and growth factors that may result in amounts less than optimal in the cases of RI and RRI, i.e; Immune factors: Immunoglobulins (IgA - IgG - IgM - IgD - IgE), proline-rich rich Polypeptides (PRP), lactoferrin, cytokines, enzymes, glycoproteins, tryptic ryptic inhibitors, inhibitor lysozyme, lymphokines, oligo-polysaccharides polysaccharides and glycoconjugates Growth factors:: epidermal growth factor (EGF), (EGF fibroblast growth factor (FGF), insulin-like like growth factors I and II II, transformed growth factors (TGF A & B) Phenylethylamine is a monoamine alkaloid bio-synthesized synthesized by enzymatic decarboxylation of phenylalanine aminoacid. Its supplementation contributes directly to increasing physiologically the amount of freely circulating dopamine dopamine, enhancing, in this way, the dopaminergic transmission. transmission This ability to modulate dopaminergic transmission results in improved concentration both of the mood and appetite regulation, that is in improving the general physical conditions, often compromised during RI and RRI. MANUFACTURING Manufactured by Galsor srl in the establishment in Via al Santuario NS della Guardia 36r Genova (GE) GALSOR S.r.l. Via Filippo Bonavitacola, 83048 Montella (AV) www.galsor.it