Download CAMB 605 Course Syllabus (Fall 2016) Presentation 1: Faculty

CAMB 605 (Fall 2016)
CAMB 605 Course Syllabus (Fall 2016)
Tuesdays 1-4pm
September 13 to December 13, 2016
John Seykora (Course Director)
215 898 0170
[email protected]
1011 BRB II/III Dermatology
Presentation 1: Faculty Chosen Papers
September 13
Paper 1 (MVP1): Sun et al., Cyclic GMP-AMP synthase is a cytosolic DNA sensor that
activates the type 1 interferon pathway. Science 339: 786-91. 2013
Paper 2: (GGR1): Hay D, et. al. Genetic dissection of the α-globin super-enhancer in vivo.
Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4. PubMed
PMID: 27376235.
September 20
Paper 3: (CPM1): Molliex A, et. al., Phase separation by low complexity domains
promotes stress granule assembly and drives pathological fibrillization. Cell. 2015 Sep
24;163(1):123-33. doi: 10.1016/j.cell.2015.09.015. PubMed PMID: 26406374.
Paper 4: (GTV1): Pasetto A, et. al., Tumor- and Neoantigen-Reactive T-cell Receptors
Can Be Identified Based on Their Frequency in Fresh Tumor. Cancer Immunol Res. 2016
Jun 28. [Epub ahead of print] PubMed PMID: 27354337.
September 27
Paper 5: (DSRB1): Chen W et. al. PDGFB-based stem cell gene therapy increases bone
strength in the mouse. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3893-900. doi:
10.1073/pnas.1501759112. Epub 2015 Jul 6. PubMed PMID: 26150503; PubMed Central
PMCID: PMC4517286.
Paper 6: (CB1): Denny SK, et. al., Nfib Promotes Metastasis through a Widespread
Increase in Chromatin Accessibility. Cell. 2016 Jul 14;166(2):328-42. doi:
10.1016/j.cell.2016.05.052. Epub 2016 Jun 30. PubMed PMID: 27374332.
October 4
Paper 7: (MVP2): Dey B, et al. A bacterial cyclic dinucleotide activates the cytosolic
surveillance pathway and mediates innate resistance to tuberculosis. Nat Med. 2015
Apr;21(4):401-6. doi: 10.1038/nm.3813. Epub 2015 Mar 2; PubMed Central PMCID:
PMC4390473.
CAMB 605 (Fall 2016)
Paper 8: (GGR2): Lewis SC, Uchiyama LF, Nunnari J. ER-mitochondria contacts couple
mtDNA synthesis with mitochondrial division in human cells. Science. 2016 Jul
15;353(6296):aaf5549. doi: 10.1126/science.aaf5549. PubMed PMID: 27418514.
October 11
Paper 9: (CPM2): Su X, et. al., Phase separation of signaling molecules promotes T cell
receptor signal transduction. Science. 2016 Apr 29;352(6285):595-9. doi:
10.1126/science.aad9964. Epub 2016 Apr 7. PubMed PMID: 27056844; PubMed Central
PMCID: PMC4892427.
Paper 10: (GTV2): Pulko V, et. al., Human memory T cells with a naive phenotype
accumulate with aging and respond to persistent viruses. Nat Immunol. 2016
Aug;17(8):966-75. doi: 10.1038/ni.3483. Epub 2016 Jun 6. PubMed PMID: 27270402;
PubMed Central PMCID: PMC4955715.
October 18
Paper 11: (DSRB2): Farin HF et. al. Visualization of a short-range Wnt
gradient in the intestinal stem-cell niche. Nature. 2016 Feb 18;530(7590):340-3.
doi: 10.1038/nature16937. Epub 2016 Feb 10. PubMed PMID: 26863187.
Paper 12: (CB2): Puram RV et. al., Core Circadian Clock Genes
Regulate Leukemia Stem Cells in AML. Cell. 2016 Apr 7;165(2):303-16. doi:
10.1016/j.cell.2016.03.015. PubMed PMID: 27058663; PubMed Central PMCID:
PMC4826477.
October 25
Open Date
Presentation 2: Student Chosen Papers From List of Following Topics
November 1
Topic 1: (MVP1): Cytosolic immune defense against intracellular pathogens
Topic 2: (GGR1): Transcription factors, cellular plasticity and disease
November 8
Topic 3: (CPM1): Phase separation in cell biology, and aberrant phase transitions in
disease
Topic 4: (GTV1): Cancer Immunotherapy
November 15
Topic 5: (DSRB1): Stem cells in tissue self-renewal and maintenance
Topic 6: (CB1): Emerging Cancer Paradigms: At the intersection of biology and
therapeutics
CAMB 605 (Fall 2016)
November 29
Topic 1: (MVP2): Cytosolic immune defense against intracellular pathogens
Topic 2: (GGR2): Transcription factors, cellular plasticity and disease
December 6
Topic 3: (CPM2): Phase separation in cell biology, and aberrant phase transitions in
disease
Topic 4: (GTV2): Cancer Immunotherapy
December 13
Topic 5: (DSRB2): Stem cells in tissue self-renewal and maintenance
Topic 6: (CB2): Emerging Cancer Paradigms: At the intersection of biology and
therapeutics