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Cardiovascular System 1 【Objectives】 1. To identify and describe: A. Structure of the heart wall-- endocardium, myocardium, epicardium and Purkinje fibers. B. Structure of the different arteries-tunica intima, tunica media, tunica adventitia, internal and external elastic lamina. 2. To understand and describe the common features of veins and three layers in their walls; differentiate these from those in the arteries. 3. To understand and describe the main histological structure of the capillaries. 2 Heart Veins Arteries Capillaries Lymphatic vascular Interstitial fluid Cells , tissues Lymph Capillariers 3 The structure of the Heart wall Endocardium * Myocardium * Epicardium What is the principal component in the wall of the heart? Cardiac muscle cells 4 Endocardium endothelium Subendothelial layer subendocardial layer (contain Purkinje fibers) Cardiac conduction system Myocardium Question How to distinguish endocardium and epicardium? Epicardium loose connective tissue 5 mesothelium General Structure of blood vessels endothelium subendothelium Tunica intima internal elastic lamina Tunica media smooth muscle cells elastic elastic laminae Tunica adventitia external elastic lamina connective tissue 6 Comparison of large, medium small arteries and arterioles Tunica intima Large A (elastic A) (>10mm) Tunica media Tunica adenvential smooth muscle making the blood flux uniform . numerous elastic lamellae prominent internal numerous smooth muscle prominent Medium A relatively little external (Muscular artery) elastic lamina elastic tissue elastic lamina (2-10mm) Small A prominent internal (Muscular artery) elastic membrane (0.1-0.3mm) Arterioles (10-100um) smooth muscle (8-10 cell layers) smooth muscle (1-2 cell layers) Function control the affluence of blood to the organs help control and modulate blood pressure responsible for the regulating of blood pressure 7 Medium Artery Tunica media Tunica media 8 Tunica adventitia Small artery 9 artery artery vein Larger lumen and thinner wall compared with the same grade of artery, usually shows an irregular shape when sectioned. The boundaries between 3 layers are obscure. 10 Arterioles: 11 Vein: Larger lumen and thinner wall compared with the same grade of artery, usually shows an irregular shape when sectioned. The boundaries between 3 layers are obscure. 12 The tunica adventitia is relatively thick. In tunica adventitia of some large veins, longitudinally arranged smooth muscle fibers can be found. 13 Medium Artery Medium vein 14 Small artery and small vein 15 Arterioles capillary 16 Homework Compare the structure of elastic and Muscular artery 17 THANK YOU 18