Download Genetics - Video course Biotechnology

NPTEL Syllabus
Genetics - Video course
COURSE OUTLINE
Introduction, Reproduction as the basis of heredity, Mendelian principles of
genetics, Gene interactions, Quantitative inheritance, Chromosomal basis of
inheritance and linkage, Construction of genetic and physical maps, Molecular
Genetics: DNA Replication, Transcription, Translation, Regulation of Gene
expression, Gene mutations and chromosomal changes, Recombinant DNA
technology, Population genetics, Genetic disorders and genetic counseling,
Applications of genetics.
COURSE DETAIL
S.No
Syllabus
No. of
Lectures
NPTEL
http://nptel.iitm.ac.in
Biotechnology
Pre-requisites:
Basic biology.
1.
Introduction:
The relationship between genes and traits, the
branches of genetics, relationship of genetics to
other areas of biology, genetics and society.
2.
Additional Reading:
1
Watson, J.D., Baker, T.A., Bell, S.P.,
Gann, A., Levine, M. and Losick, R..
"Molecular Biology of the Gene", 5th
Ed., Pearson Education. 2004.
Reproduction as the basis of heredity:
The cell as the unit of life, overview of
chromosomes, cell division, gametogenesis,
the life cycles of some genetically important
organisms.
Hyperlinks:
2
1. www.nobelprize.org
Coordinators:
3.
Mendelian principles of genetics:
The principles of dominance and segregation,
the principle of independent assortment,
applications of Mendelian principles.
4.
Gene interactions:
Gene interactions that produce new
phenotypes, epistasis.
5.
2
Quantitative inheritance:
Quantitative traits, polygenic inheritance,
heritability,
Extranuclear genomes
and
inheritance: Organization of extranuclear
genomes, role of extranuclear inheritance,
examples of extranuclear inheritance, maternal
effect, genomic imprinting.
6.
2
3
Chromosomal basis of inheritance and
linkage:
Experimental evidence linking the inheritance
of genes to chromosomes, chromosomes as
3
Prof. G. S. Randhawa
Department of BiotechnologyIIT
Roorkee
arrays of genes, non-disjunction as proof of the
chromosome theory, the chromosomal basis of
Mendelian principles.
7.
Construction of genetic and physical maps:
Linkage and crossing over, genetic mapping in
eukaryotes, genetic transfer and mapping in
bacteria, intragenic mapping in bacteriophages.
8.
3
Molecular Genetics:
DNA Replication
in
prokaryote
and
eukaryotes, enzymes and accessory proteins,
telomere replication.
DNA
repair, Transcription process in
prokaryote
&
eukaryotes, regulation of
transcription. RNA processing, nuclear export
and
stability
of m R N A , Translation in
prokaryote
and
eukaryotes
translation,
translational control , co and post translational
modification of proteins, Regulation of Gene
expression in prokaryotes & eukaryotes.
9.
Gene mutations and chromosomal changes:
Occurrence and causes of DNA mutations,
spontaneous and induced mutations, DNA
repair, Types of chromosomal mutations,
variations in chromosome structure, variations
i n chromosome
number,
chromosome
rearrangements, consequences of mutations,
Transposable elements.
10.
Recombinant DNA technology:
Population genetics:
Genetic structure of populations, the HardyWeinberg law, factors that change allele
frequencies in populations.
12.
3
Genetic disorders and genetic counseling:
Examples of genetic disorders in humans,
carrier detection, foetal analysis.
13.
4
4
DNA cloning, genome sequencing.
11.
10
2
Applications of genetics:
Genetic advances in agriculture and medicine,
eugenics and euphenics.
Total
1
40
References:
1. Snustad, S., "Principles of Genetics", John Willey & Sons Inc.
Hoboken.(2003).
2. Klug, W.S. and Cummings, M.R., "Concepts of Genetics", Pearson
Education Inc. (2004).
3. Russel, P.J., "Genetics", 6th Ed., Benjamin Cumming Comp.Inc. (2006).
4. Miglani, G.S. "Basic Genetics", Narosa Publishing House. (2000).
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