Download New Haven, CT

Revised Sept 14, 2014
Sabet W. Hashim, M.D.
CURRICULUM VITAE
Name:
Sabet W. Hashim, M.D., FACS.
School:
Yale University School of Medicine
Education:
Baccalauréat: Mathematics, Lycée Français of Beirut, 1968 (High Honors)
M.D.
St. Joseph’s University School of Medicine, Beirut, 1975 (Honors)
Ranked 1st in medical school admission exam
Specialized Training:
1983
1984
2008
2009
2012
2012
Mitral Valve Repair, Broussais University Hospital, Paris, France
Heart Transplantation, Stanford University, Palo Alto, CA, University of
Pittsburgh, Pittsburgh, PA and Columbia University/New York Presbyterian
Hospital, New York, NY
Robotic Cardiac Surgery, St. Joseph’s Hospital, Atlanta, GA and Good Samaritan
Hospital, Cincinnati, OH
Minimally Invasive Mitral Valve Repair through Right Thoracotomy, OLV
Clinic, Aalst, Belgium and Lankenau Hospital, Wynnewood, PA
Trans-femoral Aortic Valve Replacement (TAVR), Edwards Sapien Course,
Vancouver, Canada
Trans-apical Aortic Valve Replacement (TAVR), Edwards Sapien Course,
Atlanta, Georgia
Career and Academic Appointments:
Internship, General Surgery, St. Luke’s Hospital Medical Center, New York, NY
First Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY
1977-1978
Third Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY (promoted by bypassing Second Year Residency)
1978-1979
Chief Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY
Instructor in Surgery, Columbia University School of Medicine
1979-1981
Resident, Cardiothoracic Surgery, Yale New Haven Hospital, New Haven, CT
1981-1983
Attending Surgeon, VA Hospital, West Haven, CT
1981-Present Attending Surgeon, Yale New Haven Hospital, New Haven, CT
1981-1986
Assistant Professor of Surgery, Yale University School of Medicine, New
Haven, CT
1975-1976
1976-1977
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Sabet W. Hashim, M.D.
1986-2006
President of Cardiothoracic Surgeons of New Haven, P.C., New
Haven, CT
2007-Present Associate Professor of Surgery, Yale University School of Medicine, New
Haven, CT
Administrative Positions:
2006-Present Director of Cardiac Valve Surgery, Yale New Haven Hospital, New Haven, CT
2010-2011
Surgical Director, Heart and Vascular Center, Yale New Haven Hospital,
New Haven, CT
2010-2011
Clinical Chief, Section of Cardiac Surgery, Yale University School of Medicine,
New Haven, CT
1981-1986
Co-Director of Cardiac Transplantation, Yale New Haven Hospital, New Haven,
CT
Board Certification:
American Board of Surgery, 1980
American Board of Thoracic Surgery, 1982
American Board of Thoracic Surgery, Recertification, 1992, 2001, 2012
Professional Honors & Recognition:
2010-2014
2010-2014
2010-2014
2010-2013
2010-2013
Best Doctors in New York, New York Magazine
NY Metro Area’s Top Doctors, Castle Connolly Medical Ltd.
America’s Top Doctors, Castle Connolly Medical Ltd.
Patients' Choice Award, Vitals
Most Compassionate Doctor, Vitals
Professional Organizations:
American College of Surgeons, Fellow
Society of Thoracic Surgeons, Member
American Medical Association, Member
Yale Surgical Society, Member
Lebanese American University School of Medicine, Founding Faculty
American-Lebanese Medical Association, Board Member
New Haven Medical Association, Member
Connecticut Medical Association, Member
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Sabet W. Hashim, M.D.
Clinical Trials, Current and Past:
Agency: Medtronic, Inc.
I.D.# NCT01586910
Title: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of
Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic
Valve Replacement (SURTAVI).
P.I.: Sabet Hashim, M.D.
Role on Project: Yale Site P.I.
Project period: 2013-2018
Agency: Abbott, Inc.
I.D.# NCT01626079
Title: “Clinical Outcomes Assessment of the MitraClip Therapy Percutaneous Therapy for
High Surgical Risk Patients (COAPT)”
P.I.: Sabet Hashim, M.D.
Role on Project: Yale Site P.I.
Project period: 2013-2018
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title: CoreValve Pivotal Clinical trial to evaluate the safety and efficacy of the Medtronic
CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects
necessitating aortic valve replacement, with predicted operative mortality or serious,
irreversible morbidity risk of ≥ 50% at 30 days
P.I.: Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title: CoreValve Continued Access clinical trial to evaluate the safety and efficacy of the
Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in
subjects necessitating aortic valve replacement, with predicted operative mortality or
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Sabet W. Hashim, M.D.
serious, irreversible morbidity risk of ≥15% and <50% (High Risk) or ≥ 50% (Extreme
Risk) at 30 days.
P.I.: Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title: CoreValve Expanded Use clinical trial to evaluate the safety and efficacy of the
Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis in
subjects with significant comorbidities
in whom the risk of surgical aortic valve replacement has a predicted operative mortality
or serious, irreversible morbidity risk of ≥50% at 30 days.
P.I.: Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Agency:
Abbott, Inc
Title:
Indicators of Acute Kidney Injury in Patients Undergoing Cardiac Surgery
P.I.:
Chirag Parikh, M.D.
Role on Project: Collaborator
Project period: 2007-2011
Pending Clinical Trials:
Agency:
Edwards LifeSciences, Inc.
Title: “Commence” trial comparing valve preparations: Glutaraldehyde versus dry preparation
P.I: Sabet Hashim, M.D.
Direct Cost: $550,000
Peer-Reviewed Presentations & Symposia:
National:
2012
2011
Annual American Heart Association Scientific Sessions Meeting, Los Angeles, CA:
“The Free Right Internal Thoracic Artery: A Versatile and Durable Conduit”
American Association for Thoracic Surgeons Mitral Valve Conclave Meeting, New
York, NY: “Identification of Pseudo Prolapse of the Anterior Leaflet in a Subgroup of
Patients with Chronic Ischemic Mitral Regurgitation and Correction with Neochordae
Improves Late Mid-term Outcomes of Mitral Valve Repair”
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Sabet W. Hashim, M.D.
2011
2007
1984
1984
Annual American Heart Association Scientific Sessions Meeting, Orlando, FL:
“Modulation of Transforming Growth Factor-β Signaling and Extracellular Matrix in
Myxomatous Mitral Valve Degeneration by Angiotensin II Receptor Blocker Losartan”
Valves in the Heart of the Big Apple Symposium, New York, NY: “Improved Results
of Tricuspid Valve Repair Using Undersized Annuloplasty Rings”
New England Surgical Society, NH: “Non-Cardiogenic Pulmonary Edema
Following Cardiopulmonary Bypass: An Anaphylactic Reaction to Fresh Frozen
Plasma”
American College of Surgeons, Surgical Forum, San Francisco, CA: “A Safer Method
of Cardioplegia Delivery in Aortic Valve Surgery
International:
28th EACTS Annual Meeting, Milan, Italy: “Radial Artery Versus Right Internal
Thoracic Artery as the Best Second Conduit in Multi Arterial CABG-A Multi
Institutional Study.” Accepted.
2011 6th International Congress on Cardiovascular Diseases, New Delhi, India:
“Towards Adopting Right-Sided Pacemaker Implantation: A Safer Surgical Practice”
(Awarded "Best Paper in Clinical Cardiology”)
2011 21st World Congress, World Society of Cardio-Thoracic Surgeons, Berlin, Germany:
“Durable Mitral Valve Repair in Chronic Ischemic Mitral Regurgitation Requires
Identification and Correction of Pseudo-Prolapse of Anterior Leaflet, When Present”
2010 90th Annual Meeting of the American Association for Thoracic Surgeons,
Toronto, Canada: “Transforming Growth Factor-B Induces the Expression of
Extracellular Matrix Molecules in Myxomatous Mitral Valves”
2014
Invited Speaking Engagements, Presentations, Symposia & Workshops Not Affiliated With
Yale:
International/National:
2014 American University of Beirut Symposium: “The Role of Surgery in Ischemic
Mitral Regurgitation”
2013 Edwards Lifesciences Fellow Program, Irvine, CA: Three day program for U.S. and
international cardiothoracic surgery residents (Faculty)
Lecture: “Mitral Valve Surgery: Helpful Techniques to Enhance Your Repair Rate”
Workshop: wet lab for surgical techniques
2009 American Lebanese Medical Association, Beirut: “The Future of Mitral Valve Repair”
2008 Symposia Mitral, Medellin, Columbia: “New Techniques of Mitral Valve
Reconstruction”
2008 American Association of Thoracic Surgery, San Diego, CA: “Evolving Techniques of
Mitral Valve Repair”
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Sabet W. Hashim, M.D.
Regional:
2014 Department of Surgery Grand Rounds, Yale School of Medicine, New Haven, CT: “Did
Surgery Fail Ischemic Mitral Regurgitation?”
2013 2nd Annual Yale Advanced Heart Failure Symposium, New Haven, CT: “Surgical
Approach to Ischemic Mitral Regurgitation”
2013 Cardiology Conference Bridgeport Hospital, Bridgeport, CT: “Surgery for Ischemic
Mitral Regurgitation”
2013 Homestead Inn, Greenwich, CT: “The Role of Surgery in Ischemic Mitral Regurgitation”
2009 Seventeenth Annual Bradley Memorial Cardiovascular Symposium, Southington, CT:
“Mitral Valve Repair: The Third Decade”
2004 American Heart Association, Middletown, CT: “Atrial Fibrillation Roundtable”
2002 Greenwich Hospital, Greenwich, CT: “Trends in Cardiac Surgery”.
2002 Norwalk Hospital, Norwalk, CT: “Mitral Valve Repair”
2001 Annual Meeting of Physicians Assistants, Ledyard, CT: “Progress or Gimmick n Cardiac
Surgery”
Professional Service:
For Journals:
2010-present
2010-present
Guest Reviewer, Cardiology
Guest Reviewer, Cardioexchange, An NEJM Practice Community
For Organizations:
Abbott Laboratories
2012-present Acute Kidney Injury Advisory Board
Edwards Lifesciences LLC
2009-present Consultant
Yale Service:
Hospital Boards & Committees:
2013-present
2010-present
2009-2010
2004-2006
1985
Patient Safety and Quality Subcommittee, Yale Heart and Vascular Center
Council on Cardiothoracic Surgery
Heart & Vascular Service Task Force
Operating Room Committee
Task Force on Coronary Bypass Surgery
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Sabet W. Hashim, M.D.
Hospital Programs Initiated:
2012
2005
2005
2001
1984
1984
Trans-femoral and Trans-apical Aortic Valve Replacement (TAVR) using the
Edwards Lifesciences Sapien Valve, in collaboration with Drs. Cleman,
Thompson, Geirsson and Forrest
Minimally-invasive techniques of mitral valve repair: Mini-sternotomy, submammary incision and the right mini-thoracotomy approach
Aortic valve replacement using mini-upper sternotomy incision
Atrial fibrillation surgery
Co-directed the heart transplant program and performed the first heart transplant
in Connecticut
Mitral valve repair program
BIBLIOGRAPHY
Peer-Reviewed Original Publications:
1. Kay H, Barash P, Geha A, Kopf G, Hashim SW and Kopriva C: A PlaceboControlled, Randomized Blind Study of Parenteral Nitroglycerin During Open
Heart Operations. Surg Forum 33:251-253, 1982.
2. Barash PG, Seinfeld F, Kay H, Condos SG, Hashim SW, Tinker J and Geha
AS: RPP: May it R.I.P. Anesthesiol 57:A22, 1982.
3. Stavens B, Hashim SW, Hammond GL, Stansel HC, Gatehouse J, Kopf GS
and Geha AS: Optimal Methods of Repair of Descending Thoracic Aortic
Disruptions and Aneurysm. Am J Surg 145(4):508-513, 1983.
4. Hashim SW, Hammond GL, Condos S, Kopf GS and Geha AS: A Safer
Method of Cardioplegia Delivery in Aortic Valve Surgery. Surg Forum 35:
286-287, 1984.
5. Hashim SW, Kay HR, Hammond GL, Kopf GS and Gela AS:
Noncardiogenic Pulmonary Edema following Cardiopulmonary Bypass: An
Anaphylactic Reaction to Fresh Frozen Plasma. Am J Surg 147(4):560-564,
1984. Chosen for the Year Book of Surgery, 1984
6. Geha AS, Hashim SW, Kopf GS and Hammond GL: Early and Late Results
of Combined Valve Replacement and Myocardial Revascularization: The
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Sabet W. Hashim, M.D.
Problem of Severe Ischemic Mitral Regurgitation. Chest 86:292, 1984.
7. Breisblatt WM, Berger RB, Cabin HS, Cleman MW, Cerqueira MD,
Neumann RD, Ezekowitz MD, Hashim SW and Berger HJ: Unsuspected Left
Ventricular Pseudoaneurysm in a Patient with Coronary Artery Disease. Am J
Roent 142:680-682, 1984.
8. Geha AS, Francis CK, and Hammond GL, Laks H, Kopf GS and Hashim
SW: Combined Valve Replacement and Myocardial Revascularization. J Vasc
Surg 1:27-35, 1984.
9. Zahler R, Breisblatt W, Hashim SW, Kleinman C, Langou R: Isolated Right
Atrial Tamponade by Serous Fluid Simulating Tricuspid Stenosis. Am J Med
79:531-534, 1985.
10. Kopf GS, Hume AL, Durkin MA, Hammond GL, Hashim SW and Geha AS:
Measurement of Central Somatosensory Conduction Time in Patients
Undergoing Cardiopulmonary Bypass: An Index of Neurological Function.
Am J Surg 149:445-448, 1985.
11. Gertler J, Elefteriades JA, Kopf GS, Hammond GL, Hashim SW, and Geha
AS: Predictors of Outcome following Early and Delayed Revascularization
for Acute Myocardial infarction. Am J Surg 149:441-444, 1985.
12. Hashim SW: Safe Technique for Aortic Anastomosis in Orthopedic Canine
Cardiac Transplantation. Ann Thorac Surg 39:389-390, 1985.
13. Morse SS, Strauss ED, Hashim SW, Greenwood CH, Denny DF and
Sniderman KW: Percutaneous Retrieval of an Unusually Large Nonopaque
Intravascular Foreign Body. Am J Radiol 146:863-864, April 1986.
14. Kopf GS, Hammond GL, Geha AS, Elefteriades JE and Hashim SW: Long
Term Performance of St. Jude Medical Valve: Low Incidence of
Thromboembolism and Hemorrhagic Complications with Modest Doses of
Warfarin. Circulation 76 (3 Pt 2): III 132-136, 1987.
15. Hammond GL, Geha AS, Kopf GS, and Hashim SW: Biological Versus
Mechanical Valves: Analysis of 1,116 valves inserted in 1,012 adult patients
with a 4,818 patient-year and a 5,327 valve year follow up. J Thorac
Cardiovas Surg 93:182-198, 1987.
16. Passik CS, Hashim SW: Right Ventricular Failure. Ann Thorac Surg 62:
630,1996.
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Sabet W. Hashim, M.D.
17. Rafferty TD, Hasel R, Tousignant G, Woodruff A, Braxton JH, Hashim SW:
TEE diagnosis of excessive motion of the mitral leaflets. Video J Echocard 5:
59-77, 1995.
18. Jovin A, Hashim SW, Jovin IS, Clancy JF, Klovekorn WP and MullerBerghaus G: Atrial Fibrillation at Discharge from the Hospital in Patients
Undergoing Mitral Valve Repair. J Thorac Cardiovasc Surg 53: 41-45, 2005.
19. Oprea D, Memet R, Jovin A, Duggal M, Collazo S, Jovin IS, Hashim SW,
Clancy JF. Anticoagulation at Discharge after Mitral Valve Repair and LongTerm Mortality. Circulation 114 (Suppl.): II-734, 2006.
20. Kurup V, Perrino A, Barash P, Hashim SW: Echo Rounds: Infundibular
Pulmonary Stenosis. Anesthes Analges 104, 507-508, 2007.
21. Hashim SW, Rousou AJ, Geirsson A, Sigurdur R: Solving the Puzzle of
Chronic Ischemic Mitral Regurgitation. Yale J Bio Med 81; 167-173, 2008.
22. Jovin A, Oprea D, Jovin IS, Hashim SW, Clancy JF: Atrial Fibrillation and
Mitral Valve Repair. Pacing and Clinical Electrophysiology 31;1057-62,
2008.
23. Hashim SW, Youssef SJ, Ayyash B, Ragnarsson S, Collazo S, Geirsson A.
Pseudo-Prolapse of the Anterior Leaflet in Chronic Ischemic Mitral
Regurgitation: Identification and Repair. J Thorac Cardiovasc Surg 143 (4
suppl): S33-7, April 2012.
24. Coca S, Jammalamadaka, D, Sint K, Thiessen Philbrook H, Shlipak M,
Zappitelli M, Devarajan P, Hashim SW, Garg A, MD, Parikh C. Preoperative
Proteinuria Predicts Acute Kidney Injury in Patients Undergoing Cardiac
Surgery. J Thorac Cardiovasc Surg 143 (2): 497-502, 2012.
25. Dodson J, Wang Y, Desai MM, Filho J, Sugeng L, Hashim SW, Krumholz
HM: Outcomes for Mitral Valve Surgery among Medicare Fee-for Service
Beneficiaries, 1999-2008. Circ Cardiovasc Qual Outcomes 5(3); 298-307,
2012.
26. Geirsson A, Singh M, Ali R, Abbas H, Li W, Sanchez J, Hashim SW,
Tellides G. Modulation of TGF-B signaling and Extracellular Matrix
Production in Myxomatous Mitral Valves by Angiotensin II Receptor
Blockers. Circulation 126: S189-S197, 2012.
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Sabet W. Hashim, M.D.
27. Hashim PW, Hashim SW. Aortic Cannulation with a Single Purse-String
Suture. J Thorac Cardiovasc Surg 147(4):1430-31, April 2014.
28. Hashim PW, Hashim SW. Liver laceration from a Diaphragmatic Suture in
Minithoracotomy Mitral Valve Repair. J Card Surg 29(4):476-7. July 2014.
29. Khan UA, Coca SG, Hong K, Koyner JL, Garg AX, Passik CS, Swaminathan
M, Garwood S, Patel UD, Hashim SW, Quantz MA, Parikh CR. Blood
Transfusions Are Associated with Urinary Biomarkers of Kidney Injury in
Cardiac Surgery. J Thorac Cardiovasc Surg 148(2):726-32. August 2014.
30. Hashim PW, Assi R, Hashim SW. The Imbrication Technique: An
Alternative to the Sliding Leaflet Technique. Ann Thorac Surg 98:1124-26.
September 2014.
31. Assi R, Youssef SJ, Almarzooq Z, Al-Raweshidy Y, Hashim PW, Geirsson A,
Hashim SW: The “Free” Right Internal Thoracic Artery: A Versatile and
Durable Conduit. J Card Surg 29(5):609-15. September 2014.
Chapters, Books and Reviews:
32. Hashim SW, Baue AE and Geha AS: The Role of Mediastinoscopy and
Mediastinotomy in Lung Cancer. Clin Chest Med 3:353-359, 1982.
Invited Editorial and Commentaries:
33. Adams D, Hashim SW, Sarano ME, Elefteriades JA. Mitral Valve Surgery
and Mitral Prolapse. Medical Roundtable-CV Edition 1(2) 79-85. April 2010.
34. Hashim SW, Hashim PW. Minimally Invasive Repair with Gore-Tex for
Barlow’s Disease: Will it Fly? Cardiology 128:95-96, 2014
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Sabet W. Hashim, M.D.
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