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Definitions – Extra Requirements- Dentistry DENTISTRY STUDENTS Definitions– Extra Requirements vitamins (A, B, C, D, E, H, K) 1. Vitamins Albert Szent-Györgyi 1. What is Life? organization reproduction growth ontogeny respiration excitability motion homeostasis evolution Louis Pasteur 1. Origin of Life Oparin's hypothesis Miller's experiment primordial soup, primordial pizza monophyletic life homochirality RNA-Cell Hypothesis 1. The Cell phosphatidyl choline endosymbiotic theory 2. DNA is the genetic material Linus Pauling 2. Structure of DNA 2. Mutations and Repair spontaneous mutation induced mutation keto and enol forms peroxide non-random mutations (global, directional mutation .... etc.). free radical The Central Dogma 3. RNAs for protein synthesis ribozyme 3. Non-coding RNA small nuclear RNA (snRNA) DICER RNA interference antisense RNA Micro RNA (miRNA), pri-miRNA, pre-miRNA Drosha pre-initiation complex mRNA transport RNA polymerase I and III 3. Transcription Fall Semester 2012 Page: 1 Definitions – Extra Requirements- Dentistry polysome mRNA editing 3. Post-transcriptional processes deaminase mRNA stability supramolecular structure of proteins 3. Proteins molecular chaperone and chaperonin laws of thermodynamics 3. Enzymes bioluminescence translation 3. Protein Synthesis translation initiation, elongation, termination initiation, elongation, termination factors charge (amino acid attachment to tRNA) amino-acyl transferase Shine-Dalgarno sequence A-site, P-and E-site (on Ribosome) peptide bond translocation polysome anchored junction 4. Cytoskeleton, cell cycle adherent junction hemidesmosome microfilament actin intermediate filaments nuclear lamina microtubule centrosome centriole M phase promoting factor (MPF) Quality control in the ER 5.Protein Transport N-linked and O-linked oligosaccharides protein disulfide isomerase lectin: calnexin, calreticulin Tom (the outer membrane translocon) Tim (the inner membrane translocon) v-SNARE 5. Vesicular Transport t-SNARE COP and COP-I-II clathrin sorting signal WAMP importin 5. Nuclear transport exportin Ran, Ran/GTP, Ran/GEF, Ran Gap cargo NLS (nuclear localization sequence) Fall Semester 2012 Page: 2 Definitions – Extra Requirements- Dentistry NES (nuclear export signal) Exporter mRNA complex Human Genome Project 6. Structure of Human Genome Human genome: raw and full version Human Variome Projects 1000 Genome Project South Africa Project conservative genes One gene, one enzyme hypothesis one cistron one polypeptide hypothesis genome annotation pseudogene genefragment copy number variation (CNV) LINE SINE Alu sequences MIR (mammalian interspersed repeats) retrogene phenotypic complexity c-value paradox / c-value enigma theories about the role of non-coding DNA partial diploid 8. lac operon transcription factor 8. Transcription regulation in eukaryotes origin of replication alternative promoter usage alternative splicing alternative polyadenylation induced gene expression steroid hormones interferon heat shock protein hsp90 GRE (glucocorticoid response element) STAT-1 negative and positive feedback (feedback) siRNA 8. RNA interference DICER RISC RITS RNA-dependent RNA polymerase chromogenic substrate modification of histones: phosphorylation 8.Epigenetic Regulation kinase Fall Semester 2012 Page: 3 Definitions – Extra Requirements- Dentistry phosphatase Epigenom Human Project cloning Histone Code Hypothesis epigenetic code epigenetic program maternal effect 8. Epigenetic inheritance genetic imprinting paternal and maternal imprinting imprinting in Ethology (Konrad Lorenz) Prader-Willi syndrome Angelman syndrome the post-genome era 9. The limits of Mendelian genetics nystagmus Mendel’s radio 9. Gene interactions Common Variant Hypothesis 9. Polygenic traits Rare variant Hypothesis 9. Phenotype fossils 10. General aspects of evolution continental drift common descent natural selection sexual selection artificial selection speciation isolation barrier Red Queen Hypothesis 10. Molecular evolution exon duplication evolution exon shuffling poliploidization homologous ortologous monophyletic polyphyletic Molecular phylogenetics and molecular phylogenetic tree molecular clock genetic markers "r" and "K" reproductive strategies 10. General aspects of evolution good genes theory and runaway selection theory Modern Synthesis - population genetics Fall Semester 2012 Page: 4 Definitions – Extra Requirements- Dentistry fitness the selfish gene theory sociobiology and evolution speciation 10. Evolution of man the origin of Homo sapiens: Outbound from Africa and the Multi-Regional Theory Savannah and Aquatic ape hypothesis heterochrony allometry the superfamily of globin genes 10. Molecular evolution de novo gene generation Hox gene clusters horizontal gene transfer phylogenetic tree convergent evolution heterochrony allometry bottle neck effect Mitochondrial Eve Y-chromosomal Adam VNTR analysis the origin of viruses: the 4 Hypothesis 11. Viruses-I IRES (internal ribosome recognition site) leaky scanning Theta and rolling circle -type replication endemic pandemic epidemic the Baltimore classification 13. Techniques of Molecular and Cell Biology -I 13. Techniques of Molecular and Cell Biology -II Neuroendocrine Theory 14. Aging Mutation Theory Autoimmune Theory Cross-Binding Theory Stem Cell Theory Evolutionary Theories sex-determination system 14. Sex determination XX / XY system SRY gene and TDF Swyer syndrome Testosterone "Z" gene Fall Semester 2012 Page: 5 Definitions – Extra Requirements- Dentistry XX/X0 system ZZ / ZW system DMRT1 gene haplodiploidy non-genetic sex-determination systems parasexuality biodiversity 14. Human and Ecology Red Book Global Warming the Kyoto Climate Change Conference Ozone depletion Bioremediation Metagenomics Please note that the definition list contains only the "Definitions" section of the exam paper. To learn this list does not substitute for meaningful learning all of the materials. Fall Semester 2012 Page: 6