Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download X-MAN - Horizon Discovery
Document related concepts
no text concepts found
Transcript
GENOMICS Product Catalog X-MAN® Cell Lines Patient-relevant, isogenic somatic models of human genetic diseases www.horizondiscovery.com X-MAN® GENOMICS X-MAN® Product and Service Range X-MAN® Cell Lines Over 1,200 cell lines containing defined genomic alterations available, genetically validated and ready to ship Presenting the X-MAN® human cell line collection: over 1,200 diploid and haploid cell lines containing defined genomic modifications. An unparalleled resource for the characterization of genes and their role in disease biology and drug response. X-MAN® Custom Cell Line Engineering Tailor a cell line to your exact specifications! Do you want to understand the effect of specific genetic modifications on disease biology, drug responses or resistance mechanisms? Partner with Horizon for your cell line engineering projects to access our CRISPR, rAAV and ZFN technologies and benefit from almost a decade’s experience in planning and executing more than 400 gene-editing projects. We’ll tailor a cell line to your exact specifications. X-MAN® Custom Haploid Knockout Service Custom human gene knockout in haploid cells in 10 weeks X-MAN® Custom Haploid Knockout service is the most effective and rapid way to access endogenous, loss-offunction cell line models for your research. Your cell line is manufactured by combining the flexibility of CRISPR/ Cas9 and the efficiency of haploid allele modification. Horizon’s precision gene-editing platform consists of: rAAV ZFN CRISPR • • • • 2 3 Precise genetic modifications difficult with other approaches Effective approach for hard to transfect cell lines • Ideal for rapid and costeffective knockout generation Well suited for multi-allelic alterations • “Nickase” version can introduce subtle genomic changes Nickase avoids double strand breaks X-MAN® X-MAN® Reporter Kits Best-in-class endogenous pathway tag and reporter cell lines Enabling functional cell-based assays to be carried out at the endogenous level, looking at natural levels of protein and promoter activity. This affords researchers a higher level of confidence in their results, by more accurately reflecting the changes seen in real disease biology. X-MAN® Genome Editing Tools Maximize your chances of gene editing success with Horizon’s suite of CRISPR and rAAV gene-editing tools Genome editing is the most physiological way to study the role of genes and mutations in biological processes, as the effect of loss or gain of function at the endogenous level can be monitored, and compared with a non-modified control. Maximize your chances of success, and benefit from Horizon’s 8+ years generating over 1,200 cell lines by accessing the same tools and reagents we use in our own projects. X-MAN® CRISPR/Cas9 Microinjection-Ready Reagents Take advantage of the most advanced gene editing reagents available! Our X-MAN® CRISPR/Cas9 reagents come with everything you need to get started with these exciting new tools. Included are an sgRNA designed for your target gene along with the Cas9 nuclease. Both are supplied as microinjection-ready mRNA. Prevalidation of the reagents is also available. Contents Off-The-Shelf Cell Lines Tagged Cell Lines X-MAN® Reporter Kits Pricing 4 –65 66 – 67 68 – 69 70 43 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID AAK1 AAK1 KO HAP1 knock out of AAK1 in haploid cell line, 4bp deletion HG 248-27 AATK AATK KO AATK KO AATK KO HAP1 HAP1 HAP1 knock out of AATK in haploid cell line, 1bp insertion knock out of AATK in haploid cell line, 1bp insertion knock out of AATK in haploid cell line, 11bp deletion HG 354-11 HG 354-17 HG 354-20 ABCB1 ABCB1 KO ABCB1 KO ABCB1 KO HAP1 HAP1 HAP1 knock out of ABCB1 in haploid cell line, 1bp insertion knock out of ABCB1 in haploid cell line, 1bp insertion knock out of ABCB1 in haploid cell line, 7bp deletion HG 2430-1 HG 2430-12 HG 2430-5 ABCB5 ABCB5 KO HAP1 knock out of ABCB5 in haploid cell line, 2bp insertion HG 800-9 ABL1 ABL1 (T315I/+) ABL1 KO HCT116 HAP1 Heterozygous knock-in of ABL1 mutation (T315I) conferring drug resistance knock out of ABL1 in haploid cell line, 7bp deletion HD 104-023 HG 243-19 ABL2 ABL2 KO ABL2 KO HAP1 HAP1 knock out of ABL2 in haploid cell line, 2bp deletion knock out of ABL2 in haploid cell line, 10bp deletion HG 29163-1 HG 29163-14 ACBD3 ACBD3 KO HAP1 knock out of ACBD3 in haploid cell line, 2bp insertion HG 673-9 ACTB ACTB KO ACTB KO HAP1 HAP1 knock out of ACTB in haploid cell line, 13bp deletion knock out of ACTB in haploid cell line, 4bp deletion HG 2471-10 HG 2471-2 ACVR1 ACVR1 KO HAP1 knock out of ACVR1 in haploid cell line, 2bp insertion HG 195-1 ACVR1B ACVR1B KO HAP1 knock out of ACVR1B in haploid cell line, 5bp deletion HG 254-9 ACVR2A ACVR2A KO HAP1 knock out of ACVR2A in haploid cell line, 8bp deletion HG 400-3 ACVR2B ACVR2B KO HAP1 knock out of ACVR2B in haploid cell line, 8bp deletion HG 196-21 ADAM9 ADAM9 KO ADAM9 KO HAP1 HAP1 knock out of ADAM9 in haploid cell line, 5bp deletion knock out of ADAM9 in haploid cell line, 14bp deletion HG 687-11 HG 687-7 ADAM10 ADAM10 KO ADAM10 KO HAP1 HAP1 knock out of ADAM10 in haploid cell line, 2bp deletion knock out of ADAM10 in haploid cell line, 20bp deletion HG 1517-11 HG 1517-12 ADAM17 ADAM17 KO ADAM17 KO ADAM17 KO HAP1 HAP1 HAP1 knock out of ADAM17 in haploid cell line, 1bp insertion knock out of ADAM17 in haploid cell line, 8bp deletion knock out of ADAM17 in haploid cell line, 1bp insertion HG 1515-12 HG 1515-2 HG 1515-3 ADAR ADAR KO ADAR KO HAP1 HAP1 knock out of ADAR in haploid cell line, 17bp deletion knock out of ADAR in haploid cell line, 31bp deletion HG 1513-10 HG 1513-11 ADCK2 ADCK2 KO HAP1 knock out of ADCK2 in haploid cell line, 17bp deletion HG 1492-14 ADCK3 ADCK3 KO ADCK3 KO HAP1 HAP1 knock out of ADCK3 in haploid cell line, 2bp deletion knock out of ADCK3 in haploid cell line, 1bp insertion HG 1506-11 HG 1506-3 ADCK4 ADCK4 KO ADCK4 KO HAP1 HAP1 knock out of ADCK4 in haploid cell line, 2bp insertion knock out of ADCK4 in haploid cell line, 8bp deletion HG 315-16 HG 315-19 ADCK5 ADCK5 KO ADCK5 KO ADCK5 KO HAP1 HAP1 HAP1 knock out of ADCK5 in haploid cell line, 16bp deletion knock out of ADCK5 in haploid cell line, 13bp deletion knock out of ADCK5 in haploid cell line, 4bp deletion HG 316-10 HG 316-15 HG 316-19 ADRBK1 ADRBK1 KO HAP1 knock out of ADRBK1 in haploid cell line, 32bp deletion HG 706-12 ADRBK2 ADRBK2 KO HAP1 knock out of ADRBK2 in haploid cell line, 7bp deletion HG 41-10 4 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 5 Genotype Cell Line Description Catalogue ID ADRBK2 ADRBK2 KO ADRBK2 KO HAP1 HAP1 knock out of ADRBK2 in haploid cell line, 13bp deletion knock out of ADRBK2 in haploid cell line, 4bp insertion HG 41-11 HG 41-14 AEBP2 AEBP2 KO AEBP2 KO HAP1 HAP1 knock out of AEBP2 in haploid cell line, 2bp deletion knock out of AEBP2 in haploid cell line, 38bp deletion HG 1394-12 HG 1394-6 AFTPH AFTPH KO AFTPH KO HAP1 HAP1 knock out of AFTPH in haploid cell line, 4bp deletion knock out of AFTPH in haploid cell line, 13bp deletion HG 847-2 HG 847-5 AGO1 AGO1 KO HAP1 knock out of AGO1 in haploid cell line, 11bp deletion HG 1541-5 AGRN AGRN KO AGRN KO HAP1 HAP1 knock out of AGRN in haploid cell line, 13bp deletion knock out of AGRN in haploid cell line, 10bp deletion HG 1296-10 HG 1296-7 AKT1 AKT1 (-/-) AKT1 (-/-) AKT1 (-/-); AKT2 (-/-) AKT1 (-/-); AKT2 (-/-) AKT1 (E17K/+) AKT1 (E17K/+) AKT1 KO DLD-1 HCT116 DLD-1 HCT116 MCF10A MCF10A HAP1 Homozygous knock-out of AKT1 Homozygous knock-out of AKT1 Double homozygous knock-out of AKT1 and AKT2 Double homozygous knock-out of AKT1 and AKT2 Heterozygous knock-in of AKT1 PH domain activating mutation Heterozygous knock-in of AKT1 PH domain activating mutation knock out of AKT1 in haploid cell line, 5bp deletion HD R00-001 HD R02-004 HD R00-003 HD R02-006 HD 101-007 HD 101-045 HG 127-7 AKT2 AKT2 (-/-); AKT1 (-/-) AKT2 (-/-); AKT1 (-/-) AKT2 (-/-) AKT2 (-/-) AKT2 KO DLD-1 HCT116 HCT116 DLD-1 HAP1 Double homozygous knock-out of AKT1 and AKT2 Double homozygous knock-out of AKT1 and AKT2 Homozygous knock-out of AKT2 Homozygous knock-out of AKT2 knock out of AKT2 in haploid cell line, 13bp deletion HD R00-003 HD R02-006 HD R02-005 HD R00-002 HG 206-6 AKT3 AKT3 KO AKT3 KO HAP1 HAP1 knock out of AKT3 in haploid cell line, 100bp insertion knock out of AKT3 in haploid cell line, 1bp insertion HG 9800-15 HG 9800-16 ALAS1 ALAS1 KO ALAS1 KO HAP1 HAP1 knock out of ALAS1 in haploid cell line, 5bp insertion knock out of ALAS1 in haploid cell line, 2bp insertion HG 614-4 HG 614-7 ALK ALK (F1174L/+) ALK KO ALK KO ; EML4-ALK cDNA KI HCT116 HAP1 HAP1 HCT116 Heterozygous knock-in of ALK activating mutation (F1174L) knock out of ALK in haploid cell line, 8bp deletion knock out of ALK in haploid cell line, 10bp deletion Heterozygous knock-in of exons 20-29 of ALK cDNA into exon 13 of EML4 to recreate the E13:A20 fusion (variant 1) resulting from a 2p21 and 2p23 inversion HD 104-024 HG 2406-12 HG 2406-5 HD 104-104 ALKBH2 ALKBH2 KO ALKBH2 KO HAP1 HAP1 knock out of ALKBH2 in haploid cell line, 13bp deletion knock out of ALKBH2 in haploid cell line, 7bp deletion HG 425-19 HG 425-2 ALPK1 ALPK1 KO HAP1 knock out of ALPK1 in haploid cell line, 13bp deletion HG 1243-12 ALPK2 ALPK2 KO ALPK2 KO ALPK2 KO HAP1 HAP1 HAP1 knock out of ALPK2 in haploid cell line, 5bp deletion knock out of ALPK2 in haploid cell line, 19bp deletion knock out of ALPK2 in haploid cell line, 13bp deletion HG 42-18 HG 42-22 HG 42-5 ANKRD17 ANKRD17 KO ANKRD17 KO HAP1 HAP1 knock out of ANKRD17 in haploid cell line, 2bp deletion knock out of ANKRD17 in haploid cell line, 23bp deletion HG 822-3 HG 822-5 ANO5 ANO5 KO HAP1 knock out of ANO5 in haploid cell line, 7bp deletion HG 1300-4 ANTXR1 ANTXR1 KO ANTXR1 KO HAP1 HAP1 knock out of ANTXR1 in haploid cell line, 1bp insertion knock out of ANTXR1 in haploid cell line, 47bp deletion HG 603-1 HG 603-12 ANTXR2 ANTXR2 KO ANTXR2 KO HAP1 HAP1 knock out of ANTXR2 in haploid cell line, 7bp deletion knock out of ANTXR2 in haploid cell line, 11bp deletion HG 600-6 HG 600-8 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID AP1G1 AP1G1 KO AP1G1 KO HAP1 HAP1 knock out of AP1G1 in haploid cell line, 13bp deletion knock out of AP1G1 in haploid cell line, 124bp insertion HG 770-6 HG 770-8 AP1G2 AP1G2 KO AP1G2 KO AP1G2 KO HAP1 HAP1 HAP1 knock out of AP1G2 in haploid cell line, 1bp insertion knock out of AP1G2 in haploid cell line, 1bp insertion knock out of AP1G2 in haploid cell line, 1bp insertion HG 852-2 HG 852-6 HG 852-7 AP1S1 AP1S1 KO AP1S1 KO HAP1 HAP1 knock out of AP1S1 in haploid cell line, 2bp deletion knock out of AP1S1 in haploid cell line, 4bp deletion HG 866-11 HG 866-2 AP1S2 AP1S2 KO AP1S2 KO HAP1 HAP1 knock out of AP1S2 in haploid cell line, 23bp deletion knock out of AP1S2 in haploid cell line, 14bp deletion HG 868-4 HG 868-7 AP1S3 AP1S3 KO AP1S3 KO HAP1 HAP1 knock out of AP1S3 in haploid cell line, 16bp deletion knock out of AP1S3 in haploid cell line, 5bp deletion HG 864-2 HG 864-6 AP2M1 AP2M1 KO HAP1 knock out of AP2M1 in haploid cell line, 10bp deletion HG 878-5 AP3D1 AP3D1 KO AP3D1 KO HAP1 HAP1 knock out of AP3D1 in haploid cell line, 1bp insertion knock out of AP3D1 in haploid cell line, 2bp insertion HG 772-10 HG 772-12 AP4E1 AP4E1 KO AP4E1 KO HAP1 HAP1 knock out of AP4E1 in haploid cell line, 1bp deletion knock out of AP4E1 in haploid cell line, 64bp insertion HG 768-2 HG 768-3 AP5Z1 AP5Z1 KO AP5Z1 KO HAP1 HAP1 knock out of AP5Z1 in haploid cell line, 7bp insertion knock out of AP5Z1 in haploid cell line, 13bp deletion HG 843-10 HG 843-6 APC APC KO APC KO HAP1 HAP1 knock out of APC in haploid cell line, 16bp deletion knock out of APC in haploid cell line, 22bp deletion HG 998-4 HG 998-5 APLP2 APLP2 KO APLP2 KO HAP1 HAP1 knock out of APLP2 in haploid cell line, 8bp deletion knock out of APLP2 in haploid cell line, 14bp deletion HG 837-11 HG 837-12 APOBEC3F APOBEC3F (+/-) CEM2n Heterozygous knock-out of APOBEC3F HD 117-002 APOBEC3G APOBEC3G (+/-) CEM2n Heterozygous knock-out of APOBEC3G HD 117-004 APOC1 APOC1 (-/-) HCT116 Homozygous knock-out of APOC1 HD R02-007 APTX APTX KO APTX KO APTX KO HAP1 HAP1 HAP1 knock out of APTX in haploid cell line, 2bp insertion knock out of APTX in haploid cell line, 11bp deletion knock out of APTX in haploid cell line, 19bp deletion HG 431-14 HG 431-2 HG 431-23 ARAF ARAF KO HAP1 knock out of ARAF in haploid cell line, 1bp deletion HG 1-13 ARAP3 ARAP3 KO ARAP3 KO ARAP3 KO HAP1 HAP1 HAP1 knock out of ARAP3 in haploid cell line, 1bp insertion knock out of ARAP3 in haploid cell line, 5bp deletion knock out of ARAP3 in haploid cell line, 1bp insertion HG 606-3 HG 606-5 HG 606-6 ARHGEF1 ARHGEF1 KO ARHGEF1 KO HAP1 HAP1 knock out of ARHGEF1 in haploid cell line, 8bp deletion knock out of ARHGEF1 in haploid cell line, 20bp deletion HG 776-2 HG 776-4 ARID1A ARID1A (Q456*/+) ARID1A (Q456*/Q456*) ARID1A (Q456*/Q456*) ARID1A KO ARID1A KO HCT116 MCF10A HCT116 HAP1 HAP1 Heterozygous knock-out of ARID1A by knock-in of premature stop codon (Q456*) Homozygous knock-in of ARID1A nonsense mutation Q456* Homozygous knock-out of ARID1A by knock-in of premature stop codon (Q456*) knock out of ARID1A in haploid cell line, 13bp deletion knock out of ARID1A in haploid cell line, 2bp deletion HD 104-031 HD 101-022 HD 104-049 HG 618-10 HG 618-3 ARID1B ARID1B KO HAP1 knock out of ARID1B in haploid cell line, 5bp deletion HG 582-5 6 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 7 Genotype Cell Line Description Catalogue ID ARID1B ARID1B KO HAP1 knock out of ARID1B in haploid cell line, 13bp deletion HG 582-7 ARID2 ARID2 KO HAP1 knock out of ARID2 in haploid cell line, 7bp deletion HG 907-9 ASH1L ASH1L KO ASH1L KO HAP1 HAP1 knock out of ASH1L in haploid cell line, 53bp deletion knock out of ASH1L in haploid cell line, 20bp deletion HG 942-1 HG 942-10 ASXL2 ASXL2 KO ASXL2 KO HAP1 HAP1 knock out of ASXL2 in haploid cell line, 1bp insertion knock out of ASXL2 in haploid cell line, 1bp deletion HG 1119-10 HG 1119-8 ATAD2 ATAD2 KO ATAD2 KO HAP1 HAP1 knock out of ATAD2 in haploid cell line, 2bp deletion knock out of ATAD2 in haploid cell line, 1bp deletion HG 924-4 HG 924-6 ATAD2B ATAD2B KO HAP1 knock out of ATAD2B in haploid cell line, 130bp insertion HG 947-12 ATG4B ATG4B KO ATG4B KO HAP1 HAP1 knock out of ATG4B in haploid cell line, 8bp deletion knock out of ATG4B in haploid cell line, 16bp deletion HG 1241-10 HG 1241-11 ATG5 ATG5 KO ATG5 KO ATG5 KO HAP1 HAP1 HAP1 knock out of ATG5 in haploid cell line, 8bp deletion knock out of ATG5 in haploid cell line, 2bp deletion knock out of ATG5 in haploid cell line, 11bp deletion HG 16335-10 HG 16335-6 HG 16335-9 ATG7 ATG7 (+/-) ATG7 (cKO+/-) ATG7 KO ATG7 KO ATG7 KO DLD-1 DLD-1 HAP1 HAP1 HAP1 Heterozygous knock-out of ATG7 Heterozygous knock-out of first ATG7 allele, conditional knock-out of second allele knock out of ATG7 in haploid cell line, 2bp deletion knock out of ATG7 in haploid cell line, 7bp deletion knock out of ATG7 in haploid cell line, 8bp deletion HD 105-016 HD 105-023 HG 302-22 HG 302-23 HG 302-3 ATG9A ATG9A KO ATG9A KO ATG9A KO HAP1 HAP1 HAP1 knock out of ATG9A in haploid cell line, 1bp insertion knock out of ATG9A in haploid cell line, 2bp insertion knock out of ATG9A in haploid cell line, 34bp deletion HG 297-14 HG 297-17 HG 297-20 ATG13 ATG13 KO ATG13 KO ATG13 KO HAP1 HAP1 HAP1 knock out of ATG13 in haploid cell line, 1bp insertion knock out of ATG13 in haploid cell line, 1bp insertion knock out of ATG13 in haploid cell line, 1bp insertion HG 304-1 HG 304-2 HG 304-3 ATG14 ATG14 KO ATG14 KO ATG14 KO HAP1 HAP1 HAP1 knock out of ATG14 in haploid cell line, 1bp deletion knock out of ATG14 in haploid cell line, 103bp insertion knock out of ATG14 in haploid cell line, 7bp deletion HG 24663-12 HG 24663-3 HG 24663-6 ATG16L1 ATG16L1 KO ATG16L1 KO HAP1 HAP1 knock out of ATG16L1 in haploid cell line, 10bp deletion knock out of ATG16L1 in haploid cell line, 14bp deletion HG 296-10 HG 296-11 ATPIF1 ATPIF1 KO HAP1 knock out of ATPIF1 in haploid cell line, 23bp deletion HG 2416-4 ATR ATR (a2101g/+); TP53 (S241F/sil) DLD-1 HD R00-025 ATR (a2101g/a2101g); TP53 (+/sil) ATR (a2101g/a2101g); TP53 (S241F/sil) DLD-1 DLD-1 ATR (shRNA rescue/+) RKO Heterozygous hypomorphic ATR mutation (Seckel); TP53 mutant (S241F) background Homozygous hypomorphic ATR mutation (Seckel); knock-in of wild type TP53 Homozygous hypomorphic ATR mutation (Seckel); TP53 mutant (S241F) background Heterozygous knock-in of ATR shRNA rescue sequence ATRX ATRX KO HAP1 knock out of ATRX in haploid cell line, 7bp deletion HG 627-7 ATXN3 ATXN3 KO ATXN3 KO HAP1 HAP1 knock out of ATXN3 in haploid cell line, 16bp deletion knock out of ATXN3 in haploid cell line, 2bp insertion HG 727-10 HG 727-8 AXIN1 AXIN1 KO AXIN1 KO HAP1 HAP1 knock out of AXIN1 in haploid cell line, 20bp deletion knock out of AXIN1 in haploid cell line, 1bp insertion HG 355-10 HG 355-11 HD 202-001 HD 105-010 HD 106-012 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID AXIN1 AXIN1 KO AXIN1 KO AXIN1 KO HAP1 HAP1 HAP1 knock out of AXIN1 in haploid cell line, 26bp deletion knock out of AXIN1 in haploid cell line, 31bp deletion knock out of AXIN1 in haploid cell line, 13bp deletion HG 355-19 HG 355-21 HG 355-24 AXL AXL KO AXL KO HAP1 HAP1 knock out of AXL in haploid cell line, 1bp insertion knock out of AXL in haploid cell line, 1bp insertion HG 695-10 HG 695-12 B3GALNT2 B3GALNT2 KO HAP1 knock out of B3GALNT2 in haploid cell line, 8bp deletion HG 1336-3 B3GNT1 B3GNT1 KO B3GNT1 KO B3GNT1 KO HAP1 HAP1 HAP1 knock out of B3GNT1 in haploid cell line, 2bp deletion knock out of B3GNT1 in haploid cell line, 1bp deletion knock out of B3GNT1 in haploid cell line, 2bp deletion HG 119-11 HG 119-17 HG 119-19 BAX BAX (-/-) BAX (-/-); CDKN1A (-/-) BAX KO BAX KO BAX KO HCT116 HCT116 HAP1 HAP1 HAP1 Homozygous knock-out of BAX Double homozygous knock-out of BAX and CDKN1A knock out of BAX in haploid cell line, 230bp insertion knock out of BAX in haploid cell line, 7bp insertion knock out of BAX in haploid cell line, 350bp insertion HD R02-008 HD R02-010 HG 879-10 HG 879-5 HG 879-9 BAZ1A BAZ1A KO BAZ1A KO HAP1 HAP1 knock out of BAZ1A in haploid cell line, 11bp deletion knock out of BAZ1A in haploid cell line, 202bp insertion HG 927-12 HG 927-8 BAZ1B BAZ1B KO HAP1 knock out of BAZ1B in haploid cell line, 10bp deletion HG 925-10 BAZ2A BAZ2A KO BAZ2A KO BAZ2A KO HAP1 HAP1 HAP1 knock out of BAZ2A in haploid cell line, 1bp insertion knock out of BAZ2A in haploid cell line, 1bp deletion knock out of BAZ2A in haploid cell line, 16bp deletion HG 931-1 HG 931-10 HG 931-11 BAZ2B BAZ2B KO BAZ2B KO HAP1 HAP1 knock out of BAZ2B in haploid cell line, 2bp insertion knock out of BAZ2B in haploid cell line, 16bp deletion HG 523-10 HG 523-5 BBC3 BBC3 (-/-) BBC3 (-/-) BBC3 (-/-); CDKN1A (-/-) BBC3 (ΔTP53BS/ΔTP53BS) BBC3 (ΔTP53BS/ΔTP53BS) DLD-1 HCT116 HCT116 DLD-1 HCT116 Homozygous knock-out of BBC3 Homozygous knock-out of BBC3 Double homozygous knock-out of CDKN1A and BBC3 Homozygous knock-out of TP53 binding site in BBC3 promoter Homozygous knock-out of TP53 binding site in BBC3 promoter HD R00-029 HD R02-040 HD R02-041 HD R00-042 HD R02-098 BCKDK BCKDK KO HAP1 knock out of BCKDK in haploid cell line, 10bp deletion HG 197-6 BCL7A BCL7A KO HAP1 knock out of BCL7A in haploid cell line, 7bp deletion HG 2434-10 BCL11A BCL11A KO BCL11A KO HAP1 HAP1 knock out of BCL11A in haploid cell line, 13bp deletion knock out of BCL11A in haploid cell line, 19bp deletion HG 2426-10 HG 2426-5 BCL11B BCL11B KO BCL11B KO HAP1 HAP1 knock out of BCL11B in haploid cell line, 4bp deletion knock out of BCL11B in haploid cell line, 8bp deletion HG 2432-10 HG 2432-5 BCR BCR KO HAP1 knock out of BCR in haploid cell line, 8bp deletion HG 1276-25 BEND3 BEND3 KO HAP1 knock out of BEND3 in haploid cell line, 10bp deletion HG 1754-2 BHLHE40 BHLHE40 (-/-) HACAT Homozygous knock-out of BHLHE40 HD R01-001 BIRC2 BIRC2 KO BIRC2 KO HAP1 HAP1 knock out of BIRC2 in haploid cell line, 5bp deletion knock out of BIRC2 in haploid cell line, 11bp deletion HG 2590-10 HG 2590-11 BLM BLM (-/-) BLM (+/-) BLM KO HCT116 NALM-6 HAP1 Homozygous deletion of exon 5 and partial deletion of exon 6 Heterozygous knock-out of BLM knock out of BLM in haploid cell line, 1bp insertion HD R02-011 HD 115-038 HG 629-5 8 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 9 Genotype Cell Line Description Catalogue ID BLM BLM KO BLM (+/-); LIG4 (-/-) HAP1 NALM-6 knock out of BLM in haploid cell line, 5bp deletion Heterozygous knock-out of BLM; homozygous knock out of LIG4 HG 629-7 HD 115-078 BMI1 BMI1 KO BMI1 KO BMI1 KO HAP1 HAP1 HAP1 knock out of BMI1 in haploid cell line, 11bp deletion knock out of BMI1 in haploid cell line, 1bp deletion knock out of BMI1 in haploid cell line, 1bp insertion HG 1110-2 HG 1110-4 HG 1110-8 BMP2K BMP2K KO BMP2K KO BMP2K KO HAP1 HAP1 HAP1 knock out of BMP2K in haploid cell line, 4bp deletion knock out of BMP2K in haploid cell line, 4bp deletion knock out of BMP2K in haploid cell line, 7bp insertion HG 128-16 HG 128-19 HG 128-9 BMPR1A BMPR1A KO BMPR1A KO HAP1 HAP1 knock out of BMPR1A in haploid cell line, 5bp deletion knock out of BMPR1A in haploid cell line, 10bp deletion HG 30151-5 HG 30151-8 BMPR1B BMPR1B KO BMPR1B KO HAP1 HAP1 knock out of BMPR1B in haploid cell line, 4bp deletion knock out of BMPR1B in haploid cell line, 2bp insertion HG 366-11 HG 366-4 BMPR2 BMPR2 KO BMPR2 KO HAP1 HAP1 knock out of BMPR2 in haploid cell line, 4bp insertion knock out of BMPR2 in haploid cell line, 11bp deletion HG 76-11 HG 76-5 BPTF BPTF KO BPTF KO HAP1 HAP1 knock out of BPTF in haploid cell line, 8bp deletion knock out of BPTF in haploid cell line, 16bp deletion HG 1369-10 HG 1369-12 BRAF BRAF (-/-) BRAF (-/-) BRAF (+/-/-) BRAF (V600E/-) BRAF (V600E/-/-) DLD-1 HCT116 RKO VACO 432 RKO HD R00-004 HD R02-012 HD 106-003 HD 107-002 HD 106-004 BRAF (V600E/+) BRAF (V600E/+) BRAF (V600E/+) BRAF (V600E/+) BRAF (V600E/+) BRAF (V600E/+); EGFR (ΔE746-A750/+) BRAF (V600E/+/-) BRAF (V600E/+/+) BRAF (V600G/+) BRAF (V600K/+) BRAF (V600K/+) BRAF (V600M/+) BRAF (V600R/+) BRAF KO BRAF KO BRAF KO BRAF (V600E/+); TP53 (-/-) hTERT-HME1 MCF10A HCT116 LIM1215 MCF10A hTERT-HME1 RKO SW48 HCT116 MCF10A HCT116 HCT116 HCT116 HAP1 HAP1 HAP1 MCF10A BRAF (V600K/+); TP53 (-/-) MCF10A Homozygous knock-out of BRAF Homozygous knock-out of BRAF Knock-out of both mutant BRAF alleles (V600E) in triploid parental cells Heterozygous knock-out of wild type BRAF Knock-out of wild type allele and one mutant BRAF allele (V600E) in triploid parental cells Heterozygous knock-in of BRAF activating mutation (V600E) Heterozygous knock-in of BRAF activating mutation (V600E) Heterozygous knock-in of BRAF activating mutation (V600E) Heterozygous knock-in of B-Raf activating mutation (V600E) Heterozygous knock-in of BRAF activating mutation (V600E), Pre-Cre recombinase Double heterozygous knock-in of BRAF and EGFR activating mutations Knock-out of single mutant BRAF allele (V600E) in triploid parental cells Heterozygous knock-in of BRAF activating mutation (V600E) Heterozygous knock-in of BRAF mutation (V600G) Heterozygous knock-in of BRAF activating mutation (V600K) Heterozygous knock-in of BRAF activating mutation (V600K) Heterozygous knock-in of BRAF mutation (V600M) Heterozygous knock-in of BRAF activating mutation (V600R) knock out of BRAF in haploid cell line, 19bp deletion knock out of BRAF in haploid cell line, 2bp deletion knock out of BRAF in haploid cell line, 5bp deletion Homozygous knock-out of TP53; heterozygous knockin of BRAF activating mutation (V600E) Homozygous knock-out of TP53; heterozygous knockin of BRAF activating mutation (V600K) BRCA1 BRCA1 (185delAG/+) MCF10A HD 101-018 BRCA1 (185delAG/+) hTERT-IMECs Heterozygous knock-in of 2-bp deletion in BRCA1 resulting in a premature termination codon at position 39 Heterozygous knock-out of BRCA1 by knock-in of premature stop codon (AG185del) BRCA2 BRCA2 (-/-) BRCA2 (+/-) BRCA2 (S3291E/-) DLD-1 DLD-1 DLD-1 HD 105-007 HD 105-027 HD 105-009 BRCA2 (Y3308X/-) DLD-1 Homozygous knock-out of BRCA2 Heterozygous knock-out of BRCA2 Heterozygous knock-in of BRCA2 hypomorphic point mutation and knock-out of wild type allele Heterozygous knock-in of BRCA2 inactivating point mutation and knock-out of wild type allele HD 100-005 HD 101-012 HD 104-048 HD 116-011 HD 101-026 HD 200-002 HD R05-012 HD 103-003 HD 104-066 HD 101-015 HD 104-022 HD 104-067 HD 104-037 HG 2-1 HG 2-15 HG 2-16 HD 101-024 HD 101-025 HD 119-001 HD 105-008 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID BRCC3 BRCC3 KO HAP1 knock out of BRCC3 in haploid cell line, 1bp insertion HG 498-9 BRD1 BRD1 KO BRD1 KO HAP1 HAP1 knock out of BRD1 in haploid cell line, 106bp insertion knock out of BRD1 in haploid cell line, 14bp deletion HG 941-1 HG 941-6 BRD2 BRD2 KO BRD2 KO BRD2 KO HAP1 HAP1 HAP1 knock out of BRD2 in haploid cell line, 2bp deletion knock out of BRD2 in haploid cell line, 4bp deletion knock out of BRD2 in haploid cell line, 4bp deletion HG 356-10 HG 356-15 HG 356-17 BRD3 BRD3 KO HAP1 knock out of BRD3 in haploid cell line, 22bp deletion HG 244-4 BRD4 BRD4 KO BRD4 KO BRD4 KO HAP1 HAP1 HAP1 knock out of BRD4 in haploid cell line, 2bp insertion knock out of BRD4 in haploid cell line, 178bp insertion knock out of BRD4 in haploid cell line, 4bp deletion HG 937-4 HG 937-6 HG 937-7 BRD7 BRD7 KO HAP1 knock out of BRD7 in haploid cell line, 11bp deletion HG 923-1 BRD8 BRD8 KO BRD8 KO HAP1 HAP1 knock out of BRD8 in haploid cell line, 7bp deletion knock out of BRD8 in haploid cell line, 8bp deletion HG 926-5 HG 926-7 BRD9 BRD9 KO BRD9 KO HAP1 HAP1 knock out of BRD9 in haploid cell line, 8bp deletion knock out of BRD9 in haploid cell line, 2bp deletion HG 934-10 HG 934-3 BRDT BRDT KO BRDT KO HAP1 HAP1 knock out of BRDT in haploid cell line, 1bp insertion knock out of BRDT in haploid cell line, 2bp deletion HG 1321-5 HG 1321-8 BRPF1 BRPF1 KO HAP1 knock out of BRPF1 in haploid cell line, 13bp deletion HG 958-1 BRPF3 BRPF3 KO BRPF3 KO HAP1 HAP1 knock out of BRPF3 in haploid cell line, 19bp deletion knock out of BRPF3 in haploid cell line, 7bp deletion HG 950-12 HG 950-4 BRSK1 BRSK1 KO BRSK1 KO BRSK1 KO HAP1 HAP1 HAP1 knock out of BRSK1 in haploid cell line, 16bp deletion knock out of BRSK1 in haploid cell line, 16bp deletion knock out of BRSK1 in haploid cell line, 1bp insertion HG 347-19 HG 347-3 HG 347-5 BRSK2 BRSK2 KO BRSK2 KO BRSK2 KO HAP1 HAP1 HAP1 knock out of BRSK2 in haploid cell line, 4bp deletion knock out of BRSK2 in haploid cell line, 7bp deletion knock out of BRSK2 in haploid cell line, 10bp deletion HG 345-17 HG 345-22 HG 345-23 BRWD1 BRWD1 KO BRWD1 KO HAP1 HAP1 knock out of BRWD1 in haploid cell line, 11bp deletion knock out of BRWD1 in haploid cell line, 10bp deletion HG 932-12 HG 932-3 BRWD3 BRWD3 KO BRWD3 KO HAP1 HAP1 knock out of BRWD3 in haploid cell line, 10bp deletion knock out of BRWD3 in haploid cell line, 4bp deletion HG 940-5 HG 940-6 C1orf43 C1orf43 KO C1orf43 KO HAP1 HAP1 knock out of C1orf43 in haploid cell line, 2bp deletion knock out of C1orf43 in haploid cell line, 4bp deletion HG 678-10 HG 678-12 C10orf32 C10orf32 KO C10orf32 KO HAP1 HAP1 knock out of C10orf32 in haploid cell line, 22bp deletion knock out of C10orf32 in haploid cell line, 16bp deletion HG 874-5 HG 874-9 C12orf44 C12orf44 KO HAP1 knock out of C12orf44 in haploid cell line, 10bp deletion HG 1024-12 C17orf59 C17orf59 KO C17orf59 KO C17orf59 KO HAP1 HAP1 HAP1 knock out of C17orf59 in haploid cell line, 1bp insertion knock out of C17orf59 in haploid cell line, 1bp insertion knock out of C17orf59 in haploid cell line, 1bp insertion HG 693-10 HG 693-11 HG 693-12 CALM2 CALM2 KO HAP1 knock out of CALM2 in haploid cell line, 4bp deletion HG 1217-12 10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 11 Genotype Cell Line Description Catalogue ID CALM3 CALM3 KO HAP1 knock out of CALM3 in haploid cell line, 17bp deletion HG 1214-12 CALR CALR KO CALR KO CALR KO HAP1 HAP1 HAP1 knock out of CALR in haploid cell line, 8bp deletion knock out of CALR in haploid cell line, 2bp deletion knock out of CALR in haploid cell line, 5bp deletion HG 18222-12 HG 18222-16 HG 18222-19 CAMK1D CAMK1D KO CAMK1D KO HAP1 HAP1 knock out of CAMK1D in haploid cell line, 23bp deletion knock out of CAMK1D in haploid cell line, 16bp deletion HG 129-18 HG 129-20 CAMK2D CAMK2D KO CAMK2D KO HAP1 HAP1 knock out of CAMK2D in haploid cell line, 2bp deletion knock out of CAMK2D in haploid cell line, 8bp deletion HG 130-11 HG 130-16 CAMK2G CAMK2G KO HAP1 knock out of CAMK2G in haploid cell line, 4bp deletion HG 278-1 CAMKK1 CAMKK1 KO CAMKK1 KO CAMKK1 KO HAP1 HAP1 HAP1 knock out of CAMKK1 in haploid cell line, 1bp insertion knock out of CAMKK1 in haploid cell line, 7bp deletion knock out of CAMKK1 in haploid cell line, 1bp deletion HG 309-1 HG 309-18 HG 309-5 CAMKK2 CAMKK2 KO HAP1 knock out of CAMKK2 in haploid cell line, 10bp deletion HG 279-3 CAMKV CAMKV KO CAMKV KO CAMKV KO HAP1 HAP1 HAP1 knock out of CAMKV in haploid cell line, 1bp deletion knock out of CAMKV in haploid cell line, 1bp deletion knock out of CAMKV in haploid cell line, 5bp deletion HG 77-16 HG 77-23 HG 77-3 CANX CANX KO CANX KO HAP1 HAP1 knock out of CANX in haploid cell line, 2bp insertion knock out of CANX in haploid cell line, 2bp deletion HG 597-2 HG 597-6 CAPNS1 CAPNS1 KO CAPNS1 KO HAP1 HAP1 knock out of CAPNS1 in haploid cell line, 17bp deletion knock out of CAPNS1 in haploid cell line, 2bp insertion HG 1298-4 HG 1298-6 CARKD CARKD KO CARKD KO HAP1 HAP1 knock out of CARKD in haploid cell line, 5bp deletion knock out of CARKD in haploid cell line, 2bp deletion HG 2518-11 HG 2518-4 CARM1 CARM1 KO CARM1 KO CARM1 KO HAP1 HAP1 HAP1 knock out of CARM1 in haploid cell line, 4bp deletion knock out of CARM1 in haploid cell line, 1bp deletion knock out of CARM1 in haploid cell line, 8bp deletion HG 1129-12 HG 1129-3 HG 1129-7 CASD1 CASD1 KO HAP1 knock out of CASD1 in haploid cell line, 16bp deletion HG 520-3 CASK CASK KO HAP1 knock out of CASK in haploid cell line, 17bp deletion HG 404-23 CASP2 CASP2 KO CASP2 KO CASP2 KO HAP1 HAP1 HAP1 knock out of CASP2 in haploid cell line, 1bp insertion knock out of CASP2 in haploid cell line, 233bp insertion knock out of CASP2 in haploid cell line, 1bp deletion HG 1507-1 HG 1507-3 HG 1507-8 CASP3 CASP3 KO CASP3 KO HAP1 HAP1 knock out of CASP3 in haploid cell line, 1bp insertion knock out of CASP3 in haploid cell line, 1bp insertion HG 1508-4 HG 1508-7 CASP6 CASP6 KO CASP6 KO HAP1 HAP1 knock out of CASP6 in haploid cell line, 157bp insertion knock out of CASP6 in haploid cell line, 5bp deletion HG 1509-10 HG 1509-4 CASP7 CASP7 KO CASP7 KO HAP1 HAP1 knock out of CASP7 in haploid cell line, 14bp deletion knock out of CASP7 in haploid cell line, 2bp deletion HG 1510-3 HG 1510-4 CASP8 CASP8 KO CASP8 KO HAP1 HAP1 knock out of CASP8 in haploid cell line, 2bp insertion knock out of CASP8 in haploid cell line, 2bp deletion HG 1511-11 HG 1511-7 CASP9 CASP9 KO HAP1 knock out of CASP9 in haploid cell line, 1bp deletion HG 1512-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID CBX1 CBX1 KO CBX1 KO CBX1 KO HAP1 HAP1 HAP1 knock out of CBX1 in haploid cell line, 32bp deletion knock out of CBX1 in haploid cell line, 7bp deletion knock out of CBX1 in haploid cell line, 10bp deletion HG 1178-1 HG 1178-2 HG 1178-3 CBX3 CBX3 KO HAP1 knock out of CBX3 in haploid cell line, 14bp deletion HG 2482-5 CBX5 CBX5 KO CBX5 KO CBX5 KO HAP1 HAP1 HAP1 knock out of CBX5 in haploid cell line, 1bp deletion knock out of CBX5 in haploid cell line, 5bp deletion knock out of CBX5 in haploid cell line, 1bp deletion HG 1330-10 HG 1330-5 HG 1330-8 CCDC132 CCDC132 KO CCDC132 KO HAP1 HAP1 knock out of CCDC132 in haploid cell line, 5bp deletion knock out of CCDC132 in haploid cell line, 7bp deletion HG 858-6 HG 858-8 CCR5 CCR5 (+/-) hTERT RPE-1 Heterozygous knock-out of CCR5 HD R10-002 CDC42BPA CDC42BPA KO CDC42BPA KO HAP1 HAP1 knock out of CDC42BPA in haploid cell line, 13bp deletion knock out of CDC42BPA in haploid cell line, 2bp deletion HG 131-1 HG 131-23 CDC42BPB CDC42BPB KO CDC42BPB KO HAP1 HAP1 knock out of CDC42BPB in haploid cell line, 16bp deletion knock out of CDC42BPB in haploid cell line, 4bp deletion HG 234-17 HG 234-2 CDC42BPG CDC42BPG KO HAP1 knock out of CDC42BPG in haploid cell line, 14bp deletion HG 361-14 CDK2 CDK2 (-/-) CDK2 (-/-); TP53 (-/-) CDK2 (D145N/+) CDK2 (D145N/D145N) CDK2 KO HCT116 HCT116 HCT116 HCT116 HAP1 Homozygous knock-out of CDK2 Double homozygous knock-out of CDK2 and TP53 Heterozygous knock-in of CDK2 dominant negative mutation (D145N) Homozygous knock-in of CDK2 dominant negative mutation (D145N) knock out of CDK2 in haploid cell line, 17bp deletion HD R02-015 HD R02-016 HD 104-029 HD 104-042 HG 133-11 CDK3 CDK3 KO CDK3 KO CDK3 KO HAP1 HAP1 HAP1 knock out of CDK3 in haploid cell line, 5bp deletion knock out of CDK3 in haploid cell line, 20bp deletion knock out of CDK3 in haploid cell line, 10bp deletion HG 79-11 HG 79-3 HG 79-6 CDK4 CDK4 KO CDK4 KO CDK4 KO HAP1 HAP1 HAP1 knock out of CDK4 in haploid cell line, 5bp deletion knock out of CDK4 in haploid cell line, 4bp deletion knock out of CDK4 in haploid cell line, 4bp deletion HG 44-11 HG 44-20 HG 44-5 CDK5 CDK5 KO HAP1 knock out of CDK5 in haploid cell line, 11bp deletion HG 205-23 CDK5RAP1 CDK5RAP1 KO CDK5RAP1 KO HAP1 HAP1 knock out of CDK5RAP1 in haploid cell line, 22bp deletion knock out of CDK5RAP1 in haploid cell line, 5bp deletion HG 2612-12 HG 2612-6 CDK6 CDK6 KO HAP1 knock out of CDK6 in haploid cell line, 14bp deletion HG 7052-10 CDK8 CDK8 KO CDK8 KO HAP1 HAP1 knock out of CDK8 in haploid cell line, 1bp insertion knock out of CDK8 in haploid cell line, 1bp insertion HG 325-1 HG 325-17 CDK10 CDK10 KO HAP1 knock out of CDK10 in haploid cell line, 11bp deletion HG 270-5 CDK13 CDK13 KO CDK13 KO CDK13 KO HAP1 HAP1 HAP1 knock out of CDK13 in haploid cell line, 2bp insertion knock out of CDK13 in haploid cell line, 14bp deletion knock out of CDK13 in haploid cell line, 8bp deletion HG 317-16 HG 317-2 HG 317-7 CDK14 CDK14 KO CDK14 KO CDK14 KO HAP1 HAP1 HAP1 knock out of CDK14 in haploid cell line, 14bp deletion knock out of CDK14 in haploid cell line, 4bp deletion knock out of CDK14 in haploid cell line, 2bp insertion HG 43-10 HG 43-19 HG 43-20 CDK16 CDK16 KO HAP1 knock out of CDK16 in haploid cell line, 10bp deletion HG 235-10 12 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 13 Genotype Cell Line Description CDK17 CDK17 KO CDK17 KO HAP1 HAP1 knock out of CDK17 in haploid cell line, 7bp deletion knock out of CDK17 in haploid cell line, 10bp deletion HG 132-4 HG 132-9 CDK18 CDK18 KO CDK18 KO CDK18 KO HAP1 HAP1 HAP1 knock out of CDK18 in haploid cell line, 14bp deletion knock out of CDK18 in haploid cell line, 1bp insertion knock out of CDK18 in haploid cell line, 1bp insertion HG 305-11 HG 305-13 HG 305-20 CDK19 CDK19 KO CDK19 KO CDK19 KO HAP1 HAP1 HAP1 knock out of CDK19 in haploid cell line, 1bp insertion knock out of CDK19 in haploid cell line, 1bp insertion knock out of CDK19 in haploid cell line, 1bp insertion HG 78-19 HG 78-20 HG 78-21 CDKL1 CDKL1 KO CDKL1 KO CDKL1 KO HAP1 HAP1 HAP1 knock out of CDKL1 in haploid cell line, 1bp insertion knock out of CDKL1 in haploid cell line, 8bp deletion knock out of CDKL1 in haploid cell line, 1bp insertion HG 332-10 HG 332-11 HG 332-12 CDKL3 CDKL3 KO CDKL3 KO CDKL3 KO HAP1 HAP1 HAP1 knock out of CDKL3 in haploid cell line, 10bp deletion knock out of CDKL3 in haploid cell line, 2bp deletion knock out of CDKL3 in haploid cell line, 13bp deletion HG 134-1 HG 134-10 HG 134-12 CDKL5 CDKL5 KO HAP1 knock out of CDKL5 in haploid cell line, 10bp deletion HG 1261-9 CDKN1A CDKN1A (-/-); BAX (-/-) CDKN1A (-/-); BBC3 (-/-) CDKN1A (-/-) CDKN1A (-/-) CDKN1A (-/-); SFN (-/-) HCT116 HCT116 DLD-1 HCT116 HCT116 Double homozygous knock-out of BAX and CDKN1A Double homozygous knock-out of CDKN1A and BBC3 Homozygous knock-out of CDKN1A Homozygous knock-out of CDKN1A Double homozygous knock-out of SFN and CDKN1A HD R02-010 HD R02-041 HD R00-020 HD R02-035 HD R02-003 CDKN2A CDKN2A (R24fs*20/-); DNMT1 (Δexons3-5/+); DNMT3A (-/-); DNMT3B (-/-) HCT116 HD R02-027 CDKN2A (R24fs*20/-); DNMT1 (Δexons3-5/+); DNMT3B (-/-) HCT116 CDKN2A (R24fs*20/-); DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-) CDKN2A (sil/-); DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-) HCT116 Heterozygous knock-out of DNMT1 exons 3-5; double homozygous knock-out of DNMT3A and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental cells Heterozygous knock-out of DNMT1 exons 3-5; homozygous knock-out of DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of frameshift mutant (R24fs*20) CDKN2A allele in heterozygous parental cells HCT116 Catalogue ID HD R02-026 HD R02-024 HD R02-025 CDS1 CDS1 KO HAP1 knock out of CDS1 in haploid cell line, 23bp deletion HG 209-22 CECR2 CECR2 KO CECR2 KO HAP1 HAP1 knock out of CECR2 in haploid cell line, 13bp deletion knock out of CECR2 in haploid cell line, 191bp insertion HG 946-1 HG 946-11 CHD3 CHD3 KO HAP1 knock out of CHD3 in haploid cell line, 25bp deletion HG 1372-8 CHEK1 CHEK1 (+/-); TP53 (+/+) CHEK1 (+/-); TP53 (+/sil) CHEK1 (+/-); TP53 (-/-) CHEK1 (S317A/-); TP53 (S241F/sil) HCT116 DLD-1 HCT116 DLD-1 Heterozygous knock-out of CHEK1; TP53 wild type background Heterozygous knock-out of CHEK1; knock-in of wild type TP53 Heterozygous knock-out of CHEK1; TP53 null background Heterozygous knock-in of phosphorylation site mutant and knock-out of wild type CHEK1; TP53 (S241F) mutant background HD R02-077 HD R00-026 HD R02-078 HD R00-007 CHEK2 CHEK2 (-/-); TP53 (-/-) CHEK2 (-/-); TP53 (+/+) CHEK2 KO CHEK2 KO CHEK2 KO HCT116 HCT116 HAP1 HAP1 HAP1 Homozygous knock-out of CHEK2; TP53 null background Homozygous knock-out of CHEK2; TP53 wild type background knock out of CHEK2 in haploid cell line, 10bp deletion knock out of CHEK2 in haploid cell line, 23bp deletion knock out of CHEK2 in haploid cell line, 20bp deletion HD R02-018 HD R02-017 HG 13714-10 HG 13714-21 HG 13714-24 CHUK CHUK KO HAP1 knock out of CHUK in haploid cell line, 26bp deletion HG 3-11 CKAP4 CKAP4 KO HAP1 knock out of CKAP4 in haploid cell line, 1bp insertion HG 590-7 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID CLK1 CLK1 KO CLK1 KO CLK1 KO HAP1 HAP1 HAP1 knock out of CLK1 in haploid cell line, 5bp insertion knock out of CLK1 in haploid cell line, 11bp deletion knock out of CLK1 in haploid cell line, 2bp deletion HG 135-20 HG 135-6 HG 135-9 CLK2 CLK2 KO CLK2 KO CLK2 KO HAP1 HAP1 HAP1 knock out of CLK2 in haploid cell line, 10bp deletion knock out of CLK2 in haploid cell line, 19bp deletion knock out of CLK2 in haploid cell line, 7bp insertion HG 80-12 HG 80-14 HG 80-7 CLK3 CLK3 KO CLK3 KO HAP1 HAP1 knock out of CLK3 in haploid cell line, 14bp deletion knock out of CLK3 in haploid cell line, 1bp insertion HG 136-23 HG 136-7 CLK4 CLK4 KO CLK4 KO CLK4 KO HAP1 HAP1 HAP1 knock out of CLK4 in haploid cell line, 19bp deletion knock out of CLK4 in haploid cell line, 25bp deletion knock out of CLK4 in haploid cell line, 19bp deletion HG 81-1 HG 81-12 HG 81-14 CLN6 CLN6 KO HAP1 knock out of CLN6 in haploid cell line, 229bp insertion HG 2536-12 CMAS CMAS KO HAP1 knock out of CMAS in haploid cell line, 10bp deletion HG 743-1 CNKSR1 CNKSR1 KO HAP1 knock out of CNKSR1 in haploid cell line, 8bp deletion HG 2409-2 CNKSR2 CNKSR2 KO CNKSR2 KO HAP1 HAP1 knock out of CNKSR2 in haploid cell line, 14bp deletion knock out of CNKSR2 in haploid cell line, 25bp deletion HG 2411-1 HG 2411-2 COPS5 COPS5 KO COPS5 KO HAP1 HAP1 knock out of COPS5 in haploid cell line, 38bp deletion knock out of COPS5 in haploid cell line, 163bp insertion HG 445-1 HG 445-5 COPS6 COPS6 KO COPS6 KO HAP1 HAP1 knock out of COPS6 in haploid cell line, 40bp deletion knock out of COPS6 in haploid cell line, 37bp deletion HG 446-1 HG 446-5 COPS7A COPS7A KO COPS7A KO HAP1 HAP1 knock out of COPS7A in haploid cell line, 2bp deletion knock out of COPS7A in haploid cell line, 25bp deletion HG 914-1 HG 914-3 COPS7B COPS7B KO COPS7B KO HAP1 HAP1 knock out of COPS7B in haploid cell line, 26bp deletion knock out of COPS7B in haploid cell line, 2bp deletion HG 636-11 HG 636-3 CREBBP CREBBP KO HAP1 knock out of CREBBP in haploid cell line, 1bp insertion HG 1109-5 CSK CSK KO HAP1 knock out of CSK in haploid cell line, 13bp deletion HG 198-3 CSNK1D CSNK1D KO HAP1 knock out of CSNK1D in haploid cell line, 26bp deletion HG 274-10 CSNK1E CSNK1E KO HAP1 knock out of CSNK1E in haploid cell line, 13bp deletion HG 362-4 CSNK1G1 CSNK1G1 KO CSNK1G1 KO CSNK1G1 KO HAP1 HAP1 HAP1 knock out of CSNK1G1 in haploid cell line, 8bp deletion knock out of CSNK1G1 in haploid cell line, 263bp insertion knock out of CSNK1G1 in haploid cell line, 10bp deletion HG 82-21 HG 82-24 HG 82-7 CSNK1G2 CSNK1G2 KO CSNK1G2 KO CSNK1G2 KO HAP1 HAP1 HAP1 knock out of CSNK1G2 in haploid cell line, 1bp insertion knock out of CSNK1G2 in haploid cell line, 77bp insertion knock out of CSNK1G2 in haploid cell line, 77bp insertion HG 45-10 HG 45-15 HG 45-23 CSNK1G3 CSNK1G3 KO CSNK1G3 KO CSNK1G3 KO CSNK1G3 KO HAP1 HAP1 HAP1 HAP1 knock out of CSNK1G3 in haploid cell line, 14bp deletion knock out of CSNK1G3 in haploid cell line, 14bp deletion knock out of CSNK1G3 in haploid cell line, 1bp insertion knock out of CSNK1G3 in haploid cell line, 31bp deletion HG 138-13 HG 138-16 HG 138-18 HG 138-8 CSNK2A1 CSNK2A1 KO HAP1 knock out of CSNK2A1 in haploid cell line, 7bp deletion HG 703-4 14 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 15 Genotype Cell Line Description Catalogue ID CSNK2A2 CSNK2A2 KO CSNK2A2 KO CSNK2A2 KO HAP1 HAP1 HAP1 knock out of CSNK2A2 in haploid cell line, 13bp deletion knock out of CSNK2A2 in haploid cell line, 14bp deletion knock out of CSNK2A2 in haploid cell line, 4bp deletion HG 83-15 HG 83-17 HG 83-2 CTNNB1 CTNNB1 (+/-) CTNNB1 (Δ45/-) CTNNB1 (T41A/+) CTNNB1 KO HCT116 HCT116 MCF10A HAP1 Knock-out of CTNNB1 mutant allele (Δ45) in heterozygous parental cells Knock-out of CTNNB1 wild type allele in heterozygous parental cells Heterozygous knock-in of CTNNB1 activating mutation knock out of CTNNB1 in haploid cell line, 25bp deletion HD 104-009 HD 104-010 HD 101-009 HG 1032-12 CYLD CYLD KO CYLD KO HAP1 HAP1 knock out of CYLD in haploid cell line, 1bp insertion knock out of CYLD in haploid cell line, 172bp insertion HG 471-12 HG 471-4 DAG1 DAG1 KO DAG1 KO DAG1 KO HAP1 HAP1 HAP1 knock out of DAG1 in haploid cell line, 17bp deletion knock out of DAG1 in haploid cell line, 1bp deletion knock out of DAG1 in haploid cell line, 17bp deletion HG 120-13 HG 120-16 HG 120-20 DAPK1 DAPK1 KO DAPK1 KO DAPK1 KO HAP1 HAP1 HAP1 knock out of DAPK1 in haploid cell line, 2bp deletion knock out of DAPK1 in haploid cell line, 2bp deletion knock out of DAPK1 in haploid cell line, 2bp deletion HG 626-10 HG 626-4 HG 626-6 DAPK2 DAPK2 KO HAP1 knock out of DAPK2 in haploid cell line, 1bp insertion HG 5-18 DAPK3 DAPK3 KO DAPK3 KO HAP1 HAP1 knock out of DAPK3 in haploid cell line, 1bp insertion knock out of DAPK3 in haploid cell line, 4bp deletion HG 84-1 HG 84-19 DCK DCK KO DCK KO HAP1 HAP1 knock out of DCK in haploid cell line, 8bp deletion knock out of DCK in haploid cell line, 7bp deletion HG 2417-1 HG 2417-11 DCLK2 DCLK2 KO HAP1 knock out of DCLK2 in haploid cell line, 4bp deletion HG 352-5 DCLRE1C DCLRE1C (-/-) DCLRE1C (+/-) DCLRE1C KO DCLRE1C KO DCLRE1C KO NALM-6 NALM-6 HAP1 HAP1 HAP1 Homozygous knock-out of DCLRE1C Heterozygous knock-out of DCLRE1C knock out of DCLRE1C in haploid cell line, 4bp deletion knock out of DCLRE1C in haploid cell line, 1bp insertion knock out of DCLRE1C in haploid cell line, 28bp deletion HD 115-045 HD 115-044 HG 429-12 HG 429-2 HG 429-6 DDI2 DDI2 KO DDI2 KO HAP1 HAP1 knock out of DDI2 in haploid cell line, 1bp insertion knock out of DDI2 in haploid cell line, 4bp deletion HG 182-23 HG 182-6 DDIT4 DDIT4 KO DDIT4 KO HAP1 HAP1 knock out of DDIT4 in haploid cell line, 7bp deletion knock out of DDIT4 in haploid cell line, 2bp deletion HG 1351-1 HG 1351-5 DDIT4L DDIT4L KO DDIT4L KO HAP1 HAP1 knock out of DDIT4L in haploid cell line, 10bp deletion knock out of DDIT4L in haploid cell line, 79bp insertion HG 1352-10 HG 1352-4 DDR1 DDR1 KO HAP1 knock out of DDR1 in haploid cell line, 2bp deletion HG 1244-13 DDR2 DDR2 KO HAP1 knock out of DDR2 in haploid cell line, 1bp deletion HG 694-27 DDX6 DDX6 KO DDX6 KO HAP1 HAP1 knock out of DDX6 in haploid cell line, 1bp insertion knock out of DDX6 in haploid cell line, 169bp insertion HG 116-1 HG 116-5 DDX58 DDX58 KO HAP1 knock out of DDX58 in haploid cell line, 11bp deletion HG 1441-1 DEPDC5 DEPDC5 KO DEPDC5 KO HAP1 HAP1 knock out of DEPDC5 in haploid cell line, 16bp deletion knock out of DEPDC5 in haploid cell line, 2bp deletion HG 1288-12 HG 1288-5 DIABLO DIABLO (-/-) HCT116 Homozygous knock-out of DIABLO HD R02-045 DICER1 DICER1 (-/-) DLD-1 Homozygous disruption of DICER1 exon 5 helicase domain HD R00-009 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID DICER1 DICER1 (-/-) DICER1 (-/-) DICER1 KO DICER1 KO HCT116 RKO HAP1 HAP1 Homozygous disruption of DICER1 exon 5 helicase domain Homozygous disruption of DICER1 exon 5 helicase domain knock out of DICER1 in haploid cell line, 2bp insertion knock out of DICER1 in haploid cell line, 5bp insertion HD R02-019 HD R05-001 HG 434-1 HG 434-10 DIS3L DIS3L KO DIS3L KO DIS3L KO HAP1 HAP1 HAP1 knock out of DIS3L in haploid cell line, 1bp insertion knock out of DIS3L in haploid cell line, 1bp insertion knock out of DIS3L in haploid cell line, 1bp deletion HG 1554-1 HG 1554-10 HG 1554-8 DMD DMD KO DMD KO HAP1 HAP1 knock out of DMD in haploid cell line, 19bp deletion knock out of DMD in haploid cell line, 7bp deletion HG 1380-10 HG 1380-11 DMPK DMPK KO HAP1 knock out of DMPK in haploid cell line, 10bp deletion HG 194-10 DNMT1 DNMT1 (Δexons3-5/+) DNMT1 (Δexons3-5/+); DNMT3A (-/-); DNMT3B (-/-); CD KN2A (R24fs*20/-) HCT116 HCT116 HD R02-021 HD R02-027 DNMT1 (Δexons3-5/+); DNMT3B (-/-); CDKN2A (R24fs*20/-) HCT116 DNMT1 (Δexons3-5/Δexons3-5) DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-) HCT116 HCT116 DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-) retains CH3 HCT116 DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-); CDKN2A (R24fs*20/-) DNMT1 (Δexons3-5/Δexons3-5); DNMT3B (-/-); CDKN2A (sil/-) HCT116 DNMT1 KO DNMT1 KO HAP1 HAP1 Heterozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain Heterozygous knock-out of DNMT1 exons 3-5; double homozygous knock-out of DNMT3A and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental cells Heterozygous knock-out of DNMT1 exons 3-5; homozygous knock-out of DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous Homozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain Double homozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain and DNMT3B Double homozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain and DNMT3B, retains methylation Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of frameshift mutant (R24fs*20) CDKN2A allele in heterozygous parental cells knock out of DNMT1 in haploid cell line, 8bp deletion knock out of DNMT1 in haploid cell line, 20bp deletion DNMT3A DNMT3A (-/-); DNMT1 (Δexons3-5/+); DNMT3B (-/-); C DKN2A (R24fs*20/-) HCT116 HD R02-027 DNMT3A KO DNMT3A KO HAP1 HAP1 Heterozygous knock-out of DNMT1 exons 3-5; double homozygous knock-out of DNMT3A and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental cells knock out of DNMT3A in haploid cell line, 17bp deletion knock out of DNMT3A in haploid cell line, 13bp deletion DNMT3B DNMT3B (-/-); DNMT1 (Δexons3-5/+); DNMT3A (-/-); C DKN2A (R24fs*20/-) HCT116 HD R02-027 DNMT3B (-/-); DNMT1 (Δexons3-5/+); CDKN2A (R24fs*20/-) HCT116 DNMT3B (-/-); DNMT1 (Δexons3-5/Δexons3-5) HCT116 DNMT3B (-/-) retains CH3; DNMT1 (Δexons3-5/Δexons3-5) HCT116 DNMT3B (-/-); DNMT1 (Δexons3-5/Δexons3-5); CDKN2A (R24fs*20/-) DNMT3B (-/-); DNMT1 (Δexons3-5/Δexons3-5); CDKN2A (sil/-) HCT116 DNMT3B (-/-) DNMT3B KO DNMT3B KO HCT116 HAP1 HAP1 Heterozygous knock-out of DNMT1 exons 3-5; double homozygous knock-out of DNMT3A and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental cells Heterozygous knock-out of DNMT1 exons 3-5; homozygous knock-out of DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous Double homozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain and DNMT3B Double homozygous knock-out of DNMT1 exons 3-5 encoding PCNA binding domain and DNMT3B, retains methylation Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of wild type CDKN2A allele in heterozygous parental Double homozygous knock-out of DNMT1 exons 3-5 and DNMT3B; heterozygous knock-out of frameshift mutant (R24fs*20) CDKN2A allele in heterozygous parental cells Homozygous knock-out of DNMT3B knock out of DNMT3B in haploid cell line, 1bp insertion knock out of DNMT3B in haploid cell line, 26bp deletion DSTYK DSTYK KO DSTYK KO HAP1 HAP1 knock out of DSTYK in haploid cell line, 5bp deletion knock out of DSTYK in haploid cell line, 17bp deletion HG 139-18 HG 139-5 DXO DXO KO HAP1 knock out of DXO in haploid cell line, 32bp deletion HG 1555-1 HCT116 HCT116 HD R02-026 HD R02-020 HD R02-022 HD R02-079 HD R02-024 HD R02-025 HG 1017-10 HG 1017-6 HG 1018-1 HG 1018-6 HD R02-026 HD R02-022 HD R02-079 HD R02-024 HD R02-025 HD R02-023 HG 1168-1 HG 1168-2 16 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 17 Genotype Cell Line Description Catalogue ID DXO DXO KO HAP1 knock out of DXO in haploid cell line, 20bp deletion HG 1555-9 DYRK1B DYRK1B KO DYRK1B KO HAP1 HAP1 knock out of DYRK1B in haploid cell line, 16bp deletion knock out of DYRK1B in haploid cell line, 16bp deletion HG 363-10 HG 363-4 DYRK2 DYRK2 KO DYRK2 KO DYRK2 KO HAP1 HAP1 HAP1 knock out of DYRK2 in haploid cell line, 1bp insertion knock out of DYRK2 in haploid cell line, 16bp deletion knock out of DYRK2 in haploid cell line, 1bp deletion HG 140-5 HG 140-6 HG 140-9 DYRK3 DYRK3 KO HAP1 knock out of DYRK3 in haploid cell line, 10bp deletion HG 185-6 DYRK4 DYRK4 KO HAP1 knock out of DYRK4 in haploid cell line, 5bp deletion HG 30332-6 EAPP EAPP KO EAPP KO HAP1 HAP1 knock out of EAPP in haploid cell line, 11bp deletion knock out of EAPP in haploid cell line, 5bp deletion HG 1378-12 HG 1378-3 ECE2 ECE2 KO ECE2 KO HAP1 HAP1 knock out of ECE2 in haploid cell line, 17bp deletion knock out of ECE2 in haploid cell line, 2bp deletion HG 530-10 HG 530-8 EED EED KO EED KO HAP1 HAP1 knock out of EED in haploid cell line, 16bp deletion knock out of EED in haploid cell line, 4bp deletion HG 1200-1 HG 1200-4 EEF2K EEF2K KO EEF2K KO EEF2K KO HAP1 HAP1 HAP1 knock out of EEF2K in haploid cell line, 11bp deletion knock out of EEF2K in haploid cell line, 7bp deletion knock out of EEF2K in haploid cell line, 1bp insertion HG 85-14 HG 85-16 HG 85-21 EGFR EGFR (ΔE746-A750/+); BRAF (V600E/+) EGFR (C240Y/+) EGFR (G719A/+) EGFR (G719S/+) hTERT-HME1 RKO RKO RKO HD 200-002 HD 106-022 HD 106-029 HD 106-018 EGFR (ΔE746-A750/+) EGFR (ΔE746-A750/+) EGFR (ΔE746-A750/+) EGFR (ΔE746-A750/+) EGFR (ΔE746-A750/+); PIK3CA (H1047R/+) EGFR (ΔE746-A750/+); PIK3CA (H1047R/+) EGFR (I491M/+/+) MCF10A hTERT-HME1 RKO NCI-H838 hTERT-HME1 MCF10A SW48 EGFR (L65V/+/+) EGFR (L858R/+) EGFR (L858R/+) EGFR (L858R/+) EGFR (L858R/+/+) EGFR (L861Q/+) EGFR (L861Q/+) EGFR (S492R/+/+) SW48 MCF10A RKO NCI-H838 SW48 MCF10A RKO SW48 EGFR (S492R/+/+) SW48 EGFR (S768I/+) EGFR (T790M/+) EGFR (T790M/+) EGFR (V769_D770insASV/+) EGFR KO EGFR (ΔE746-A750/+); TP53 (-/-) RKO MCF10A RKO RKO HAP1 MCF10A EGFR (L858R/+); TP53 (-/-) MCF10A Double heterozygous knock-in of BRAF and EGFR activating mutations Heterozygous knock-in of EGFR point mutation (C240Y) Heterozygous knock-in of EGFR point mutation (G719A) Heterozygous knock-in of point mutation (G719S) associated with resistance to tyrosine-kinase inhibitors Heterozygous knock-in of EGFR activating mutation (ΔE746-A750/+) Heterozygous knock-in of EGFR activating mutation (ΔE746-A750/+) Heterozygous knock-in of EGFR activating mutation (ΔE746-A750/+) Heterozygous knock-in of EGFR activating mutation (ΔE746-A750/+) Double heterozygous knock-in of EGFR and PIK3CA activating mutations Double heterozygous knock-in of EGFR and PIK3CA activating mutations Heterozygous knock-in of EGFR I491M mutation in cis configuration with endogenous G719S mutation Heterozygous knock-in of EGFR point mutation (L65V) Heterozygous knock-in of EGFR activating mutation (L858R) Heterozygous knock-in of EGFR activating mutation (L858R) Heterozygous knock-in of EGFR activating mutation (L858R) Heterozygous knock-in of EGFR activating mutation (L858R) Heterozygous knock-in of EGFR activating mutation (L861Q) Heterozygous knock-in of EGFR activating mutation (L861Q) Heterozygous knock-in of EGFR S492R mutation in cis configuration with endogenous G719S mutation Heterozygous knock-in of EGFR S492R mutation in trans configuration with endogenous G719S mutation Heterozygous knock-in of EGFR point mutation (S768I) Heterozygous knock-in of EGFR mutation (T790M) conferring drug resistance Heterozygous knock-in of EGFR mutation (T790M) conferring drug resistance Heterozygous insertion of an ASV repeat in EGFR V769_D770 knock out of EGFR in haploid cell line, 7bp deletion Homozygous knock-out of TP53; heterozygous knockin of EGFR activating mutation (ΔE746-A750) Homozygous knock-out of TP53; heterozygous knockin of EGFR activating mutation (L858R) EGLN1 EGLN1 KO HAP1 knock out of EGLN1 in haploid cell line, 5bp deletion HG 2490-4 HD 101-010 HD 100-001 HD 106-009 HD 114-004 HD 200-001 HD 201-001 HD 103-042 HD 103-046 HD 101-016 HD 106-006 HD 114-005 HD 103-045 HD 101-017 HD 106-007 HD 103-044 HD 103-041 HD 106-021 HD 101-019 HD 106-005 HD 106-020 HG 2293-11 HD 101-029 HD 101-040 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID EHMT1 EHMT1 KO EHMT1 KO EHMT1 KO EHMT1 KO HAP1 HAP1 HAP1 HAP1 knock out of EHMT1 in haploid cell line, 7bp deletion knock out of EHMT1 in haploid cell line, 155bp insertion knock out of EHMT1 in haploid cell line, 1bp deletion knock out of EHMT1 in haploid cell line, 34bp deletion HG 1128-11 HG 1128-2 HG 1128-5 HG 1128-9 EHMT2 EHMT2 KO EHMT2 KO HAP1 HAP1 knock out of EHMT2 in haploid cell line, 34bp deletion knock out of EHMT2 in haploid cell line, 188bp insertion HG 1106-3 HG 1106-4 EIF2AK1 EIF2AK1 KO EIF2AK1 KO HAP1 HAP1 knock out of EIF2AK1 in haploid cell line, 7bp deletion knock out of EIF2AK1 in haploid cell line, 1bp deletion HG 141-11 HG 141-6 EIF2AK2 EIF2AK2 KO EIF2AK2 KO HAP1 HAP1 knock out of EIF2AK2 in haploid cell line, 13bp deletion knock out of EIF2AK2 in haploid cell line, 4bp deletion HG 338-10 HG 338-20 EIF2AK3 EIF2AK3 KO HAP1 knock out of EIF2AK3 in haploid cell line, 5bp deletion HG 2033-5 EIF2AK4 EIF2AK4 KO HAP1 knock out of EIF2AK4 in haploid cell line, 17bp deletion HG 1245-40 EIF3H EIF3H KO HAP1 knock out of EIF3H in haploid cell line, 173bp insertion HG 472-2 EIF4EBP1 EIF4EBP1 KO HAP1 knock out of EIF4EBP1 in haploid cell line, 14bp deletion HG 1353-2 EIF4EBP2 EIF4EBP2 KO EIF4EBP2 KO HAP1 HAP1 knock out of EIF4EBP2 in haploid cell line, 2bp deletion knock out of EIF4EBP2 in haploid cell line, 13bp deletion HG 2414-4 HG 2414-5 EME1 EME1 KO EME1 KO HAP1 HAP1 knock out of EME1 in haploid cell line, 5bp deletion knock out of EME1 in haploid cell line, 10bp deletion HG 899-3 HG 899-4 EME2 EME2 KO EME2 KO EME2 KO HAP1 HAP1 HAP1 knock out of EME2 in haploid cell line, 2bp deletion knock out of EME2 in haploid cell line, 1bp deletion knock out of EME2 in haploid cell line, 1bp insertion HG 897-11 HG 897-12 HG 897-3 EML4 EML4-ALK cDNA KI HCT116 Heterozygous knock-in of exons 20-29 of ALK cDNA into exon 13 of EML4 to recreate the E13:A20 fusion (variant 1) resulting from a 2p21 and 2p23 inversion HD 104-104 ENDOG ENDOG KO ENDOG KO HAP1 HAP1 knock out of ENDOG in haploid cell line, 23bp deletion knock out of ENDOG in haploid cell line, 16bp deletion HG 2510-11 HG 2510-2 ENTHD2 ENTHD2 KO ENTHD2 KO ENTHD2 KO HAP1 HAP1 HAP1 knock out of ENTHD2 in haploid cell line, 7bp deletion knock out of ENTHD2 in haploid cell line, 1bp insertion knock out of ENTHD2 in haploid cell line, 7bp deletion HG 845-1 HG 845-2 HG 845-3 EP300 EP300 KO EP300 KO HAP1 HAP1 knock out of EP300 in haploid cell line, 13bp deletion knock out of EP300 in haploid cell line, 17bp deletion HG 1318-11 HG 1318-12 EPHA2 EPHA2 KO HAP1 knock out of EPHA2 in haploid cell line, 16bp deletion HG 222-11 EPHA3 EPHA3 KO EPHA3 KO HAP1 HAP1 knock out of EPHA3 in haploid cell line, 17bp deletion knock out of EPHA3 in haploid cell line, 13bp deletion HG 295-11 HG 295-19 EPHA4 EPHA4 KO HAP1 knock out of EPHA4 in haploid cell line, 7bp deletion HG 223-7 EPHA6 EPHA6 KO EPHA6 KO HAP1 HAP1 knock out of EPHA6 in haploid cell line, 4bp deletion knock out of EPHA6 in haploid cell line, 10bp deletion HG 143-24 HG 143-5 EPHB1 EPHB1 KO HAP1 knock out of EPHB1 in haploid cell line, 14bp deletion HG 699-28 EPHB2 EPHB2 KO HAP1 knock out of EPHB2 in haploid cell line, 10bp deletion HG 251-16 18 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 19 Genotype Cell Line Description Catalogue ID EPHB2 EPHB2 KO HAP1 knock out of EPHB2 in haploid cell line, 25bp deletion HG 251-32 EPHB3 EPHB3 KO HAP1 knock out of EPHB3 in haploid cell line, 11bp deletion HG 707-29 EPHB4 EPHB4 KO HAP1 knock out of EPHB4 in haploid cell line, 13bp deletion HG 1278-11 EPHB6 EPHB6 KO EPHB6 KO EPHB6 KO HAP1 HAP1 HAP1 knock out of EPHB6 in haploid cell line, 1bp insertion knock out of EPHB6 in haploid cell line, 1bp insertion knock out of EPHB6 in haploid cell line, 1bp insertion HG 46-10 HG 46-13 HG 46-15 ERBB2 ERBB2 KO ERBB2 KO ERBB2 KO HAP1 HAP1 HAP1 knock out of ERBB2 in haploid cell line, 17bp deletion knock out of ERBB2 in haploid cell line, 8bp deletion knock out of ERBB2 in haploid cell line, 10bp deletion HG 342-1 HG 342-17 HG 342-2 ERBB3 ERBB3 KO HAP1 knock out of ERBB3 in haploid cell line, 4bp deletion HG 211-30 ERCC6 ERCC6 KO ERCC6 KO ERCC6 KO HAP1 HAP1 HAP1 knock out of ERCC6 in haploid cell line, 26bp deletion knock out of ERCC6 in haploid cell line, 4bp deletion knock out of ERCC6 in haploid cell line, 5bp deletion HG 422-11 HG 422-3 HG 422-5 ERCC6L ERCC6L KO ERCC6L KO HAP1 HAP1 knock out of ERCC6L in haploid cell line, 23bp insertion knock out of ERCC6L in haploid cell line, 2bp deletion HG 751-11 HG 751-6 ERCC8 ERCC8 KO ERCC8 KO HAP1 HAP1 knock out of ERCC8 in haploid cell line, 7bp deletion knock out of ERCC8 in haploid cell line, 14bp deletion HG 421-13 HG 421-24 ERN1 ERN1 KO HAP1 knock out of ERN1 in haploid cell line, 8bp deletion HG 742-18 ETFB ETFB KO HAP1 knock out of ETFB in haploid cell line, 4bp deletion HG 1787-10 EXD2 EXD2 KO EXD2 KO HAP1 HAP1 knock out of EXD2 in haploid cell line, 4bp deletion knock out of EXD2 in haploid cell line, 8bp deletion HG 1557-3 HG 1557-7 EXO1 EXO1 KO HAP1 knock out of EXO1 in haploid cell line, 1bp insertion HG 752-11 EZH1 EZH1 KO EZH1 KO EZH1 KO HAP1 HAP1 HAP1 knock out of EZH1 in haploid cell line, 2bp deletion knock out of EZH1 in haploid cell line, 2bp insertion knock out of EZH1 in haploid cell line, 4bp deletion HG 1130-1 HG 1130-10 HG 1130-2 EZH2 EZH2 KO EZH2 KO HAP1 HAP1 knock out of EZH2 in haploid cell line, 16bp deletion knock out of EZH2 in haploid cell line, 11bp deletion HG 2494-1 HG 2494-4 FAM173A FAM173A KO FAM173A KO HAP1 HAP1 knock out of FAM173A in haploid cell line, 1bp insertion knock out of FAM173A in haploid cell line, 1bp insertion HG 532-5 HG 532-6 FAM173B FAM173B KO FAM173B KO HAP1 HAP1 knock out of FAM173B in haploid cell line, 2bp deletion knock out of FAM173B in haploid cell line, 5bp deletion HG 533-6 HG 533-8 FAM175A FAM175A KO HAP1 knock out of FAM175A in haploid cell line, 271bp insertion HG 1193-4 FANCA FANCA KO FANCA KO FANCA KO HAP1 HAP1 HAP1 knock out of FANCA in haploid cell line, 7bp deletion knock out of FANCA in haploid cell line, 2bp insertion knock out of FANCA in haploid cell line, 1bp insertion HG 648-5 HG 648-6 HG 648-7 FANCB FANCB (-/Y) FANCB KO FANCB (-/Y); MUS81 (-/-) NALM-6 HAP1 NALM-6 Knock-out of X-linked FANCB allele in male parental cells knock out of FANCB in haploid cell line, 2bp insertion Knock-out of X-linked FANCB allele in male parental cells; homozygous knock-out of MUS81 HD 115-065 HG 649-5 HD 115-092 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID FANCC FANCC (-/-/-) FANCC (+/-/-) FANCC KO FANCC KO RKO RKO HAP1 HAP1 Knock-out of all three FANCC alleles in triploid parental cells Knock-out of two FANCC alleles in triploid parental cells knock out of FANCC in haploid cell line, 1bp insertion knock out of FANCC in haploid cell line, 1bp insertion HD R05-006 HD R05-004 HG 650-4 HG 650-7 FANCE FANCE KO FANCE KO HAP1 HAP1 knock out of FANCE in haploid cell line, 184bp insertion knock out of FANCE in haploid cell line, 8bp deletion HG 645-12 HG 645-5 FANCG FANCG (-/-) FANCG (+/-) FANCG KO FANCG KO FANCG KO RKO RKO HAP1 HAP1 HAP1 Homozygous knock-out of FANCG Heterozygous knock-out of FANCG knock out of FANCG in haploid cell line, 1bp insertion knock out of FANCG in haploid cell line, 1bp insertion knock out of FANCG in haploid cell line, 2bp insertion HD R05-005 HD R05-002 HG 646-6 HG 646-7 HG 646-9 FANCI FANCI KO HAP1 knock out of FANCI in haploid cell line, 1bp insertion HG 641-4 FANCL FANCL KO FANCL KO HAP1 HAP1 knock out of FANCL in haploid cell line, 11bp deletion knock out of FANCL in haploid cell line, 10bp deletion HG 761-1 HG 761-3 FASTK FASTK KO HAP1 knock out of FASTK in haploid cell line, 1bp deletion HG 734-56 FBXW7 FBXW7 (-/-) HCT116 HD R02-013 FBXW7 (-/-) DLD-1 FBXW7 (+/-) DLD-1 Homozygous knock-out of FBXW7 exon 5 which encodes F-box domain of the protein Homozygous knock-out of FBXW7 exon 5 which encodes F-box domain of the protein Heterozygous knock-out of FBXW7 exon 5 which encodes F-box domain of the protein FCHO1 FCHO1 KO FCHO1 KO HAP1 HAP1 knock out of FCHO1 in haploid cell line, 2bp deletion knock out of FCHO1 in haploid cell line, 2bp insertion HG 580-1 HG 580-2 FCHO2 FCHO2 KO HAP1 knock out of FCHO2 in haploid cell line, 28bp deletion HG 611-4 FER FER KO HAP1 knock out of FER in haploid cell line, 1bp insertion HG 1349-2 FES FES KO FES KO FES KO HAP1 HAP1 HAP1 knock out of FES in haploid cell line, 38bp deletion knock out of FES in haploid cell line, 29bp deletion knock out of FES in haploid cell line, 17bp deletion HG 307-16 HG 307-19 HG 307-23 FGFR1 FGFR1 KO FGFR1 KO HAP1 HAP1 knock out of FGFR1 in haploid cell line, 20bp deletion knock out of FGFR1 in haploid cell line, 16bp deletion HG 1427-11 HG 1427-12 FGFR2 FGFR2 (S252W/+/+) FGFR2 KO HCT116 HAP1 Heterozygous knock-in of FGFR2 activating mutation (S252W) knock out of FGFR2 in haploid cell line, 13bp deletion HD 104-030 HG 203-10 FGFR3 FGFR3 (S249C/+) FGFR3 KO HCT116 HAP1 Heterozygous knock-in of FGFR3 activating mutation (S249C) knock out of FGFR3 in haploid cell line, 5bp deletion HD 104-044 HG 1346-24 FGFR4 FGFR4 KO HAP1 knock out of FGFR4 in haploid cell line, 8bp deletion HG 257-7 FKBP8 FKBP8 KO HAP1 knock out of FKBP8 in haploid cell line, 2bp deletion HG 1404-2 FKRP FKRP KO FKRP KO HAP1 HAP1 knock out of FKRP in haploid cell line, 2bp deletion knock out of FKRP in haploid cell line, 17bp deletion HG 726-4 HG 726-9 FKTN FKTN KO FKTN KO HAP1 HAP1 knock out of FKTN in haploid cell line, 16bp deletion knock out of FKTN in haploid cell line, 8bp deletion HG 721-10 HG 721-2 FLT1 FLT1 KO HAP1 knock out of FLT1 in haploid cell line, 5bp deletion HG 358-10 HD R00-005 HD R00-006 20 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 21 Genotype Cell Line Description Catalogue ID FLT1 FLT1 KO HAP1 knock out of FLT1 in haploid cell line, 20bp deletion HG 358-6 FLT3 FLT3 (D835Y/+) FLT3 (ΔI836/+) HCT116 HCT116 Heterozygous knock-in of FLT3 activating mutation (D835Y) Heterozygous knock-in of FLT3 activating mutation (ΔI836) HD 104-041 HD 104-036 FLT4 FLT4 KO HAP1 knock out of FLT4 in haploid cell line, 5bp deletion HG 1246-39 FLVCR1 FLVCR1 KO FLVCR1 KO HAP1 HAP1 knock out of FLVCR1 in haploid cell line, 151bp insertion knock out of FLVCR1 in haploid cell line, 7bp deletion HG 1469-3 HG 1469-4 FOXM1 FOXM1 KO FOXM1 KO FOXM1 KO HAP1 HAP1 HAP1 knock out of FOXM1 in haploid cell line, 1bp insertion knock out of FOXM1 in haploid cell line, 1bp insertion knock out of FOXM1 in haploid cell line, 2bp insertion HG 835-12 HG 835-2 HG 835-6 FOXRED1 FOXRED1 KO HAP1 knock out of FOXRED1 in haploid cell line, 4bp deletion HG 2525-6 FURIN FURIN KO FURIN KO HAP1 HAP1 knock out of FURIN in haploid cell line, 2bp deletion knock out of FURIN in haploid cell line, 4bp deletion HG 1302-1 HG 1302-10 FUS FUS KO FUS KO HAP1 HAP1 knock out of FUS in haploid cell line, 10bp deletion knock out of FUS in haploid cell line, 5bp deletion HG 1314-2 HG 1314-6 FYN FYN KO FYN KO FYN KO HAP1 HAP1 HAP1 knock out of FYN in haploid cell line, 19bp deletion knock out of FYN in haploid cell line, 2bp deletion knock out of FYN in haploid cell line, 13bp deletion HG 22023-20 HG 22023-23 HG 22023-8 FZD1 FZD1 KO HAP1 knock out of FZD1 in haploid cell line, 2bp deletion HG 1072-3 FZD2 FZD2 KO HAP1 knock out of FZD2 in haploid cell line, 10bp deletion HG 1527-5 FZD3 FZD3 KO FZD3 KO HAP1 HAP1 knock out of FZD3 in haploid cell line, 17bp deletion knock out of FZD3 in haploid cell line, 10bp deletion HG 1074-2 HG 1074-4 FZD4 FZD4 KO HAP1 knock out of FZD4 in haploid cell line, 16bp deletion HG 1079-8 FZD5 FZD5 KO HAP1 knock out of FZD5 in haploid cell line, 25bp deletion HG 1528-1 FZD6 FZD6 KO FZD6 KO HAP1 HAP1 knock out of FZD6 in haploid cell line, 2bp deletion knock out of FZD6 in haploid cell line, 7bp deletion HG 1049-11 HG 1049-12 FZD7 FZD7 KO HAP1 knock out of FZD7 in haploid cell line, 14bp deletion HG 1080-12 FZD8 FZD8 KO HAP1 knock out of FZD8 in haploid cell line, 17bp deletion HG 1525-2 FZD9 FZD9 KO HAP1 knock out of FZD9 in haploid cell line, 8bp deletion HG 1065-1 GAK GAK KO GAK KO GAK KO HAP1 HAP1 HAP1 knock out of GAK in haploid cell line, 2bp deletion knock out of GAK in haploid cell line, 14bp deletion knock out of GAK in haploid cell line, 10bp deletion HG 86-20 HG 86-4 HG 86-7 GALT GALT KO GALT KO GALT KO HAP1 HAP1 HAP1 knock out of GALT in haploid cell line, 2bp deletion knock out of GALT in haploid cell line, 1bp insertion knock out of GALT in haploid cell line, 2bp deletion HG 518-3 HG 518-5 HG 518-7 GBP1 GBP1 KO HAP1 knock out of GBP1 in haploid cell line, 5bp deletion HG 1497-5 GBP2 GBP2 KO HAP1 knock out of GBP2 in haploid cell line, 10bp deletion HG 1500-2 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID GBP5 GBP5 KO GBP5 KO HAP1 HAP1 knock out of GBP5 in haploid cell line, 8bp deletion knock out of GBP5 in haploid cell line, 25bp deletion HG 1503-10 HG 1503-3 GCDH GCDH KO HAP1 knock out of GCDH in haploid cell line, 22bp deletion HG 1789-10 GCN1L1 GCN1L1 KO HAP1 knock out of GCN1L1 in haploid cell line, 17bp deletion HG 815-12 GNA11 GNA11 (Q209L/+) HCT116 Heterozygous knock-in of GNA11 activating mutation (Q209L) HD 104-052 GNAQ GNAQ (Q209L/+) HCT116 Heterozygous knock-in of GNAQ activating mutation (Q209L) HD 104-045 GNAS GNAS (R201C/+) GNAS (R201C/+) HCT116 SW48 Heterozygous knock-in of GNAS activating mutation (R201C) Heterozygous knock-in of GNAS activating mutation R201C HD 104-083 HD 103-040 GNE GNE KO GNE KO GNE KO HAP1 HAP1 HAP1 knock out of GNE in haploid cell line, 2bp insertion knock out of GNE in haploid cell line, 184bp insertion knock out of GNE in haploid cell line, 40bp deletion HG 32395-10 HG 32395-20 HG 32395-7 GNPTAB GNPTAB KO HAP1 knock out of GNPTAB in haploid cell line, 4bp deletion HG 1785-4 GNPTG GNPTG KO GNPTG KO HAP1 HAP1 knock out of GNPTG in haploid cell line, 2bp deletion knock out of GNPTG in haploid cell line, 14bp deletion HG 1784-12 HG 1784-5 GPC4 GPC4 KO GPC4 KO HAP1 HAP1 knock out of GPC4 in haploid cell line, 10bp deletion knock out of GPC4 in haploid cell line, 4bp deletion HG 672-2 HG 672-6 GRK4 GRK4 KO HAP1 knock out of GRK4 in haploid cell line, 13bp deletion HG 1264-12 GRK5 GRK5 KO GRK5 KO HAP1 HAP1 knock out of GRK5 in haploid cell line, 11bp deletion knock out of GRK5 in haploid cell line, 10bp deletion HG 87-13 HG 87-16 GRK6 GRK6 KO HAP1 knock out of GRK6 in haploid cell line, 7bp deletion HG 364-14 GRM8 GRM8 KO GRM8 KO HAP1 HAP1 knock out of GRM8 in haploid cell line, 22bp deletion knock out of GRM8 in haploid cell line, 11bp deletion HG 1325-12 HG 1325-2 GSG2 GSG2 KO GSG2 KO GSG2 KO HAP1 HAP1 HAP1 knock out of GSG2 in haploid cell line, 2bp insertion knock out of GSG2 in haploid cell line, 2bp insertion knock out of GSG2 in haploid cell line, 2bp insertion HG 47-16 HG 47-2 HG 47-22 GSK3A GSK3A KO GSK3A KO HAP1 HAP1 knock out of GSK3A in haploid cell line, 2bp insertion knock out of GSK3A in haploid cell line, 286bp deletion HG 6-13 HG 6-23 GSK3B GSK3B KO GSK3B KO HAP1 HAP1 knock out of GSK3B in haploid cell line, 31bp deletion knock out of GSK3B in haploid cell line, 8bp deletion HG 7-11 HG 7-24 H2AFZ H2AFZ KO H2AFZ KO H2AFZ KO H2AFZ KO HAP1 HAP1 HAP1 HAP1 knock out of H2AFZ in haploid cell line, 1bp deletion knock out of H2AFZ in haploid cell line, 7bp deletion knock out of H2AFZ in haploid cell line, 4bp insertion knock out of H2AFZ in haploid cell line, 2bp deletion HG 1140-10 HG 1140-3 HG 1140-4 HG 1140-6 H3F3A H3F3A KO H3F3A KO H3F3A KO HAP1 HAP1 HAP1 knock out of H3F3A in haploid cell line, 137bp insertion knock out of H3F3A in haploid cell line, 2bp insertion knock out of H3F3A in haploid cell line, 2bp insertion HG 1174-3 HG 1174-6 HG 1174-7 HADHA HADHA KO HADHA KO HAP1 HAP1 knock out of HADHA in haploid cell line, 13bp deletion knock out of HADHA in haploid cell line, 7bp deletion HG 2529-2 HG 2529-4 HCK HCK KO HAP1 knock out of HCK in haploid cell line, 20bp deletion HG 8-13 22 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 23 Genotype Cell Line Description Catalogue ID HCK HCK KO HAP1 knock out of HCK in haploid cell line, 8bp deletion HG 8-16 HDAC1 HDAC1 KO HDAC1 KO HAP1 HAP1 knock out of HDAC1 in haploid cell line, 14bp deletion knock out of HDAC1 in haploid cell line, 7bp deletion HG 1013-10 HG 1013-8 HDAC2 HDAC2 KO HDAC2 KO HAP1 HAP1 knock out of HDAC2 in haploid cell line, 182bp insertion knock out of HDAC2 in haploid cell line, 11bp deletion HG 1012-4 HG 1012-6 HDAC3 HDAC3 KO HAP1 knock out of HDAC3 in haploid cell line, 2bp insertion HG 579-6 HDAC4 HDAC4 KO HDAC4 KO HAP1 HAP1 knock out of HDAC4 in haploid cell line, 8bp deletion knock out of HDAC4 in haploid cell line, 2bp deletion HG 1011-11 HG 1011-3 HDAC5 HDAC5 KO HDAC5 KO HAP1 HAP1 knock out of HDAC5 in haploid cell line, 4bp deletion knock out of HDAC5 in haploid cell line, 13bp deletion HG 1010-11 HG 1010-7 HDAC6 HDAC6 KO HDAC6 KO HDAC6 KO HAP1 HAP1 HAP1 knock out of HDAC6 in haploid cell line, 1bp insertion knock out of HDAC6 in haploid cell line, 1bp insertion knock out of HDAC6 in haploid cell line, 1bp insertion HG 806-1 HG 806-2 HG 806-3 HDAC7 HDAC7 KO HDAC7 KO HAP1 HAP1 knock out of HDAC7 in haploid cell line, 19bp deletion knock out of HDAC7 in haploid cell line, 7bp deletion HG 1016-1 HG 1016-2 HDAC8 HDAC8 KO HDAC8 KO HAP1 HAP1 knock out of HDAC8 in haploid cell line, 154bp insertion knock out of HDAC8 in haploid cell line, 5bp deletion HG 1015-1 HG 1015-10 HDAC9 HDAC9 KO HDAC9 KO HAP1 HAP1 knock out of HDAC9 in haploid cell line, 22bp deletion knock out of HDAC9 in haploid cell line, 23bp deletion HG 1014-10 HG 1014-11 HDAC10 HDAC10 KO HDAC10 KO HAP1 HAP1 knock out of HDAC10 in haploid cell line, 8bp deletion knock out of HDAC10 in haploid cell line, 14bp deletion HG 1003-2 HG 1003-5 HDAC11 HDAC11 KO HDAC11 KO HDAC11 KO HAP1 HAP1 HAP1 knock out of HDAC11 in haploid cell line, 1bp insertion knock out of HDAC11 in haploid cell line, 10bp deletion knock out of HDAC11 in haploid cell line, 10bp deletion HG 1007-12 HG 1007-2 HG 1007-3 HELLS HELLS KO HAP1 knock out of HELLS in haploid cell line, 1bp insertion HG 1202-3 HEXDC HEXDC KO HEXDC KO HAP1 HAP1 knock out of HEXDC in haploid cell line, 5bp deletion knock out of HEXDC in haploid cell line, 2bp deletion HG 1958-10 HG 1958-2 HIF1A HIF1A KO HIF1A KO HAP1 HAP1 knock out of HIF1A in haploid cell line, 1bp insertion knock out of HIF1A in haploid cell line, 17bp deletion HG 1165-10 HG 1165-3 HIPK1 HIPK1 KO HIPK1 KO HIPK1 KO HAP1 HAP1 HAP1 knock out of HIPK1 in haploid cell line, 2bp deletion knock out of HIPK1 in haploid cell line, 2bp insertion knock out of HIPK1 in haploid cell line, 5bp deletion HG 8753-18 HG 8753-20 HG 8753-23 HIPK2 HIPK2 KO HIPK2 KO HIPK2 KO HAP1 HAP1 HAP1 knock out of HIPK2 in haploid cell line, 11bp deletion knock out of HIPK2 in haploid cell line, 17bp deletion knock out of HIPK2 in haploid cell line, 29bp deletion HG 335-10 HG 335-11 HG 335-22 HIPK3 HIPK3 KO HIPK3 KO HIPK3 KO HAP1 HAP1 HAP1 knock out of HIPK3 in haploid cell line, 1bp insertion knock out of HIPK3 in haploid cell line, 1bp insertion knock out of HIPK3 in haploid cell line, 2bp deletion HG 334-10 HG 334-11 HG 334-12 HRAS HRAS (G12V/+) SW48 Heterozygous knock-in of HRAS activating mutation (G12V) HD 103-034 HRASLS2 HRASLS2 KO HAP1 knock out of HRASLS2 in haploid cell line, 4bp deletion HG 640-1 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID HSF1 HSF1 (+/+/-) HCT116 Knock-out of one HSF1 allele in triploid parental cells HD R12-008 HSPA8 HSPA8 (+cKO/-) HCT116 Knock-out of allele 1 of HSPA8. Conditional knock-out of allele 2 by introduction of re-recombinase. HD 104-058 HUNK HUNK KO HAP1 knock out of HUNK in haploid cell line, 5bp deletion HG 88-5 ICK ICK KO HAP1 knock out of ICK in haploid cell line, 4bp deletion HG 144-17 IDE IDE KO IDE KO HAP1 HAP1 knock out of IDE in haploid cell line, 22bp deletion knock out of IDE in haploid cell line, 4bp deletion HG 716-10 HG 716-12 IDH1 IDH1 (+cKO/R132C) IDH1 (R132C/+) HT-1080 HCT116 HD 148-001 HD 104-021 IDH1 (R132C/R132C cKO) HT-1080 IDH1 (R132H/+) IDH1 (R132H/+) MCF10A HCT116 Conditional heterozygous knock-out of wild type allele Heterozygous knock-in of IDH1 mutation (R132C) implicated in altered metabolic activity Conditional heterozygous knock-out of IDH1 mutation (R132C) implicated in altered metabolic activity Heterozygous knock-in of IDH1 dominant-negative (R132H) point mutation Heterozygous knock-in of IDH1 dominant-negative (R132H) point mutation IDH2 IDH2 (R140Q/+) HCT116 HD 104-020 IDH2 (R172K/+) HCT116 Heterozygous knock-in of IDH2 mutation (R140Q) implicated in altered metabolic activity Heterozygous knock-in of IDH2 mutation (R172K) implicated in altered metabolic activity IFIH1 IFIH1 KO IFIH1 KO HAP1 HAP1 knock out of IFIH1 in haploid cell line, 13bp deletion knock out of IFIH1 in haploid cell line, 5bp deletion HG 1448-12 HG 1448-6 IGF1R IGF1R KO HAP1 knock out of IGF1R in haploid cell line, 7bp deletion HG 184-15 IKBKB IKBKB KO IKBKB KO IKBKB KO HAP1 HAP1 HAP1 knock out of IKBKB in haploid cell line, 11bp deletion knock out of IKBKB in haploid cell line, 14bp deletion knock out of IKBKB in haploid cell line, 2bp insertion HG 23808-11 HG 23808-14 HG 23808-3 ILK ILK KO HAP1 knock out of ILK in haploid cell line, 7bp deletion HG 19082-1 INPP4A INPP4A KO HAP1 knock out of INPP4A in haploid cell line, 8bp deletion HG 831-3 INSR INSR KO HAP1 knock out of INSR in haploid cell line, 22bp deletion HG 730-14 IQGAP1 IQGAP1 KO IQGAP1 KO HAP1 HAP1 knock out of IQGAP1 in haploid cell line, 2bp deletion knock out of IQGAP1 in haploid cell line, 14bp deletion HG 784-1 HG 784-9 IRAK1 IRAK1 KO IRAK1 KO HAP1 HAP1 knock out of IRAK1 in haploid cell line, 2bp insertion knock out of IRAK1 in haploid cell line, 4bp deletion HG 9-19 HG 9-5 IRAK2 IRAK2 KO IRAK2 KO HAP1 HAP1 knock out of IRAK2 in haploid cell line, 1bp insertion knock out of IRAK2 in haploid cell line, 1bp insertion HG 10-12 HG 10-2 IRAK3 IRAK3 KO HAP1 knock out of IRAK3 in haploid cell line, 4bp insertion HG 201-6 IRAK4 IRAK4 KO HAP1 knock out of IRAK4 in haploid cell line, 1bp deletion HG 204-7 IRG1 IRG1 KO IRG1 KO HAP1 HAP1 knock out of IRG1 in haploid cell line, 26bp deletion knock out of IRG1 in haploid cell line, 10bp deletion HG 1502-2 HG 1502-5 IRS1 IRS1 KO IRS1 KO HAP1 HAP1 knock out of IRS1 in haploid cell line, 11bp deletion knock out of IRS1 in haploid cell line, 16bp deletion HG 1355-2 HG 1355-4 HD 148-002 HD 101-013 HD 104-013 HD 104-019 24 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 25 Genotype Cell Line Description Catalogue ID ISPD ISPD KO ISPD KO HAP1 HAP1 knock out of ISPD in haploid cell line, 2bp deletion knock out of ISPD in haploid cell line, 26bp deletion HG 745-10 HG 745-12 ITCH ITCH KO ITCH KO HAP1 HAP1 knock out of ITCH in haploid cell line, 2bp deletion knock out of ITCH in haploid cell line, 4bp deletion HG 2597-8 HG 2597-9 ITGA1 ITGA1 KO HAP1 knock out of ITGA1 in haploid cell line, 5bp deletion HG 1039-1 ITGA2 ITGA2 KO HAP1 knock out of ITGA2 in haploid cell line, 11bp deletion HG 1073-10 ITGA3 ITGA3 KO HAP1 knock out of ITGA3 in haploid cell line, 2bp insertion HG 1043-8 ITGA4 ITGA4 KO HAP1 knock out of ITGA4 in haploid cell line, 32bp deletion HG 1077-9 ITGA5 ITGA5 KO HAP1 knock out of ITGA5 in haploid cell line, 11bp deletion HG 1085-1 ITGA6 ITGA6 KO ITGA6 KO HAP1 HAP1 knock out of ITGA6 in haploid cell line, 10bp deletion knock out of ITGA6 in haploid cell line, 34bp deletion HG 1052-10 HG 1052-2 ITGA7 ITGA7 KO ITGA7 KO HAP1 HAP1 knock out of ITGA7 in haploid cell line, 19bp deletion knock out of ITGA7 in haploid cell line, 2bp deletion HG 1054-1 HG 1054-12 ITGA9 ITGA9 KO ITGA9 KO HAP1 HAP1 knock out of ITGA9 in haploid cell line, 13bp deletion knock out of ITGA9 in haploid cell line, 5bp insertion HG 1050-2 HG 1050-9 ITGAE ITGAE KO ITGAE KO HAP1 HAP1 knock out of ITGAE in haploid cell line, 7bp deletion knock out of ITGAE in haploid cell line, 4bp deletion HG 1026-7 HG 1026-8 ITGB1 ITGB1 KO ITGB1 KO HAP1 HAP1 knock out of ITGB1 in haploid cell line, 40bp insertion knock out of ITGB1 in haploid cell line, 2bp deletion HG 1029-12 HG 1029-3 ITGB4 ITGB4 KO ITGB4 KO HAP1 HAP1 knock out of ITGB4 in haploid cell line, 8bp deletion knock out of ITGB4 in haploid cell line, 1bp insertion HG 1027-11 HG 1027-2 ITGB5 ITGB5 KO ITGB5 KO HAP1 HAP1 knock out of ITGB5 in haploid cell line, 11bp deletion knock out of ITGB5 in haploid cell line, 4bp deletion HG 1028-1 HG 1028-10 ITK ITK KO ITK KO HAP1 HAP1 knock out of ITK in haploid cell line, 1bp insertion knock out of ITK in haploid cell line, 1bp insertion HG 11-4 HG 11-5 JAK1 JAK1 KO JAK1 KO HAP1 HAP1 knock out of JAK1 in haploid cell line, 16bp deletion knock out of JAK1 in haploid cell line, 1bp deletion HG 12-1 HG 12-22 JAK2 JAK2 (V617F/+) JAK2 (V617F/+) JAK2 KO JAK2 KO JAK2 KO SW48 HCT116 HAP1 HAP1 HAP1 Heterozygous knock-in of JAK2 activating mutation (V617F) Heterozygous knock-in of JAK2 activating mutation (V617F) knock out of JAK2 in haploid cell line, 1bp insertion knock out of JAK2 in haploid cell line, 1bp insertion knock out of JAK2 in haploid cell line, 55bp insertion HD 103-027 HD 104-025 HG 13-10 HG 13-19 HG 13-5 JARID2 JARID2 KO JARID2 KO JARID2 KO HAP1 HAP1 HAP1 knock out of JARID2 in haploid cell line, 11bp deletion knock out of JARID2 in haploid cell line, 13bp deletion knock out of JARID2 in haploid cell line, 2bp deletion HG 16202-18 HG 16202-22 HG 16202-23 JMJD6 JMJD6 KO HAP1 knock out of JMJD6 in haploid cell line, 2bp insertion HG 22063-12 JOSD1 JOSD1 KO JOSD1 KO HAP1 HAP1 knock out of JOSD1 in haploid cell line, 10bp deletion knock out of JOSD1 in haploid cell line, 8bp deletion HG 456-1 HG 456-12 JOSD2 JOSD2 KO HAP1 knock out of JOSD2 in haploid cell line, 1bp insertion HG 458-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID JOSD2 JOSD2 KO JOSD2 KO HAP1 HAP1 knock out of JOSD2 in haploid cell line, 1bp insertion knock out of JOSD2 in haploid cell line, 343bp insertion HG 458-11 HG 458-12 KAT2A KAT2A KO KAT2A KO HAP1 HAP1 knock out of KAT2A in haploid cell line, 1bp insertion knock out of KAT2A in haploid cell line, 1bp deletion HG 929-1 HG 929-2 KAT2B KAT2B KO KAT2B KO HAP1 HAP1 knock out of KAT2B in haploid cell line, 31bp deletion knock out of KAT2B in haploid cell line, 17bp deletion HG 948-12 HG 948-4 KDM1A KDM1A KO KDM1A KO HAP1 HAP1 knock out of KDM1A in haploid cell line, 10bp deletion knock out of KDM1A in haploid cell line, 4bp deletion HG 509-10 HG 509-12 KDM1B KDM1B KO KDM1B KO HAP1 HAP1 knock out of KDM1B in haploid cell line, 13bp deletion knock out of KDM1B in haploid cell line, 32bp deletion HG 525-11 HG 525-5 KDM2B KDM2B KO HAP1 knock out of KDM2B in haploid cell line, 5bp deletion HG 14730-21 KDM4A KDM4A KO KDM4A KO KDM4A KO HAP1 HAP1 HAP1 knock out of KDM4A in haploid cell line, 17bp deletion knock out of KDM4A in haploid cell line, 4bp insertion knock out of KDM4A in haploid cell line, 1bp insertion HG 1122-10 HG 1122-11 HG 1122-12 KDM4D KDM4D KO KDM4D KO HAP1 HAP1 knock out of KDM4D in haploid cell line, 4bp deletion knock out of KDM4D in haploid cell line, 11bp deletion HG 1561-4 HG 1561-5 KDM4E KDM4E KO HAP1 knock out of KDM4E in haploid cell line, 2bp deletion HG 1562-1 KDM5A KDM5A (-/-) KDM5A (+/-) HCT116 HCT116 Homozygous knock-out of KDM5A Heterozygous knock-out of KDM5A HD 104-105 HD 104-053 KDM5C KDM5C (-/Y) KDM5C KO KDM5C KO KDM5C KO HCT116 HAP1 HAP1 HAP1 Knock-out of X-linked KDM5C allele in male parental cells knock out of KDM5C in haploid cell line, 7bp deletion knock out of KDM5C in haploid cell line, 11bp deletion knock out of KDM5C in haploid cell line, 5bp deletion HD 104-063 HG 1177-1 HG 1177-10 HG 1177-2 KDM6B KDM6B KO KDM6B KO HAP1 HAP1 knock out of KDM6B in haploid cell line, 1bp insertion knock out of KDM6B in haploid cell line, 62bp deletion HG 1123-1 HG 1123-2 KIAA0196 KIAA0196 KO KIAA0196 KO HAP1 HAP1 knock out of KIAA0196 in haploid cell line, 10bp deletion knock out of KIAA0196 in haploid cell line, 2bp deletion HG 2497-11 HG 2497-2 KIAA1804 KIAA1804 KO HAP1 knock out of KIAA1804 in haploid cell line, 11bp deletion HG 1268-20 KIF1C KIF1C KO KIF1C KO HAP1 HAP1 knock out of KIF1C in haploid cell line, 23bp deletion knock out of KIF1C in haploid cell line, 13bp deletion HG 2429-10 HG 2429-6 KIF15 KIF15 KO HAP1 knock out of KIF15 in haploid cell line, 10bp deletion HG 2440-4 KIT KIT (D816V/+) HCT116 Heterozygous knock-in of KIT activating mutation (D816V) HD 104-026 KLF4 KLF4 KO KLF4 KO KLF4 KO HAP1 HAP1 HAP1 knock out of KLF4 in haploid cell line, 2bp deletion knock out of KLF4 in haploid cell line, 8bp deletion knock out of KLF4 in haploid cell line, 4bp deletion HG 1143-10 HG 1143-3 HG 1143-8 KLHL3 KLHL3 KO KLHL3 KO HAP1 HAP1 knock out of KLHL3 in haploid cell line, 14bp deletion knock out of KLHL3 in haploid cell line, 2bp insertion HG 840-10 HG 840-5 KMT2A KMT2A KO KMT2A KO HAP1 HAP1 knock out of KMT2A in haploid cell line, 32bp deletion knock out of KMT2A in haploid cell line, 19bp deletion HG 1319-12 HG 1319-8 KMT2B KMT2B KO HAP1 knock out of KMT2B in haploid cell line, 2bp deletion HG 1115-7 26 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 27 Genotype Cell Line Description Catalogue ID KMT2B KMT2B KO KMT2B KO HAP1 HAP1 knock out of KMT2B in haploid cell line, 8bp deletion knock out of KMT2B in haploid cell line, 185bp insertion HG 1115-8 HG 1115-9 KRAS KRAS (+/-) KRAS (+/-) KRAS (+/-) KRAS (A146T/+) KRAS (G12A/+) KRAS (G12A/+) KRAS (G12C/+) KRAS (G12C/+) KRAS (G12C/+) KRAS (G12D/+) KRAS (G12D/+) KRAS (G12D/+) KRAS (G12D/+/+/+) KRAS (G12D/+9n) HCT116 DLD-1 DLD-1 SW48 SW48 LIM1215 SW48 Cal12T LIM1215 SW48 LIM1215 NCI-H1975 EBC-1 NCI-H838 HD 104-008 HD 105-002 HD 105-040 HD 103-036 HD 103-009 HD 116-003 HD 103-006 HD 113-001 HD 116-007 HD 103-011 HD 116-005 HD 120-001 HD 121-001 HD 114-002 KRAS (G12R/+) KRAS (G12R/+) KRAS (G12S/+) KRAS (G12S/+) KRAS (G12V/+) KRAS (G12V/+) KRAS (G12V/+) KRAS (G12V/+); PIK3CA (E545K/+) KRAS (G12V/+9n) SW48 LIM1215 SW48 LIM1215 MCF10A SW48 LIM1215 MCF10A NCI-H838 KRAS (G13D/-) KRAS (G13D/-) KRAS (G13D/-) KRAS (G13D/+) KRAS (G13D/+) KRAS (G13D/+) KRAS (G13D/+); PIK3CA (H1047R/+) KRAS (Q61H/+) KRAS (G12V/+); PIK3CA (H1047R/+) KRAS (G12V/+); TP53 (-/-) HCT116 DLD-1 DLD-1 hTERT-HME1 SW48 LIM1215 hTERT-HME1 SW48 MCF10A MCF10A Knock-out of mutant KRAS allele in heterozygous parental cells Knock-out of mutant KRAS allele in heterozygous parental cells Knock-out of mutant KRAS allele in heterozygous parental cells Heterozygous knockin of KRAS activating mutation (A146T) Heterozygous knock-in of KRAS activating mutation (G12A) Heterozygous knock-in of KRAS activating mutation (G12A) Heterozygous knock-in of KRAS activating mutation (G12C) Heterozygous knock-in of KRAS activating mutation (G12C) Heterozygous knock-in of KRAS activating mutation (G12C) Heterozygous knock-in of KRAS activating mutation (G12D) Heterozygous knock-in of KRAS activating mutation (G12D) Heterozygous knock-in of KRAS activating mutation (G12D) Heterozygous knock-in of KRAS activating mutation (G12D) Heterozygous knock-in of KRAS activating mutation (G12D); Gene copy number = 10 Heterozygous knock-in of KRAS activating mutation (G12R) Heterozygous knock-in of KRAS activating mutation (G12R) Heterozygous knock-in of KRAS activating mutation (G12S) Heterozygous knock-in of KRAS activating mutation (G12S) Heterozygous knock-in of KRAS activating mutation (G12V) Heterozygous knock-in of KRAS activating mutation (G12V) Heterozygous knock-in of KRAS activating mutation (G12V) Double heterozygous knock-in of KRAS and PIK3CA activating mutations Heterozygous knock-in of KRAS activating mutation (G12V); Gene copy number = 10 Knock-out of wild type KRAS allele in heterozygous parental cells Knock-out of wild type KRAS allele in heterozygous parental cells Knock-out of wild type KRAS allele in heterozygous parental cells Heterozygous knock-in of KRAS activating mutation (G13D) Heterozygous knock-in of KRAS activating mutation (G13D) Heterozygous knock-in of KRAS activating mutation (G13D) Double heterozygous knock-in of KRAS and PIK3CA activating mutations Heterozygous knock-in of KRAS activating mutation (Q61H) Double heterozygous knock-in of KRAS and PIK3CA activating mutations Homozygous knock-out of TP53; heterozygous knockin of KRAS activating mutation (G12V) KSR1 KSR1 KO KSR1 KO HAP1 HAP1 knock out of KSR1 in haploid cell line, 10bp deletion knock out of KSR1 in haploid cell line, 19bp deletion HG 369-1 HG 369-3 KSR2 KSR2 KO KSR2 KO HAP1 HAP1 knock out of KSR2 in haploid cell line, 1bp insertion knock out of KSR2 in haploid cell line, 29bp deletion HG 48-3 HG 48-9 KXD1 KXD1 KO KXD1 KO HAP1 HAP1 knock out of KXD1 in haploid cell line, 68bp insertion knock out of KXD1 in haploid cell line, 2bp deletion HG 872-5 HG 872-6 L3MBTL2 L3MBTL2 KO L3MBTL2 KO L3MBTL2 KO HAP1 HAP1 HAP1 knock out of L3MBTL2 in haploid cell line, 8bp deletion knock out of L3MBTL2 in haploid cell line, 17bp deletion knock out of L3MBTL2 in haploid cell line, 8bp deletion HG 1126-11 HG 1126-3 HG 1126-6 LAMTOR4 LAMTOR4 KO LAMTOR4 KO LAMTOR4 KO HAP1 HAP1 HAP1 knock out of LAMTOR4 in haploid cell line, 8bp deletion knock out of LAMTOR4 in haploid cell line, 1bp insertion knock out of LAMTOR4 in haploid cell line, 2bp deletion HG 374-10 HG 374-12 HG 374-9 LARGE LARGE KO LARGE KO LARGE KO HAP1 HAP1 HAP1 knock out of LARGE in haploid cell line, 1bp insertion knock out of LARGE in haploid cell line, 1bp insertion knock out of LARGE in haploid cell line, 1bp insertion HG 122-5 HG 122-6 HG 122-7 LATS1 LATS1 KO HAP1 knock out of LATS1 in haploid cell line, 1bp insertion HG 308-1 HD 103-010 HD 116-002 HD 103-013 HD 116-001 HD 101-004 HD 103-007 HD 116-006 HD 201-002 HD 114-003 HD 104-011 HD 105-011 HD 105-043 HD 100-004 HD 103-002 HD 116-009 HD 200-003 HD 103-053 HD 201-003 HD 101-027 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID LATS1 LATS1 KO HAP1 knock out of LATS1 in haploid cell line, 2bp insertion HG 308-4 LATS2 LATS2 KO LATS2 KO HAP1 HAP1 knock out of LATS2 in haploid cell line, 17bp insertion knock out of LATS2 in haploid cell line, 4bp deletion HG 89-13 HG 89-3 LGR4 LGR4 KO HAP1 knock out of LGR4 in haploid cell line, 5bp deletion HG 1031-6 LIG3 LIG3 (+floxed/-) HCT116 HD R02-061 LIG3 KO LIG3 KO HAP1 HAP1 Knock-out of one LIG3 allele and flanking of exon 4 in remaining allele with LoxP sites knock out of LIG3 in haploid cell line, 185bp insertion knock out of LIG3 in haploid cell line, 86bp insertion LIG4 LIG4 (-/-) LIG4 (-/-) LIG4 (-/-); BLM (+/-) LIG4 (-/-); RAD54B (+/-/-) NALM-6 HCT116 NALM-6 HCT116 HD 115-041 HD R02-063 HD 115-078 HD R02-066 LIG4 (-/-); RAD54L (-/-) LIG4 (-/-); XRCC6 (+/-) LIG4 (+/-) LIG4 (+/-) LIG4 KO LIG4 KO LIG4 (-/-); XRCC5 (+floxed/-) NALM-6 HCT116 NALM-6 HCT116 HAP1 HAP1 HCT116 LIG4 (-/-); XRCC5 (+floxed/-) HCT116 Homozygous knock-out of LIG4 Homozygous knock-out of LIG4 Heterozygous knock-out of BLM; homozygous knock out of LIG4 Homozygous knock-out of LIG4; double knock-out of RAD54B in triploid parental cells Double homozygous knock-out of LIG4 and RAD54L Heterozygous knock-out of XRCC6; Homozygous knock-out of LIG4 Heterozygous knock-out of LIG4 Heterozygous knock-out of LIG4 knock out of LIG4 in haploid cell line, 10bp deletion knock out of LIG4 in haploid cell line, 1bp insertion Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; homozygous knock-out of LIG4 Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; homozygous knock-out of LIG4 LIMK2 LIMK2 KO HAP1 knock out of LIMK2 in haploid cell line, 5bp deletion HG 405-15 LMNA LMNA KO HAP1 knock out of LMNA in haploid cell line, 101bp insertion HG 758-1 LMNB1 LMNB1 KO LMNB1 KO LMNB1 KO HAP1 HAP1 HAP1 knock out of LMNB1 in haploid cell line, 2bp insertion knock out of LMNB1 in haploid cell line, 1bp insertion knock out of LMNB1 in haploid cell line, 1bp insertion HG 808-11 HG 808-12 HG 808-2 LMTK2 LMTK2 KO HAP1 knock out of LMTK2 in haploid cell line, 5bp deletion HG 708-8 LMTK3 LMTK3 KO HAP1 knock out of LMTK3 in haploid cell line, 1bp insertion HG 702-4 LOH12CR1 LOH12CR1 KO LOH12CR1 KO HAP1 HAP1 knock out of LOH12CR1 in haploid cell line, 10bp deletion knock out of LOH12CR1 in haploid cell line, 8bp deletion HG 869-4 HG 869-5 LRBA LRBA KO LRBA KO HAP1 HAP1 knock out of LRBA in haploid cell line, 7bp deletion knock out of LRBA in haploid cell line, 13bp deletion HG 1309-4 HG 1309-6 LRP1 LRP1 KO HAP1 knock out of LRP1 in haploid cell line, 5bp deletion HG 1773-1 LRP5 LRP5 KO LRP5 KO HAP1 HAP1 knock out of LRP5 in haploid cell line, 4bp deletion knock out of LRP5 in haploid cell line, 23bp deletion HG 1055-3 HG 1055-5 LRP6 LRP6 KO LRP6 KO HAP1 HAP1 knock out of LRP6 in haploid cell line, 4bp deletion knock out of LRP6 in haploid cell line, 5bp deletion HG 598-10 HG 598-7 LRRC8A LRRC8A KO LRRC8A KO HAP1 HAP1 knock out of LRRC8A in haploid cell line, 1bp deletion knock out of LRRC8A in haploid cell line, 2bp deletion HG 574-10 HG 574-6 LRRC8D LRRC8D KO LRRC8D KO HAP1 HAP1 knock out of LRRC8D in haploid cell line, 20bp deletion knock out of LRRC8D in haploid cell line, 4bp deletion HG 577-5 HG 577-7 LRRK1 LRRK1 KO HAP1 knock out of LRRK1 in haploid cell line, 13bp deletion HG 1345-12 HG 1530-1 HG 1530-7 HD 115-075 HD R02-064 HD 115-040 HD R02-062 HG 759-5 HG 759-6 HD R02-056 HD R02-057 28 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 29 Genotype Cell Line Description Catalogue ID LRRK2 LRRK2 KO LRRK2 KO HAP1 HAP1 knock out of LRRK2 in haploid cell line, 4bp deletion knock out of LRRK2 in haploid cell line, 2bp deletion HG 2500-5 HG 2500-7 LTK LTK KO LTK KO LTK KO HAP1 HAP1 HAP1 knock out of LTK in haploid cell line, 7bp deletion knock out of LTK in haploid cell line, 37bp deletion knock out of LTK in haploid cell line, 23bp deletion HG 357-13 HG 357-18 HG 357-19 LYN LYN KO LYN KO HAP1 HAP1 knock out of LYN in haploid cell line, 22bp deletion knock out of LYN in haploid cell line, 13bp deletion HG 1664-23 HG 1664-5 LYPLA1 LYPLA1 KO LYPLA1 KO HAP1 HAP1 knock out of LYPLA1 in haploid cell line, 2bp deletion knock out of LYPLA1 in haploid cell line, 10bp deletion HG 594-5 HG 594-6 LYPLA2 LYPLA2 KO LYPLA2 KO HAP1 HAP1 knock out of LYPLA2 in haploid cell line, 16bp deletion knock out of LYPLA2 in haploid cell line, 2bp deletion HG 593-12 HG 593-8 LYPLAL1 LYPLAL1 KO LYPLAL1 KO HAP1 HAP1 knock out of LYPLAL1 in haploid cell line, 2bp deletion knock out of LYPLAL1 in haploid cell line, 148bp insertion HG 604-10 HG 604-4 MAK MAK KO HAP1 knock out of MAK in haploid cell line, 71bp insertion HG 1342-13 MAP2K1 MAP2K1 (-/-) MAP2K1 (-/-) MAP2K1 (-/-) MAP2K1 (-/-) MAP2K1 (P124L/+) DLD-1 HCT116 RKO VACO 432 HCT116 HD R00-017 HD R02-030 HD R05-010 HD R07-001 HD 104-034 MAP2K1 KO HAP1 Homozygous knock-out of MAP2K1 Homozygous knock-out of MAP2K1 Homozygous knock-out of MAP2K1 Homozygous knock-out of MAP2K1 Heterozygous knock-in of MAP2K1 activating mutation (P124L) conferring drug resistance knock out of MAP2K1 in haploid cell line, 1bp insertion MAP2K2 MAP2K2 (-/-) MAP2K2 (-/-) MAP2K2 (-/-) MAP2K2 (-/-) MAP2K2 (+/-) MAP2K2 (+/-) MAP2K2 (+/-) MAP2K2 (+/-) MAP2K2 KO MAP2K2 KO DLD-1 HCT116 RKO VACO 432 DLD-1 VACO 432 HCT116 RKO HAP1 HAP1 Homozygous knock-out of MAP2K2 Homozygous knock-out of MAP2K2 Homozygous knock-out of MAP2K2 Homozygous knock-out of MAP2K2 Heterozygous knock-out of MAP2K2 Heterozygous knock-out of MAP2K2 Heterozygous knock-out of MAP2K2 Heterozygous knock-out of MAP2K2 knock out of MAP2K2 in haploid cell line, 2bp deletion knock out of MAP2K2 in haploid cell line, 7bp deletion HD R00-018 HD R02-031 HD R05-007 HD R07-002 HD R00-019 HD R07-003 HD R02-032 HD R05-008 HG 16-12 HG 16-18 MAP2K3 MAP2K3 KO MAP2K3 KO MAP2K3 KO HAP1 HAP1 HAP1 knock out of MAP2K3 in haploid cell line, 14bp deletion knock out of MAP2K3 in haploid cell line, 139bp insertion knock out of MAP2K3 in haploid cell line, 2bp deletion HG 145-15 HG 145-21 HG 145-5 MAP2K4 MAP2K4 KO HAP1 knock out of MAP2K4 in haploid cell line, 13bp deletion HG 1253-16 MAP2K5 MAP2K5 KO MAP2K5 KO MAP2K5 KO HAP1 HAP1 HAP1 knock out of MAP2K5 in haploid cell line, 26bp deletion knock out of MAP2K5 in haploid cell line, 1bp insertion knock out of MAP2K5 in haploid cell line, 10bp deletion HG 146-19 HG 146-23 HG 146-4 MAP2K6 MAP2K6 KO HAP1 knock out of MAP2K6 in haploid cell line, 7bp deletion HG 213-22 MAP2K7 MAP2K7 KO MAP2K7 KO MAP2K7 KO HAP1 HAP1 HAP1 knock out of MAP2K7 in haploid cell line, 10bp deletion knock out of MAP2K7 in haploid cell line, 116bp insertion knock out of MAP2K7 in haploid cell line, 14bp deletion HG 49-1 HG 49-8 HG 49-9 MAP3K1 MAP3K1 KO HAP1 knock out of MAP3K1 in haploid cell line, 7bp deletion HG 740-17 MAP3K2 MAP3K2 KO HAP1 knock out of MAP3K2 in haploid cell line, 8bp deletion HG 92-1 HG 15-6 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID MAP3K2 MAP3K2 KO MAP3K2 KO HAP1 HAP1 knock out of MAP3K2 in haploid cell line, 11bp deletion knock out of MAP3K2 in haploid cell line, 5bp deletion HG 92-14 HG 92-6 MAP3K3 MAP3K3 KO MAP3K3 KO MAP3K3 KO HAP1 HAP1 HAP1 knock out of MAP3K3 in haploid cell line, 2bp insertion knock out of MAP3K3 in haploid cell line, 8bp deletion knock out of MAP3K3 in haploid cell line, 7bp deletion HG 148-15 HG 148-4 HG 148-5 MAP3K4 MAP3K4 KO HAP1 knock out of MAP3K4 in haploid cell line, 17bp deletion HG 1275-13 MAP3K5 MAP3K5 KO HAP1 knock out of MAP3K5 in haploid cell line, 17bp deletion HG 93-1 MAP3K6 MAP3K6 KO HAP1 knock out of MAP3K6 in haploid cell line, 2bp deletion HG 225-11 MAP3K7 MAP3K7 KO HAP1 knock out of MAP3K7 in haploid cell line, 2bp deletion HG 149-18 MAP3K8 MAP3K8 KO HAP1 knock out of MAP3K8 in haploid cell line, 10bp deletion HG 228-2 MAP3K9 MAP3K9 KO MAP3K9 KO HAP1 HAP1 knock out of MAP3K9 in haploid cell line, 14bp deletion knock out of MAP3K9 in haploid cell line, 13bp deletion HG 311-12 HG 311-20 MAP3K10 MAP3K10 KO MAP3K10 KO MAP3K10 KO HAP1 HAP1 HAP1 knock out of MAP3K10 in haploid cell line, 2bp deletion knock out of MAP3K10 in haploid cell line, 20bp deletion knock out of MAP3K10 in haploid cell line, 14bp deletion HG 90-11 HG 90-14 HG 90-9 MAP3K11 MAP3K11 KO MAP3K11 KO HAP1 HAP1 knock out of MAP3K11 in haploid cell line, 17bp deletion knock out of MAP3K11 in haploid cell line, 17bp deletion HG 91-2 HG 91-7 MAP3K12 MAP3K12 KO MAP3K12 KO MAP3K12 KO HAP1 HAP1 HAP1 knock out of MAP3K12 in haploid cell line, 14bp deletion knock out of MAP3K12 in haploid cell line, 8bp deletion knock out of MAP3K12 in haploid cell line, 2bp deletion HG 147-1 HG 147-14 HG 147-24 MAP3K14 MAP3K14 KO HAP1 knock out of MAP3K14 in haploid cell line, 29bp deletion HG 218-19 MAP4K3 MAP4K3 KO HAP1 knock out of MAP4K3 in haploid cell line, 14bp deletion HG 17-14 MAP4K4 MAP4K4 KO HAP1 knock out of MAP4K4 in haploid cell line, 13bp deletion HG 732-22 MAP4K5 MAP4K5 KO HAP1 knock out of MAP4K5 in haploid cell line, 19bp deletion HG 18-7 MAPK1 MAPK1 KO MAPK1 KO HAP1 HAP1 knock out of MAPK1 in haploid cell line, 4bp deletion knock out of MAPK1 in haploid cell line, 1bp insertion HG 19-10 HG 19-6 MAPK3 MAPK3 KO HAP1 knock out of MAPK3 in haploid cell line, 7bp deletion HG 22-10 MAPK4 MAPK4 KO MAPK4 KO MAPK4 KO HAP1 HAP1 HAP1 knock out of MAPK4 in haploid cell line, 2bp deletion knock out of MAPK4 in haploid cell line, 2bp deletion knock out of MAPK4 in haploid cell line, 196bp insertion HG 333-12 HG 333-22 HG 333-5 MAPK7 MAPK7 KO MAPK7 KO MAPK7 KO HAP1 HAP1 HAP1 knock out of MAPK7 in haploid cell line, 20bp deletion knock out of MAPK7 in haploid cell line, 37bp deletion knock out of MAPK7 in haploid cell line, 5bp deletion HG 150-10 HG 150-11 HG 150-18 MAPK8 MAPK8 KO MAPK8 KO HAP1 HAP1 knock out of MAPK8 in haploid cell line, 5bp deletion knock out of MAPK8 in haploid cell line, 2bp insertion HG 526-3 HG 526-4 MAPK9 MAPK9 KO MAPK9 KO HAP1 HAP1 knock out of MAPK9 in haploid cell line, 1bp deletion knock out of MAPK9 in haploid cell line, 2bp deletion HG 24-13 HG 24-4 MAPK11 MAPK11 KO HAP1 knock out of MAPK11 in haploid cell line, 1bp insertion HG 911-1 30 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 31 Genotype Cell Line Description Catalogue ID MAPK11 MAPK11 KO MAPK11 KO HAP1 HAP1 knock out of MAPK11 in haploid cell line, 1bp deletion knock out of MAPK11 in haploid cell line, 1bp insertion HG 911-11 HG 911-2 MAPK12 MAPK12 KO MAPK12 KO HAP1 HAP1 knock out of MAPK12 in haploid cell line, 1bp insertion knock out of MAPK12 in haploid cell line, 1bp insertion HG 21-13 HG 21-14 MAPK14 MAPK14 KO MAPK14 KO HAP1 HAP1 knock out of MAPK14 in haploid cell line, 5bp deletion knock out of MAPK14 in haploid cell line, 2bp insertion HG 2595-10 HG 2595-11 MAPK15 MAPK15 KO HAP1 knock out of MAPK15 in haploid cell line, 8bp deletion HG 738-14 MAPKAP1 MAPKAP1 KO MAPKAP1 KO HAP1 HAP1 knock out of MAPKAP1 in haploid cell line, 5bp deletion knock out of MAPKAP1 in haploid cell line, 2bp deletion HG 997-2 HG 997-7 MAPKAPK2 MAPKAPK2 KO MAPKAPK2 KO HAP1 HAP1 knock out of MAPKAPK2 in haploid cell line, 2bp deletion knock out of MAPKAPK2 in haploid cell line, 7bp deletion HG 25-13 HG 25-16 MAPKAPK3 MAPKAPK3 KO HAP1 knock out of MAPKAPK3 in haploid cell line, 5bp deletion HG 208-12 MAPKAPK5 MAPKAPK5 KO HAP1 knock out of MAPKAPK5 in haploid cell line, 4bp deletion HG 217-4 MARK1 MARK1 KO MARK1 KO MARK1 KO HAP1 HAP1 HAP1 knock out of MARK1 in haploid cell line, 4bp deletion knock out of MARK1 in haploid cell line, 11bp deletion knock out of MARK1 in haploid cell line, 34bp deletion HG 50-1 HG 50-12 HG 50-20 MARK2 MARK2 KO MARK2 KO HAP1 HAP1 knock out of MARK2 in haploid cell line, 11bp deletion knock out of MARK2 in haploid cell line, 2bp deletion HG 328-13 HG 328-14 MARK3 MARK3 KO MARK3 KO MARK3 KO HAP1 HAP1 HAP1 knock out of MARK3 in haploid cell line, 1bp insertion knock out of MARK3 in haploid cell line, 5bp deletion knock out of MARK3 in haploid cell line, 17bp deletion HG 151-1 HG 151-14 HG 151-16 MARK4 MARK4 KO MARK4 KO HAP1 HAP1 knock out of MARK4 in haploid cell line, 2bp deletion knock out of MARK4 in haploid cell line, 29bp deletion HG 152-6 HG 152-8 MAST1 MAST1 KO HAP1 knock out of MAST1 in haploid cell line, 2bp insertion HG 331-13 MAST2 MAST2 KO HAP1 knock out of MAST2 in haploid cell line, 17bp deletion HG 94-20 MAST3 MAST3 KO MAST3 KO MAST3 KO HAP1 HAP1 HAP1 knock out of MAST3 in haploid cell line, 7bp deletion knock out of MAST3 in haploid cell line, 7bp deletion knock out of MAST3 in haploid cell line, 19bp deletion HG 95-22 HG 95-24 HG 95-9 MAST4 MAST4 KO MAST4 KO MAST4 KO HAP1 HAP1 HAP1 knock out of MAST4 in haploid cell line, 26bp deletion knock out of MAST4 in haploid cell line, 2bp deletion knock out of MAST4 in haploid cell line, 13bp deletion HG 153-14 HG 153-23 HG 153-3 MATK MATK KO MATK KO MATK KO HAP1 HAP1 HAP1 knock out of MATK in haploid cell line, 2bp deletion knock out of MATK in haploid cell line, 2bp deletion knock out of MATK in haploid cell line, 2bp deletion HG 154-10 HG 154-11 HG 154-22 MAVS MAVS KO MAVS KO HAP1 HAP1 knock out of MAVS in haploid cell line, 4bp deletion knock out of MAVS in haploid cell line, 2bp deletion HG 1456-11 HG 1456-12 MBD1 MBD1 KO MBD1 KO MBD1 KO HAP1 HAP1 HAP1 knock out of MBD1 in haploid cell line, 1bp deletion knock out of MBD1 in haploid cell line, 4bp deletion knock out of MBD1 in haploid cell line, 287bp insertion HG 1171-2 HG 1171-3 HG 1171-8 MBD3 MBD3 KO HAP1 knock out of MBD3 in haploid cell line, 64bp insertion HG 1113-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID MBD3 MBD3 KO MBD3 KO MBD3 KO HAP1 HAP1 HAP1 knock out of MBD3 in haploid cell line, 1bp insertion knock out of MBD3 in haploid cell line, 8bp deletion knock out of MBD3 in haploid cell line, 11bp deletion HG 1113-12 HG 1113-8 HG 1113-9 MBD4 MBD4 KO MBD4 KO MBD4 KO MBD4 KO HAP1 HAP1 HAP1 HAP1 knock out of MBD4 in haploid cell line, 404bp insertion knock out of MBD4 in haploid cell line, 2bp deletion knock out of MBD4 in haploid cell line, 13bp deletion knock out of MBD4 in haploid cell line, 2bp deletion HG 921-11 HG 921-2 HG 921-4 HG 921-5 MBTPS1 MBTPS1 KO HAP1 knock out of MBTPS1 in haploid cell line, 5bp deletion HG 1520-9 MBTPS2 MBTPS2 KO MBTPS2 KO HAP1 HAP1 knock out of MBTPS2 in haploid cell line, 1bp insertion knock out of MBTPS2 in haploid cell line, 5bp deletion HG 1523-10 HG 1523-7 MCOLN1 MCOLN1 KO MCOLN1 KO MCOLN1 KO HAP1 HAP1 HAP1 knock out of MCOLN1 in haploid cell line, 1bp insertion knock out of MCOLN1 in haploid cell line, 1bp insertion knock out of MCOLN1 in haploid cell line, 1bp insertion HG 2538-1 HG 2538-10 HG 2538-11 MCTS1 MCTS1 (-/Y) HCT116 Knock-out of X-linked MCTS1 allele in male parental cells HD 115-094 MECP2 MECP2 KO MECP2 KO HAP1 HAP1 knock out of MECP2 in haploid cell line, 1bp insertion knock out of MECP2 in haploid cell line, 2bp insertion HG 1102-10 HG 1102-9 MEF2B MEF2B KO MEF2B KO HAP1 HAP1 knock out of MEF2B in haploid cell line, 7bp deletion knock out of MEF2B in haploid cell line, 5bp deletion HG 860-10 HG 860-8 MELK MELK KO HAP1 knock out of MELK in haploid cell line, 5bp deletion HG 401-7 MEN1 MEN1 KO MEN1 KO MEN1 KO MEN1 KO HAP1 HAP1 HAP1 HAP1 knock out of MEN1 in haploid cell line, 1bp insertion knock out of MEN1 in haploid cell line, 7bp deletion knock out of MEN1 in haploid cell line, 2bp insertion knock out of MEN1 in haploid cell line, 425bp insertion HG 1139-1 HG 1139-12 HG 1139-8 HG 1139-9 MERTK MERTK KO MERTK KO MERTK KO MERTK KO HAP1 HAP1 HAP1 HAP1 knock out of MERTK in haploid cell line, 32bp deletion knock out of MERTK in haploid cell line, 2bp deletion knock out of MERTK in haploid cell line, 1bp deletion knock out of MERTK in haploid cell line, 8bp deletion HG 15332-10 HG 15332-14 HG 15332-19 HG 15332-9 MET MET (Y1253D/+) MET KO HCT116 HAP1 Heterozygous knock-in of MET activating mutaion Y1253D knock out of MET in haploid cell line, 82bp insertion HD 104-056 HG 26-18 METTL12 METTL12 KO METTL12 KO HAP1 HAP1 knock out of METTL12 in haploid cell line, 1bp insertion knock out of METTL12 in haploid cell line, 1bp insertion HG 536-12 HG 536-4 METTL13 METTL13 KO METTL13 KO HAP1 HAP1 knock out of METTL13 in haploid cell line, 14bp deletion knock out of METTL13 in haploid cell line, 8bp deletion HG 539-12 HG 539-6 METTL18 METTL18 KO METTL18 KO METTL18 KO HAP1 HAP1 HAP1 knock out of METTL18 in haploid cell line, 4bp deletion knock out of METTL18 in haploid cell line, 2bp deletion knock out of METTL18 in haploid cell line, 1bp deletion HG 541-12 HG 541-2 HG 541-9 METTL20 METTL20 KO METTL20 KO HAP1 HAP1 knock out of METTL20 in haploid cell line, 5bp deletion knock out of METTL20 in haploid cell line, 1bp insertion HG 543-8 HG 543-9 METTL21B METTL21B KO METTL21B KO HAP1 HAP1 knock out of METTL21B in haploid cell line, 1bp insertion knock out of METTL21B in haploid cell line, 17bp deletion HG 546-12 HG 546-4 METTL22 METTL22 KO HAP1 knock out of METTL22 in haploid cell line, 1bp deletion HG 547-11 32 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 33 Genotype Cell Line Description Catalogue ID METTL22 METTL22 KO HAP1 knock out of METTL22 in haploid cell line, 97bp insertion HG 547-12 METTL23 METTL23 KO METTL23 KO HAP1 HAP1 knock out of METTL23 in haploid cell line, 32bp deletion knock out of METTL23 in haploid cell line, 2bp deletion HG 549-5 HG 549-6 MFSD2A MFSD2A KO HAP1 knock out of MFSD2A in haploid cell line, 2bp deletion HG 2418-2 MGMT MGMT KO MGMT KO MGMT KO HAP1 HAP1 HAP1 knock out of MGMT in haploid cell line, 2bp deletion knock out of MGMT in haploid cell line, 8bp deletion knock out of MGMT in haploid cell line, 20bp deletion HG 430-10 HG 430-4 HG 430-6 MINK1 MINK1 KO HAP1 knock out of MINK1 in haploid cell line, 22bp deletion HG 277-36 MIOS MIOS KO HAP1 knock out of MIOS in haploid cell line, 2bp insertion HG 1281-11 MIR21 MIR21 (-/-) RKO Homozygous knock-out of MIR21 HD R05-013 MKI67 MKI67 KO MKI67 KO HAP1 HAP1 knock out of MKI67 in haploid cell line, 1bp insertion knock out of MKI67 in haploid cell line, 8bp deletion HG 981-10 HG 981-6 MKNK1 MKNK1 KO MKNK1 KO MKNK1 KO HAP1 HAP1 HAP1 knock out of MKNK1 in haploid cell line, 7bp deletion knock out of MKNK1 in haploid cell line, 4bp deletion knock out of MKNK1 in haploid cell line, 7bp deletion HG 397-12 HG 397-18 HG 397-2 MKNK2 MKNK2 KO MKNK2 KO HAP1 HAP1 knock out of MKNK2 in haploid cell line, 4bp deletion knock out of MKNK2 in haploid cell line, 16bp deletion HG 156-20 HG 156-8 MLH1 MLH1 (+/-) MLH1 KO MLH1 KO MLH1 KO HCT116 HAP1 HAP1 HAP1 Heterozygous knock-in of wild type MLH1 allele in mutant parental cells knock out of MLH1 in haploid cell line, 2bp deletion knock out of MLH1 in haploid cell line, 19bp deletion knock out of MLH1 in haploid cell line, 13bp deletion HD 104-006 HG 343-11 HG 343-21 HG 343-22 MLKL MLKL KO HAP1 knock out of MLKL in haploid cell line, 2bp deletion HG 712-13 MLST8 MLST8 KO MLST8 KO MLST8 KO HAP1 HAP1 HAP1 knock out of MLST8 in haploid cell line, 2bp deletion knock out of MLST8 in haploid cell line, 1bp insertion knock out of MLST8 in haploid cell line, 1bp insertion HG 1356-10 HG 1356-11 HG 1356-2 MOK MOK KO MOK KO MOK KO HAP1 HAP1 HAP1 knock out of MOK in haploid cell line, 8bp deletion knock out of MOK in haploid cell line, 4bp deletion knock out of MOK in haploid cell line, 35bp deletion HG 75-11 HG 75-14 HG 75-17 MPG MPG KO HAP1 knock out of MPG in haploid cell line, 13bp deletion HG 1537-2 MPI MPI KO MPI KO HAP1 HAP1 knock out of MPI in haploid cell line, 2bp deletion knock out of MPI in haploid cell line, 7bp deletion HG 124-1 HG 124-24 MPND MPND KO HAP1 knock out of MPND in haploid cell line, 4bp deletion HG 488-7 MSH2 MSH2 KO HAP1 knock out of MSH2 in haploid cell line, 2bp deletion HG 24799-15 MSH3 MSH3 KO MSH3 KO MSH3 KO HAP1 HAP1 HAP1 knock out of MSH3 in haploid cell line, 4bp insertion knock out of MSH3 in haploid cell line, 2bp insertion knock out of MSH3 in haploid cell line, 1bp insertion HG 656-1 HG 656-10 HG 656-5 MSH5 MSH5 KO MSH5 KO HAP1 HAP1 knock out of MSH5 in haploid cell line, 11bp deletion knock out of MSH5 in haploid cell line, 2bp deletion HG 1367-10 HG 1367-11 MSH6 MSH6 KO HAP1 knock out of MSH6 in haploid cell line, 2bp deletion HG 653-3 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID MSH6 MSH6 KO MSH6 KO HAP1 HAP1 knock out of MSH6 in haploid cell line, 14bp deletion knock out of MSH6 in haploid cell line, 8bp deletion HG 653-5 HG 653-7 MST4 MST4 KO MST4 KO HAP1 HAP1 knock out of MST4 in haploid cell line, 8bp deletion knock out of MST4 in haploid cell line, 7bp deletion HG 157-14 HG 157-15 MTAP MTAP (-/-) MTAP (-/-) DLD-1 HCT116 Homozygous knock-out of MTAP Homozygous knock-out of MTAP HD R00-021 HD R02-033 MTCH1 MTCH1 KO HAP1 knock out of MTCH1 in haploid cell line, 113bp insertion HG 1651-2 MTF2 MTF2 KO MTF2 KO HAP1 HAP1 knock out of MTF2 in haploid cell line, 2bp deletion knock out of MTF2 in haploid cell line, 1bp insertion HG 984-11 HG 984-12 MTOR MTOR (D2338A/D2338A cKI) HCT116 HD 104-065 MTOR (S2035I/+) MTOR (S2035I/S2035I) HCT116 HCT116 Heterozygous knock-in of kinase-dead mutation D2338A into the first allele, heterozygous conditional knockin of kinase-dead mutation D2338A into the second allele Heterozygous knock-in of MTOR (S2035I) rapamycin resistance mutation Homozygous knock-in of MTOR (S2035I) rapamycin resistance mutation MUS81 MUS81 (-/-) MUS81 (-/-); FANCB (-/Y) NALM-6 NALM-6 HD 115-055 HD 115-092 MUS81 (+/-) MUS81 KO MUS81 KO MUS81 KO NALM-6 HAP1 HAP1 HAP1 Homozygous knock-out of MUS81 Knock-out of X-linked FANCB allele in male parental cells; homozygous knock-out of MUS81 Heterozygous knock-out of MUS81 knock out of MUS81 in haploid cell line, 1bp deletion knock out of MUS81 in haploid cell line, 28bp deletion knock out of MUS81 in haploid cell line, 1bp insertion MUTYH MUTYH KO HAP1 knock out of MUTYH in haploid cell line, 5bp deletion HG 788-8 MYH9 MYH9 KO HAP1 knock out of MYH9 in haploid cell line, 5bp deletion HG 1088-12 MYLK MYLK KO MYLK KO MYLK KO HAP1 HAP1 HAP1 knock out of MYLK in haploid cell line, 5bp deletion knock out of MYLK in haploid cell line, 4bp deletion knock out of MYLK in haploid cell line, 4bp deletion HG 7194-10 HG 7194-22 HG 7194-3 MYLK3 MYLK3 KO MYLK3 KO MYLK3 KO MYLK3 KO MYLK3 KO HAP1 HAP1 HAP1 HAP1 HAP1 knock out of MYLK3 in haploid cell line, 158bp insertion knock out of MYLK3 in haploid cell line, 4bp deletion knock out of MYLK3 in haploid cell line, 32bp deletion knock out of MYLK3 in haploid cell line, 8bp deletion knock out of MYLK3 in haploid cell line, 68bp insertion HG 51-12 HG 51-15 HG 51-2 HG 51-7 HG 51-8 MYSM1 MYSM1 KO MYSM1 KO HAP1 HAP1 knock out of MYSM1 in haploid cell line, 7bp deletion knock out of MYSM1 in haploid cell line, 1bp insertion HG 504-5 HG 504-8 MYT1 MYT1 KO MYT1 KO MYT1 KO HAP1 HAP1 HAP1 knock out of MYT1 in haploid cell line, 4bp deletion knock out of MYT1 in haploid cell line, 4bp deletion knock out of MYT1 in haploid cell line, 5bp deletion HG 370-10 HG 370-15 HG 370-21 NANP NANP KO NANP KO NANP KO HAP1 HAP1 HAP1 knock out of NANP in haploid cell line, 16bp deletion knock out of NANP in haploid cell line, 26bp deletion knock out of NANP in haploid cell line, 4bp deletion HG 36488-12 HG 36488-18 HG 36488-24 NANS NANS KO NANS KO HAP1 HAP1 knock out of NANS in haploid cell line, 10bp deletion knock out of NANS in haploid cell line, 4bp deletion HG 10617-15 HG 10617-17 NBEAL1 NBEAL1 KO HAP1 knock out of NBEAL1 in haploid cell line, 10bp deletion HG 720-11 NBEAL2 NBEAL2 KO NBEAL2 KO HAP1 HAP1 knock out of NBEAL2 in haploid cell line, 16bp deletion knock out of NBEAL2 in haploid cell line, 2bp insertion HG 717-1 HG 717-4 HD 104-014 HD 104-018 HD 115-054 HG 901-10 HG 901-12 HG 901-2 34 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 35 Genotype Cell Line Description Catalogue ID NDUFA9 NDUFA9 KO NDUFA9 KO HAP1 HAP1 knock out of NDUFA9 in haploid cell line, 11bp deletion knock out of NDUFA9 in haploid cell line, 28bp deletion HG 2487-4 HG 2487-6 NEIL1 NEIL1 KO HAP1 knock out of NEIL1 in haploid cell line, 1bp insertion HG 418-13 NEIL2 NEIL2 KO HAP1 knock out of NEIL2 in haploid cell line, 5bp deletion HG 1545-11 NEIL3 NEIL3 KO HAP1 knock out of NEIL3 in haploid cell line, 2bp deletion HG 1536-2 NEK1 NEK1 KO NEK1 KO NEK1 KO HAP1 HAP1 HAP1 knock out of NEK1 in haploid cell line, 2bp deletion knock out of NEK1 in haploid cell line, 10bp deletion knock out of NEK1 in haploid cell line, 2bp deletion HG 344-10 HG 344-12 HG 344-13 NEK2 NEK2 KO NEK2 KO HAP1 HAP1 knock out of NEK2 in haploid cell line, 1bp insertion knock out of NEK2 in haploid cell line, 25bp deletion HG 158-2 HG 158-23 NEK3 NEK3 KO NEK3 KO NEK3 KO HAP1 HAP1 HAP1 knock out of NEK3 in haploid cell line, 5bp deletion knock out of NEK3 in haploid cell line, 8bp deletion knock out of NEK3 in haploid cell line, 1bp deletion HG 3237-10 HG 3237-22 HG 3237-5 NEK4 NEK4 KO NEK4 KO HAP1 HAP1 knock out of NEK4 in haploid cell line, 13bp deletion knock out of NEK4 in haploid cell line, 8bp deletion HG 159-14 HG 159-15 NEK7 NEK7 KO NEK7 KO NEK7 KO HAP1 HAP1 HAP1 knock out of NEK7 in haploid cell line, 4bp deletion knock out of NEK7 in haploid cell line, 13bp deletion knock out of NEK7 in haploid cell line, 2bp deletion HG 340-10 HG 340-11 HG 340-6 NEK8 NEK8 KO NEK8 KO NEK8 KO NEK8 KO HAP1 HAP1 HAP1 HAP1 knock out of NEK8 in haploid cell line, 2bp insertion knock out of NEK8 in haploid cell line, 62bp insertion knock out of NEK8 in haploid cell line, 8bp deletion knock out of NEK8 in haploid cell line, 7bp deletion HG 52-11 HG 52-2 HG 52-4 HG 52-9 NEK9 NEK9 KO HAP1 knock out of NEK9 in haploid cell line, 8bp deletion HG 711-16 NEK10 NEK10 KO HAP1 knock out of NEK10 in haploid cell line, 11bp deletion HG 1263-16 NF1 NF1 KO HAP1 knock out of NF1 in haploid cell line, 8bp deletion HG 1037-11 NF2 NF2 KO HAP1 knock out of NF2 in haploid cell line, 8bp deletion HG 1293-1 NFE2L2 NFE2L2 (E79K/+) HCT116 Heterozygous knock-in of NFE2L2 activating mutation (E79K) HD 104-095 NFKB1 NFKB1 KO NFKB1 KO HAP1 HAP1 knock out of NFKB1 in haploid cell line, 1bp insertion knock out of NFKB1 in haploid cell line, 67bp insertion HG 2602-1 HG 2602-2 NFKB2 NFKB2 KO NFKB2 KO HAP1 HAP1 knock out of NFKB2 in haploid cell line, 2bp deletion knock out of NFKB2 in haploid cell line, 7bp deletion HG 2603-11 HG 2603-2 NFKBIA NFKBIA KO HAP1 knock out of NFKBIA in haploid cell line, 1bp insertion HG 2599-2 NFKBIB NFKBIB KO HAP1 knock out of NFKBIB in haploid cell line, 1bp insertion HG 2600-2 NHEJ1 NHEJ1 (-/-) NHEJ1 (-/-); NHEJ1 (L115A) cDNA overexpression NHEJ1 (-/-); NHEJ1 (L179A) cDNA overexpression NHEJ1 (-/-); NHEJ1 cDNA overexpression NHEJ1 (+/-) NHEJ1 KO HCT116 HCT116 HCT116 HCT116 HCT116 HAP1 Homozygous knock-out of XLF Homozygous knock-out of XLF with overexpression of mutant (L115A) XLF Homozygous knock-out of XLF with overexpression of mutant (L179A) XLF Homozygous knock-out of XLF with overexpression of wild type XLF Heterozygous knock-out of XLF knock out of NHEJ1 in haploid cell line, 4bp deletion HD R02-068 HD R02-070 HD R02-071 HD R02-069 HD R02-067 HG 426-17 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID NHEJ1 NHEJ1 KO HAP1 knock out of NHEJ1 in haploid cell line, 10bp deletion HG 426-4 NLK NLK KO NLK KO HAP1 HAP1 knock out of NLK in haploid cell line, 20bp deletion knock out of NLK in haploid cell line, 8bp insertion HG 96-23 HG 96-5 NMT1 NMT1 KO NMT1 KO HAP1 HAP1 knock out of NMT1 in haploid cell line, 4bp deletion knock out of NMT1 in haploid cell line, 14bp deletion HG 565-11 HG 565-9 NMT2 NMT2 KO HAP1 knock out of NMT2 in haploid cell line, 2bp insertion HG 562-6 NOTCH1 NOTCH1 (L1601P/+) HCT116 Heterozygous knock-in of NOTCH1 activating mutation (L1601P) HD 104-027 NOXA1 NOXA1 KO NOXA1 KO NOXA1 KO HAP1 HAP1 HAP1 knock out of NOXA1 in haploid cell line, 1bp insertion knock out of NOXA1 in haploid cell line, 1bp insertion knock out of NOXA1 in haploid cell line, 1bp insertion HG 880-1 HG 880-10 HG 880-11 NPRL2 NPRL2 KO HAP1 knock out of NPRL2 in haploid cell line, 2bp insertion HG 1810-2 NPRL3 NPRL3 KO NPRL3 KO HAP1 HAP1 knock out of NPRL3 in haploid cell line, 14bp deletion knock out of NPRL3 in haploid cell line, 7bp deletion HG 1287-3 HG 1287-4 NRAS NRAS (G12V/+) NRAS (Q61H/+) NRAS (Q61K/+) NRAS (Q61K/+/+) NRAS (Q61L/+) NRAS (Q61R/+) SW48 SW48 SW48 A375 SW48 SW48 Heterozygous knock-in of NRAS activating mutation (G12V) Heterozygous knock-in of NRAS activating mutation (Q61H) Heterozygous knock-in of NRAS activating mutation (Q61K) Heterozygous knock-in of NRAS activating mutation (Q61K) Heterozygous knock-in of NRAS activating mutation (Q61L) Heterozygous knock-in of NRAS activating mutation (Q61R) HD 103-039 HD 103-035 HD 103-017 HD 118-001 HD 103-038 HD 103-022 NRBP1 NRBP1 KO NRBP1 KO NRBP1 KO HAP1 HAP1 HAP1 knock out of NRBP1 in haploid cell line, 151bp insertion knock out of NRBP1 in haploid cell line, 203bp insertion knock out of NRBP1 in haploid cell line, 172bp insertion HG 22490-17 HG 22490-18 HG 22490-4 NRBP2 NRBP2 KO NRBP2 KO HAP1 HAP1 knock out of NRBP2 in haploid cell line, 5bp deletion knock out of NRBP2 in haploid cell line, 17bp deletion HG 2436-2 HG 2436-4 NSD1 NSD1 KO NSD1 KO HAP1 HAP1 knock out of NSD1 in haploid cell line, 4bp deletion knock out of NSD1 in haploid cell line, 2bp deletion HG 1127-10 HG 1127-4 NTHL1 NTHL1 KO HAP1 knock out of NTHL1 in haploid cell line, 5bp deletion HG 1540-10 NTRK1 NTRK1 KO HAP1 knock out of NTRK1 in haploid cell line, 32bp deletion HG 1259-15 NUAK1 NUAK1 KO HAP1 knock out of NUAK1 in haploid cell line, 1bp deletion HG 247-12 NUDT1 NUDT1 KO HAP1 knock out of NUDT1 in haploid cell line, 10bp deletion HG 753-3 NUP210 NUP210 KO NUP210 KO HAP1 HAP1 knock out of NUP210 in haploid cell line, 121bp insertion knock out of NUP210 in haploid cell line, 2bp deletion HG 825-11 HG 825-3 OBSCN OBSCN KO HAP1 knock out of OBSCN in haploid cell line, 16bp deletion HG 1262-11 OGG1 OGG1 KO HAP1 knock out of OGG1 in haploid cell line, 8bp deletion HG 424-22 OSR1 OSR1 KO HAP1 knock out of OSR1 in haploid cell line, 22bp deletion HG 1269-16 OTUB1 OTUB1 KO HAP1 knock out of OTUB1 in haploid cell line, 11bp deletion HG 506-3 OTUB2 OTUB2 KO HAP1 knock out of OTUB2 in haploid cell line, 22bp deletion HG 638-1 36 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 37 Genotype Cell Line Description Catalogue ID OTUB2 OTUB2 KO HAP1 knock out of OTUB2 in haploid cell line, 17bp deletion HG 638-6 OTUD1 OTUD1 KO OTUD1 KO OTUD1 KO HAP1 HAP1 HAP1 knock out of OTUD1 in haploid cell line, 1bp insertion knock out of OTUD1 in haploid cell line, 50bp deletion knock out of OTUD1 in haploid cell line, 1bp insertion HG 904-10 HG 904-4 HG 904-5 OTUD3 OTUD3 KO OTUD3 KO HAP1 HAP1 knock out of OTUD3 in haploid cell line, 1bp insertion knock out of OTUD3 in haploid cell line, 16bp deletion HG 500-2 HG 500-3 OTUD4 OTUD4 KO HAP1 knock out of OTUD4 in haploid cell line, 4bp deletion HG 501-2 OTUD5 OTUD5 KO OTUD5 KO HAP1 HAP1 knock out of OTUD5 in haploid cell line, 2bp deletion knock out of OTUD5 in haploid cell line, 1bp deletion HG 502-2 HG 502-3 OTUD6B OTUD6B KO OTUD6B KO HAP1 HAP1 knock out of OTUD6B in haploid cell line, 14bp deletion knock out of OTUD6B in haploid cell line, 14bp deletion HG 469-4 HG 469-5 OTUD7B OTUD7B KO OTUD7B KO HAP1 HAP1 knock out of OTUD7B in haploid cell line, 16bp deletion knock out of OTUD7B in haploid cell line, 10bp deletion HG 475-11 HG 475-6 PAK1 PAK1 KO PAK1 KO PAK1 KO HAP1 HAP1 HAP1 knock out of PAK1 in haploid cell line, 8bp deletion knock out of PAK1 in haploid cell line, 10bp deletion knock out of PAK1 in haploid cell line, 1bp insertion HG 160-12 HG 160-14 HG 160-15 PAK2 PAK2 KO PAK2 KO PAK2 KO PAK2 KO HAP1 HAP1 HAP1 HAP1 knock out of PAK2 in haploid cell line, 5bp deletion knock out of PAK2 in haploid cell line, 2bp deletion knock out of PAK2 in haploid cell line, 86bp insertion knock out of PAK2 in haploid cell line, 14bp deletion HG 53-1 HG 53-15 HG 53-16 HG 53-3 PAK4 PAK4 KO PAK4 KO PAK4 KO HAP1 HAP1 HAP1 knock out of PAK4 in haploid cell line, 2bp deletion knock out of PAK4 in haploid cell line, 31bp deletion knock out of PAK4 in haploid cell line, 16bp deletion HG 161-10 HG 161-14 HG 161-22 PAK6 PAK6 KO PAK6 KO PAK6 KO HAP1 HAP1 HAP1 knock out of PAK6 in haploid cell line, 22bp deletion knock out of PAK6 in haploid cell line, 2bp insertion knock out of PAK6 in haploid cell line, 2bp deletion HG 310-12 HG 310-16 HG 310-18 PAN2 PAN2 KO PAN2 KO PAN2 KO HAP1 HAP1 HAP1 knock out of PAN2 in haploid cell line, 1bp insertion knock out of PAN2 in haploid cell line, 8bp deletion knock out of PAN2 in haploid cell line, 1bp insertion HG 454-3 HG 454-6 HG 454-8 PARK7 PARK7 KO PARK7 KO HAP1 HAP1 knock out of PARK7 in haploid cell line, 5bp deletion knock out of PARK7 in haploid cell line, 167bp insertion HG 1316-2 HG 1316-8 PARP1 PARP1 KO PARP1 KO PARP1 KO HAP1 HAP1 HAP1 knock out of PARP1 in haploid cell line, 1bp insertion knock out of PARP1 in haploid cell line, 1bp insertion knock out of PARP1 in haploid cell line, 1bp insertion HG 664-1 HG 664-3 HG 664-7 PARP2 PARP2 KO PARP2 KO PARP2 KO HAP1 HAP1 HAP1 knock out of PARP2 in haploid cell line, 17bp deletion knock out of PARP2 in haploid cell line, 17bp deletion knock out of PARP2 in haploid cell line, 2bp deletion HG 665-11 HG 665-4 HG 665-6 PARP3 PARP3 KO PARP3 KO HAP1 HAP1 knock out of PARP3 in haploid cell line, 8bp deletion knock out of PARP3 in haploid cell line, 19bp deletion HG 1196-3 HG 1196-8 PASK PASK KO PASK KO PASK KO HAP1 HAP1 HAP1 knock out of PASK in haploid cell line, 28bp deletion knock out of PASK in haploid cell line, 20bp deletion knock out of PASK in haploid cell line, 5bp deletion HG 162-21 HG 162-3 HG 162-6 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID PAXIP1 PAXIP1 KO PAXIP1 KO HAP1 HAP1 knock out of PAXIP1 in haploid cell line, 5bp deletion knock out of PAXIP1 in haploid cell line, 1bp insertion HG 762-6 HG 762-7 PBK PBK KO PBK KO PBK KO HAP1 HAP1 HAP1 knock out of PBK in haploid cell line, 22bp deletion knock out of PBK in haploid cell line, 2bp deletion knock out of PBK in haploid cell line, 8bp deletion HG 98-11 HG 98-14 HG 98-16 PBRM1 PBRM1 (-/-) PBRM1 KO PBRM1 KO PBRM1 KO HK2 HAP1 HAP1 HAP1 Homozygous Knock-out of PBRM1 knock out of PBRM1 in haploid cell line, 8bp deletion knock out of PBRM1 in haploid cell line, 4bp deletion knock out of PBRM1 in haploid cell line, 10bp deletion HD 170-002 HG 1135-10 HG 1135-12 HG 1135-6 PCDH1 PCDH1 KO HAP1 knock out of PCDH1 in haploid cell line, 26bp deletion HG 558-9 PCDH7 PCDH7 KO PCDH7 KO HAP1 HAP1 knock out of PCDH7 in haploid cell line, 1bp deletion knock out of PCDH7 in haploid cell line, 2bp deletion HG 410-10 HG 410-9 PCDH9 PCDH9 KO PCDH9 KO PCDH9 KO HAP1 HAP1 HAP1 knock out of PCDH9 in haploid cell line, 7bp deletion knock out of PCDH9 in haploid cell line, 19bp deletion knock out of PCDH9 in haploid cell line, 19bp deletion HG 372-3 HG 372-4 HG 372-8 PDGFRA PDGFRA (D842V/+) PDGFRA KO HCT116 HAP1 Heterozygous knock-in of PDGFRA activating mutation (D842V) knock out of PDGFRA in haploid cell line, 176bp insertion HD 104-064 HG 236-7 PDIK1L PDIK1L KO HAP1 knock out of PDIK1L in haploid cell line, 255bp insertion HG 399-4 PDK1 PDK1 KO PDK1 KO HAP1 HAP1 knock out of PDK1 in haploid cell line, 2bp deletion knock out of PDK1 in haploid cell line, 20bp deletion HG 27-12 HG 27-24 PDK2 PDK2 KO PDK2 KO PDK2 KO HAP1 HAP1 HAP1 knock out of PDK2 in haploid cell line, 7bp deletion knock out of PDK2 in haploid cell line, 10bp deletion knock out of PDK2 in haploid cell line, 5bp deletion HG 163-14 HG 163-20 HG 163-23 PDK3 PDK3 KO HAP1 knock out of PDK3 in haploid cell line, 5bp deletion HG 230-5 PDPK1 PDPK1 (-/-) PDPK1 (+/-) PDPK1 KO DLD-1 HCT116 HAP1 Homozygous knock-out of PDPK1 Heterozygous knock-out of PDPK1 knock out of PDPK1 in haploid cell line, 4bp deletion HD R00-028 HD R02-080 HG 416-13 PEAK1 PEAK1 KO HAP1 knock out of PEAK1 in haploid cell line, 8bp deletion HG 1505-4 PEX13 PEX13 KO HAP1 knock out of PEX13 in haploid cell line, 14bp deletion HG 820-6 PHF3 PHF3 KO PHF3 KO HAP1 HAP1 knock out of PHF3 in haploid cell line, 8bp deletion knock out of PHF3 in haploid cell line, 4bp deletion HG 1370-10 HG 1370-5 PHF6 PHF6 KO PHF6 KO PHF6 KO HAP1 HAP1 HAP1 knock out of PHF6 in haploid cell line, 1bp deletion knock out of PHF6 in haploid cell line, 2bp deletion knock out of PHF6 in haploid cell line, 1bp insertion HG 1175-10 HG 1175-2 HG 1175-6 PHIP PHIP KO PHIP KO HAP1 HAP1 knock out of PHIP in haploid cell line, 2bp deletion knock out of PHIP in haploid cell line, 4bp deletion HG 1487-6 HG 1487-8 PHKG1 PHKG1 KO PHKG1 KO PHKG1 KO HAP1 HAP1 HAP1 knock out of PHKG1 in haploid cell line, 2bp deletion knock out of PHKG1 in haploid cell line, 10bp deletion knock out of PHKG1 in haploid cell line, 7bp deletion HG 322-16 HG 322-18 HG 322-2 PHKG2 PHKG2 KO HAP1 knock out of PHKG2 in haploid cell line, 1bp insertion HG 164-18 38 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 39 Genotype Cell Line Description PHKG2 PHKG2 KO HAP1 knock out of PHKG2 in haploid cell line, 1bp insertion HG 164-21 PI4KB PI4KB KO PI4KB KO PI4KB KO HAP1 HAP1 HAP1 knock out of PI4KB in haploid cell line, 1bp insertion knock out of PI4KB in haploid cell line, 7bp deletion knock out of PI4KB in haploid cell line, 1bp insertion HG 679-3 HG 679-4 HG 679-5 PIEZO1 PIEZO1 KO PIEZO1 KO HAP1 HAP1 knock out of PIEZO1 in haploid cell line, 5bp insertion knock out of PIEZO1 in haploid cell line, 5bp deletion HG 2507-2 HG 2507-9 PIGT PIGT KO PIGT KO PIGT KO HAP1 HAP1 HAP1 knock out of PIGT in haploid cell line, 2bp deletion knock out of PIGT in haploid cell line, 28bp deletion knock out of PIGT in haploid cell line, 4bp deletion HG 11966-1 HG 11966-11 HG 11966-21 PIK3C2A PIK3C2A KO PIK3C2A KO HAP1 HAP1 knock out of PIK3C2A in haploid cell line, 10bp deletion knock out of PIK3C2A in haploid cell line, 2bp deletion HG 696-11 HG 696-2 PIK3C2B PIK3C2B KO PIK3C2B KO HAP1 HAP1 knock out of PIK3C2B in haploid cell line, 5bp deletion knock out of PIK3C2B in haploid cell line, 2bp insertion HG 697-6 HG 697-9 PIK3CA PIK3CA (H1047R/+); EGFR (ΔE746-A750/+) PIK3CA (H1047R/+); EGFR (ΔE746-A750/+) PIK3CA (E545K/+); KRAS (G12V/+) PIK3CA (H1047R/+); KRAS (G13D/+) PIK3CA (+/-) hTERT-HME1 MCF10A MCF10A hTERT-HME1 DLD-1 HD 200-001 HD 201-001 HD 201-002 HD 200-003 HD 105-001 PIK3CA (+/-) HCT116 PIK3CA (E542K/+) PIK3CA ( E545K/-) PIK3CA (E545K/+) PIK3CA (E545K/+) PIK3CA (E545K/+) PIK3CA (E545K/+) SW48 DLD-1 hTERT-HME1 MCF10A SW48 LIM1215 PIK3CA PIK3CA PIK3CA PIK3CA PIK3CA PIK3CA HCT116 hTERT-HME1 MCF10A SW48 VACO 432 LIM1215 Double heterozygous knock-in of EGFR and PIK3CA activating mutations Double heterozygous knock-in of EGFR and PIK3CA activating mutations Double heterozygous knock-in of KRAS and PIK3CA activating mutations Double heterozygous knock-in of KRAS and PIK3CA activating mutations Knock-out of PIK3CA helix domain mutant allele (E545K) in heterozygous parental cells Knock-out of PIK3CA kinase domain mutant allele (H1047R) in heterozygous parental cells Heterozygous knock-in of PIK3CA helix domain activating mutation Knock-out of PIK3CA wild type allele in heterozygous parental cells Heterozygous knock-in of PIK3CA helix domain activating mutation Heterozygous knock-in of PIK3CA helix domain activating mutation Heterozygous knock-in of PIK3CA helix domain activating mutation Knock-out of PIK3CA helix domain mutant allele (E545K) in heterozygous parental cells Knock-out of PIK3CA wild type allele in heterozygous parental cells Heterozygous knock-in of PIK3CA kinase domain activating mutation Heterozygous knock-in of PIK3CA kinase domain activating mutation Heterozygous knock-in of PIK3CA kinase domain activating mutation Heterozygous knock-in of PIK3CA kinase domain activating mutation Knock-out of PIK3CA kinase domain mutant allele (H1047R) in heterozygous parental cells Double heterozygous knock-in of KRAS and PIK3CA activating mutations Heterozygous knock-in of PIK3CA kinase domain activating mutation knock out of PIK3CA in haploid cell line, 4bp deletion knock out of PIK3CA in haploid cell line, 8bp deletion Heterozygous knock-in of PIK3CA kinase domain activating mutation in TP53 (-/-) parental cell line (H1047R/-) (H1047R/+) (H1047R/+) (H1047R/+) (H1047R/+) (H1047R/+) Catalogue ID HD 104-007 HD 103-016 HD 105-012 HD 100-003 HD 101-002 HD 103-001 HD 116-013 HD 104-012 HD 100-002 HD 101-011 HD 103-005 HD 107-003 HD 116-012 PIK3CA (H1047R/+); KRAS (G12V/+) PIK3CA (H1047R/+/+/+) PIK3CA KO PIK3CA KO PIK3CA (H1047R/+); TP53 (-/-) MCF10A WiDr HAP1 HAP1 MCF10A HD 201-003 HD 127-001 HG 691-6 HG 691-7 HD 101-043 PIK3CB PIK3CB KO PIK3CB KO HAP1 HAP1 knock out of PIK3CB in haploid cell line, 4bp deletion knock out of PIK3CB in haploid cell line, 10bp deletion HG 714-2 HG 714-3 PIK3CD PIK3CD KO PIK3CD KO PIK3CD KO HAP1 HAP1 HAP1 knock out of PIK3CD in haploid cell line, 155bp insertion knock out of PIK3CD in haploid cell line, 1bp insertion knock out of PIK3CD in haploid cell line, 1bp insertion HG 698-3 HG 698-4 HG 698-7 PIM1 PIM1 KO HAP1 knock out of PIM1 in haploid cell line, 8bp deletion HG 1348-3 PIM2 PIM2 KO HAP1 knock out of PIM2 in haploid cell line, 14bp deletion HG 1248-26 PIM3 PIM3 KO PIM3 KO HAP1 HAP1 knock out of PIM3 in haploid cell line, 4bp deletion knock out of PIM3 in haploid cell line, 5bp deletion HG 54-11 HG 54-14 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID PIM3 PIM3 KO PIM3 KO HAP1 HAP1 knock out of PIM3 in haploid cell line, 5bp deletion knock out of PIM3 in haploid cell line, 16bp deletion HG 54-3 HG 54-4 PINK1 PINK1 KO PINK1 KO HAP1 HAP1 knock out of PINK1 in haploid cell line, 28bp deletion knock out of PINK1 in haploid cell line, 1bp deletion HG 798-8 HG 798-9 PKDCC PKDCC KO HAP1 knock out of PKDCC in haploid cell line, 2bp deletion HG 737-4 PKN1 PKN1 KO PKN1 KO HAP1 HAP1 knock out of PKN1 in haploid cell line, 23bp deletion knock out of PKN1 in haploid cell line, 32bp deletion HG 165-1 HG 165-17 PKN2 PKN2 KO HAP1 knock out of PKN2 in haploid cell line, 2bp insertion HG 36174-3 PKN3 PKN3 KO PKN3 KO HAP1 HAP1 knock out of PKN3 in haploid cell line, 7bp deletion knock out of PKN3 in haploid cell line, 8bp deletion HG 100-11 HG 100-15 PLA2G16 PLA2G16 KO HAP1 knock out of PLA2G16 in haploid cell line, 7bp deletion HG 551-1 PLEKHM2 PLEKHM2 KO PLEKHM2 KO HAP1 HAP1 knock out of PLEKHM2 in haploid cell line, 173bp insertion knock out of PLEKHM2 in haploid cell line, 8bp deletion HG 851-3 HG 851-6 PLIN3 PLIN3 KO PLIN3 KO HAP1 HAP1 knock out of PLIN3 in haploid cell line, 5bp deletion knock out of PLIN3 in haploid cell line, 2bp insertion HG 675-1 HG 675-6 PLK2 PLK2 KO PLK2 KO PLK2 KO HAP1 HAP1 HAP1 knock out of PLK2 in haploid cell line, 14bp deletion knock out of PLK2 in haploid cell line, 16bp deletion knock out of PLK2 in haploid cell line, 8bp deletion HG 406-1 HG 406-10 HG 406-17 PMS2 PMS2 KO HAP1 knock out of PMS2 in haploid cell line, 1bp insertion HG 763-8 PNCK PNCK KO PNCK KO PNCK KO HAP1 HAP1 HAP1 knock out of PNCK in haploid cell line, 7bp deletion knock out of PNCK in haploid cell line, 11bp deletion knock out of PNCK in haploid cell line, 14bp deletion HG 324-11 HG 324-13 HG 324-20 POGK POGK KO POGK KO HAP1 HAP1 knock out of POGK in haploid cell line, 10bp deletion knock out of POGK in haploid cell line, 34bp deletion HG 554-10 HG 554-7 POLB POLB KO POLB KO HAP1 HAP1 knock out of POLB in haploid cell line, 5bp deletion knock out of POLB in haploid cell line, 5bp deletion HG 660-3 HG 660-5 POLE POLE KO POLE KO POLE KO HAP1 HAP1 HAP1 knock out of POLE in haploid cell line, 2bp deletion knock out of POLE in haploid cell line, 1bp insertion knock out of POLE in haploid cell line, 8bp deletion HG 659-3 HG 659-5 HG 659-6 POLH POLH KO POLH KO HAP1 HAP1 knock out of POLH in haploid cell line, 2bp deletion knock out of POLH in haploid cell line, 1bp deletion HG 655-10 HG 655-7 POLI POLI KO POLI KO HAP1 HAP1 knock out of POLI in haploid cell line, 20bp insertion knock out of POLI in haploid cell line, 2bp insertion HG 654-2 HG 654-7 POLK POLK KO POLK KO POLK KO HAP1 HAP1 HAP1 knock out of POLK in haploid cell line, 4bp deletion knock out of POLK in haploid cell line, 5bp deletion knock out of POLK in haploid cell line, 2bp insertion HG 652-2 HG 652-3 HG 652-5 POLL POLL KO POLL KO POLL KO HAP1 HAP1 HAP1 knock out of POLL in haploid cell line, 5bp deletion knock out of POLL in haploid cell line, 2bp deletion knock out of POLL in haploid cell line, 7bp deletion HG 651-2 HG 651-6 HG 651-7 POLM POLM KO HAP1 knock out of POLM in haploid cell line, 29bp insertion HG 643-2 40 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 41 Genotype Cell Line Description Catalogue ID POLM POLM KO POLM KO HAP1 HAP1 knock out of POLM in haploid cell line, 1bp deletion knock out of POLM in haploid cell line, 2bp deletion HG 643-6 HG 643-7 POLN POLN KO POLN KO POLN KO HAP1 HAP1 HAP1 knock out of POLN in haploid cell line, 7bp deletion knock out of POLN in haploid cell line, 31bp deletion knock out of POLN in haploid cell line, 160bp insertion HG 644-1 HG 644-11 HG 644-3 POLQ POLQ KO POLQ KO HAP1 HAP1 knock out of POLQ in haploid cell line, 2bp deletion knock out of POLQ in haploid cell line, 1bp insertion HG 647-11 HG 647-5 POMGNT1 POMGNT1 KO POMGNT1 KO HAP1 HAP1 knock out of POMGNT1 in haploid cell line, 8bp deletion knock out of POMGNT1 in haploid cell line, 5bp deletion HG 747-12 HG 747-3 POMGNT2 POMGNT2 KO POMGNT2 KO HAP1 HAP1 knock out of POMGNT2 in haploid cell line, 4bp deletion knock out of POMGNT2 in haploid cell line, 22bp deletion HG 1334-11 HG 1334-2 POMK POMK KO POMK KO POMK KO HAP1 HAP1 HAP1 knock out of POMK in haploid cell line, 1bp insertion knock out of POMK in haploid cell line, 1bp insertion knock out of POMK in haploid cell line, 10bp deletion HG 1338-1 HG 1338-10 HG 1338-4 POMT1 POMT1 KO HAP1 knock out of POMT1 in haploid cell line, 23bp deletion HG 723-6 PPARA PPARA KO HAP1 knock out of PPARA in haploid cell line, 2bp insertion HG 2330-3 PPARD PPARD (-/-) HCT116 Homozygous knock-out of PPARD HD R02-038 PPP1R12C PPP1R12C KO PPP1R12C KO HAP1 HAP1 knock out of PPP1R12C in haploid cell line, 5bp deletion knock out of PPP1R12C in haploid cell line, 2bp deletion HG 977-1 HG 977-2 PPP2R4 PPP2R4 KO HAP1 knock out of PPP2R4 in haploid cell line, 4bp deletion HG 1099-3 PPP3R1 PPP3R1 KO PPP3R1 KO HAP1 HAP1 knock out of PPP3R1 in haploid cell line, 2bp deletion knock out of PPP3R1 in haploid cell line, 5bp deletion HG 2540-12 HG 2540-2 PRKAA1 PRKAA1 KO PRKAA1 KO PRKAA1 KO HAP1 HAP1 HAP1 knock out of PRKAA1 in haploid cell line, 1bp insertion knock out of PRKAA1 in haploid cell line, 2bp deletion knock out of PRKAA1 in haploid cell line, 1bp insertion HG 167-10 HG 167-4 HG 167-8 PRKAA2 PRKAA2 KO PRKAA2 KO PRKAA2 KO HAP1 HAP1 HAP1 knock out of PRKAA2 in haploid cell line, 1bp insertion knock out of PRKAA2 in haploid cell line, 1bp insertion knock out of PRKAA2 in haploid cell line, 1bp insertion HG 55-13 HG 55-15 HG 55-3 PRKAB1 PRKAB1 KO PRKAB1 KO HAP1 HAP1 knock out of PRKAB1 in haploid cell line, 110bp insertion knock out of PRKAB1 in haploid cell line, 308bp insertion HG 995-11 HG 995-2 PRKAB2 PRKAB2 KO PRKAB2 KO HAP1 HAP1 knock out of PRKAB2 in haploid cell line, 56bp insertion knock out of PRKAB2 in haploid cell line, 1bp insertion HG 557-1 HG 557-2 PRKACA PRKACA KO PRKACA KO PRKACA KO HAP1 HAP1 HAP1 knock out of PRKACA in haploid cell line, 1bp insertion knock out of PRKACA in haploid cell line, 2bp deletion knock out of PRKACA in haploid cell line, 2bp deletion HG 313-1 HG 313-12 HG 313-18 PRKACB PRKACB KO PRKACB KO HAP1 HAP1 knock out of PRKACB in haploid cell line, 23bp deletion knock out of PRKACB in haploid cell line, 8bp deletion HG 314-11 HG 314-4 PRKCA PRKCA KO PRKCA KO PRKCA KO HAP1 HAP1 HAP1 knock out of PRKCA in haploid cell line, 1bp deletion knock out of PRKCA in haploid cell line, 2bp deletion knock out of PRKCA in haploid cell line, 13bp deletion HG 56-14 HG 56-18 HG 56-7 PRKCD PRKCD KO HAP1 knock out of PRKCD in haploid cell line, 13bp deletion HG 168-14 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID PRKCD PRKCD KO HAP1 knock out of PRKCD in haploid cell line, 1bp insertion HG 168-4 PRKCE PRKCE KO HAP1 knock out of PRKCE in haploid cell line, 10bp deletion HG 1271-16 PRKCG PRKCG KO PRKCG KO PRKCG KO HAP1 HAP1 HAP1 knock out of PRKCG in haploid cell line, 4bp deletion knock out of PRKCG in haploid cell line, 2bp insertion knock out of PRKCG in haploid cell line, 43bp deletion HG 326-11 HG 326-14 HG 326-7 PRKCI PRKCI KO PRKCI KO HAP1 HAP1 knock out of PRKCI in haploid cell line, 10bp deletion knock out of PRKCI in haploid cell line, 7bp deletion HG 57-7 HG 57-8 PRKCQ PRKCQ KO HAP1 knock out of PRKCQ in haploid cell line, 4bp deletion HG 237-3 PRKCZ PRKCZ KO HAP1 knock out of PRKCZ in haploid cell line, 59bp deletion HG 1273-15 PRKD1 PRKD1 KO PRKD1 KO PRKD1 KO HAP1 HAP1 HAP1 knock out of PRKD1 in haploid cell line, 2bp deletion knock out of PRKD1 in haploid cell line, 14bp deletion knock out of PRKD1 in haploid cell line, 14bp deletion HG 394-1 HG 394-11 HG 394-12 PRKD2 PRKD2 KO PRKD2 KO HAP1 HAP1 knock out of PRKD2 in haploid cell line, 11bp deletion knock out of PRKD2 in haploid cell line, 17bp deletion HG 169-23 HG 169-8 PRKD3 PRKD3 KO HAP1 knock out of PRKD3 in haploid cell line, 2bp insertion HG 102-14 PRKDC PRKDC (-/-) PRKDC (-/-); PRKDC cDNA overexpression HCT116 HCT116 HD R02-049 HD R02-050 PRKDC (-/-); XRCC6 (+/-) PRKDC (+/-) PRKDC (+/-) PRKDC (+/-) PRKDC (+/-) PRKDC KO PRKDC KO HCT116 hTERT-BJ hTERT RPE-1 NALM-6 HCT116 HAP1 HAP1 Homozygous knock-out of PRKDC Homozygous knock-out of endogenous PRKDC with overexpression of wild type PRKDC Homozygous knock-out of PRKDC; heterozygous knock-out of XRCC6 Heterozygous knock-out of PRKDC Heterozygous knock-out of PRKDC Heterozygous knock-out of PRKDC Heterozygous knock-out of PRKDC knock out of PRKDC in haploid cell line, 11bp deletion knock out of PRKDC in haploid cell line, 17bp deletion PRKG2 PRKG2 KO PRKG2 KO HAP1 HAP1 knock out of PRKG2 in haploid cell line, 2bp deletion knock out of PRKG2 in haploid cell line, 7bp deletion HG 33981-16 HG 33981-21 PRKRA PRKRA KO PRKRA KO HAP1 HAP1 knock out of PRKRA in haploid cell line, 10bp deletion knock out of PRKRA in haploid cell line, 16bp deletion HG 515-3 HG 515-7 PRKX PRKX KO PRKX KO HAP1 HAP1 knock out of PRKX in haploid cell line, 13bp deletion knock out of PRKX in haploid cell line, 14bp deletion HG 58-12 HG 58-19 PRMT3 PRMT3 KO PRMT3 KO HAP1 HAP1 knock out of PRMT3 in haploid cell line, 32bp deletion knock out of PRMT3 in haploid cell line, 1bp insertion HG 1131-10 HG 1131-11 PRNP PRNP KO HAP1 knock out of PRNP in haploid cell line, 19bp deletion HG 1519-10 PROCR PROCR KO HAP1 knock out of PROCR in haploid cell line, 10bp deletion HG 2030-4 PRPF39 PRPF39 KO HAP1 knock out of PRPF39 in haploid cell line, 1bp insertion HG 811-10 PSKH1 PSKH1 KO HAP1 knock out of PSKH1 in haploid cell line, 41bp deletion HG 240-9 PTEN PTEN (-/-) PTEN (-/-) MCF10A HCT116 HD 101-006 HD 104-004 PTEN (+/-) HCT116 Homozygous knock-out of PTEN by deletion of exon 2 resulting in a frameshift Homozygous knock-out of PTEN by deletion of exon 5 which encodes active site of protein Heterozygous knock-out of PTEN by deletion of exons 6 and 7 HD R02-051 HD R09-001 HD R10-003 HD R08-001 HD R02-048 HG 24034-11 HG 24034-5 HD 104-057 42 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 43 Genotype Cell Line Description Catalogue ID PTEN PTEN (R130*/R130*) PTEN KO PTEN KO SW48 HAP1 HAP1 Homozygous knock-out of PTEN by knock-in of premature stop codon (R130*) knock out of PTEN in haploid cell line, 8bp deletion knock out of PTEN in haploid cell line, 5bp deletion HD 103-012 HG 624-4 HG 624-9 PTK2B PTK2B KO PTK2B KO HAP1 HAP1 knock out of PTK2B in haploid cell line, 20bp deletion knock out of PTK2B in haploid cell line, 13bp deletion HG 350-12 HG 350-20 PTK7 PTK7 KO HAP1 knock out of PTK7 in haploid cell line, 7bp deletion HG 276-9 PTPN1 PTPN1 KO PTPN1 KO HAP1 HAP1 knock out of PTPN1 in haploid cell line, 1bp insertion knock out of PTPN1 in haploid cell line, 5bp deletion HG 1294-10 HG 1294-12 PTPN11 PTPN11 KO PTPN11 KO HAP1 HAP1 knock out of PTPN11 in haploid cell line, 1bp deletion knock out of PTPN11 in haploid cell line, 1bp insertion HG 686-10 HG 686-11 PTTG1 PTTG1 (-/-) HCT116 Homozygous knock-out of PTTG1 HD R02-043 PXK PXK KO PXK KO HAP1 HAP1 knock out of PXK in haploid cell line, 1bp insertion knock out of PXK in haploid cell line, 11bp deletion HG 103-13 HG 103-20 RAB1B RAB1B KO HAP1 knock out of RAB1B in haploid cell line, 11bp deletion HG 1225-11 RAB2A RAB2A KO RAB2A KO RAB2A KO HAP1 HAP1 HAP1 knock out of RAB2A in haploid cell line, 10bp deletion knock out of RAB2A in haploid cell line, 13bp deletion knock out of RAB2A in haploid cell line, 14bp deletion HG 17214-1 HG 17214-14 HG 17214-9 RAB2B RAB2B KO RAB2B KO RAB2B KO HAP1 HAP1 HAP1 knock out of RAB2B in haploid cell line, 1bp insertion knock out of RAB2B in haploid cell line, 19bp deletion knock out of RAB2B in haploid cell line, 1bp deletion HG 2023-3 HG 2023-6 HG 2023-7 RAB3A RAB3A KO HAP1 knock out of RAB3A in haploid cell line, 10bp deletion HG 1219-1 RAB4A RAB4A KO HAP1 knock out of RAB4A in haploid cell line, 8bp deletion HG 1224-6 RAB5A RAB5A KO HAP1 knock out of RAB5A in haploid cell line, 19bp deletion HG 1809-1 RAB6A RAB6A KO RAB6A KO HAP1 HAP1 knock out of RAB6A in haploid cell line, 5bp deletion knock out of RAB6A in haploid cell line, 17bp deletion HG 1233-1 HG 1233-12 RAB7A RAB7A KO RAB7A KO HAP1 HAP1 knock out of RAB7A in haploid cell line, 2bp deletion knock out of RAB7A in haploid cell line, 17bp deletion HG 635-1 HG 635-22 RAB8A RAB8A KO HAP1 knock out of RAB8A in haploid cell line, 1bp insertion HG 1221-1 RAB12 RAB12 KO RAB12 KO HAP1 HAP1 knock out of RAB12 in haploid cell line, 1bp insertion knock out of RAB12 in haploid cell line, 1bp insertion HG 1232-4 HG 1232-5 RAB13 RAB13 KO RAB13 KO HAP1 HAP1 knock out of RAB13 in haploid cell line, 5bp deletion knock out of RAB13 in haploid cell line, 2bp deletion HG 1234-1 HG 1234-2 RAB14 RAB14 KO HAP1 knock out of RAB14 in haploid cell line, 1bp insertion HG 1230-7 RAB20 RAB20 KO RAB20 KO RAB20 KO HAP1 HAP1 HAP1 knock out of RAB20 in haploid cell line, 1bp insertion knock out of RAB20 in haploid cell line, 64bp insertion knock out of RAB20 in haploid cell line, 1bp insertion HG 1236-11 HG 1236-3 HG 1236-7 RAB21 RAB21 KO RAB21 KO HAP1 HAP1 knock out of RAB21 in haploid cell line, 11bp deletion knock out of RAB21 in haploid cell line, 1bp insertion HG 1239-11 HG 1239-5 RAB27A RAB27A KO HAP1 knock out of RAB27A in haploid cell line, 2bp deletion HG 1240-1 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID RAB31 RAB31 KO HAP1 knock out of RAB31 in haploid cell line, 2bp deletion HG 1226-10 RAC1 RAC1 (Q61L/+) RAC1 (Q61L/+/+) MCF10A SW48 Heterozygous knock-in of RAC1 mutant (Q61L) Heterozygous knock-in of RAC1 mutant (Q61L) HD 101-014 HD 103-014 RAD52 RAD52 KO RAD52 KO HAP1 HAP1 knock out of RAD52 in haploid cell line, 28bp deletion knock out of RAD52 in haploid cell line, 2bp insertion HG 623-1 HG 623-2 RAD54B RAD54B (+/-/-); LIG4 (-/-) HCT116 HD R02-066 RAD54B (+/-/-); XRCC5 (+floxed/-) HCT116 Homozygous knock-out of LIG4; double knock-out of RAD54B in triploid parental cells Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; double knock-out of RAD54B in triploid parental cells RAD54L RAD54L (-/-); LIG4 (-/-) RAD54L (-/-) NALM-6 NALM-6 Double homozygous knock-out of LIG4 and RAD54L Homozygous knock-out of RAD54L HD 115-075 HD 115-043 RAF1 RAF1 KO HAP1 knock out of RAF1 in haploid cell line, 1bp insertion HG 214-11 RARRES3 RARRES3 KO HAP1 knock out of RARRES3 in haploid cell line, 2bp deletion HG 552-11 RASD1 RASD1 KO HAP1 knock out of RASD1 in haploid cell line, 5bp deletion HG 1546-3 RB1 RB1 (+/-) RB1 (c2520+3G>T/+) hTERT RPE-1 hTERT RPE-1 Heterozygous knock-out of RB1 Heterozygous knock-in of disease-relevant de novo c2520+3G>T mutation HD 102-005 HD 102-004 RB1CC1 RB1CC1 KO RB1CC1 KO HAP1 HAP1 knock out of RB1CC1 in haploid cell line, 2bp deletion knock out of RB1CC1 in haploid cell line, 2bp deletion HG 567-7 HG 567-8 RBBP7 RBBP7 KO RBBP7 KO RBBP7 KO HAP1 HAP1 HAP1 knock out of RBBP7 in haploid cell line, 1bp insertion knock out of RBBP7 in haploid cell line, 5bp deletion knock out of RBBP7 in haploid cell line, 1bp deletion HG 1138-10 HG 1138-12 HG 1138-8 RECQL4 RECQL4 KO RECQL4 KO RECQL4 KO HAP1 HAP1 HAP1 knock out of RECQL4 in haploid cell line, 5bp deletion knock out of RECQL4 in haploid cell line, 2bp deletion knock out of RECQL4 in haploid cell line, 1bp insertion HG 427-11 HG 427-3 HG 427-9 RELA RELA KO RELA KO HAP1 HAP1 knock out of RELA in haploid cell line, 1bp insertion knock out of RELA in haploid cell line, 20bp deletion HG 2605-2 HG 2605-4 RER1 RER1 KO RER1 KO HAP1 HAP1 knock out of RER1 in haploid cell line, 2bp deletion knock out of RER1 in haploid cell line, 118bp insertion HG 2443-2 HG 2443-6 RET RET KO HAP1 knock out of RET in haploid cell line, 2bp deletion HG 1368-11 REV1 REV1 KO REV1 KO HAP1 HAP1 knock out of REV1 in haploid cell line, 28bp deletion knock out of REV1 in haploid cell line, 5bp deletion HG 754-2 HG 754-5 RFWD3 RFWD3 KO HAP1 knock out of RFWD3 in haploid cell line, 28bp deletion HG 2532-2 RICTOR RICTOR KO RICTOR KO HAP1 HAP1 knock out of RICTOR in haploid cell line, 10bp deletion knock out of RICTOR in haploid cell line, 2bp deletion HG 1020-10 HG 1020-3 RIF1 RIF1 KO RIF1 KO RIF1 KO HAP1 HAP1 HAP1 knock out of RIF1 in haploid cell line, 37bp insertion knock out of RIF1 in haploid cell line, 14bp deletion knock out of RIF1 in haploid cell line, 16bp deletion HG 663-10 HG 663-12 HG 663-3 RING1 RING1 KO RING1 KO HAP1 HAP1 knock out of RING1 in haploid cell line, 1bp deletion knock out of RING1 in haploid cell line, 1bp insertion HG 1111-1 HG 1111-12 HD R02-059 44 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 45 Genotype Cell Line Description Catalogue ID RING1 RING1 KO HAP1 knock out of RING1 in haploid cell line, 2bp deletion HG 1111-3 RIOK3 RIOK3 KO RIOK3 KO HAP1 HAP1 knock out of RIOK3 in haploid cell line, 14bp deletion knock out of RIOK3 in haploid cell line, 7bp deletion HG 59-11 HG 59-6 RIPK1 RIPK1 KO RIPK1 KO HAP1 HAP1 knock out of RIPK1 in haploid cell line, 14bp deletion knock out of RIPK1 in haploid cell line, 1bp insertion HG 60-15 HG 60-18 RIPK2 RIPK2 KO RIPK2 KO HAP1 HAP1 knock out of RIPK2 in haploid cell line, 4bp deletion knock out of RIPK2 in haploid cell line, 5bp deletion HG 28-20 HG 28-5 RNASEK RNASEK KO RNASEK KO RNASEK KO RNASEK KO HAP1 HAP1 HAP1 HAP1 knock out of RNASEK in haploid cell line, 2bp deletion knock out of RNASEK in haploid cell line, 40bp insertion knock out of RNASEK in haploid cell line, 2bp insertion knock out of RNASEK in haploid cell line, 152bp insertion HG 436-11 HG 436-12 HG 436-3 HG 436-9 RNASEL RNASEL KO HAP1 knock out of RNASEL in haploid cell line, 13bp deletion HG 704-1 RNF2 RNF2 KO RNF2 KO RNF2 KO HAP1 HAP1 HAP1 knock out of RNF2 in haploid cell line, 7bp deletion knock out of RNF2 in haploid cell line, 2bp insertion knock out of RNF2 in haploid cell line, 10bp deletion HG 1181-2 HG 1181-3 HG 1181-5 RNF8 RNF8 KO HAP1 knock out of RNF8 in haploid cell line, 152bp insertion HG 662-11 RNF41 RNF41 KO RNF41 KO HAP1 HAP1 knock out of RNF41 in haploid cell line, 2bp deletion knock out of RNF41 in haploid cell line, 8bp deletion HG 609-6 HG 609-9 RNF123 RNF123 KO HAP1 knock out of RNF123 in haploid cell line, 1bp insertion HG 980-11 ROCK1 ROCK1 KO ROCK1 KO ROCK1 KO HAP1 HAP1 HAP1 knock out of ROCK1 in haploid cell line, 7bp deletion knock out of ROCK1 in haploid cell line, 2bp deletion knock out of ROCK1 in haploid cell line, 13bp deletion HG 320-11 HG 320-12 HG 320-16 ROCK2 ROCK2 KO ROCK2 KO ROCK2 KO HAP1 HAP1 HAP1 knock out of ROCK2 in haploid cell line, 8bp deletion knock out of ROCK2 in haploid cell line, 23bp deletion knock out of ROCK2 in haploid cell line, 2bp insertion HG 61-17 HG 61-18 HG 61-21 ROR1 ROR1 KO HAP1 knock out of ROR1 in haploid cell line, 8bp deletion HG 1343-15 ROR2 ROR2 KO HAP1 knock out of ROR2 in haploid cell line, 5bp deletion HG 336-4 RPS6KA1 RPS6KA1 KO HAP1 knock out of RPS6KA1 in haploid cell line, 16bp deletion HG 215-18 RPS6KA2 RPS6KA2 KO RPS6KA2 KO RPS6KA2 KO HAP1 HAP1 HAP1 knock out of RPS6KA2 in haploid cell line, 2bp insertion knock out of RPS6KA2 in haploid cell line, 8bp deletion knock out of RPS6KA2 in haploid cell line, 13bp deletion HG 170-14 HG 170-2 HG 170-8 RPS6KA3 RPS6KA3 KO HAP1 knock out of RPS6KA3 in haploid cell line, 17bp deletion HG 731-10 RPS6KA4 RPS6KA4 KO HAP1 knock out of RPS6KA4 in haploid cell line, 10bp deletion HG 1494-11 RPS6KA6 RPS6KA6 KO HAP1 knock out of RPS6KA6 in haploid cell line, 2bp deletion HG 705-4 RPS6KB1 RPS6KB1 KO HAP1 knock out of RPS6KB1 in haploid cell line, 2bp deletion HG 104-11 RPS6KB2 RPS6KB2 KO HAP1 knock out of RPS6KB2 in haploid cell line, 16bp deletion HG 105-11 RPS6KC1 RPS6KC1 KO HAP1 knock out of RPS6KC1 in haploid cell line, 13bp deletion HG 171-11 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID RPS6KC1 RPS6KC1 KO RPS6KC1 KO HAP1 HAP1 knock out of RPS6KC1 in haploid cell line, 7bp deletion knock out of RPS6KC1 in haploid cell line, 2bp deletion HG 171-2 HG 171-5 RPS6KL1 RPS6KL1 KO HAP1 knock out of RPS6KL1 in haploid cell line, 1bp insertion HG 1347-2 RRM2B RRM2B KO RRM2B KO HAP1 HAP1 knock out of RRM2B in haploid cell line, 10bp deletion knock out of RRM2B in haploid cell line, 16bp deletion HG 572-10 HG 572-9 RYK RYK KO RYK KO RYK KO HAP1 HAP1 HAP1 knock out of RYK in haploid cell line, 19bp deletion knock out of RYK in haploid cell line, 40bp deletion knock out of RYK in haploid cell line, 2bp insertion HG 8066-5 HG 8066-6 HG 8066-9 S100A4 S100A4 (-/-) HCT116 Homozygous knock-out of S100A4 HD 115-096 SAMHD1 SAMHD1 KO SAMHD1 KO SAMHD1 KO HAP1 HAP1 HAP1 knock out of SAMHD1 in haploid cell line, 454bp insertion knock out of SAMHD1 in haploid cell line, 1bp insertion knock out of SAMHD1 in haploid cell line, 2bp insertion HG 813-4 HG 813-5 HG 813-7 SBK1 SBK1 KO SBK1 KO SBK1 KO HAP1 HAP1 HAP1 knock out of SBK1 in haploid cell line, 5bp deletion knock out of SBK1 in haploid cell line, 28bp deletion knock out of SBK1 in haploid cell line, 4bp deletion HG 106-10 HG 106-17 HG 106-18 SCFD2 SCFD2 KO SCFD2 KO HAP1 HAP1 knock out of SCFD2 in haploid cell line, 7bp deletion knock out of SCFD2 in haploid cell line, 17bp deletion HG 1227-3 HG 1227-9 SCYL1 SCYL1 KO SCYL1 KO HAP1 HAP1 knock out of SCYL1 in haploid cell line, 5bp deletion knock out of SCYL1 in haploid cell line, 1bp insertion HG 286-3 HG 286-5 SCYL2 SCYL2 KO SCYL2 KO HAP1 HAP1 knock out of SCYL2 in haploid cell line, 22bp deletion knock out of SCYL2 in haploid cell line, 19bp deletion HG 173-11 HG 173-13 SCYL3 SCYL3 KO SCYL3 KO HAP1 HAP1 knock out of SCYL3 in haploid cell line, 8bp deletion knock out of SCYL3 in haploid cell line, 22bp deletion HG 174-4 HG 174-5 SEC22A SEC22A KO HAP1 knock out of SEC22A in haploid cell line, 7bp deletion HG 1229-11 SEC22C SEC22C KO SEC22C KO HAP1 HAP1 knock out of SEC22C in haploid cell line, 13bp deletion knock out of SEC22C in haploid cell line, 11bp deletion HG 1231-1 HG 1231-6 SEC23A SEC23A KO HAP1 knock out of SEC23A in haploid cell line, 22bp deletion HG 1218-1 SEC23B SEC23B KO SEC23B KO SEC23B KO HAP1 HAP1 HAP1 knock out of SEC23B in haploid cell line, 4bp deletion knock out of SEC23B in haploid cell line, 2bp insertion knock out of SEC23B in haploid cell line, 11bp deletion HG 20241-10 HG 20241-16 HG 20241-5 SEC23IP SEC23IP KO SEC23IP KO HAP1 HAP1 knock out of SEC23IP in haploid cell line, 2bp deletion knock out of SEC23IP in haploid cell line, 10bp deletion HG 1237-1 HG 1237-10 SEC24A SEC24A KO HAP1 knock out of SEC24A in haploid cell line, 5bp deletion HG 1223-10 SEC24B SEC24B KO SEC24B KO HAP1 HAP1 knock out of SEC24B in haploid cell line, 7bp deletion knock out of SEC24B in haploid cell line, 5bp deletion HG 1222-10 HG 1222-2 SEC24C SEC24C KO SEC24C KO HAP1 HAP1 knock out of SEC24C in haploid cell line, 1bp deletion knock out of SEC24C in haploid cell line, 236bp insertion HG 1235-1 HG 1235-3 SEC24D SEC24D KO HAP1 knock out of SEC24D in haploid cell line, 7bp deletion HG 1238-11 SEMA7A SEMA7A KO HAP1 knock out of SEMA7A in haploid cell line, 2bp insertion HG 2328-4 46 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 47 Genotype Cell Line Description Catalogue ID SETD2 SETD2 (R1492*/+) SETD2 KO HCT116 HAP1 Heterozygous knock-out of SETD2 by knock-in of premature stop codon (R1492*) knock out of SETD2 in haploid cell line, 2bp deletion HD 104-068 HG 1172-1 SETDB1 SETDB1 KO SETDB1 KO HAP1 HAP1 knock out of SETDB1 in haploid cell line, 14bp deletion knock out of SETDB1 in haploid cell line, 5bp deletion HG 1331-1 HG 1331-10 SETDB2 SETDB2 KO SETDB2 KO SETDB2 KO SETDB2 KO HAP1 HAP1 HAP1 HAP1 knock out of SETDB2 in haploid cell line, 2bp deletion knock out of SETDB2 in haploid cell line, 2bp deletion knock out of SETDB2 in haploid cell line, 5bp deletion knock out of SETDB2 in haploid cell line, 23bp deletion HG 1180-11 HG 1180-12 HG 1180-7 HG 1180-8 SETX SETX KO SETX KO HAP1 HAP1 knock out of SETX in haploid cell line, 25bp deletion knock out of SETX in haploid cell line, 5bp deletion HG 1565-1 HG 1565-5 SFN SFN (-/-) SFN (-/-); CDKN1A (-/-) SFN (+/-) HCT116 HCT116 HCT116 Homozygous knock-out of SFN Double homozygous knock-out of SFN and CDKN1A Heterozygous knock-out of SFN HD R02-001 HD R02-003 HD R02-002 SGK3 SGK3 KO HAP1 knock out of SGK3 in haploid cell line, 1bp insertion HG 735-9 SGK223 SGK223 KO HAP1 knock out of SGK223 in haploid cell line, 23bp deletion HG 1344-15 SGK494 SGK494 KO SGK494 KO HAP1 HAP1 knock out of SGK494 in haploid cell line, 10bp deletion knock out of SGK494 in haploid cell line, 4bp deletion HG 62-13 HG 62-21 SHMT2 SHMT2 KO HAP1 knock out of SHMT2 in haploid cell line, 2bp deletion HG 1954-6 SIAE SIAE KO SIAE KO HAP1 HAP1 knock out of SIAE in haploid cell line, 8bp deletion knock out of SIAE in haploid cell line, 16bp deletion HG 1490-5 HG 1490-6 SIK1 SIK1 KO SIK1 KO SIK1 KO HAP1 HAP1 HAP1 knock out of SIK1 in haploid cell line, 1bp insertion knock out of SIK1 in haploid cell line, 7bp deletion knock out of SIK1 in haploid cell line, 2bp deletion HG 63-12 HG 63-15 HG 63-22 SIK2 SIK2 KO SIK2 KO HAP1 HAP1 knock out of SIK2 in haploid cell line, 1bp insertion knock out of SIK2 in haploid cell line, 1bp insertion HG 107-12 HG 107-15 SIK3 SIK3 KO SIK3 KO SIK3 KO HAP1 HAP1 HAP1 knock out of SIK3 in haploid cell line, 2bp deletion knock out of SIK3 in haploid cell line, 13bp deletion knock out of SIK3 in haploid cell line, 4bp deletion HG 64-18 HG 64-21 HG 64-8 SIN3A SIN3A KO HAP1 knock out of SIN3A in haploid cell line, 1bp insertion HG 1133-3 SIRT1 SIRT1 KO SIRT1 KO HAP1 HAP1 knock out of SIRT1 in haploid cell line, 23bp deletion knock out of SIRT1 in haploid cell line, 20bp deletion HG 1008-2 HG 1008-8 SIRT2 SIRT2 KO SIRT2 KO HAP1 HAP1 knock out of SIRT2 in haploid cell line, 11bp deletion knock out of SIRT2 in haploid cell line, 4bp deletion HG 803-6 HG 803-8 SIRT3 SIRT3 KO SIRT3 KO HAP1 HAP1 knock out of SIRT3 in haploid cell line, 2bp deletion knock out of SIRT3 in haploid cell line, 26bp deletion HG 1009-12 HG 1009-2 SIRT4 SIRT4 KO SIRT4 KO HAP1 HAP1 knock out of SIRT4 in haploid cell line, 2bp deletion knock out of SIRT4 in haploid cell line, 5bp deletion HG 1002-1 HG 1002-2 SIRT5 SIRT5 KO SIRT5 KO HAP1 HAP1 knock out of SIRT5 in haploid cell line, 1bp deletion knock out of SIRT5 in haploid cell line, 35bp deletion HG 1004-4 HG 1004-9 SIRT6 SIRT6 KO HAP1 knock out of SIRT6 in haploid cell line, 14bp deletion HG 1005-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID SIRT6 SIRT6 KO HAP1 knock out of SIRT6 in haploid cell line, 4bp insertion HG 1005-4 SIRT7 SIRT7 KO HAP1 knock out of SIRT7 in haploid cell line, 1bp deletion HG 2412-4 SLC1A4 SLC1A4 KO HAP1 knock out of SLC1A4 in haploid cell line, 8bp deletion HG 1585-2 SLC1A5 SLC1A5 KO SLC1A5 KO HAP1 HAP1 knock out of SLC1A5 in haploid cell line, 116bp insertion knock out of SLC1A5 in haploid cell line, 53bp insertion HG 1590-1 HG 1590-10 SLC2A1 GLUT1 (-/-) GLUT1 (-/-) DLD-1 RKO Homozygous knock-out of GLUT1 Homozygous knock-out of GLUT1 HD R00-024 HD R05-011 SLC2A8 SLC2A8 KO HAP1 knock out of SLC2A8 in haploid cell line, 2bp deletion HG 2276-1 SLC4A2 SLC4A2 KO HAP1 knock out of SLC4A2 in haploid cell line, 2bp deletion HG 1880-4 SLC4A8 SLC4A8 KO SLC4A8 KO HAP1 HAP1 knock out of SLC4A8 in haploid cell line, 5bp deletion knock out of SLC4A8 in haploid cell line, 8bp deletion HG 1987-1 HG 1987-10 SLC4A10 SLC4A10 KO HAP1 knock out of SLC4A10 in haploid cell line, 1bp insertion HG 2062-12 SLC5A4 SLC5A4 KO HAP1 knock out of SLC5A4 in haploid cell line, 1bp insertion HG 2107-1 SLC5A6 SLC5A6 KO HAP1 knock out of SLC5A6 in haploid cell line, 2bp deletion HG 1869-12 SLC7A1 SLC7A1 KO SLC7A1 KO HAP1 HAP1 knock out of SLC7A1 in haploid cell line, 2bp deletion knock out of SLC7A1 in haploid cell line, 4bp deletion HG 1741-10 HG 1741-12 SLC7A3 SLC7A3 KO SLC7A3 KO HAP1 HAP1 knock out of SLC7A3 in haploid cell line, 5bp deletion knock out of SLC7A3 in haploid cell line, 137bp insertion HG 2044-11 HG 2044-5 SLC7A6 SLC7A6 KO HAP1 knock out of SLC7A6 in haploid cell line, 8bp deletion HG 1688-11 SLC9A3R1 SLC9A3R1 KO SLC9A3R1 KO HAP1 HAP1 knock out of SLC9A3R1 in haploid cell line, 2bp deletion knock out of SLC9A3R1 in haploid cell line, 13bp deletion HG 781-12 HG 781-2 SLC9A3R2 SLC9A3R2 KO SLC9A3R2 KO HAP1 HAP1 knock out of SLC9A3R2 in haploid cell line, 2bp deletion knock out of SLC9A3R2 in haploid cell line, 4bp deletion HG 782-10 HG 782-12 SLC9A7 SLC9A7 KO SLC9A7 KO HAP1 HAP1 knock out of SLC9A7 in haploid cell line, 1bp insertion knock out of SLC9A7 in haploid cell line, 1bp deletion HG 1918-1 HG 1918-8 SLC9C1 SLC9C1 KO SLC9C1 KO HAP1 HAP1 knock out of SLC9C1 in haploid cell line, 10bp deletion knock out of SLC9C1 in haploid cell line, 22bp deletion HG 2145-12 HG 2145-4 SLC11A2 SLC11A2 KO HAP1 knock out of SLC11A2 in haploid cell line, 11bp deletion HG 1897-11 SLC12A4 SLC12A4 KO HAP1 knock out of SLC12A4 in haploid cell line, 11bp deletion HG 1720-6 SLC12A5 SLC12A5 KO HAP1 knock out of SLC12A5 in haploid cell line, 4bp deletion HG 1825-4 SLC12A6 SLC12A6 KO HAP1 knock out of SLC12A6 in haploid cell line, 10bp deletion HG 1702-2 SLC12A7 SLC12A7 KO SLC12A7 KO HAP1 HAP1 knock out of SLC12A7 in haploid cell line, 7bp deletion knock out of SLC12A7 in haploid cell line, 2bp deletion HG 1697-5 HG 1697-6 SLC12A9 SLC12A9 KO HAP1 knock out of SLC12A9 in haploid cell line, 16bp deletion HG 1677-1 48 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 49 Genotype Cell Line Description Catalogue ID SLC12A9 SLC12A9 KO HAP1 knock out of SLC12A9 in haploid cell line, 11bp deletion HG 1677-12 SLC16A3 SLC16A3 KO HAP1 knock out of SLC16A3 in haploid cell line, 2bp deletion HG 1844-1 SLC16A10 SLC16A10 KO SLC16A10 KO HAP1 HAP1 knock out of SLC16A10 in haploid cell line, 5bp deletion knock out of SLC16A10 in haploid cell line, 8bp deletion HG 2232-4 HG 2232-7 SLC16A13 SLC16A13 KO HAP1 knock out of SLC16A13 in haploid cell line, 1bp insertion HG 2176-10 SLC17A5 SLC17A5 KO SLC17A5 KO HAP1 HAP1 knock out of SLC17A5 in haploid cell line, 2bp insertion knock out of SLC17A5 in haploid cell line, 1bp insertion HG 2214-12 HG 2214-6 SLC17A9 SLC17A9 KO SLC17A9 KO HAP1 HAP1 knock out of SLC17A9 in haploid cell line, 22bp deletion knock out of SLC17A9 in haploid cell line, 34bp deletion HG 2153-5 HG 2153-8 SLC19A1 SLC19A1 KO SLC19A1 KO HAP1 HAP1 knock out of SLC19A1 in haploid cell line, 10bp deletion knock out of SLC19A1 in haploid cell line, 8bp deletion HG 1771-12 HG 1771-2 SLC20A2 SLC20A2 KO HAP1 knock out of SLC20A2 in haploid cell line, 122bp insertion HG 2158-3 SLC22A5 SLC22A5 KO HAP1 knock out of SLC22A5 in haploid cell line, 34bp deletion HG 2234-3 SLC22A18 SLC22A18 KO HAP1 knock out of SLC22A18 in haploid cell line, 11bp deletion HG 1911-11 SLC25A1 SLC25A1 KO HAP1 knock out of SLC25A1 in haploid cell line, 2bp insertion HG 1753-3 SLC25A3 SLC25A3 KO SLC25A3 KO HAP1 HAP1 knock out of SLC25A3 in haploid cell line, 5bp deletion knock out of SLC25A3 in haploid cell line, 1bp insertion HG 792-10 HG 792-6 SLC25A4 SLC25A4 KO SLC25A4 KO HAP1 HAP1 knock out of SLC25A4 in haploid cell line, 5bp deletion knock out of SLC25A4 in haploid cell line, 56bp insertion HG 778-11 HG 778-5 SLC25A5 SLC25A5 KO HAP1 knock out of SLC25A5 in haploid cell line, 1bp deletion HG 779-2 SLC25A6 SLC25A6 KO HAP1 knock out of SLC25A6 in haploid cell line, 232bp insertion HG 780-11 SLC25A10 SLC25A10 KO SLC25A10 KO HAP1 HAP1 knock out of SLC25A10 in haploid cell line, 5bp deletion knock out of SLC25A10 in haploid cell line, 26bp deletion HG 790-1 HG 790-2 SLC25A11 SLC25A11 KO SLC25A11 KO HAP1 HAP1 knock out of SLC25A11 in haploid cell line, 17bp deletion knock out of SLC25A11 in haploid cell line, 8bp deletion HG 2127-10 HG 2127-12 SLC25A13 SLC25A13 KO SLC25A13 KO HAP1 HAP1 knock out of SLC25A13 in haploid cell line, 2bp insertion knock out of SLC25A13 in haploid cell line, 16bp deletion HG 789-1 HG 789-6 SLC25A15 SLC25A15 KO SLC25A15 KO HAP1 HAP1 knock out of SLC25A15 in haploid cell line, 2bp deletion knock out of SLC25A15 in haploid cell line, 19bp deletion HG 797-2 HG 797-4 SLC25A18 SLC25A18 KO SLC25A18 KO HAP1 HAP1 knock out of SLC25A18 in haploid cell line, 1bp insertion knock out of SLC25A18 in haploid cell line, 13bp deletion HG 1981-11 HG 1981-2 SLC25A20 SLC25A20 KO SLC25A20 KO HAP1 HAP1 knock out of SLC25A20 in haploid cell line, 22bp deletion knock out of SLC25A20 in haploid cell line, 2bp deletion HG 787-3 HG 787-4 SLC25A22 SLC25A22 KO SLC25A22 KO SLC25A22 KO HAP1 HAP1 HAP1 knock out of SLC25A22 in haploid cell line, 1bp insertion knock out of SLC25A22 in haploid cell line, 1bp insertion knock out of SLC25A22 in haploid cell line, 2bp insertion HG 791-4 HG 791-5 HG 791-8 SLC25A25 SLC25A25 KO HAP1 knock out of SLC25A25 in haploid cell line, 2bp deletion HG 1999-1 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID SLC25A25 SLC25A25 KO HAP1 knock out of SLC25A25 in haploid cell line, 4bp deletion HG 1999-3 SLC25A29 SLC25A29 KO HAP1 knock out of SLC25A29 in haploid cell line, 5bp insertion HG 2012-4 SLC25A30 SLC25A30 KO SLC25A30 KO SLC25A30 KO HAP1 HAP1 HAP1 knock out of SLC25A30 in haploid cell line, 1bp insertion knock out of SLC25A30 in haploid cell line, 1bp insertion knock out of SLC25A30 in haploid cell line, 1bp insertion HG 2288-1 HG 2288-10 HG 2288-12 SLC25A32 SLC25A32 KO HAP1 knock out of SLC25A32 in haploid cell line, 8bp deletion HG 1715-10 SLC25A37 SLC25A37 KO SLC25A37 KO HAP1 HAP1 knock out of SLC25A37 in haploid cell line, 5bp deletion knock out of SLC25A37 in haploid cell line, 2bp deletion HG 1952-1 HG 1952-10 SLC25A38 SLC25A38 KO HAP1 knock out of SLC25A38 in haploid cell line, 1bp insertion HG 2134-8 SLC25A40 SLC25A40 KO HAP1 knock out of SLC25A40 in haploid cell line, 26bp deletion HG 1757-5 SLC25A46 SLC25A46 KO SLC25A46 KO HAP1 HAP1 knock out of SLC25A46 in haploid cell line, 2bp deletion knock out of SLC25A46 in haploid cell line, 26bp deletion HG 793-10 HG 793-2 SLC26A2 SLC26A2 KO HAP1 knock out of SLC26A2 in haploid cell line, 1bp insertion HG 1849-10 SLC27A1 SLC27A1 KO SLC27A1 KO HAP1 HAP1 knock out of SLC27A1 in haploid cell line, 13bp deletion knock out of SLC27A1 in haploid cell line, 4bp deletion HG 1838-11 HG 1838-2 SLC27A2 SLC27A2 KO SLC27A2 KO SLC27A2 KO HAP1 HAP1 HAP1 knock out of SLC27A2 in haploid cell line, 283bp insertion knock out of SLC27A2 in haploid cell line, 1bp insertion knock out of SLC27A2 in haploid cell line, 1bp insertion HG 796-11 HG 796-3 HG 796-4 SLC27A3 SLC27A3 KO SLC27A3 KO HAP1 HAP1 knock out of SLC27A3 in haploid cell line, 8bp deletion knock out of SLC27A3 in haploid cell line, 191bp insertion HG 1727-12 HG 1727-2 SLC27A4 SLC27A4 KO SLC27A4 KO HAP1 HAP1 knock out of SLC27A4 in haploid cell line, 43bp deletion knock out of SLC27A4 in haploid cell line, 4bp deletion HG 1656-1 HG 1656-2 SLC29A1 SLC29A1 KO HAP1 knock out of SLC29A1 in haploid cell line, 14bp deletion HG 785-4 SLC29A4 SLC29A4 KO SLC29A4 KO SLC29A4 KO HAP1 HAP1 HAP1 knock out of SLC29A4 in haploid cell line, 1bp insertion knock out of SLC29A4 in haploid cell line, 14bp deletion knock out of SLC29A4 in haploid cell line, 1bp insertion HG 2139-3 HG 2139-5 HG 2139-9 SLC30A1 SLC30A1 KO SLC30A1 KO HAP1 HAP1 knock out of SLC30A1 in haploid cell line, 1bp insertion knock out of SLC30A1 in haploid cell line, 1bp insertion HG 1777-10 HG 1777-11 SLC30A3 SLC30A3 KO SLC30A3 KO HAP1 HAP1 knock out of SLC30A3 in haploid cell line, 17bp deletion knock out of SLC30A3 in haploid cell line, 5bp deletion HG 1903-11 HG 1903-12 SLC30A5 SLC30A5 KO HAP1 knock out of SLC30A5 in haploid cell line, 2bp insertion HG 2056-6 SLC30A7 SLC30A7 KO SLC30A7 KO HAP1 HAP1 knock out of SLC30A7 in haploid cell line, 28bp deletion knock out of SLC30A7 in haploid cell line, 20bp deletion HG 1751-12 HG 1751-5 SLC31A1 SLC31A1 KO HAP1 knock out of SLC31A1 in haploid cell line, 10bp deletion HG 2093-5 SLC33A1 SLC33A1 KO SLC33A1 KO HAP1 HAP1 knock out of SLC33A1 in haploid cell line, 2bp deletion knock out of SLC33A1 in haploid cell line, 5bp deletion HG 1384-2 HG 1384-7 SLC34A2 SLC34A2 KO HAP1 knock out of SLC34A2 in haploid cell line, 2bp deletion HG 1922-10 50 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 51 Genotype Cell Line Description Catalogue ID SLC35A1 SLC35A1 KO SLC35A1 KO SLC35A1 KO HAP1 HAP1 HAP1 knock out of SLC35A1 in haploid cell line, 2bp deletion knock out of SLC35A1 in haploid cell line, 2bp insertion knock out of SLC35A1 in haploid cell line, 8bp deletion HG 10158-10 HG 10158-15 HG 10158-5 SLC35A3 SLC35A3 KO SLC35A3 KO HAP1 HAP1 knock out of SLC35A3 in haploid cell line, 7bp deletion knock out of SLC35A3 in haploid cell line, 5bp deletion HG 783-12 HG 783-3 SLC35A5 SLC35A5 KO SLC35A5 KO HAP1 HAP1 knock out of SLC35A5 in haploid cell line, 343bp insertion knock out of SLC35A5 in haploid cell line, 22bp deletion HG 2170-6 HG 2170-9 SLC35C1 SLC35C1 KO SLC35C1 KO HAP1 HAP1 knock out of SLC35C1 in haploid cell line, 5bp deletion knock out of SLC35C1 in haploid cell line, 2bp deletion HG 1942-6 HG 1942-7 SLC35E1 SLC35E1 KO HAP1 knock out of SLC35E1 in haploid cell line, 16bp deletion HG 2613-11 SLC35E2B SLC35E2B KO SLC35E2B KO HAP1 HAP1 knock out of SLC35E2B in haploid cell line, 7bp deletion knock out of SLC35E2B in haploid cell line, 22bp deletion HG 2191-3 HG 2191-8 SLC35F2 SLC35F2 KO HAP1 knock out of SLC35F2 in haploid cell line, 1bp insertion HG 2119-3 SLC36A4 SLC36A4 KO HAP1 knock out of SLC36A4 in haploid cell line, 2bp deletion HG 1862-5 SLC37A4 SLC37A4 KO HAP1 knock out of SLC37A4 in haploid cell line, 2bp deletion HG 1454-4 SLC38A2 SLC38A2 KO SLC38A2 KO SLC38A2 KO HAP1 HAP1 HAP1 knock out of SLC38A2 in haploid cell line, 1bp insertion knock out of SLC38A2 in haploid cell line, 1bp insertion knock out of SLC38A2 in haploid cell line, 1bp insertion HG 1975-2 HG 1975-3 HG 1975-6 SLC38A5 SLC38A5 KO HAP1 knock out of SLC38A5 in haploid cell line, 28bp deletion HG 1691-11 SLC38A9 SLC38A9 KO SLC38A9 KO HAP1 HAP1 knock out of SLC38A9 in haploid cell line, 2bp deletion knock out of SLC38A9 in haploid cell line, 5bp deletion HG 777-11 HG 777-6 SLC38A10 SLC38A10 KO SLC38A10 KO HAP1 HAP1 knock out of SLC38A10 in haploid cell line, 17bp deletion knock out of SLC38A10 in haploid cell line, 5bp deletion HG 1745-6 HG 1745-9 SLC39A1 SLC39A1 KO SLC39A1 KO HAP1 HAP1 knock out of SLC39A1 in haploid cell line, 5bp deletion knock out of SLC39A1 in haploid cell line, 16bp deletion HG 2125-12 HG 2125-6 SLC39A3 SLC39A3 KO HAP1 knock out of SLC39A3 in haploid cell line, 29bp deletion HG 2246-5 SLC39A6 SLC39A6 KO HAP1 knock out of SLC39A6 in haploid cell line, 7bp deletion HG 1832-4 SLC39A8 SLC39A8 KO SLC39A8 KO SLC39A8 KO HAP1 HAP1 HAP1 knock out of SLC39A8 in haploid cell line, 67bp insertion knock out of SLC39A8 in haploid cell line, 1bp insertion knock out of SLC39A8 in haploid cell line, 1bp insertion HG 2069-1 HG 2069-10 HG 2069-11 SLC39A9 SLC39A9 KO SLC39A9 KO HAP1 HAP1 knock out of SLC39A9 in haploid cell line, 1bp insertion knock out of SLC39A9 in haploid cell line, 2bp deletion HG 2017-11 HG 2017-7 SLC39A14 SLC39A14 KO SLC39A14 KO HAP1 HAP1 knock out of SLC39A14 in haploid cell line, 56bp deletion knock out of SLC39A14 in haploid cell line, 2bp deletion HG 775-11 HG 775-6 SLC41A3 SLC41A3 KO SLC41A3 KO HAP1 HAP1 knock out of SLC41A3 in haploid cell line, 2bp deletion knock out of SLC41A3 in haploid cell line, 2bp deletion HG 2098-7 HG 2098-9 SLC43A1 SLC43A1 KO SLC43A1 KO HAP1 HAP1 knock out of SLC43A1 in haploid cell line, 2bp insertion knock out of SLC43A1 in haploid cell line, 1bp insertion HG 1814-1 HG 1814-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID SLC43A1 SLC43A1 KO HAP1 knock out of SLC43A1 in haploid cell line, 1bp deletion HG 1814-8 SLC43A2 SLC43A2 KO HAP1 knock out of SLC43A2 in haploid cell line, 2bp deletion HG 1877-8 SLC43A3 SLC43A3 KO SLC43A3 KO HAP1 HAP1 knock out of SLC43A3 in haploid cell line, 1bp insertion knock out of SLC43A3 in haploid cell line, 7bp deletion HG 2241-1 HG 2241-5 SLC44A1 SLC44A1 KO HAP1 knock out of SLC44A1 in haploid cell line, 2bp deletion HG 1665-1 SLC46A3 SLC46A3 KO SLC46A3 KO SLC46A3 KO HAP1 HAP1 HAP1 knock out of SLC46A3 in haploid cell line, 1bp insertion knock out of SLC46A3 in haploid cell line, 1bp insertion knock out of SLC46A3 in haploid cell line, 13bp deletion HG 2222-1 HG 2222-6 HG 2222-9 SLC52A2 SLC52A2 KO HAP1 knock out of SLC52A2 in haploid cell line, 4bp deletion HG 2164-9 SLK SLK KO HAP1 knock out of SLK in haploid cell line, 7bp deletion HG 1258-10 SLX4 SLX4 KO HAP1 knock out of SLX4 in haploid cell line, 1bp deletion HG 902-12 SMAD4 SMAD4 (-/-) HCT116 Homozygous knock-out of SMAD4 HD 104-005 SMARCA2 SMARCA2 KO HAP1 knock out of SMARCA2 in haploid cell line, 11bp deletion HG 945-4 SMARCA4 SMARCA4 KO HAP1 knock out of SMARCA4 in haploid cell line, 37bp deletion HG 922-3 SMARCC1 SMARCC1 KO SMARCC1 KO HAP1 HAP1 knock out of SMARCC1 in haploid cell line, 2bp insertion knock out of SMARCC1 in haploid cell line, 4bp deletion HG 2476-11 HG 2476-12 SMARCD1 SMARCD1 KO SMARCD1 KO SMARCD1 KO HAP1 HAP1 HAP1 knock out of SMARCD1 in haploid cell line, 1bp deletion knock out of SMARCD1 in haploid cell line, 1bp insertion knock out of SMARCD1 in haploid cell line, 16bp deletion HG 2478-1 HG 2478-10 HG 2478-6 SMARCD3 SMARCD3 KO SMARCD3 KO HAP1 HAP1 knock out of SMARCD3 in haploid cell line, 8bp deletion knock out of SMARCD3 in haploid cell line, 7bp deletion HG 2480-12 HG 2480-2 SMOX SMOX KO SMOX KO HAP1 HAP1 knock out of SMOX in haploid cell line, 11bp deletion knock out of SMOX in haploid cell line, 17bp deletion HG 1955-10 HG 1955-11 SNAP23 SNAP23 KO SNAP23 KO HAP1 HAP1 knock out of SNAP23 in haploid cell line, 2bp deletion knock out of SNAP23 in haploid cell line, 5bp deletion HG 2609-10 HG 2609-3 SNRK SNRK KO HAP1 knock out of SNRK in haploid cell line, 319bp insertion HG 252-8 SORT1 SORT1 KO HAP1 knock out of SORT1 in haploid cell line, 2bp deletion HG 1782-11 SP1 SP1 KO SP1 KO HAP1 HAP1 knock out of SP1 in haploid cell line, 1bp insertion knock out of SP1 in haploid cell line, 2bp deletion HG 1141-1 HG 1141-2 SP3 SP3 KO SP3 KO SP3 KO HAP1 HAP1 HAP1 knock out of SP3 in haploid cell line, 10bp deletion knock out of SP3 in haploid cell line, 1bp insertion knock out of SP3 in haploid cell line, 2bp deletion HG 1142-1 HG 1142-10 HG 1142-7 SP100 SP100 KO SP100 KO HAP1 HAP1 knock out of SP100 in haploid cell line, 20bp deletion knock out of SP100 in haploid cell line, 8bp deletion HG 952-5 HG 952-8 SP110 SP110 KO SP110 KO HAP1 HAP1 knock out of SP110 in haploid cell line, 7bp deletion knock out of SP110 in haploid cell line, 2bp deletion HG 949-10 HG 949-4 SP140 SP140 KO HAP1 knock out of SP140 in haploid cell line, 7bp deletion HG 953-3 52 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 53 Genotype Cell Line Description Catalogue ID SP140 SP140 KO HAP1 knock out of SP140 in haploid cell line, 11bp deletion HG 953-7 SPEG SPEG KO SPEG KO SPEG KO HAP1 HAP1 HAP1 knock out of SPEG in haploid cell line, 2bp deletion knock out of SPEG in haploid cell line, 1bp deletion knock out of SPEG in haploid cell line, 4bp deletion HG 351-12 HG 351-16 HG 351-2 SQSTM1 SQSTM1 KO SQSTM1 KO HAP1 HAP1 knock out of SQSTM1 in haploid cell line, 4bp deletion knock out of SQSTM1 in haploid cell line, 7bp deletion HG 298-15 HG 298-2 SRC SRC KO SRC KO SRC KO HAP1 HAP1 HAP1 knock out of SRC in haploid cell line, 7bp deletion knock out of SRC in haploid cell line, 14bp deletion knock out of SRC in haploid cell line, 8bp deletion HG 348-14 HG 348-17 HG 348-23 SREBF1 SREBF1 KO SREBF1 KO SREBF1 KO HAP1 HAP1 HAP1 knock out of SREBF1 in haploid cell line, 1bp insertion knock out of SREBF1 in haploid cell line, 1bp insertion knock out of SREBF1 in haploid cell line, 19bp deletion HG 1361-1 HG 1361-10 HG 1361-12 SREBF2 SREBF2 KO HAP1 knock out of SREBF2 in haploid cell line, 146bp insertion HG 683-7 SRPK1 SRPK1 KO HAP1 knock out of SRPK1 in haploid cell line, 8bp deletion HG 108-13 SRPK2 SRPK2 KO HAP1 knock out of SRPK2 in haploid cell line, 4bp deletion HG 280-20 STAMBP STAMBP KO STAMBP KO HAP1 HAP1 knock out of STAMBP in haploid cell line, 1bp insertion knock out of STAMBP in haploid cell line, 1bp insertion HG 484-7 HG 484-8 STAMBPL1 STAMBPL1 KO STAMBPL1 KO HAP1 HAP1 knock out of STAMBPL1 in haploid cell line, 2bp deletion knock out of STAMBPL1 in haploid cell line, 5bp deletion HG 474-3 HG 474-7 STAT3 STAT3 (Y705F/Y705F) DLD-1 Homozygous knock-in of STAT3 Y705F mutation HD 115-016 STK3 STK3 KO HAP1 knock out of STK3 in haploid cell line, 5bp deletion HG 1256-12 STK4 STK4 KO HAP1 knock out of STK4 in haploid cell line, 2bp insertion HG 109-7 STK10 STK10 KO HAP1 knock out of STK10 in haploid cell line, 2bp deletion HG 233-8 STK11 STK11 (+/Q37*) STK11 KO HCT116 HAP1 Heterozygous knock-in of Q37* point mutation resulting in truncation of STK11 knock out of STK11 in haploid cell line, 17bp deletion HD 104-098 HG 2413-4 STK16 STK16 KO STK16 KO STK16 KO HAP1 HAP1 HAP1 knock out of STK16 in haploid cell line, 10bp deletion knock out of STK16 in haploid cell line, 1bp insertion knock out of STK16 in haploid cell line, 2bp insertion HG 65-2 HG 65-20 HG 65-7 STK17A STK17A KO HAP1 knock out of STK17A in haploid cell line, 20bp deletion HG 1251-11 STK17B STK17B KO STK17B KO STK17B KO HAP1 HAP1 HAP1 knock out of STK17B in haploid cell line, 10bp deletion knock out of STK17B in haploid cell line, 14bp deletion knock out of STK17B in haploid cell line, 10bp deletion HG 66-17 HG 66-19 HG 66-5 STK19 STK19 KO STK19 KO HAP1 HAP1 knock out of STK19 in haploid cell line, 23bp deletion knock out of STK19 in haploid cell line, 2bp insertion HG 353-3 HG 353-8 STK25 STK25 KO STK25 KO STK25 KO HAP1 HAP1 HAP1 knock out of STK25 in haploid cell line, 5bp deletion knock out of STK25 in haploid cell line, 10bp deletion knock out of STK25 in haploid cell line, 10bp deletion HG 34364-11 HG 34364-12 HG 34364-2 STK32B STK32B KO HAP1 knock out of STK32B in haploid cell line, 4bp deletion HG 349-12 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID STK32B STK32B KO STK32B KO HAP1 HAP1 knock out of STK32B in haploid cell line, 1bp insertion knock out of STK32B in haploid cell line, 8bp deletion HG 349-20 HG 349-6 STK32C STK32C KO STK32C KO HAP1 HAP1 knock out of STK32C in haploid cell line, 14bp insertion knock out of STK32C in haploid cell line, 13bp deletion HG 67-21 HG 67-6 STK33 STK33 KO STK33 KO STK33 KO HAP1 HAP1 HAP1 knock out of STK33 in haploid cell line, 2bp deletion knock out of STK33 in haploid cell line, 5bp deletion knock out of STK33 in haploid cell line, 10bp deletion HG 68-10 HG 68-12 HG 68-18 STK38 STK38 KO HAP1 knock out of STK38 in haploid cell line, 1bp insertion HG 242-35 STK38L STK38L KO HAP1 knock out of STK38L in haploid cell line, 37bp deletion HG 249-1 STK39 STK39 KO STK39 KO HAP1 HAP1 knock out of STK39 in haploid cell line, 10bp deletion knock out of STK39 in haploid cell line, 2bp deletion HG 69-12 HG 69-20 STK40 STK40 KO HAP1 knock out of STK40 in haploid cell line, 146bp insertion HG 263-5 STRADA STRADA KO STRADA KO STRADA KO HAP1 HAP1 HAP1 knock out of STRADA in haploid cell line, 35bp deletion knock out of STRADA in haploid cell line, 1bp insertion knock out of STRADA in haploid cell line, 2bp deletion HG 176-10 HG 176-11 HG 176-9 STRADB STRADB KO HAP1 knock out of STRADB in haploid cell line, 8bp deletion HG 1495-19 STRN3 STRN3 KO STRN3 KO HAP1 HAP1 knock out of STRN3 in haploid cell line, 5bp deletion knock out of STRN3 in haploid cell line, 185bp insertion HG 833-10 HG 833-6 STYK1 STYK1 KO STYK1 KO STYK1 KO HAP1 HAP1 HAP1 knock out of STYK1 in haploid cell line, 8bp deletion knock out of STYK1 in haploid cell line, 2bp insertion knock out of STYK1 in haploid cell line, 11bp deletion HG 70-19 HG 70-2 HG 70-9 SURF4 SURF4 KO SURF4 KO HAP1 HAP1 knock out of SURF4 in haploid cell line, 13bp deletion knock out of SURF4 in haploid cell line, 10bp deletion HG 2442-1 HG 2442-2 SUV39H1 SUV39H1 KO SUV39H1 KO SUV39H1 KO HAP1 HAP1 HAP1 knock out of SUV39H1 in haploid cell line, 142bp insertion knock out of SUV39H1 in haploid cell line, 5bp deletion knock out of SUV39H1 in haploid cell line, 244bp insertion HG 1132-12 HG 1132-3 HG 1132-5 SYK SYK KO HAP1 knock out of SYK in haploid cell line, 29bp deletion HG 6898-17 TAB1 TAB1 KO HAP1 knock out of TAB1 in haploid cell line, 2bp deletion HG 2591-8 TAB3 TAB3 KO HAP1 knock out of TAB3 in haploid cell line, 1bp insertion HG 2593-3 TAF1L TAF1L KO TAF1L KO TAF1L KO HAP1 HAP1 HAP1 knock out of TAF1L in haploid cell line, 1bp insertion knock out of TAF1L in haploid cell line, 1bp insertion knock out of TAF1L in haploid cell line, 1bp insertion HG 954-11 HG 954-12 HG 954-3 TAOK1 TAOK1 KO TAOK1 KO HAP1 HAP1 knock out of TAOK1 in haploid cell line, 14bp deletion knock out of TAOK1 in haploid cell line, 2bp deletion HG 29-15 HG 29-20 TAOK2 TAOK2 KO TAOK2 KO HAP1 HAP1 knock out of TAOK2 in haploid cell line, 1bp deletion knock out of TAOK2 in haploid cell line, 5bp deletion HG 30-10 HG 30-2 TAOK3 TAOK3 KO TAOK3 KO TAOK3 KO HAP1 HAP1 HAP1 knock out of TAOK3 in haploid cell line, 5bp deletion knock out of TAOK3 in haploid cell line, 5bp deletion knock out of TAOK3 in haploid cell line, 7bp deletion HG 71-13 HG 71-14 HG 71-16 TARBP2 TARBP2 KO HAP1 knock out of TARBP2 in haploid cell line, 11bp deletion HG 516-1 54 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 55 Genotype Cell Line Description Catalogue ID TARBP2 TARBP2 KO HAP1 knock out of TARBP2 in haploid cell line, 11bp deletion HG 516-8 TBCK TBCK KO HAP1 knock out of TBCK in haploid cell line, 11bp deletion HG 267-23 TBK1 TBK1 KO TBK1 KO HAP1 HAP1 knock out of TBK1 in haploid cell line, 2bp deletion knock out of TBK1 in haploid cell line, 2bp insertion HG 31-10 HG 31-12 TDG TDG KO TDG KO HAP1 HAP1 knock out of TDG in haploid cell line, 2bp insertion knock out of TDG in haploid cell line, 109bp insertion HG 632-8 HG 632-9 TDP1 TDP1 KO TDP1 KO TDP1 KO HAP1 HAP1 HAP1 knock out of TDP1 in haploid cell line, 2bp insertion knock out of TDP1 in haploid cell line, 13bp deletion knock out of TDP1 in haploid cell line, 1bp insertion HG 423-3 HG 423-5 HG 423-6 TEC TEC KO HAP1 knock out of TEC in haploid cell line, 187bp deletion HG 1272-19 TESK1 TESK1 KO TESK1 KO HAP1 HAP1 knock out of TESK1 in haploid cell line, 5bp deletion knock out of TESK1 in haploid cell line, 8bp deletion HG 294-13 HG 294-8 TESK2 TESK2 KO TESK2 KO HAP1 HAP1 knock out of TESK2 in haploid cell line, 4bp deletion knock out of TESK2 in haploid cell line, 7bp deletion HG 33-12 HG 33-2 TET1 TET1 KO TET1 KO HAP1 HAP1 knock out of TET1 in haploid cell line, 1bp insertion knock out of TET1 in haploid cell line, 20bp deletion HG 1121-10 HG 1121-2 TET2 TET2 KO TET2 KO TET2 KO HAP1 HAP1 HAP1 knock out of TET2 in haploid cell line, 19bp deletion knock out of TET2 in haploid cell line, 5bp deletion knock out of TET2 in haploid cell line, 2bp deletion HG 1091-10 HG 1091-12 HG 1091-9 TET3 TET3 KO TET3 KO TET3 KO HAP1 HAP1 HAP1 knock out of TET3 in haploid cell line, 154bp insertion knock out of TET3 in haploid cell line, 14bp deletion knock out of TET3 in haploid cell line, 122bp insertion HG 1112-10 HG 1112-4 HG 1112-8 TGFBR1 TGFBR1 KO TGFBR1 KO HAP1 HAP1 knock out of TGFBR1 in haploid cell line, 2bp insertion knock out of TGFBR1 in haploid cell line, 5bp deletion HG 34-11 HG 34-12 TGFBR2 TGFBR2 KO TGFBR2 KO TGFBR2 KO HAP1 HAP1 HAP1 knock out of TGFBR2 in haploid cell line, 7bp deletion knock out of TGFBR2 in haploid cell line, 13bp deletion knock out of TGFBR2 in haploid cell line, 2bp deletion HG 35-14 HG 35-15 HG 35-20 TLK1 TLK1 KO HAP1 knock out of TLK1 in haploid cell line, 26bp deletion HG 200-7 TM9SF1 TM9SF1 KO TM9SF1 KO HAP1 HAP1 knock out of TM9SF1 in haploid cell line, 2bp insertion knock out of TM9SF1 in haploid cell line, 16bp deletion HG 437-1 HG 437-2 TM9SF2 TM9SF2 KO TM9SF2 KO HAP1 HAP1 knock out of TM9SF2 in haploid cell line, 4bp deletion knock out of TM9SF2 in haploid cell line, 13bp deletion HG 439-5 HG 439-6 TM9SF3 TM9SF3 KO TM9SF3 KO HAP1 HAP1 knock out of TM9SF3 in haploid cell line, 5bp deletion knock out of TM9SF3 in haploid cell line, 8bp deletion HG 444-5 HG 444-6 TM9SF4 TM9SF4 KO TM9SF4 KO HAP1 HAP1 knock out of TM9SF4 in haploid cell line, 28bp deletion knock out of TM9SF4 in haploid cell line, 7bp deletion HG 441-10 HG 441-8 TMEM5 TMEM5 KO TMEM5 KO HAP1 HAP1 knock out of TMEM5 in haploid cell line, 17bp deletion knock out of TMEM5 in haploid cell line, 14bp deletion HG 511-11 HG 511-7 TMEM209 TMEM209 KO HAP1 knock out of TMEM209 in haploid cell line, 13bp deletion HG 817-10 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID TMEM209 TMEM209 KO HAP1 knock out of TMEM209 in haploid cell line, 28bp deletion HG 817-11 TNFRSF1A TNFRSF1A KO HAP1 knock out of TNFRSF1A in haploid cell line, 4bp deletion HG 2585-8 TNIK TNIK KO HAP1 knock out of TNIK in haploid cell line, 11bp deletion HG 709-2 TNK1 TNK1 KO HAP1 knock out of TNK1 in haploid cell line, 26bp deletion HG 177-2 TNK2 TNK2 KO HAP1 knock out of TNK2 in haploid cell line, 13bp deletion HG 2454-26 TOP1 TOP1 (+/-) TOP1 KO TOP1 KO NALM-6 HAP1 HAP1 Heterozygous knock-out of TOP1 knock out of TOP1 in haploid cell line, 8bp deletion knock out of TOP1 in haploid cell line, 23bp deletion HD 115-072 HG 1210-3 HG 1210-9 TOP2B TOP2B (-/-) NALM-6 Homozygous knock-out of TOP2B HD 115-061 TOX TOX KO TOX KO HAP1 HAP1 knock out of TOX in haploid cell line, 5bp deletion knock out of TOX in haploid cell line, 4bp deletion HG 1324-2 HG 1324-3 TP53 TP53 (S241F/sil); ATR (a2101g/+) DLD-1 HD R00-025 TP53 (+/sil); ATR (a2101g/a2101g) TP53 (S241F/sil); ATR (a2101g/a2101g) DLD-1 DLD-1 TP53 (-/-); CDK2 (-/-) TP53 (+/+); CHEK1 (+/-) TP53 (+/sil); CHEK1 (+/-) TP53 (-/-); CHEK1 (+/-) TP53 (S241F/sil); CHEK1 (S317A/-) HCT116 HCT116 DLD-1 HCT116 DLD-1 TP53 (-/-); CHEK2 (-/-) TP53 (+/+); CHEK2 (-/-) TP53 (-/-) TP53 (-/-) TP53 (-/-) TP53 (-/-) TP53 (-/-) TP53 (-/-); BRAF (V600E/+) HCT116 HCT116 NALM-6 MCF10A SW48 HCT116 RKO MCF10A TP53 (-/-); BRAF (V600K/+) MCF10A TP53 (-/-); EGFR (ΔE746-A750/+) MCF10A TP53 (-/-); EGFR (L858R/+) MCF10A TP53 (-/-); KRAS (G12V/+) MCF10A TP53 (-/-); PIK3CA (H1047R/+) MCF10A TP53 (+/-) TP53 (+/-) TP53 (+/-) TP53 (+/-) TP53 (+/sil) TP53 (R248W/-) TP53 (R248W/+) TP53 (R273H/+) TP53 (S241F/-) TP53 (sil/-) TP53 KO TP53 (-/-); XRCC5 (+/-) RKO NALM-6 HCT116 SW48 DLD-1 HCT116 HCT116 SW48 DLD-1 DLD-1 HAP1 HCT116 Heterozygous hypomorphic ATR mutation (Seckel); TP53 mutant (S241F) background Homozygous hypomorphic ATR mutation (Seckel); knock-in of wild type TP53 Homozygous hypomorphic ATR mutation (Seckel); TP53 mutant (S241F) background Double homozygous knock-out of CDK2 and TP53 Heterozygous knock-out of CHEK1; TP53 wild type background Heterozygous knock-out of CHEK1; knock-in of wild type TP53 Heterozygous knock-out of CHEK1; TP53 null background Heterozygous knock-in of phosphorylation site mutant and knock-out of wild type CHEK1; TP53 (S241F) mutant background Homozygous knock-out of CHEK2; TP53 null background Homozygous knock-out of CHEK2; TP53 wild type background Homozygous knock-out of TP53 Homozygous knock-out of TP53 Homozygous knock-out of TP53 Homozygous knock-out of TP53 Homozygous knock-out of TP53 Homozygous knock-out of TP53; heterozygous knockin of BRAF activating mutation (V600E) Homozygous knock-out of TP53; heterozygous knockin of BRAF activating mutation (V600K) Homozygous knock-out of TP53; heterozygous knockin of EGFR activating mutation (ΔE746-A750) Homozygous knock-out of TP53; heterozygous knockin of EGFR activating mutation (L858R) Homozygous knock-out of TP53; heterozygous knockin of KRAS activating mutation (G12V) Heterozygous knock-in of PIK3CA kinase domain activating mutation in TP53 (-/-) parental cell line Heterozygous knock-out of TP53 Heterozygous knock-out of TP53 Heterozygous knock-out of TP53 Heterozygous knock-out of TP53 Heterozygous knock-in of wild type TP53; second allele silenced Knock-in of mutant (R248W) TP53 and knock-out of wild type allele Heterozygous knock-in of mutant (R248W) TP53 Heterozygous knock-in of mutant (R273H) TP53 Knock-out of silenced TP53 allele Heterozygous knock-out of TP53 mutant (S241F) allele; second allele silenced knock out of TP53 in haploid cell line, 1bp insertion Heterozygous knock-out of XRCC5; homozygous knock-out of TP53 HD 202-001 HD 105-010 HD R02-016 HD R02-077 HD R00-026 HD R02-078 HD R00-007 HD R02-018 HD R02-017 HD 115-049 HD 101-005 HD 103-004 HD 104-001 HD 106-002 HD 101-024 HD 101-025 HD 101-029 HD 101-040 HD 101-027 HD 101-043 HD R05-009 HD 115-048 HD R02-037 HD R06-001 HD 105-005 HD 104-003 HD 104-002 HD 103-008 HD 105-014 HD 105-004 HG 1068-1 HD 115-101 56 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 57 Genotype Cell Line Description Catalogue ID TP53BP1 TP53BP1 KO TP53BP1 KO HAP1 HAP1 knock out of TP53BP1 in haploid cell line, 40bp deletion knock out of TP53BP1 in haploid cell line, 1bp deletion HG 413-10 HG 413-11 TRAF2 TRAF2 KO TRAF2 KO HAP1 HAP1 knock out of TRAF2 in haploid cell line, 20bp deletion knock out of TRAF2 in haploid cell line, 1bp insertion HG 2588-10 HG 2588-2 TRAF3 TRAF3 KO HAP1 knock out of TRAF3 in haploid cell line, 1bp insertion HG 2608-1 TRAF5 TRAF5 KO HAP1 knock out of TRAF5 in haploid cell line, 1bp deletion HG 2589-2 TRDMT1 TRDMT1 KO TRDMT1 KO TRDMT1 KO HAP1 HAP1 HAP1 knock out of TRDMT1 in haploid cell line, 1bp deletion knock out of TRDMT1 in haploid cell line, 1bp insertion knock out of TRDMT1 in haploid cell line, 1bp insertion HG 1019-10 HG 1019-11 HG 1019-8 TREX1 TREX1 KO TREX1 KO TREX1 KO HAP1 HAP1 HAP1 knock out of TREX1 in haploid cell line, 1bp insertion knock out of TREX1 in haploid cell line, 2bp deletion knock out of TREX1 in haploid cell line, 5bp deletion HG 419-10 HG 419-11 HG 419-20 TRIB1 TRIB1 KO HAP1 knock out of TRIB1 in haploid cell line, 25bp deletion HG 1267-24 TRIB2 TRIB2 KO TRIB2 KO TRIB2 KO HAP1 HAP1 HAP1 knock out of TRIB2 in haploid cell line, 1bp insertion knock out of TRIB2 in haploid cell line, 2bp deletion knock out of TRIB2 in haploid cell line, 242bp insertion HG 110-10 HG 110-17 HG 110-18 TRIB3 TRIB3 KO TRIB3 KO TRIB3 KO HAP1 HAP1 HAP1 knock out of TRIB3 in haploid cell line, 11bp deletion knock out of TRIB3 in haploid cell line, 4bp deletion knock out of TRIB3 in haploid cell line, 13bp deletion HG 111-10 HG 111-22 HG 111-9 TRIM24 TRIM24 KO TRIM24 KO HAP1 HAP1 knock out of TRIM24 in haploid cell line, 2bp deletion knock out of TRIM24 in haploid cell line, 14bp deletion HG 928-11 HG 928-4 TRIM28 TRIM28 KO TRIM28 KO HAP1 HAP1 knock out of TRIM28 in haploid cell line, 4bp deletion knock out of TRIM28 in haploid cell line, 7bp deletion HG 293-1 HG 293-3 TRIM33 TRIM33 KO HAP1 knock out of TRIM33 in haploid cell line, 13bp deletion HG 266-11 TRIM66 TRIM66 KO TRIM66 KO HAP1 HAP1 knock out of TRIM66 in haploid cell line, 20bp deletion knock out of TRIM66 in haploid cell line, 4bp deletion HG 951-12 HG 951-3 TRIO TRIO KO TRIO KO HAP1 HAP1 knock out of TRIO in haploid cell line, 1bp deletion knock out of TRIO in haploid cell line, 1bp deletion HG 359-7 HG 359-9 TSC1 TSC1 KO HAP1 knock out of TSC1 in haploid cell line, 2bp deletion HG 1290-11 TSC2 TSC2 KO TSC2 KO HAP1 HAP1 knock out of TSC2 in haploid cell line, 2bp deletion knock out of TSC2 in haploid cell line, 13bp deletion HG 1363-10 HG 1363-4 TSPAN13 TSPAN13 KO HAP1 knock out of TSPAN13 in haploid cell line, 10bp deletion HG 1100-2 TSSC1 TSSC1 KO TSSC1 KO TSSC1 KO HAP1 HAP1 HAP1 knock out of TSSC1 in haploid cell line, 1bp deletion knock out of TSSC1 in haploid cell line, 1bp deletion knock out of TSSC1 in haploid cell line, 5bp deletion HG 857-6 HG 857-7 HG 857-8 TSSK2 TSSK2 KO HAP1 knock out of TSSK2 in haploid cell line, 2bp deletion HG 701-10 TSSK3 TSSK3 KO HAP1 knock out of TSSK3 in haploid cell line, 16bp deletion HG 368-13 TSSK4 TSSK4 KO HAP1 knock out of TSSK4 in haploid cell line, 28bp deletion HG 367-16 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID TSSK4 TSSK4 KO HAP1 knock out of TSSK4 in haploid cell line, 1bp insertion HG 367-2 TTBK2 TTBK2 KO TTBK2 KO TTBK2 KO HAP1 HAP1 HAP1 knock out of TTBK2 in haploid cell line, 19bp deletion knock out of TTBK2 in haploid cell line, 11bp deletion knock out of TTBK2 in haploid cell line, 7bp deletion HG 113-1 HG 113-11 HG 113-21 TUBA1C TUBA1C KO TUBA1C KO HAP1 HAP1 knock out of TUBA1C in haploid cell line, 4bp deletion knock out of TUBA1C in haploid cell line, 10bp deletion HG 2323-1 HG 2323-10 TWF2 TWF2 KO TWF2 KO HAP1 HAP1 knock out of TWF2 in haploid cell line, 7bp deletion knock out of TWF2 in haploid cell line, 22bp deletion HG 114-4 HG 114-5 TYK2 TYK2 KO TYK2 KO HAP1 HAP1 knock out of TYK2 in haploid cell line, 1bp deletion knock out of TYK2 in haploid cell line, 1bp deletion HG 36-3 HG 36-8 TYRO3 TYRO3 KO TYRO3 KO TYRO3 KO HAP1 HAP1 HAP1 knock out of TYRO3 in haploid cell line, 4bp deletion knock out of TYRO3 in haploid cell line, 2bp insertion knock out of TYRO3 in haploid cell line, 8bp deletion HG 115-11 HG 115-15 HG 115-16 UBAC1 UBAC1 KO UBAC1 KO UBAC1 KO HAP1 HAP1 HAP1 knock out of UBAC1 in haploid cell line, 1bp insertion knock out of UBAC1 in haploid cell line, 1bp insertion knock out of UBAC1 in haploid cell line, 1bp deletion HG 992-1 HG 992-10 HG 992-3 UCHL1 UCHL1 KO UCHL1 KO HAP1 HAP1 knock out of UCHL1 in haploid cell line, 1bp insertion knock out of UCHL1 in haploid cell line, 1bp insertion HG 631-10 HG 631-2 UCHL3 UCHL3 KO UCHL3 KO HAP1 HAP1 knock out of UCHL3 in haploid cell line, 11bp deletion knock out of UCHL3 in haploid cell line, 19bp deletion HG 637-11 HG 637-3 UCP1 UCP1 KO HAP1 knock out of UCP1 in haploid cell line, 11bp deletion HG 1409-3 UHMK1 UHMK1 KO UHMK1 KO UHMK1 KO HAP1 HAP1 HAP1 knock out of UHMK1 in haploid cell line, 4bp deletion knock out of UHMK1 in haploid cell line, 2bp insertion knock out of UHMK1 in haploid cell line, 2bp deletion HG 178-10 HG 178-16 HG 178-22 UIMC1 UIMC1 KO UIMC1 KO HAP1 HAP1 knock out of UIMC1 in haploid cell line, 10bp deletion knock out of UIMC1 in haploid cell line, 23bp deletion HG 760-1 HG 760-10 ULK1 ULK1 (K46I/+cKO) DLD-1 HD 105-025 ULK1 KO HAP1 Conditional knock-out of allele 1 by introduction of cre-recombinase. Heterozygous knock-in of K46I point mutation into allele 2. knock out of ULK1 in haploid cell line, 1bp insertion ULK3 ULK3 KO ULK3 KO ULK3 KO HAP1 HAP1 HAP1 knock out of ULK3 in haploid cell line, 2bp deletion knock out of ULK3 in haploid cell line, 8bp deletion knock out of ULK3 in haploid cell line, 14bp deletion HG 11004-14 HG 11004-24 HG 11004-9 ULK4 ULK4 KO ULK4 KO ULK4 KO HAP1 HAP1 HAP1 knock out of ULK4 in haploid cell line, 4bp deletion knock out of ULK4 in haploid cell line, 10bp deletion knock out of ULK4 in haploid cell line, 19bp deletion HG 346-1 HG 346-16 HG 346-9 UNG UNG KO UNG KO HAP1 HAP1 knock out of UNG in haploid cell line, 10bp deletion knock out of UNG in haploid cell line, 28bp deletion HG 630-1 HG 630-7 USP1 USP1 KO USP1 KO HAP1 HAP1 knock out of USP1 in haploid cell line, 5bp deletion knock out of USP1 in haploid cell line, 11bp deletion HG 620-12 HG 620-5 USP2 USP2 KO USP2 KO HAP1 HAP1 knock out of USP2 in haploid cell line, 10bp deletion knock out of USP2 in haploid cell line, 13bp deletion HG 467-10 HG 467-6 USP3 USP3 KO HAP1 knock out of USP3 in haploid cell line, 2bp deletion HG 881-11 HG 72-11 58 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 59 Genotype Cell Line Description Catalogue ID USP3 USP3 KO HAP1 knock out of USP3 in haploid cell line, 1bp insertion HG 881-12 USP4 USP4 KO USP4 KO HAP1 HAP1 knock out of USP4 in haploid cell line, 29bp deletion knock out of USP4 in haploid cell line, 2bp insertion HG 470-11 HG 470-3 USP6 USP6 KO USP6 KO HAP1 HAP1 knock out of USP6 in haploid cell line, 2bp deletion knock out of USP6 in haploid cell line, 2bp deletion HG 628-11 HG 628-12 USP7 USP7 (-/-) USP7 (-/-) USP7 (+/-) USP7 KO USP7 KO DLD-1 HCT116 HCT116 HAP1 HAP1 Homozygous knock-out of USP7 Homozygous knock-out of USP7 Heterozygous knock-out of USP7 knock out of USP7 in haploid cell line, 1bp insertion knock out of USP7 in haploid cell line, 1bp insertion HD 115-028 HD R02-028 HD R02-029 HG 464-2 HG 464-3 USP8 USP8 KO USP8 KO HAP1 HAP1 knock out of USP8 in haploid cell line, 181bp insertion knock out of USP8 in haploid cell line, 98bp insertion HG 503-3 HG 503-5 USP9X USP9X KO USP9X KO HAP1 HAP1 knock out of USP9X in haploid cell line, 17bp deletion knock out of USP9X in haploid cell line, 16bp deletion HG 468-3 HG 468-7 USP10 USP10 KO HAP1 knock out of USP10 in haploid cell line, 8bp deletion HG 450-1 USP11 USP11 KO USP11 KO HAP1 HAP1 knock out of USP11 in haploid cell line, 2bp deletion knock out of USP11 in haploid cell line, 4bp deletion HG 494-2 HG 494-5 USP12 USP12 KO USP12 KO HAP1 HAP1 knock out of USP12 in haploid cell line, 19bp deletion knock out of USP12 in haploid cell line, 14bp deletion HG 493-1 HG 493-6 USP13 USP13 KO USP13 KO HAP1 HAP1 knock out of USP13 in haploid cell line, 19bp deletion knock out of USP13 in haploid cell line, 2bp deletion HG 453-5 HG 453-6 USP14 USP14 KO USP14 KO HAP1 HAP1 knock out of USP14 in haploid cell line, 62bp insertion knock out of USP14 in haploid cell line, 1bp deletion HG 497-2 HG 497-8 USP15 USP15 KO USP15 KO USP15 KO HAP1 HAP1 HAP1 knock out of USP15 in haploid cell line, 32bp deletion knock out of USP15 in haploid cell line, 16bp deletion knock out of USP15 in haploid cell line, 1bp deletion HG 451-1 HG 451-2 HG 451-3 USP16 USP16 KO USP16 KO HAP1 HAP1 knock out of USP16 in haploid cell line, 2bp deletion knock out of USP16 in haploid cell line, 7bp deletion HG 495-2 HG 495-7 USP18 USP18 KO HAP1 knock out of USP18 in haploid cell line, 4bp deletion HG 492-11 USP19 USP19 KO USP19 KO HAP1 HAP1 knock out of USP19 in haploid cell line, 25bp deletion knock out of USP19 in haploid cell line, 2bp insertion HG 491-2 HG 491-8 USP20 USP20 KO USP20 KO HAP1 HAP1 knock out of USP20 in haploid cell line, 5bp deletion knock out of USP20 in haploid cell line, 22bp deletion HG 460-8 HG 460-9 USP21 USP21 KO USP21 KO HAP1 HAP1 knock out of USP21 in haploid cell line, 4bp deletion knock out of USP21 in haploid cell line, 14bp deletion HG 459-1 HG 459-2 USP22 USP22 KO USP22 KO USP22 KO HAP1 HAP1 HAP1 knock out of USP22 in haploid cell line, 1bp insertion knock out of USP22 in haploid cell line, 1bp insertion knock out of USP22 in haploid cell line, 11bp deletion HG 461-10 HG 461-11 HG 461-9 USP24 USP24 KO USP24 KO HAP1 HAP1 knock out of USP24 in haploid cell line, 1bp insertion knock out of USP24 in haploid cell line, 1bp insertion HG 463-1 HG 463-11 USP25 USP25 KO HAP1 knock out of USP25 in haploid cell line, 1bp insertion HG 462-1 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID USP25 USP25 KO HAP1 knock out of USP25 in haploid cell line, 1bp insertion HG 462-2 USP27X USP27X KO HAP1 knock out of USP27X in haploid cell line, 1bp insertion HG 448-2 USP28 USP28 KO USP28 KO HAP1 HAP1 knock out of USP28 in haploid cell line, 7bp deletion knock out of USP28 in haploid cell line, 10bp deletion HG 499-5 HG 499-6 USP30 USP30 KO HAP1 knock out of USP30 in haploid cell line, 1bp insertion HG 465-2 USP31 USP31 KO USP31 KO HAP1 HAP1 knock out of USP31 in haploid cell line, 43bp deletion knock out of USP31 in haploid cell line, 10bp deletion HG 483-1 HG 483-9 USP32 USP32 KO USP32 KO HAP1 HAP1 knock out of USP32 in haploid cell line, 16bp deletion knock out of USP32 in haploid cell line, 227bp insertion HG 482-10 HG 482-9 USP33 USP33 KO USP33 KO HAP1 HAP1 knock out of USP33 in haploid cell line, 175bp insertion knock out of USP33 in haploid cell line, 2bp insertion HG 481-6 HG 481-8 USP34 USP34 KO HAP1 knock out of USP34 in haploid cell line, 2bp insertion HG 480-1 USP35 USP35 KO HAP1 knock out of USP35 in haploid cell line, 10bp deletion HG 613-12 USP38 USP38 KO USP38 KO HAP1 HAP1 knock out of USP38 in haploid cell line, 263bp insertion knock out of USP38 in haploid cell line, 1bp insertion HG 476-12 HG 476-4 USP40 USP40 KO USP40 KO HAP1 HAP1 knock out of USP40 in haploid cell line, 55bp insertion knock out of USP40 in haploid cell line, 16bp deletion HG 505-8 HG 505-9 USP42 USP42 KO HAP1 knock out of USP42 in haploid cell line, 4bp insertion HG 489-9 USP45 USP45 KO USP45 KO USP45 KO HAP1 HAP1 HAP1 knock out of USP45 in haploid cell line, 1bp insertion knock out of USP45 in haploid cell line, 1bp insertion knock out of USP45 in haploid cell line, 2bp insertion HG 910-1 HG 910-10 HG 910-4 USP46 USP46 KO USP46 KO HAP1 HAP1 knock out of USP46 in haploid cell line, 1bp insertion knock out of USP46 in haploid cell line, 1bp insertion HG 486-4 HG 486-5 USP47 USP47 KO USP47 KO HAP1 HAP1 knock out of USP47 in haploid cell line, 13bp deletion knock out of USP47 in haploid cell line, 7bp deletion HG 906-10 HG 906-11 USP48 USP48 KO USP48 KO HAP1 HAP1 knock out of USP48 in haploid cell line, 5bp deletion knock out of USP48 in haploid cell line, 2bp deletion HG 915-11 HG 915-12 USP49 USP49 KO USP49 KO HAP1 HAP1 knock out of USP49 in haploid cell line, 10bp deletion knock out of USP49 in haploid cell line, 16bp deletion HG 487-11 HG 487-6 USP53 USP53 KO USP53 KO HAP1 HAP1 knock out of USP53 in haploid cell line, 5bp insertion knock out of USP53 in haploid cell line, 4bp deletion HG 447-10 HG 447-7 USP54 USP54 KO HAP1 knock out of USP54 in haploid cell line, 2bp deletion HG 449-10 UTRN UTRN KO UTRN KO HAP1 HAP1 knock out of UTRN in haploid cell line, 14bp deletion knock out of UTRN in haploid cell line, 19bp deletion HG 1381-10 HG 1381-12 VCPIP1 VCPIP1 KO HAP1 knock out of VCPIP1 in haploid cell line, 2bp deletion HG 452-2 VPS26A VPS26A KO HAP1 knock out of VPS26A in haploid cell line, 5bp deletion HG 875-11 VPS35 VPS35 KO HAP1 knock out of VPS35 in haploid cell line, 2bp deletion HG 863-10 60 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 61 Genotype Cell Line Description Catalogue ID VPS35 VPS35 KO HAP1 knock out of VPS35 in haploid cell line, 11bp deletion HG 863-12 VPS36 VPS36 KO HAP1 knock out of VPS36 in haploid cell line, 20bp deletion HG 1070-11 VPS54 VPS54 KO VPS54 KO HAP1 HAP1 knock out of VPS54 in haploid cell line, 14bp deletion knock out of VPS54 in haploid cell line, 190bp insertion HG 854-12 HG 854-7 VRK1 VRK1 KO VRK1 KO VRK1 KO HAP1 HAP1 HAP1 knock out of VRK1 in haploid cell line, 11bp deletion knock out of VRK1 in haploid cell line, 2bp deletion knock out of VRK1 in haploid cell line, 4bp deletion HG 73-14 HG 73-19 HG 73-24 VRK2 VRK2 KO HAP1 knock out of VRK2 in haploid cell line, 7bp deletion HG 403-6 VRK3 VRK3 KO HAP1 knock out of VRK3 in haploid cell line, 1bp insertion HG 189-11 WDR24 WDR24 KO WDR24 KO HAP1 HAP1 knock out of WDR24 in haploid cell line, 17bp deletion knock out of WDR24 in haploid cell line, 64bp insertion HG 1282-11 HG 1282-7 WDR62 WDR62 KO WDR62 KO HAP1 HAP1 knock out of WDR62 in haploid cell line, 2bp deletion knock out of WDR62 in haploid cell line, 11bp deletion HG 408-10 HG 408-2 WDR73 WDR73 KO HAP1 knock out of WDR73 in haploid cell line, 10bp insertion HG 1033-1 WHAMM WHAMM KO HAP1 knock out of WHAMM in haploid cell line, 7bp deletion HG 1060-1 WHSC1 WHSC1 (+/-) WHSC1 (trans/-) WHSC1 KO KMS-11 KMS-11 HAP1 Knock-out of translocated WHSC1 allele in heterozygous parental cells Knock-out of non-translocated WHSC1 allele in heterozygous parental cells knock out of WHSC1 in haploid cell line, 1bp insertion HD 108-002 HD 108-001 HG 1116-1 WNK1 WNK1 KO HAP1 knock out of WNK1 in haploid cell line, 11bp deletion HG 802-3 WNK2 WNK2 KO WNK2 KO WNK2 KO HAP1 HAP1 HAP1 knock out of WNK2 in haploid cell line, 1bp insertion knock out of WNK2 in haploid cell line, 1bp insertion knock out of WNK2 in haploid cell line, 1bp insertion HG 622-10 HG 622-11 HG 622-12 WNK3 WNK3 KO WNK3 KO HAP1 HAP1 knock out of WNK3 in haploid cell line, 4bp deletion knock out of WNK3 in haploid cell line, 20bp deletion HG 38-13 HG 38-24 WRN WRN KO WRN KO WRN KO HAP1 HAP1 HAP1 knock out of WRN in haploid cell line, 17bp deletion knock out of WRN in haploid cell line, 1bp insertion knock out of WRN in haploid cell line, 1bp insertion HG 432-1 HG 432-2 HG 432-3 WT1 WT1 KO HAP1 knock out of WT1 in haploid cell line, 1bp insertion HG 126-20 XBP1 XBP1 KO XBP1 KO HAP1 HAP1 knock out of XBP1 in haploid cell line, 23bp deletion knock out of XBP1 in haploid cell line, 2bp deletion HG 1364-11 HG 1364-12 XIAP XIAP (-/Y) XIAP (-/Y) DLD-1 HCT116 Knock-out of X-linked XIAP allele in male parental cells Knock-out of X-linked XIAP allele in male parental cells HD R00-023 HD R02-047 XPA XPA KO XPA KO HAP1 HAP1 knock out of XPA in haploid cell line, 4bp deletion knock out of XPA in haploid cell line, 2bp deletion HG 433-1 HG 433-11 XPC XPC KO XPC KO XPC KO HAP1 HAP1 HAP1 knock out of XPC in haploid cell line, 2bp deletion knock out of XPC in haploid cell line, 4bp deletion knock out of XPC in haploid cell line, 10bp deletion HG 19996-1 HG 19996-16 HG 19996-7 XRCC4 XRCC4 (-/-) XRCC4 (+/-) HCT116 HCT116 Homozygous knock-out of XRCC4 Heterozygous knock-out of XRCC4 HD R02-076 HD R02-075 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines Genotype Cell Line Description Catalogue ID XRCC4 XRCC4 (+/-) XRCC4 KO hTERT RPE-1 HAP1 Heterozygous knock-out of XRCC4 knock out of XRCC4 in haploid cell line, 8bp deletion HD R10-004 HG 428-19 XRCC5 XRCC5 (+/-) XRCC5 (+/-) XRCC5 (+/-); TP53 (-/-) XRCC5 (+floxed/-) HCT116 NALM-6 HCT116 HCT116 HD 115-097 HD 115-102 HD 115-101 HD R02-055 XRCC5 (+floxed/-); LIG4 (-/-) HCT116 XRCC5 (+floxed/-); LIG4 (-/-) HCT116 XRCC5 (+floxed/-); RAD54B (+/-/-) HCT116 XRCC5 (+floxed/+) HCT116 Heterozygous knock-out of XRCC5 Heterozygous knock-out of XRCC5 Heterozygous knock-out of XRCC5; homozygous knock-out of TP53 Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; homozygous knock-out of LIG4 Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; homozygous knock-out of LIG4 Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; double knock-out of RAD54B in triploid parental cells Heterozygous flanking of XRCC5 exon 3 with LoxP sites XRCC6 XRCC6 (+/-); LIG4 (-/-) XRCC6 (+/-); PRKDC (-/-) XRCC6 (+/-) HCT116 HCT116 HCT116 Heterozygous knock-out of XRCC6; Homozygous knock-out of LIG4 Homozygous knock-out of PRKDC; heterozygous knock-out of XRCC6 Heterozygous knock-out of XRCC6 HD R02-064 HD R02-051 HD R02-053 YES1 YES1 KO YES1 KO YES1 KO HAP1 HAP1 HAP1 knock out of YES1 in haploid cell line, 17bp deletion knock out of YES1 in haploid cell line, 1bp deletion knock out of YES1 in haploid cell line, 1bp deletion HG 22696-1 HG 22696-13 HG 22696-7 ZAK ZAK KO ZAK KO ZAK KO HAP1 HAP1 HAP1 knock out of ZAK in haploid cell line, 11bp deletion knock out of ZAK in haploid cell line, 1bp insertion knock out of ZAK in haploid cell line, 17bp deletion HG 39-1 HG 39-15 HG 39-3 ZBTB33 ZBTB33 (-/Y) ZBTB33 KO ZBTB33 KO HCT116 HAP1 HAP1 Knock-out of X-linked ZBTB33 allele in male parental cells knock out of ZBTB33 in haploid cell line, 46bp deletion knock out of ZBTB33 in haploid cell line, 10bp deletion HD 115-034 HG 918-7 HG 918-8 ZDHHC1 ZDHHC1 KO HAP1 knock out of ZDHHC1 in haploid cell line, 4bp deletion HG 1791-12 ZDHHC2 ZDHHC2 KO ZDHHC2 KO HAP1 HAP1 knock out of ZDHHC2 in haploid cell line, 181bp insertion knock out of ZDHHC2 in haploid cell line, 2bp deletion HG 584-1 HG 584-3 ZDHHC3 ZDHHC3 KO HAP1 knock out of ZDHHC3 in haploid cell line, 10bp deletion HG 1792-10 ZDHHC4 ZDHHC4 KO ZDHHC4 KO ZDHHC4 KO HAP1 HAP1 HAP1 knock out of ZDHHC4 in haploid cell line, 1bp insertion knock out of ZDHHC4 in haploid cell line, 1bp insertion knock out of ZDHHC4 in haploid cell line, 2bp insertion HG 1794-1 HG 1794-5 HG 1794-7 ZDHHC5 ZDHHC5 KO ZDHHC5 KO HAP1 HAP1 knock out of ZDHHC5 in haploid cell line, 10bp deletion knock out of ZDHHC5 in haploid cell line, 2bp deletion HG 589-12 HG 589-8 ZDHHC6 ZDHHC6 KO ZDHHC6 KO HAP1 HAP1 knock out of ZDHHC6 in haploid cell line, 5bp deletion knock out of ZDHHC6 in haploid cell line, 2bp deletion HG 586-1 HG 586-2 ZDHHC7 ZDHHC7 KO HAP1 knock out of ZDHHC7 in haploid cell line, 2bp deletion HG 1796-10 ZDHHC8 ZDHHC8 KO HAP1 knock out of ZDHHC8 in haploid cell line, 1bp insertion HG 1799-11 ZDHHC9 ZDHHC9 KO HAP1 knock out of ZDHHC9 in haploid cell line, 14bp deletion HG 1801-12 ZDHHC12 ZDHHC12 KO ZDHHC12 KO HAP1 HAP1 knock out of ZDHHC12 in haploid cell line, 1bp insertion knock out of ZDHHC12 in haploid cell line, 25bp deletion HG 2445-10 HG 2445-9 ZDHHC13 ZDHHC13 KO HAP1 knock out of ZDHHC13 in haploid cell line, 13bp deletion HG 2447-11 HD R02-056 HD R02-057 HD R02-059 HD R02-054 62 X-MAN® X-MAN® You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Available Cell Lines 63 Genotype Cell Line Description Catalogue ID ZDHHC13 ZDHHC13 KO HAP1 knock out of ZDHHC13 in haploid cell line, 2bp deletion HG 2447-3 ZDHHC14 ZDHHC14 KO ZDHHC14 KO HAP1 HAP1 knock out of ZDHHC14 in haploid cell line, 7bp deletion knock out of ZDHHC14 in haploid cell line, 10bp deletion HG 2450-3 HG 2450-6 ZDHHC15 ZDHHC15 KO HAP1 knock out of ZDHHC15 in haploid cell line, 8bp deletion HG 2452-7 ZDHHC16 ZDHHC16 KO ZDHHC16 KO ZDHHC16 KO HAP1 HAP1 HAP1 knock out of ZDHHC16 in haploid cell line, 1bp insertion knock out of ZDHHC16 in haploid cell line, 2bp insertion knock out of ZDHHC16 in haploid cell line, 1bp deletion HG 1305-11 HG 1305-6 HG 1305-9 ZDHHC18 ZDHHC18 KO ZDHHC18 KO HAP1 HAP1 knock out of ZDHHC18 in haploid cell line, 2bp deletion knock out of ZDHHC18 in haploid cell line, 4bp deletion HG 1308-11 HG 1308-12 ZDHHC21 ZDHHC21 KO ZDHHC21 KO HAP1 HAP1 knock out of ZDHHC21 in haploid cell line, 8bp deletion knock out of ZDHHC21 in haploid cell line, 4bp deletion HG 1303-11 HG 1303-2 ZDHHC22 ZDHHC22 KO ZDHHC22 KO HAP1 HAP1 knock out of ZDHHC22 in haploid cell line, 1bp deletion knock out of ZDHHC22 in haploid cell line, 1bp deletion HG 1803-1 HG 1803-10 ZDHHC23 ZDHHC23 KO HAP1 knock out of ZDHHC23 in haploid cell line, 19bp deletion HG 1805-12 ZDHHC24 ZDHHC24 KO HAP1 knock out of ZDHHC24 in haploid cell line, 13bp deletion HG 1806-10 ZFYVE1 ZFYVE1 KO ZFYVE1 KO ZFYVE1 KO HAP1 HAP1 HAP1 knock out of ZFYVE1 in haploid cell line, 14bp deletion knock out of ZFYVE1 in haploid cell line, 2bp deletion knock out of ZFYVE1 in haploid cell line, 8bp deletion HG 301-13 HG 301-21 HG 301-23 ZMIZ2 ZMIZ2 KO ZMIZ2 KO HAP1 HAP1 knock out of ZMIZ2 in haploid cell line, 14bp deletion knock out of ZMIZ2 in haploid cell line, 2bp deletion HG 2513-4 HG 2513-8 ZMYM3 ZMYM3 KO ZMYM3 KO ZMYM3 KO HAP1 HAP1 HAP1 knock out of ZMYM3 in haploid cell line, 74bp insertion knock out of ZMYM3 in haploid cell line, 2bp deletion knock out of ZMYM3 in haploid cell line, 1bp deletion HG 1118-2 HG 1118-4 HG 1118-9 ZMYND8 ZMYND8 KO ZMYND8 KO HAP1 HAP1 knock out of ZMYND8 in haploid cell line, 8bp deletion knock out of ZMYND8 in haploid cell line, 10bp deletion HG 930-3 HG 930-6 ZMYND11 ZMYND11 KO ZMYND11 KO HAP1 HAP1 knock out of ZMYND11 in haploid cell line, 31bp deletion knock out of ZMYND11 in haploid cell line, 4bp deletion HG 936-3 HG 936-4 ZNF267 ZNF267 KO ZNF267 KO HAP1 HAP1 knock out of ZNF267 in haploid cell line, 2bp insertion knock out of ZNF267 in haploid cell line, 11bp deletion HG 2324-4 HG 2324-5 ZNF764 ZNF764 KO ZNF764 KO ZNF764 KO HAP1 HAP1 HAP1 knock out of ZNF764 in haploid cell line, 1bp insertion knock out of ZNF764 in haploid cell line, 1bp insertion knock out of ZNF764 in haploid cell line, 20bp deletion HG 2326-1 HG 2326-10 HG 2326-8 ZRANB1 ZRANB1 KO ZRANB1 KO HAP1 HAP1 knock out of ZRANB1 in haploid cell line, 14bp deletion knock out of ZRANB1 in haploid cell line, 128bp insertion HG 485-7 HG 485-9 X-MAN® X-MAN® In Development Cell Lines You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description Catalogue ID APC APC (wtinducible) HT-29 Overexpression of wild type APC induced in the presence of zinc HD R03-001 ARID1A ARID1A (Q456*/+) MCF10A Heterozygous knock-out of ARID1A by knock-in of premature stop codon (Q456*) HD 101-020 BAX BAX (+/-) HCT116 Heterozygous knock-out of BAX HD R02-009 BHLHE40 BHLHE40 (+/-) HACAT Heterozygous knock-out of BHLHE40 HD R01-002 BLM BLM (-/-); TP53 (-/-) NALM-6 Double homozygous knock-out of BLM and TP53 HD 115-091 CDKN1A CDKN1A (+/-) CDKN1A (-/-); SFN (-/-) HCT116 HCT116 Heterozygous knock-out of CDKN1A Double homozygous knock-out of SFN and CDKN1A HD R02-036 HD R02-003 CHEK1 CHEK1 (+/-); TP53 (S241F/sil) DLD-1 Heterozygous knock-out of CHEK1; TP53 (S241F) mutant background HD R00-027 FANCC FANCC (+/+/-) RKO Knock-out of single FANCC allele in triploid parental cells HD R05-003 FBXW7 FBXW7 (-/-) FBXW7 (+/-) HCT116 HCT116 HD 104-069 HD R02-014 FBXW7α (-/-) FBXW7β (-/-) FBXW7γ (-/-) HCT116 HCT116 HCT116 Homoygous knock-out of FBXW7 Heterozygous knock-out of FBXW7 exon 5 which encodes F-box domain of the protein Homoygous knock-out of FBXW7 alpha isoform Homoygous knock-out of FBXW7 beta isoform Homoygous knock-out of FBXW7 gamma isoform HPRT1 HPRT (-/Y) HCT116 Knock-out of X-linked HPRT allele in male parental cells HD R02-052 KDM5A KDM5A (+/-) HCT116 Heterozygous knock-out of KDM5A post-cre of 1st allele selection cassette HD 104-085 LIG1 LIG1 (+/-) NALM-6 Heterozygous knock-out of LIG1 HD 115-066 LIG3 LIG3 (+floxed/+) HCT116 Heterozygous flanking of LIG3 exon 4 with LoxP sites HD R02-060 LIG4 LIG4 (-/-); RAD54B (+/+/-) HCT116 HD R02-065 LIG4 (-/-); RAD54L (+/-) LIG4 (-/-); TDP1 (+/-) LIG4 (-/-); TOP2B (+/-) NALM-6 NALM-6 NALM-6 Homozygous knock-out of LIG4; single knock-out of RAD54B in triploid parental cells Homozygous knock-out of LIG4; heterozygous knock-out of RAD54L Homozygous knock-out of LIG4; heterozygous knock-out of TDP1 Homozygous knock-out of LIG4; heterozygous knock-out of TOP2B MCTS1 MCTS1 (-/Y) HCT116 Knock-out of X-linked MCTS1 allele in male parental cells HD 115-094 MET MET (Δexon16/Δexon16) DLD-1 Homozygous double knockout of exon 16 in MET resulting in a kinase dead receptor. HD 115-093 MTOR MTOR (D2338A/+) HCT116 Heterozygous knock-in of kinase-dead mutation D2338A HD 104-043 Non-coding SNPs 8q24 rs6983267 (T/T/T) MCF10A Heterozygous introduction of non-coding SNP rs6983267 HD 101-047 PPARD PPARD (+/-) HCT116 Homozygous knock-out of PPARD HD R02-039 PRKAB1 PRKAB1 (T183A/+) RKO Heterozygous knock-in of PRKAB1 kinase-dead mutation (T183A) HD 106-008 PTEN PTEN (+/-) MCF10A Heterozygous knock-out of PTEN HD R11-001 PTTG1 PTTG1 (+/-) HCT116 Heterozygous knock-out of PTTG1 HD R02-044 PXN PXN (Y88F/Y88F) DLD-1 Homozygous knock-in of PXN Y88F mutation HD 115-029 HD 104-070 HD 104-071 HD 104-072 HD 115-074 HD 115-086 HD 115-088 64 X-MAN® X-MAN® In Development Cell Lines 65 You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description Catalogue ID PXN PXN (Y88F/Y88F) HCT116 Homozygous knock-in of PXN Y88F mutation HD 115-030 RAD54B RAD54B (+/+/-); LIG4 (-/-) HCT116 HD R02-065 RAD54B (+/-/-); XRCC5 (+floxed/-) HCT116 Homozygous knock-out of LIG4; single knock-out of RAD54B in triploid parental cells Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; double knock-out of RAD54B in triploid parental cells RAD54L RAD54L (+/-); LIG4 (-/-) RAD54L (+/-) NALM-6 NALM-6 Homozygous knock-out of LIG4; heterozygous knock-out of RAD54L Heterozygous knock-out of RAD54L HD 115-074 HD 115-042 RB1 RB1 (c2520+3G>T/+) hTERT RPE-1 Heterozygous knock-in of disease-relevant de novo c2520+3G>T mutation HD 102-004 S100A4 S100A4 (+/-) HCT116 Heterozygous knock-out of S100A4 HD 115-095 SFN SFN (-/-); CDKN1A (-/-) SFN (+/-) HCT116 HCT116 Double homozygous knock-out of SFN and CDKN1A Heterozygous knock-out of SFN HD R02-003 HD R02-002 SGK3 SGK3 (shRNA resistant/+) LS513 Heterozygous knock-in of SGK3 shRNA rescue sequence HD 143-001 SMAD4 SMAD4 (+/-) HCT116 Heterozygous knock-out of SMAD4 HD R02-046 STAT3 STAT3 (-/-) STAT3 (Y705F/Y705F) DLD-1 RKO Homozygous knock-out of STAT3 Homozygous knock-in of STAT3 Y705F mutation HD 115-017 HD 115-019 TDP1 TDP1 (+/-); LIG4 (-/-) TDP1 (+/-) NALM-6 NALM-6 Homozygous knock-out of LIG4; heterozygous knock-out of TDP1 Heterozygous knock-out of TDP1 HD 115-086 HD 115-056 TOP2B TOP2B (+/-); LIG4 (-/-) NALM-6 Homozygous knock-out of LIG4; heterozygous knock-out of TOP2B HD 115-088 TP53 TP53 (S241F/sil); CHEK1 (+/-) TP53 (-/-); BLM (-/-) DLD-1 NALM-6 Heterozygous knock-out of CHEK1; TP53 (S241F) mutant background Double homozygous knock-out of BLM and TP53 HD R00-027 HD 115-091 XRCC5 XRCC5 (+/-) + XRCC5 cDNA HCT116 HD 115-099 XRCC5 (+floxed/-); RAD54B (+/-/-) HCT116 Heterozygous knock-out of endogenous XRCC5 with overexpression of wild type XRCC5 Knock-out of single XRCC5 allele and flanking of exon 3 in remaining allele with LoxP sites; double knock-out of RAD54B in triploid parental cells XRCC6 XRCC6 (+/-) NALM-6 Heterozygous knock-out of XRCC6 HD R08-002 HD R02-058 HD R02-058 X-MAN® X-MAN® Available Tagged and Reporter Cell Lines You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description Catalogue ID APC APC (+SBP-DYKDDDDK/+) HCT116 Heterozygous SBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous APC HD 115-001 ASF1A ASF1A (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous ASF1 HD 115-003 BAZ2A BAZ2A (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous BAZ2A HD 115-004 BMI1 BMI1 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous BMI1 HD 115-005 BRAF BRAF (+CBP-DYKDDDDK/V600E/V600E) RKO HD 115-027 BRAF (V600E CBP-DYKDDDDK/V600E/+) RKO Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous wild type BRAF Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous mutant BRAF CHD2 CHD2 (+CBP-DYKDDDDK/+) DLD-1 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous CHD2 HD 115-035 DOT1L DOT1L (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous DOT1L HD 115-006 E2F1 E2F1 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous E2F1 HD 115-009 EED EED (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous EED HD 115-007 EZH2 EZH2 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous EZH2 HD 115-008 IDH1 IDH1 (+SBP-DYKDDDDK/+) HCT116 Heterozygous SBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous IDH1 HD 115-002 MRE11A MRE11A (+CBP-DYKDDDDK/+) RKO Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous MRE11A HD 115-020 PTPN14 PTPN14 (+CBP-DYKDDDDK/+CBP-DYKDDDDK) DLD-1 Homozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous PTPN14 HD 115-022 STAT3 STAT3 (+CBP-DYKDDDDK/+) DLD-1 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous STAT3 HD 115-015 TRIM37 TRIM37 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous TRIM37 HD 115-013 ZBTB33 ZBTB33 (+SBP-DYKDDDDK/Y) HCT116 Heterozygous SBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous X-linked ZBTB33 allele in male parental cells HD 115-033 ZCCHC4 ZCCHC4 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous ZCCHC4 HD 115-014 HD 115-026 66 X-MAN® X-MAN® In Development Tagged and Reporter Cell Lines 67 You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description Catalogue ID C20orf20 MRGBP (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous MRGBP HD 115-010 CHD7 CHD7 (+CBP-DYKDDDDK/+) DLD-1 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous CHD7 HD 115-036 CHD8 CHD8 (+SBP-DYKDDDDK/+) DLD-1 Heterozygous SBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous CHD8 HD 115-037 DNMT1 DNMT1 (+CBP-DYKDDDDK/+) RKO Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous DNMT1 HD 115-023 DNMT3B DNMT3B (+CBP-DYKDDDDK/+) RKO Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous DNMT3B HD 115-024 RCOR2 RCOR2 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous RCOR2 HD 115-011 SIRT6 SIRT6 (+CBP-DYKDDDDK/+) HCT116 Heterozygous CBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous SIRT6 HD 115-012 UHRF1 UHRF1 (+SBP-DYKDDDDK/+) HCT116 Heterozygous SBP-DYKDHD-G-DYKDHD-I-DYKDDDDK-tagged endogenous UHRF1 HD 115-025 X-MAN® X-MAN® Available X-MAN® NanoLuc® Reporter Kits You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description X-MAN® MYC NanoLuc®-PEST promoter reporter X-MAN® CDKN1A NanoLuc®-PEST promoter reporter X-MAN® CTNNB1 (+NanoLuc®/+) protein reporter X-MAN® HIF1A (+NanoLuc®/+) protein reporter X-MAN® NFE2L2 (+NanoLuc®/+) protein reporter X-MAN® GLI1 NanoLuc®-PEST promoter reporter X-MAN® HIF1A NanoLuc®-PEST promoter reporter X-MAN® HMGCR (+NanoLuc®/+) protein reporter HCT116 HCT116 RKO HCT116 HCT116 HCT116 HCT116 HCT116 Heterozygous (3n) MYC NanoLuc®-PEST promoter trap reporter Heterozygous CDKN1A NanoLuc®-PEST promoter trap reporter Heterozygous C-Terminal NanoLuc® fusion to wild type Heterozygous C-Terminal NanoLuc® fusion to wild type Heterozygous C-Terminal NanoLuc® fusion to wild type Heterozygous GLI1 NanoLuc®-PEST promoter trap reporter Heterozygous HIF1A NanoLuc®-PEST promoter trap reporter Heterozygous C-Terminal NanoLuc® fusion to wild type Catalogue ID Contact Us Contact Us Contact Us Contact Us Contact Us Contact Us Contact Us Contact Us 68 X-MAN® X-MAN® Available X-MAN® HaloTag® Reporter Kits 69 You can order online: www.horizondiscovery.com Email: [email protected] or Tel: +1 (844) 655 7800 Genotype Cell Line Description X-MAN® HIF1A (+HaloTag®/+) protein reporter X-MAN® NFE2L2 (+HaloTag®/+) protein reporter X-MAN® KRAS (G12CHaloTag®/+) protein reporter X-MAN® KRAS (G12VHaloTag®/+) protein reporter X-MAN® KRAS (G13DHaloTag®/+) protein reporter X-MAN® KRAS (+HaloTag®/+) protein reporter X-MAN® KRAS (G12DHaloTag®/+) protein reporter HCT116 HCT116 SW48 SW48 SW48 SW48 SW48 Heterozygous C-Terminal HaloTag® Heterozygous C-Terminal HaloTag® Heterozygous N-Terminal HaloTag® Heterozygous N-Terminal HaloTag® Heterozygous N-Terminal HaloTag® Heterozygous N-Terminal HaloTag® Heterozygous N-Terminal HaloTag® Catalogue ID fusion to wild type fusion to wild type NFE2L2 fusion to KRAS activating mutation (G12C) fusion to KRAS activating mutation (G12V) fusion to KRAS activating mutation (G13D) fusion to wild type fusion to KRAS activating mutation (G12D) Contact Us Contact Us Contact Us Contact Us Contact Us Contact Us Contact Us Pricing We ship direct to the USA, Canada, UK and parts of Europe and work closely with distributors in a number of countries to provide a service which is local to you, please contact us at [email protected] for more information. For direct shipments we aim to ship your order direct within 5 business days and we will notify you of your expected delivery date. X-MAN® Cell Lines Product Customer type Off-The-Shelf Cell Lines Price USD ($) Academic pricing $990 Commercial < 250 employees $3,465 Commercial > 250 employees $6,930 Customer type Price USD ($) Academic pricing $1,980* Commercial < 250 employees $4,900 Commercial > 250 employees $9,800 No. of Reactions Price USD ($) X-MAN® Custom Haploid Knockout Service Product Custom HAP1 Knockout Service All cells are sold with a wild type matched control - *Includes a free off the shelf HAP1 X-MAN® Nanoluc® Reporter Kits X-MAN® NanoLuc® Reporter Kit Volume 10ml 100 (in 96-well plates) $550 100ml 1,000 (in 96-well plates) $1,250 500ml 5,000 (in 96-well plates) $3,250 1,000 ml 10,000 (in 96-well plates) $5,500 Volume No. of Reactions Price USD ($) Imaging (TMR or Oregon Green) 15µl 150 (in 96-well plates) $950 Imaging (TMR or Oregon Green) 30 µl 300 (in 96-well plates) $1,250 X-MAN® HaloTag® Reporter Kits X-MAN® HaloTag® Reporter Kit Ligand Protein Pull-Down 24 Reactions $990 For information on custom services or for any of our gene-editing products and services visit www.horizondiscovery.com 706 How Order Howtoto Order Online Our online catalog and ordering system can be used to search our full menu of available products. Select your desired X-MAN® Cell Lines and add them to the shopping basket. Your order can be submitted instantly using credit card, telephone ordering or a purchase order number as the preferred payment method. Shipping cost detailed at checkout - Cost ranges from $65 - $350 depending on destination We accept the following cards: Offline If you prefer to send us orders outside our online ordering system, please use the contact details below for telephone, fax, and email ordering. To order offline we will require the following information: • • • • • • Product code(s) of the item(s) you wish to order (e.g. “HD123”) Your name, email address, title and organization Shipping address and billing address with contact names Purchase Order number if you have one Telephone number VAT Number (European Countries only) For general enquiries: Telephone Fax Email UK USA UK +44 (0)1223 655 581 USA +1 (800) 860 3546 [email protected] (Information) [email protected] (Orders) +44 (0)1223 655 580 +1 (844) 655 7800 Horizon Discovery 7100 Cambridge Research Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom
Related documents