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January 11, 2012 To whom it may concern NanoCarrier Co., Ltd. Ichiro Nakatomi, Ph.D., President & CEO (Code No.; 4571 Tokyo Stock Exchange Mothers) Contact: Takuma Nakatsuka, CFO and Director Administration, Head of President’s Office TEL. +81-3-3548-0217 Substance Patent of Nucleic Acid Delivery Technology was allowed in Japan A patent application regarding a drug carrier for the nucleic acids* delivery was allowed on the basis of an notice of allowance* by the Japanese patent office. NanoCarrier and Kyoto University proceeds a basic research regarding a next generation platform technology in relation to a polymeric carrier for an “artificial RNA system” on a basis of the Research Collaboration Agreement. We, therefore, obtain a substance patent that is applicable to the platform delivery technology for such nucleic acids due to the allowance in Japan. Title of the invention: PARTICULATE COMPOSITION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME Patent application number: 2011-528907 Patentee: NanoCarrier Co., Ltd. Biotechnology-based drugs such as a nucleic acid are widely recognized as the next generation drugs. However, the stability of such nucleic acids in body is very low and accordingly the utilization of a carrier is inevitable to deliver appropriately to the target cells, the development of a great potential carrier is now anticipated. The Research Collaboration Agreement is intended to develop a novel nucleic acid pharmaceutical due to a combination of the NanoCarrier’s polymeric micelle and the Kyoto University’s novel nucleic acid system as is released on August 9, 2011 (http://www.nanocarrier.co.jp/en/news/topics/pdf/e20110809_2.pdf) and we are running a chemosynthesis and drug efficiency evaluation of the novel pharmaceutical. The financial forecast for the FY 2012 (April 2011~ March 2012) will not be affected by the allowance. * Nucleic acids: A drug candidate constituting of nucleic acids such as DNA and RNA. *Notice of Allowance: An official letter from the patent office that shows a good prosecution result when the patent application is evaluated as a valuable invention to be granted. A patent right will be granted to the applicant when the notice of allowance is issued and the patent registration fee is paid in by the applicant.