Download Xue Y, Clopton P, Peacock WF, Maisel AS. Serial changes in high

Supplemental Material.
Supplemental Data 1. Table 1 – References.
Perna ER, Macin SM, Cimbaro Canella JP, Alvarenga PM, Ríos NG, Pantich R, et al. Minor
myocardial damage detected by troponin T is a powerful predictor of long-term prognosis in
patients with acute decompensated heart failure. Int J Cardiol 2005;99:253-61.
Rudiger A, Harjola VP, Müller A, Mattila E, Säila P, Nieminen M, Follath F. Acute heart failure:
clinical presentation, one-year mortality and prognostic factors. Eur J Heart Fail 2005;7:66270.
Metra M, Nodari S, Parrinello G, Specchia C, Brentana L, Rocca P, et al. The role of plasma
biomarkers in acute heart failure. Serial changes and independent prognostic value of NTproBNP and cardiac troponin-T. Eur J Heart Fail 2007;9:776-86.
Sakhuja R, Green S, Oestreicher EM, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB,
Januzzi JL Jr.. Amino-terminal pro-brain natriuretic peptide, brain natriuretic peptide, and
troponin T for prediction of mortality in acute heart failure. Clin Chem 2007;53:412-20.
You JJ, Austin PC, Alter DA, Ko DT, Tu JV. Relation between cardiac troponin i and mortality in
acute decompensated heart failure. Am Heart J 2007;153:462-70.
Nishio Y, Sato Y, Taniguchi R, Shizuta S, Doi T, Morimoto T, et al.Cardiac troponin T vs other
biochemical markers in patients with congestive heart failure. Circ J 2007;71:631-5.
Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, et al. Heart-type fatty
acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial
damage in chronic heart failure patients. J Card Fail 2007;13:120-7.
Peacock WF, De Marco T, Fonarow GC, Diercks D, Wynne J, Apple FS, Wu AH, et al. Cardiac
troponin and outcome in acute heart failure. N Engl J Med 2008;358:2117-26.
Ilva T, Lassus J, Siirilä-Waris K, Melin J, Peuhkurinen K, Pulkki K, et al. Clinical significance of
cardiac troponins I and T in acute heart failure. Eur J Heart Fail 2008;10:772-9.
Zairis MN, Tsiaousis GZ, Georgilas AT, Makrygiannis SS, Adamopoulou EN, Handanis SM, et
al. Multimarker strategy for the prediction of 31 days cardiac death in patients with acutely
decompensated chronic heart failure. Int J Cardiol 2010;141:284-90.
Xue Y, Clopton P, Peacock WF, Maisel AS. Serial changes in high-sensitive troponin I predict
outcome in patients with decompensated heart failure. Eur J Heart Fail 2011;13:37-42.
Braga JR, Tu JV, Austin PC, Chong A, You JJ, Farkouh ME, et al. Outcomes and care of patients
with acute heart failure syndromes and cardiac troponin elevation. Circ Heart Fail
2013;6:193-202.
1
Guisado Espartero ME, Salamanca-Bautista P, Aramburu-Bodas O, Arias-Jimenez JL, Formiga
F, Roca-Villanueva B, et al. Troponin T in acute heart failure: clinical implications and
prognosis in the Spanish National Registry on Heart Failure. Eur J Intern Med 2014;25:73944.
Le Corvoisier P, Bastuji-Garin S, Renaud B, Mahé I, Bergmann JF, Perchet H, et al. Functional
status and co-morbidities are associated with in-hospital mortality among older patients
with acute decompensated heart failure: a multicentre prospective cohort study. Age Ageing
2015;44:225-31.
Nakamura Y, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, et al. High-sensitivity
cardiac troponin T predicts non-cardiac mortality in heart failure. Circ J 2014;78:890-5.
Felker GM, Mentz RJ, Teerlink JR, Voors AA, Pang PS, Ponikowski P, et al. Serial high
sensitivity cardiac troponin T measurement in acute heart failure: insights from the RELAXAHF study. Eur J Heart Fail 2015;17:1262-70.
Diez M, Talavera ML, Conde DG, Campos R, Acosta A, Trivi MS. High-sensitivity troponin is
associated with high risk clinical profile and outcome in acute heart failure. Cardiol J
2016;23:78-83.
2
Supplemental Data 2. Table 2 – References.
Kerr G, Ray G, Wu O, Stott DJ, Langhorne P. Elevated troponin after stroke: a systematic
review. Cerebrovasc Dis 2009;28:220-6.
Jensen JK, Ueland T, Aukrust P, Antonsen L, Kristensen SR, Januzzi JL, Ravkilde J. Highly
sensitive troponin T in patients with acute ischemic stroke. Eur Neurol 2012;68:287-93.
Faiz KW, Thommessen B, Einvik G, Brekke PH, Omland T, Ronning OM. Determinants of high
sensitivity cardiac troponin T elevation in acute ischemic stroke. BMC Neurol 2014;14:96.
Scheitz JF, Mochmann HC, Erdur H, Tütüncü S, Haeusler KG, Grittner U, et al. Prognostic
relevance of cardiac troponin T levels and their dynamic changes measured with a highsensitivity assay in acute ischaemic stroke: analyses from the TRELAS cohort. Int J Cardiol
2014;177:886-93.
Levy M, Heels-Ansdell D, Hiralal R, Bhandari M, Guyatt G, Yusuf S, et al. Prognostic value of
troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac
surgery: a systematic review and meta-analysis. Anesthesiology 2011;114:796-806.
Beattie WS, Karkouti K, Tait G, Steel A, Yip P, McCluskey S, et al. Use of clinically based
troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort
study in 51,701 consecutive patients. Can J Anaesth 2012;59:1013-22.
Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, et al. Association
between postoperative troponin levels and 30-day mortality among patients undergoing
noncardiac surgery. JAMA 2012;307:2295-304.
van Waes JA, Nathoe HM, de Graaff JC, Kemperman H, de Borst GJ, Peelen LM, et al.
Myocardial injury after noncardiac surgery and its association with short-term mortality.
Circulation 2013;127:2264-71.
Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, et al. Myocardial injury
after noncardiac surgery: a large, international, prospective cohort study establishing
diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology
2014;120:564-78.
van Waes JA, Grobben RB, Nathoe HM, Kemperman H, de Borst GJ, Peelen LM, et al. OneYear Mortality, Causes of Death, and Cardiac Interventions in Patients with Postoperative
Myocardial Injury [Epub ahead of print] Anesth Analg Apr 22, 2016 as PMID:27111647.
3
Supplemental Data 3. Table 3 – References.
Horwich TB, Patel J, MacLellan WR, Fonarow GC. Cardiac troponin I is associated with
impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality
rates in advanced heart failure. Circulation 2003;108:833-8.
Hudson MP, O'Connor CM, Gattis WA, Tasissa G, Hasselblad V, Holleman CM, et al.
Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a
prospective analysis. Am Heart J 2004;147:546-52.
Stanton EB, Hansen MS, Sole MJ, Gawad Y, Packer M, Pitt B, et al. Cardiac troponin I, a
possible predictor of survival in patients with stable congestive heart failure. Can J Cardiol
2005;21:39-43.
Taniguchi R, Sato Y, Nishio Y, Kimura T, Kita T. Measurements of baseline and follow-up
concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart
failure from various etiologies. Heart Vessels 2006;21:344-9.
Latini R, Masson S, Anand IS, Missov E, Carlson M, Vago T, et al. Prognostic value of very low
plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation
2007;116:1242-49.
Miller WL, Hartman KA, Burritt MF, Grill DE, Rodeheffer RJ, Burnett JC Jr, Jaffe AS. Serial
biomarker measurements in ambulatory patients with chronic heart failure: the importance
of change over time. Circulation 2007;116:249-57.
Setsuta K, Seino Y, Kitahara Y, Arau M, Ohbayashi T, Takano T, Mizuno K. Elevated levels of
both cardiomyocyte membrane and myofibril damage markers predict adverse outcomes in
patients with chronic heart failure. Circ J 2008;72:569-74.
Orea-Tejeda A, Sánchez-González LR, Castillo-Martínez L, Valdespino-Trejo A, SánchezSantillán RN, Keirns-Davies C, et al. Prognostic value of cardiac troponin T elevation is
independent of renal function and clinical findings in heart failure patients. Cardiol J
2010;17:42-8.
Tsutamoto T, Kawahara C, Nishiyama K, Yamaji M, Fujii M, Yamamoto T, Horie M. Prognostic
role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am Heart J
2010;159:63-7.
Grodin JL, Neale S, Wu Y, Hazen SL, Tang WH. Prognostic comparison of different sensitivity
cardiac troponin assays in stable heart failure. Am J Med 2015;128:276-82.
Alehagen U, Dahlström U, Rehfeld JF, Goetze JP. Prognostic assessment of elderly patients
with symptoms of heart failure by combining high-sensitivity troponin T and N-terminal pro–
B-type natriuretic peptide measurements. Clin Chem 2010;56:1718-24.
4
Tentzeris I, Jarai R, Farhan S, Perkmann T, Schwarz MA, Jakl G, et al. Complementary role of
copeptin and high-sensitivity troponin in predicting outcome in patients with stable chronic
heart failure. Eur J Heart Fail 2011;13:726-33.
Jungbauer CG, Riedlinger J, Buchner S, Birner C, Resch M, Lubnow M, et al. High-sensitive
troponin T in chronic heart failure correlates with severity of symptoms, left ventricular
dysfunction and prognosis independently from N-terminal pro-b-type natriuretic peptide.
Clin Chem Lab Med 2011;49:1899-906.
Eggers KM, Nygren M, Venge P, Jernberg T, Wikström BG. High-sensitive troponin T and I are
markers of disease severity and mortality in patients with left-ventricular dysfunction and
precapillary pulmonary hypertension - High-sensitive troponins in relation to invasive
hemodynamic data and outcome. Clin Chim Acta 2011;412:1582-8.
Egstrup M, Schou M, Tuxen CD, Kistorp CN, Hildebrandt PR, Gustafsson F, et al. Prediction of
outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular
heart failure. Am J Cardiol 2012;110:552-7.
de Antonio M, Lupon J, Galan A, Vila J, Urrutia A, Bayes-Genis A. Combined use of highsensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide improves
measurements of performance over established mortality risk factors in chronic heart
failure. Am Heart J 2012;163:821-8.
Gravning J, Askevold ET, Nymo SH, Ueland T, Wikstrand J, McMurray JJ, et al. Prognostic
effect of high-sensitive troponin T assessment in elderly patients with chronic heart failure:
results from the CORONA trial. Circ Heart Fail 2014;7:96-103.
Lok DJ, Klip IT, Lok SI, Bruggink-André de la Porte PW, Badings E, van Wijngaarden J, et al.
Incremental prognostic power of novel biomarkers (growth-differentiation factor-15, highsensitivity C-reactive protein, galectin-3, and high-sensitivity troponin-T) in patients with
advanced chronic heart failure. Am J Cardiol 2013;112:831-7.
Gaggin HK, Szymonifka J, Bhardwaj A, Belcher A, De Berardinis B, Motiwala S, et al. Head-tohead comparison of serial soluble ST2, growth differentiation factor-15, and highly-sensitive
troponin T measurements in patients with chronic heart failure. JACC Heart Fail 2014;2:6572.
5
Supplemental Data 4. Table 4 – References.
Røsjø H, Andreassen J, Edvardsen T, Omland T. Prognostic usefulness of circulating highsensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac
function and anatomy. Am J Cardiol 2011;108:88-91.
Solberg OG, Ueland T, Wergeland R, Dahl CP, Aakhus S, Aukrust P, Gullestad L. High-sensitive
troponin T and N-terminal-brain-natriuretic-peptide predict outcome in symptomatic aortic
stenosis. Scand Cardiovasc J 2012;46:278-85.
Saito T, Hojo Y, Hirose M, Ikemoto T, Katsuki T, Kario K. High-sensitivity troponin T is a
prognostic marker for patients with aortic stenosis after valve replacement surgery. J Cardiol
2013;61:342-7.
Chorianopoulos E, Krumsdorf U, Geis N, Pleger ST, Giannitsis E, Katus HA, Bekeredjian R.
Preserved prognostic value of preinterventional troponin T levels despite successful TAVI in
patients with severe aortic stenosis. Clin Res Cardiol 2014;103:65-72.
Chin CW, Shah AS, McAllister DA, Joanna Cowell S, Alam S, Langrish JP, et al. High-sensitivity
troponin I concentrations are a marker of an advanced hypertrophic response and adverse
outcomes in patients with aortic stenosis. Eur Heart J 2014;35:2312-21.
6