Download Gussak CV Nov 18 2016

November 18, 2016
Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
IHOR GUSSAK, MD, PhD, FACC
Citizenship:
Marital Status:
Address:
e-mail:
U.S. Citizen
Wife: Hiie M. Gussak, MD, BC/BE Nephrologist
Morristown, NJ
[email protected]
Employment and Academic Appointments
2014 – present
Full-time Cardiology Consultant (Pharmaceuticals and Device), Ihor Gussak Consulting LLC
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Early Stages Clinical Research & Drugs Development
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Acute and Chronic Heart Failure Programs
o Design and Implementation of Clinical Development Programs. CDP, FIH, FIP, POP, and POC studies
o Interactions with KoLs, CROs, Regulatory Authorities. IB, IND, NDA
Acute Coronary Syndrome and Myocardial Infarction
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Cardiac Telemetry
Cardiac Diagnostic Technologies
Clinical Electrocardiography and Cardiac Electrophysiology
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2004 – present
2012 – 2014
ECG Interpretation and Serial ECGs Comparison
Holter Analysis and Exercise Tests Interpretation
Ischemic Event Adjudication and Classification
Medical Device Industry
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2006 – present
Cardiac Safety Pharmacology and Medical Monitoring of Cardiac and Non-cardiac Investigational Drugs
Pre-clinical Research, Translational Medicine, and Clinical Trials
Licensing Opportunities
Hereditary and Acquired Cardiac Channelopathies. Long and Short QT Syndromes, Brugada Syndrome
Molecular, Ionic, and Genetic Aspects of Hereditary Electrical Diseases of the Heart
Iatrogenic Cardiovascular Medicine
Various Biotechnology Companies, CROs, and Advisory Boards
Clinical Professor of Medicine, Rutgers Robert Wood Johnson Medical School,
New Brunswick, NJ
Executive Editor, Journal of Electrocardiology
Full-time Consultant, ONO Pharmaceutical
Lawrenceville, NJ and London, UK. Main responsibilities:
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Heart Failure Program and Cardiac Safety
FIH, PoP, IB, IND, Interactions with FDA
Establishing key opinion leaders panel for heart failure program
2012 – 2012
Director, Cardiac Safety Pharmacology, Masonic Medical Research Laboratory
Utica, NY
2008 – 2012
Vice President and Chief Medical Officer, NewCardio, Inc
Princeton, NJ and Santa Clara, CA
Deputy Therapeutic Area Head, Cardiovascular, Boehringer Ingelheim Pharmaceuticals,
Ridgefield, CT. Main responsibilities:
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2007 – 2008
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2002 – 2007
Molecular, Ionic, and Genetic Aspects of Hereditary Electrical Diseases of the Heart
In-licensing of cardiovascular products (identifying new clinical research opportunities)
Clinical/scientific support for internal cardiovascular clinical and pre-clinical R&D
Assessment of cardiac safety of non-cardiac drugs
Establishing panels of key opinion leaders for various cardiovascular indications, scientific
presentations at advisory boards, key scientific meetings and external committee meetings
Vice President, Global Medical Affairs, eResearchTechnology, Inc
Bridgewater, NJ. Main responsibilities:
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Cardiac safety evaluations of investigational drugs
Interactions with key sponsors and regulatory agencies
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2001 – 2002
1999 – 2001
1999 – 2001
1996 – 1999
1997 – 1999
1992 – 1996
1991 – 1992
1981 – 1991
1986 – 1991
1986 – 1989
1980 – 1981
Ihor Gussak, MD, PhD, FACC
Associate Global Director, Cardiovascular Clinical R&D, Aventis Pharmaceuticals,
Bridgewater, NJ. Main responsibilities:
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2000 – 2001
Curriculum Vitae
Execution of the early phases clinical trials in anti-hypertensive program
Participation in safety assessment
Interactions with regulatory agencies, IND support
Establishing key opinion leaders panel for anti-hypertensive program
Director, Mayo ECG Core Laboratory within Mayo Clinical Trial Services (MPACT)
Mayo Clinic Rochester, MN
Professional Research Associate, Mayo Physician Alliance for Clinical Trials (MPACT)
Mayo Clinic, Rochester, MN
Cardiology Consultant (adjunct position), Biomedical Systems, St. Louis, MO
Assistant Professor, Department of Cardiology
St. Louis University Health Sciences Center, St. Louis, MO
Lecturer (adjunct position), Department of Pharmacological and Physiological Sciences
St. Louis University School of Medicine, St. Louis, MO
Postdoctoral Cardiology Research Fellow
St. Louis University, St. Louis, MO
ECG analyst, St. Joseph Hospital, Cheektowaga, NY
Attending Physician, Department of Cardiology / Intensive and Coronary Care Units
Tartu University Hospital, Tartu, Estonia
Senior Scientist, Laboratory of Clinical Physiology (adjunct position)
Tartu University School of Medicine, Tartu, Estonia
Instructor in Cardiology (adjunct position)
Department of Continuing Education, Tartu University School of Medicine, Tartu, Estonia
Intern, Department of Internal Medicine and Cardiology, Tartu University, Estonia
Education
1992 – 1996
PhD (1983-86)
MD (1974-80)
Postdoctoral Cardiology Research Fellowship
St. Louis University Health Sciences Center, St. Louis, MO
Cardiac Electrophysiology of Acute Myocardial Ischemia in Clinic and Experiments
Conducted: National Center for Surgical Treatment of Severe Cardiac Rhythm Disturbance and
Cardiac Pacing (Kaunas, Lithuania) and Tartu University (Tartu, Estonia)
Defended: Institute of Continuing Medical Education, St. Petersburg, Russia
Tartu University School of Medicine, Tartu, Estonia
Certificates
2002
2001
1988
1985
1981
1980
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Certificate of Tufts Center for the Study of Drug Development, Tufts University, Boston, MA USA
Certificate of American College of Cardiology, Bethesda, MD USA
Certificate of Surgical Treatment of Severe Cardiac Rhythm Disorders and Permanent Cardiac Pacing
Kaunas University School of Medicine, Kaunas, Lithuania
Certificate of General Methods of Electrophysiological Diagnosis and Temporary Cardiac Pacing
Kaunas University School of Medicine, Kaunas, Lithuania
Certificate of Internship in Internal Medicine, Tartu University Clinical Hospital, Tartu, Estonia
Certificate of Sport Medicine, Tartu University, Tartu, Estonia
Awards (USA Only)
“America's Top Cardiologists” by Consumer's’ Research Council of America
Certificate of Appreciation by the Asymptomatic Cardiac Ischemia Pilot Study (ACIP)
A research project of the National Heart, Lung, and Blood Institute, 1995
Certificate of Appreciation by the Physiological Investigations of Myocardial Ischemia (PIMI)
A research project of the National Heart, Lung, and Blood Institute, 1993-1995
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
Scientific Interests
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Clinical Research and Drug Development
o Clinical Trials and Cardiac Safety
o Acute and Chronic Heart Failure
Clinical Electrocardiography and Cardiac Electrophysiology
o Electrical Diseases of the Heart and Sudden Cardiac Death
o Short and Long QT Syndromes, Brugada Syndrome, Primary Idiopathic Cardiac Asystole
o Acute Coronary Syndrome and Myocardial Infarction
Iatrogenicity in Cardiovascular Medicine
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American College of Cardiology, Fellow
American Heart Association, Clinical Cardiology Council
American Academy of Pharmaceutical Physicians
International Cardiac Electrophysiology Society
International Society for Holter and Noninvasive Electrocardiology
Drug Information Association
Mayo Medical Alumni Association, Mayo Foundation
International Scientific Committee on Arrhythmogenic Right Ventricular Dysplasia-Cardiomyopathy
Ukrainian Society of Cardiology, Fellow
Ukrainian Cardiology Journal, Member of Editorial Board
Cardiac Surgery and Interventional Cardiology, Member of Editorial Board
Strazhesko Institute of Cardiology, Kyiv, Ukraine, Honorary Professor
Ukrainian Shevchenko Scientific Society, Full Member
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Memberships
Ad hoc Reviewer: Journal of the American College of Cardiology, Circulation, American Journal of Cardiology,
Pacing and Clinical Electrophysiology, Clinical Cardiology, Nature
Teaching Activities
2006 – 2010
1999
1997 -1998
1986 -1989
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Lectures and Seminars on Clinical Electrocardiology
UMDNJ-RWJ Medical School, New Brunswick, NJ
Course of “Clinical Cardiology”
University of Health Sciences Antigua School of Medicine (On-line), St. John’s, Antigua, WI
Lectures and Seminars on Cardiac Electrophysiology and Electrocardiology
Department of Pharmacological and Physiological Sciences
St. Louis University School of Medicine, St. Louis, MO
Lectures and Seminars on Clinical Cardiology, Clinical Electrophysiology and Electrocardiology
Department of Continuing Medical Education, Tartu School of Medicine, Tartu, Estonia
Numerous lectures and presentations at national and international congresses, seminars, and conferences
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
SELECTED BIBLIOGRAPHY
(only books, books chapters, and manuscripts)
Textbooks:
1.
IATROGENICITY IN CARDIOVASCULAR MEDICINE (First Edition, in progress)
Editors: Ihor B. Gussak and John B. Kostis
Co-Editors: Arshad Jahangir, Gan-XinYan, Giovanni Campanile, William J. Kostis, Ibrahim Akin, and Martin
Borggrefe
Rutgers University Press, New Brunswick, NJ, USA, 2017
2.
ELECTRICAL DISEASES OF THE HEART (Second Edition)
Volume 1. Basic Foundations and Primary Electrical Diseases. Pp. 695
Volume 2. Clinical Rhythmology: Diagnosis and Treatment of Electrical Diseases of the Heart, and
Prevention of Sudden Cardiac Death. Pp.743
Editors: Ihor Gussak and Charles Antzelevitch
Co-editors: Arthur Wilde, Brian Powell, Michael Ackerman, and Win-Kuang Shen
Springer, 2 volumes, 2013
3.
ELECTRICAL DISEASES OF THE HEART: Genetics, Mechanisms, Treatment, Prevention
Editors: Ihor Gussak and Charles Antzelevitch
Co-editors: Arthur Wilde, Paul Friedman, Michael Ackerman, and Win-Kuang Shen
Springer, 1000 pp, 2008
4.
CARDIAC SAFETY OF NONCARDIAC DRUGS: PRACTICAL GUIDELINES FOR CLINICAL
RESEARCH AND DRUG DEVELOPMENT
Edited by J. Morganroth and I. Gussak.
Humana, 361 pp, 2004
5.
CARDIAC REPOLARIZATION: BRIDGING BASIC AND CLINICAL SCIENCE
Edited by Gussak I, Antzelevitch C, Hammil SC, Shen W-K, Bjerregaard P.
Humana, 548 pp, 2003
6.
CLINICAL MANAGEMENT OF CARDIAC ARRHYTHMIAS
Gussak I, Gussak H, Teesalu R.
Tartu University, Tartu, 1989
7.
ATLAS OF COMBINED CARDIAC RHYTHM DISORDERS
Gussak I.
Tartu University, Tartu, 1984
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November 18, 2016
Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
Books Chapters:
1.
Gussak I, Jahangir A, Gan-XinYan G-X, Kostis K. Clinical Manifestations of Acute and Chronic Drug-Induced
Iatrogenic Cardiovascular Diseases and Syndromes. Chapter 7.
In: IATROGENICITY IN CARDIOVASCULAR MEDICINE (First Edition, in progress)
Editors: Ihor B. Gussak and John B. Kostis. Co-editors: Arshad Jahangir, Gan-XinYan, Giovanni Campanile,
William J. Kostis, Ibrahim Akin, and Martin Borggrefe. Rutgers University Press, First Edition, 2017 (in
progress)
2.
Maria L. Gussak, Ihor B. Gussak, and John B. Iatrogenicity: Definition, History and Modern Context.
In: IATROGENICITY IN CARDIOVASCULAR MEDICINE (First Edition, in progress)
Editors: Ihor B. Gussak and John B. Kostis. Co-editors: Arshad Jahangir, Gan-XinYan, Giovanni Campanile,
William J. Kostis, Ibrahim Akin, and Martin Borggrefe. Rutgers University Press, First Edition, 2017 (in
progress)
3.
Sulaiman Sultan, Ahad Jahangir, Ihor B Gussak, John B Kostis, A Jamil Tajik, Arshad Jahangir. Interactions
between supplements and prescription medications.
In: IATROGENICITY IN CARDIOVASCULAR MEDICINE (First Edition, in progress)
Editors: Ihor B. Gussak and John B. Kostis. Co-editors: Arshad Jahangir, Gan-XinYan, Giovanni Campanile,
William J. Kostis, Ibrahim Akin, and Martin Borggrefe. Rutgers University Press, First Edition, 2017 (in
progress)
4.
Safety of Over-the-counter “Natural Substances” and “Vitamins”: Side Effects, and Contraindications.
Sulaiman Sultan, Ahad Jahangir, Ihor B Gussak, A Jamil Tajik, Arshad Jahangir.
In: IATROGENICITY IN CARDIOVASCULAR MEDICINE (First Edition, in progress)
Editors: Ihor B. Gussak and John B. Kostis. Co-editors: Arshad Jahangir, Gan-XinYan, Giovanni Campanile,
William J. Kostis, Ibrahim Akin, and Martin Borggrefe. Rutgers University Press, First Edition, 2017 (in
progress)
5.
Gussak I and Gussak G. History of the J Wave and J Wave Syndromes. In: J Wave Syndrome. Edited by
Antzelevitch C. and Yan G-X. Springer International Publishing Switzerland, 2016
6.
Rashmi R Shah RR and Gussak I. Acquired (Drug-Induced) Long and Short QT Syndromes. Chapter 6. Pp. 73122.
In: ELECTRICAL DISEASES OF THE HEART (Second Edition)
Volume 2. Clinical Rhythmology: Diagnosis and Treatment of Electrical Diseases of the Heart, and Prevention
of Sudden Cardiac Death.
Editors: Ihor Gussak and Charles Antzelevitch
Co-editors: Arthur Wilde, Brian Powell, Michael Ackerman, and Win-Kuang Shen
Springer, 2013
7.
Passman R, Ots M, Gussak I, Gussak, H. Sudden Cardiac Arrest in Chronic Kidney Disease. Chapter 30. Pp.
475-486.
In: ELECTRICAL DISEASES OF THE HEART (Second Edition)
Volume 2. Clinical Rhythmology: Diagnosis and Treatment of Electrical Diseases of the Heart, and Prevention
of Sudden Cardiac Death.
Editors: Ihor Gussak and Charles Antzelevitch
Co-editors: Arthur Wilde, Brian Powell, Michael Ackerman, and Win-Kuang Shen
Springer, 2013
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
8.
Gussak HM, Ots M, and Gussak I. Sudden Death in Kidney Diseases. Chapter 63. Pp. 934-942
In: ELECTRICAL DISEASES OF THE HEART AND SUDDEN CARDIAC DEATH.
Edited by Gussak I. Antzelevitch C, Wilde A, Friedman P, Ackerman MJ, Shen WK.
Springer, 1000 pp, November 2008
9.
Bjerregaard P, Gussak I. Short QT Syndrome.
In: ELECTRICAL DISEASES OF THE HEART AND SUDDEN CARDIAC DEATH.
Edited by Gussak I. Antzelevitch C, Wilde A, Friedman P, Ackerman MJ, Shen WK.
Springer, 1000 pp, November 2008
10. Litwin J, Kleiman R, and Gussak I. Acquired (Drug-Induced) Long QT Syndrome.
Chapter 46, Pp. 705-718.
In: ELECTRICAL DISEASES OF THE HEART AND SUDDEN CARDIAC DEATH.
Edited by Gussak I. Antzelevitch C, Wilde A, Friedman P, Ackerman MJ, Shen WK.
Springer, 1000 pp, November 2008
11. Gussak I, Kleiman R, Litwin J. Fundamentals of ECG Interpretation in Clinical Research.
In: CARDIAC SAFETY OF NONCARDIAC DRUGS: PRACTICAL GUIDELINES FOR CLINICAL
RESEARCH AND DRUG DEVELOPMENT. Edited by J. Morganroth and I. Gussak. 361 pages. Humana, 2004
12. Gussak I. A History of the Brugada Syndrome or A Decade of Success.
In: Brugada Syndrome. Blackwell Publishing, 2005
13. Gussak I, Antzelevitch C, Bjerregaard P. ECG Phenomena of the Early Ventricular Repolarization. Early
Repolarization Syndrome. Pp 407-426.
In: Gussak I, Antzelevitch C, Hammil SC, Shen W-K, Bjerregaard P. Cardiac Repolarization: Bridging Basic
and Clinical Science. Humana, 2003
14. Gussak I, Bjerregaard P, Goodman D, Antzelevitch C. Short QT interval: ECG Phenomenon and Clinical
Syndrome. Pp. 497-506. Chapter 18.
In: Gussak I, Antzelevitch C, Hammil SC, Shen W-K, Bjerregaard P. Cardiac Repolarization: Bridging Basic
and Clinical Science. Humana, 2003
15. Gussak I, Chaitman BR. The Brugada Syndrome. Chapter 58.
In: Harrison’s Advances in Cardiology. Pp. 370-377, Edited by E. Braunwald. McGraw-Hill, 2002
16. Gussak I, Chaitman BR. The Brugada Syndrome. Chapter 231
In: Harrison’s Principles of Internal Medicine. McGraw Hill, 1999
http://www.harrisonsonline.com/server-java/Arknoid/amed/harrisons/ex_editorials/edl1915_p01.html
17. Gussak I. Cardiac Electrophysiology. Pp.6.1-6.18. Human Organ System. Cardiovascular Module.
Saint Louis University. School of Medicine. St. Louis, MO, 1998
18. Gussak I. Abnormal ECG and Cardiac Arrhythmias. Pp.11.1-11.14. Human Organ System. Cardiovascular
Module.
Saint Louis University. School of Medicine. St. Louis, MO, 1998
19. Gussak I. Clinical Cardiology
University of Health Sciences Antigua School of Medicine, St. John's, Antigua, WI, www.uhsa.ag (online
courses)
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November 18, 2016
Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
Manuscripts:
1. Clinical Significance of J waves in Patients Undergoing Therapeutic Hypothermia for Out-of-Hospital Cardiac
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Arrest. Harhash A, Gussak I, Cassuto J, Winters SL.
PACE-16-0327.R2 (in press)
Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M,
Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AA. J-Wave syndromes expert
consensus conference report: Emerging concepts and gaps in knowledge.
J Arrhythm. 2016 Oct;32(5):315-339.
Antzelevitch C, Yan G-X, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M,
Huikuri H, Ma C, Morita H, Nam G-B, Sacher F, Shimizu W, Viskin S, Wilde AAM.
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.
Endorsed by: the Asia Pacific Heart Rhythm Society (APHRS), the European Heart Rhythm Association
(EHRA), the Heart Rhythm Society (HRS), and the Latin American Society of Cardiac Pacing and
Electrophysiology (Sociedad Latinoamericana de Estimulacifin Cardíaca y Electrofisiología [SOLAECE]).
Heart Rhythm. 2016 Jul 11. pii: S1547-5271(16)30372-1. doi: 10.1016/j.hrthm.2016.05.024
Antzelevitch C, Yan G-X, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M,
Huikuri H, Ma C, Morita H, Nam G-B, Sacher F, Shimizu W, Viskin S, Wilde AAM.
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.
Endorsed by: the Asia Pacific Heart Rhythm Society (APHRS), the European Heart Rhythm Association
(EHRA), the Heart Rhythm Society (HRS), and the Latin American Society of Cardiac Pacing and
Electrophysiology (Sociedad Latinoamericana de Estimulacifin Cardíaca y Electrofisiología [SOLAECE]).
Europace. 2016 Jul 13. pii: euw235
Ward CL, Jamieson V, Nabata T, Sharpe, Dozono K, Suto F, Hashimoto Y, Gussak I. First Clinical Experience
with ONO-4232: A Randomized, Double-Blind, Placebo-Controlled Healthy Volunteer Study of a Novel
Lusitropic Agent for Acutely Decompensated Heart Failure.
Clinical Therapeutics/ 2016 Mar 18. pii: S0149-2918(16)30088-1. doi
Brugada J1, Gussak I, Brugada P. Short QT Syndrome: A Predictable Story.
Cardiology. 2014 May 6;128(3):231-233
Gussak I and Antzelevitch C. Early Repolarization Syndrome: A Decade of Progress. Editorial
J of Electrocardiology, 2013,Mar;46(2):110-3
Antzelevitch C, Gussak I. Author's response to Letter to the Editor from Perez and Froelicher.
J Electrocardiol. 2013 Mar;46(2):116
Detection of QT prolongation using a novel automated ECG analysis algorithm: Prospective blinded
evaluation using the Cardiac Safety Research Consortium ECG database. Cynthia L. Green, Paul Kligfield,
Samuel George, Ihor Gussak, Branislav Vajdic, Philip Sager, MD, Mitchell W. Krucoff, MD.
Am Heart J. 2012 Mar;163(3):365-71
Vukajlovic D, Gussak I, George S, Simic G, Bojovic B, Hadzievski L, Stojanovic B, Angelkov L, Panescu D.
Wireless monitoring of reconstructed 12-lead ECG in atrial fibrillation patients enables differential diagnosis of
recurrent arrhythmias.
Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:4741-4
Wenzel BJ, George S, Lakkireddy D, Vanga S, Bommana S, Gussak I, Simic G, Bojovic B, Hadzievski L,
Panescu D. Algorithm for quantitative 3 dimensional analysis of ECG signals improves myocardial diagnosis
over cardiologists in diabetic patients.
Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:965-8
Gussak I, Vukajlovic D, Vukcevic V, George S, Bojovic B, Hadzievski L, Simic G, Stojanovic B, Angelkov L,
Panescu D. Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using
a hand-held device.
J Electrocardiol. 2011 Nov 9. [Epub ahead of print]
Vukajlovic D, Bojovic B, Hadzievski L, George S, Gussak I, Panescu D. Wireless remote monitoring of atrial
fibrillation using reconstructed 12-lead ECGs.
Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1113-8
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November 18, 2016
Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
14. Vukcevic V, Panescu D, Bojovic B, George S, Gussak I, Giga V, Stankovic I. Wireless remote monitoring of
myocardial ischemia using reconstructed 12-lead ECGs.
Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2215-20
15. Akshay Dhawan, Brian Wenzel, Samuel George, Ihor Gussak, Bosko Bojovic, Dorin Panescu. DETECTION
OF ACUTE MYOCARDIAL INFARCTION FROM SERIAL ECG USING MULTILAYER SUPPORT
VECTOR MACHINE.
Conf Proc IEEE Eng Med Biol Soc. 2011 (in press)
16. George, S; Rodriguez, I; Ipe, D; Sager, P; Gussak, I; Vajdic, B. Computerized Extraction of
Electrocardiograms from Continuous 12-Lead Holter Recordings Reduces Measurement Variability in a
Thorough QT Study.
J Clin Pharmacol. 2012 Dec;52(12):1891-900. doi: 10.1177/0091270011430505. Epub 2011 Dec 20.
17. Ihor Gussak, Dejan Vukajlovic, Vladan Vukcevic, Samuel George, Bosko Bojovic, Ljupco Hadzievski, Goran
Simic, 1 Bojan Stojanovic, Lazar Angelkov, Dorin Panescu. Wireless Remote Monitoring of Reconstructed 12Lead ECGs After Ablation for Atrial Fibrillation Using a Hand-Held Device.
J of Electrocardiol (in press)
18. Shah RR, Bjerregaard P, Gussak I. Drug-induced QT interval shortening: an emerging component in integrated
assessment of cardiac safety of drugs.
J Electrocardiol. 2010 Sep-Oct;43(5):386-9
19. Bjerregaard P, Nallapaneni H, Gussak I. Short QT interval in clinical practice.
J Electrocardiol. 2010 Sep-Oct;43(5):390-5
20. Shvilkin A, Bojovic B, Vajdic B, Gussak I, Ho KK, Zimetbaum P, Josephson ME. Vectorcardiographic and
electrocardiographic criteria to distinguish new and old left bundle branch block.
Heart Rhythm. 2010 Aug;7(8):1085-92
21. Bojovic B, Hadzievski L, Vukcevic VD, Panescu D, Gussak I, George S, Shvilkin A, Vajdic B. Visual 3Dx:
algorithms for quantitative 3-dimensional analysis of ECG signals.
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6751-4
22. Corrado D, Pelliccia A, Heidbuchel H, Sharma S, Link M, Basso C, Biffi A, Buja G, Delise P, Gussak I et al;
on behalf of the Sections of Sports Cardiology of the European Association of Cardiovascular Prevention and
Rehabilitation; and the Working Group of Myocardial and Pericardial Disease of the European Society of
Cardiology. Recommendations for interpretation of 12-lead electrocardiogram in the athlete.
Eur Heart J. 2010 31(2):243-259
23. Bojovic B, Hadzievski L, Vukcevic VD, Panescu D, Gussak I, George S, Shvilkin A, Vajdic B. Visual 3Dx:
Algorithms for quantitative 3-dimensional analysis of ECG signals.
Conf Proc IEEE Eng Med Biol Soc. 2009;1:6751-4.
24. Shvilkin A, Bojovic B, Vajdic B, Gussak I, Zimetbaum P, Josephson ME. Vectorcardiographic determinants of
cardiac memory during normal ventricular activation and continuous ventricular pacing.
Heart Rhythm. 2009 Jul;6(7):943-8. Epub 2009 Mar 19.
25. I. Gussak, S. George, B. Bojovic, B. Vajdic. ECG Phenomena of the Early Ventricular Repolarization in the 21
Century.
Indian Pacing Electrophysiol J. 2008 Jul–Sep; 8(3). Published online 2008 July 1
26. C. Wolpert, C. Antzelevitch, C. Veltmann, R.Schimpf, I.Gussak, M. Borggrefe. Is a "Narrow and Tall" QRS
Complex an ECG Marker for Sudden Death?
Heart Rhythm Journal, 2008 (in press)
27. I. Gussak, P. Bjerregaard. Electrical Storm in Acute Myocardial Infarction.
Polish Heart Journal, September 2008
28. Gussak I, Gussak H. Sudden cardiac death in nephrology: focus on acquired long QT syndrome. Editorial
Comments.
Nephrology Dialysis Transplantation 2006; doi: 10.1093/ndt/gfl587
29. Gussak I. Molecular pathogenesis of catecholaminergic polymorphic ventricular tachycardia: Sex matters!
Heart Rhythm. 2006 Jul;3(7):806-7.
30. Bjerregaard P, Jahangir A, Gussak I. Targeted therapy for short QT syndrome.
Expert Opin Ther Targets. 2006 Jun;10(3):393-400.
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
31. Bjerregaard P, Gussak I. Short QT Syndrome.
Ann Noninvasive Electrocardiol. 2005 Oct;10(4):436-40.
32. Gussak I, Bjerregaard P. Short QT syndrome-5 years of progress.
J Electrocardiol. 2005 Oct;38(4):375-7.
33. Hong K, Bjerregaard P, Gussak I, Brugada R. Short QT syndrome and atrial fibrillation caused by mutation in
KCNH2.
J Cardiovasc Electrophysiol, v.16, 99.394-6, 2005
34. Bjerregaard P, Gussak I. Short QT syndrome: mechanisms, diagnosis and treatment.
Nature. Clinical Practice Cardiovascular Medicine (2005) 2, 84-87
35. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, Lemarec H, Nademanee
K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A. Brugada Syndrome. Report of the Second
Consensus Conference. Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.
Circulation. 2005 Feb 8;111(5):659-70. Epub 2005 Jan 17
36. Gussak I, Bjerregaard P, Kostis J. Electrocardiographic “Lambda” wave and primary idiopathic cardiac
asystole: A new clinical syndrome?
J Electrocardiol April 2004 • Volume 37 • Number 2
37. Gussak I, Litwin J, Kleiman R, Grisanti S, Joel Morganroth J. Drug-Induced Cardiac Toxicity: Emphasizing
the Role of Electrocardiography In Clinical Research and Drug Development. Editorial Review.
J of Electrocardiol 2004: 37 (1): 19-24
38. Antzelevitch C., Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H,
Nademanee K, Riera ARP, Tan H, Shimizu W, Wilde A. Brugada syndrome: report of the second consensus
conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.
Circulation. 2005 Feb 8;111(5):659-70
39. Murphy J, Wright RS, Gussak I, Williams B, Daly RN, Cain VA, Pieniaszek HJ, Sy SKB, Ebling W, Simonson
K, Wilcox R, Kopecky SL. The use of roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor
inhibitor, in patients with stable coronary artery disease.
Am J Cardiovasc Drugs 2003: 3 (2): 101-112
40. Gussak I, Startt Selvester RH. Editorial announcement.
J Electrocardiol 2004 Oct;36(2):87
41. Gussak I, Startt Selvester RH. Editorial announcement.
J Electrocardiol 2002 Oct;35(4):287
42. Antzelevitch C, Brugada P, Brugada J, Brugada R, Shimizu W, Gussak I, Riera ARP. Brugada Syndrome. A
Decade of Progress. A Historical Perspective.
Circulation Research 2002;91:1114-1118
43. Gussak I, Brugada P, Brugada J, Antzelevitch, Osbakken M, Bjerregaard P. ECG Phenomenon of Idiopathic
Short QT Interval.
Cardiac Electrophysiology Review 6:49-53, 2002
44. Gussak I, Bjerregaard P, Hammill SC. Clinical Diagnosis and Risk Stratification in Patients with Brugada
Syndrome. Editorial Comments.
Journal of the American College of Cardiology 37, No. 6,1635-8, 2001
45. Bjerregaard P, Gussak I. Brugada Syndrome – 10 Years Later.
J Electrocardiol 35 (1): 85-87, 2002
46. Gussak I, Brugada P, Brugada J, Wright RS, Kopecky SL, Chaitman BR, Bjerregaard P. Idiopathic Short QT
Interval: A New Clinical Syndrome?
Cardiology 94 (2), 99-102, 2000
47. Gussak I, Wright, RS, Bjerregaard P, Chaitman BR, Zhou SH, Hammill SC, Kopecky SL. False-Negative and
False-Positive ECG Diagnoses of Q Wave Myocardial Infarction in the Presence of Right Bundle-Branch
Block.
Cardiology 94 (3), 165-172, 2000
48. Gussak I, Wright RS, Kopecky SL, Hammill SC. Exercise-Induced ST Segment Elevation in Q Wave Leads in
Postinfarction Patients: Defining Its Meaning and Utility in Today's Practice.
Cardiology 93 (4), 205-209, 2000
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
49. Gussak I, Chaitman BR, Kopecky SL, Nerbonne JM. Rapid Ventricular Repolarization in Rodents:
Electrocardiographic Manifestations, Molecular Mechanisms, and Clinical Insights.
J Electrocardiol 33 (2):159-170, 2000
50. Gussak I, Wright RS, Stephen L. Kopecky SL. Should We Revise Our Diagnostic Methods for Q-wave
Myocardial Infarction in the Presence of Right Bundle Branch Block? Editorial Review.
Am Heart J 2000 Jul;140(1):10-11
51. Yokoyama Y, Chaitman BR, Hardison RM, Guo P, Krone R, Stocke K, Gussak I, Attubato MJ, Rautaharju
PM, Sopko G, Detre KM. Association between new electrocardiographic abnormalities after coronary
revascularization and five-year cardiac mortality in BARI randomized and registry patients.
Am J Cardiol 2000 Aug 15;86(8):819-824
52. Gussak I, Antzelevitch C. Early Repolarization Syndrome: Clinical Characteristics and Possible Cellular and
Ionic Mechanisms.
J Electrocardiol 33 (4):299-309, 2000
53. Detre KM, Lombardero MS, Brooks MM, Hardison RM, Holubkov R, Sopko G, Frye RL, Chaitman BR. The
effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute
myocardial infarction. Bypass Angioplasty Revascularization Investigation Investigators.
N Engl J Med 2000 Apr 6;342(14):989-97
54. Feit F, Brooks MM, Sopko G, Keller NM, Rosen A, Krone R, Berger PB, Shemin R, Attubato MJ, Williams
DO, Frye R, Detre KM. Long-term clinical outcome in the Bypass Angioplasty Revascularization Investigation
Registry: comparison with the randomized trial. BARI Investigators.
Circulation 2000 Jun 20;101(24):2795-802
55. Brooks MM, Jones RH, Bach RG, Chaitman BR, Kern MJ, Orszulak TA, Follmann D, Sopko G, Blackstone
EH, Califf RM. Predictors of mortality and mortality from cardiac causes in the bypass angioplasty
revascularization investigation (BARI) randomized trial and registry. For the BARI Investigators.
Circulation 2000 Jun 13;101(23):2682-9
56. Gussak I, Bjerregaard P, Antzelevitch C, Towbin J, Chaitman B.R. The Brugada Syndrome: Clinical,
Electrophysiological and Genetic Aspects.
Journal of the American College of Cardiology 33 (1): 5-15,1999
57. Bjerregaard P, Gussak I, Hurst JW. Naming of the waves in the ECG with a brief account of their genesis.
Circulation 100:e148, 1999
58. Gussak I, Liebl N, Bjerregaard P, Nouri S, Zimmerman F, Chaitman B.R. Deceleration-Dependent Shortening
of the QT Interval: a New Electrocardiographic Phenomenon?
Clinical Cardiology 22:124-126, 1999
59. Gussak I, Zhou S, Rautaharju P, Bjerregaard P, Stocke K, Osada N, Yokoyama Y, Miller M, Islam S. Chaitman
BR. Right bundle branch block as a cause of false-negative ECG diagnosis of inferior myocardial infarction.
J Electrocardiol 32 (3):275-280, 1999
60. Gussak HM, Gellens ME, Gussak I, Bjerregaard P. Q-T interval dispersion and its arrhythmogenic potential in
hemodialyzed patients: methodological aspects.
Nephron 1999;82(3):278
61. Pepine CJ, Bourassa MG, Chaitman BR, Davies RF, Kerensky RA, Sharaf B, Knatterud GL, Forman SA, Pratt
CM, Staples ED, Sopko G, Conti CR. Factors influencing clinical outcomes after revascularization in the
asymptomatic cardiac ischemia pilot (ACIP). ACIP Study Group. J Card Surg 1999 Jan-Feb;14(1):1-8
62. Bjerregaard P, Gussak I, Antzelevitch C. The enigmatic ECG manifestation of the Brugada Syndrome.
J Cardiovasc Electrophysiol 9: 109-111, 1998
63. Gussak I, Bjerregaard P. Proarrhythmic potential by K +-channel opening drugs.
Heart 77: 487-488, 1997
64. Gussak I. Effect of 4-aminopyridine on ventricular repolarization in isolated rat and guinea pig hearts. In:
Emerging Therapeutic Targets, eds. R. Anand, P. Smith, P. Warne. v. 1:133-137. London: Ashley Publications
LTD, 1997
65. Gussak I, Bjerregaard P, Greenwalt T, Chaitman BR. Electrophysiological peculiarities of the ECG J wave:
from hypothermia to Brugada syndrome. pp. 261-264.
In: Electrocardiology 96: From the Cell to the Body Surface (ed. J. Liebman). World Scientific Co.Pte. Ltd.,
Singapore, 1997
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Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
66. The Bypass Angioplasty Revascularization Investigation (BARI). Influence of Diabetes on 5-year mortality
and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease.
Circulation 96:1761-1769, 1997
67. The Writing Group for the Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Five
year clinical and functional outcome comparing bypass surgery and angioplasty in patients with multivessel
coronary disease.
JAMA 277:715-721, 1997
68. BARI Investigators. Myocardial infarction and cardiac mortality in bypass angioplasty revascularization
investigation (BARI) randomized trial.
Circulation 96:2162-2170, 1997
69. Chaitman B, Jacobs A, Ohman J, Krone R, Mullany C, Sopko G, Gussak I, Sutton-Tyrrell K, Rosen A.
Periprocedure Myocardial Infarction Rates in the Bypass Angioplasty Revascularization (BARI).
Journal of the American College of Cardiology Supplement, February 1996, 1010-115:361A
70. Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Medical care costs and quality of
life after randomization to coronary angioplasty or coronary bypass surgery.
N Engl J Med 336:92-99, 1997
71. Zhou SH, Chaitman BR, Rautaharju PM, Gussak I, Stocke KS. Gender differences in ECG Q wave serial
changes. pp. 541-544.
In: Electrocardiology 96: From the Cell to the Body Surface (ed. J. Liebman). World Scientific Co. Pte. Ltd.,
Singapore, 1997
72. Gussak I. The significance of the electrocardiographic J wave: from hypothermia to Brugada Syndrome.
Medicine around the World 2 (4): 237-239, 1997
73. The Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Comparison of coronary
bypass surgery with angioplasty in patients with multivessel disease.
N Engl J Med 335:217-225, 1996
74. Goldberg AD, Becker LC, Bonsall R, Cohen JD, Ketterer MW, Kaufman PG, Krantz DS, Light KC, McMahon
RP, Noreuil T, Pepine CJ, Raczynski J, Stone PH, Strother D, Taylor H, Sheps DS. Ischemic, hemodynamic,
and neurohormonal responses to mental and exercise stress. Experience from the Psychophysiological
Investigations of Myocardial Ischemia Study (PIMI).
Circulation 1996 Nov 15;94(10):2402-9
75. Chaitman BR, Zhou SH, Tamesis B, Rosen A, Egan T, Zumbehl KM, Stocke K, Takase B., Gussak I,
Rautaharju PM. Methodology of serial ECG classification Using an adaptation of the NOVACODE for Q wave
myocardial infarction in the Bypass Angioplasty Revascularization Investigation.
J Electrocardiol 29:265-277, 1996
76. Gussak I, Bjerregaard P, Egan T, Chaitman BR. ECG phenomenon called the J wave. History,
pathophysiology, and clinical significance.
J Electrocardiol 28: 49-58, 1995
77. Hirulog Angioplasty Study Investigators. Treatment with Bivalirudin (Hirulog) as compared with heparin
during coronary angioplasty for unstable or postinfarction angina.
N Engl J Med 333:764-769, 1995
78. Bjerregaard P, Gussak I, Kotar SL, Gessler JE, Janosik D. Recurrent syncope in a patient with prominent J
wave.
Am Heart J 126: 1427-1430, 1994
79. Gussak I, Altraja E, Teesalu R. Myocardial vulnerability diagnosis in ischemia.
Eesti Tervishoid 5: 334-345, 1986
80. Gussak I. Cardiac electrostimulation in tachycardias and tachyarrhythmias.
Eesti Tervishoid 5: 245-249, 1986
81. Gussak I. The study of cardiac arrhythmias utilizing esophageal electrocardiostimulation.
Eesti Tervishoid 4: 253-256, 1984
Abstracts (will be provided upon request)
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November 18, 2016
Curriculum Vitae
Ihor Gussak, MD, PhD, FACC
PATENTS
1.
SYSTEM AND METHODS FOR SERIAL ANALYSIS OF ELECTROCARDIOGRAMS
(Patent application number: 20110112414; Published 05-12-2011)
2.
SYSTEM FOR AUTOMATED EKG ANALYSIS
(Patent application number: 20110112414; Published 05-12-2011)
3.
SYSTEM AND METHOD FOR AUTOMATED EKG ANALYSIS
(Patent application number: 20110112415; Published 05-12-2011)
4.
SYSTEM AND METHODS FOR SERIAL ANALYSIS OF ELECTROCARDIOGRAMS
(Patent application number: 20130096447; 04-18-13)
REFERENCES
(will be provided upon request)
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