Download THE SOCIETY OF CLINICAL SURGERY

THE SOCIETY OF
CLINICAL SURGERY
November 4 - 6, 2004
161st Meeting and 100th Anniversary
University of Pennsylvania, Department of Surgery
Philadelphia, Pennsylvania
Scientific Program - Faculty Speakers
N. Scott Adzick, MD
Hansell H. Stedman, MD
Joseph H. Gorman, III, MD
Omaida C. Velazquez, MD
James F. Markmann, MD, PhD
Y. Joseph Woo, MD
Ronald M. Fairman, MD
Kim M. Olthoff, MD
Joseph B. Shrager, MD
Joseph E. Bavaria, MD
FACULTY PROFILE
N. Scott Adzick, MD
Dr. Adzick was raised in St. Louis and graduated from Harvard College and Harvard
Medical School. His general surgery training was at the Massachusetts General
Hospital, and his pediatric surgery fellowship was at the Boston Children's Hospital
with Dr. W. Hardy Hendren. During surgical residency, he did a research fellowship
with Dr. Michael Harrison at the University of California, San Francisco, and he later
joined the faculty at UCSF
from 1988-95. He was awarded the Resident Scholarship, Schering Award and Faculty
Research Fellowship from the American College of Surgeons. He has had NIH grant
support for fifteen years, and has authored over 350 peer-reviewed publications. Dr.
Adzick serves as the Surgeon-in-Chief at The Children's Hospital of Philadelphia and
the C. Everett Koop Professor of Pediatric Surgery at the University of Pennsylvania
School of Medicine. He also directs The Center for Fetal Diagnosis and Treatment.
Dr. Adzick is certified by the ABS in General Surgery, Pediatric Surgery, and Surgical
Critical Care. He is on the Editorial Boards of the Journal of Pediatric Surgery,
Annals of Surgery, Wound Repair and Regeneration, Fetal Diagnosis and Treatment,
Surgeon in Chief and Current Problems in Surgery. He was elected to the Institute of Medicine of
Children’s Hospital the National Academy of Science in 1998. His research interests focus on aspects of
of Philadelphia prenatal diagnosis and treatment.
C. Everett Koop Scott and Sandy Adzick have one son.
Professor of Surgery
Phone: 215-590-2727
[email protected]
www.uphs.upenn.edu/sur
gery/fac/nsa.html
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THE SOCIETY OF CLINICAL SURGERY
Joseph E. Bavaria, MD
Dr. Joseph Bavaria is the Vice-Chief, Division of Cardiothoracic Surgery
and a Professor of Surgery at the Hospital of the University of Pennsylvania.
He is the Director of the Complex Aortic Surgery Program at PENN which is a
multidisciplinary program encompassing all aspects of aortic disease including
thoracic aortic reconstruction. His primary interests include thoracic aortic surgery
and more broadly, cardio-aortic surgery. This includes aortic dissection, aortic root,
and ascending aortic reconstruction, aortic arch surgery and the circulation
management necessary for successful aortic arch clinical outcomes. Additionally,
Dr. Bavaria's clinical interests include thoracoabdominal aortic aneurysm surgery
and thoracic aortic stent grafting.
Dr. Bavaria's thoracic aortic surgery program at the University of Pennsylvania
presently performs over 250 reconstructive procedures a year and manages over 1,000
patients a year in the Aortic Surgery Clinic. Basic research is presently ongoing in the
microbiology and pathology of the aortic wall in bicuspid valve disease as well as
neuro-cerebral metabolism and protection during cardio-aortic surgery.
Vice-Chair
Dr. Bavaria's other clinical interests include valvular heart surgery and lung
Cardiothoracic Surgery
transplantation and has been the Director of the Penn Program since 1993. Over 300
Professor lung transplants have been performed. He leads an active clinical research group and
has been the institutional primary investigator in over 15 industry sponsored, FDA
Phone: 215-662-2017 IDE Phase I, II, and III trials.
joseph.bavaria@
Dr. Bavaria graduated with honors in chemical engineering at Tulane University
uphs.upenn.edu
where he also received his medical degree. He was awarded the "gold scalpel", the
www.uphs.upenn.edu/ highest surgical honor for a graduating Tulane medical student. He completed his
surgery/fac/jeb.html general surgery and cardiothoracic training at the University of Pennsylvania Medical
Center and Children's Hospital of Philadelphia.
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FACULTY PROFILE
Chief, Thoracic Surgery
Joseph B. Shrager, MD
Hansell H. Stedman, MD
Dr. Shrager is a summa cum lauda graduate of Amherst College and Harvard Medical
School where he won the Cabot graduation prize. At Amherst, he captained a highly
ranked squash team. He obtained his General Surgery training at the Hospital of the
University of Pennsylvania and his Thoracic Surgery training at the Massachusetts
General Hospital. He then came back to Philadelphia where he joined the staff at
PENN in 1998, rising to his current position as Associate Professor and Chief of
General Thoracic Surgery. He also serves as associate program director for the
Thoracic Surgery Residency at Penn.
Hansell H. Stedman, M.D. was promoted to Associate Professor in the Tenure Track in the
Department of Surgery at the University of Pennsylvania on July 1, 2003. Prior to that he
served as the Director of Muscular Dystrophy Research within the Institute for Human
Gene Therapy as well as an Assistant Professor in the Department of Surgery.
Dr. Shrager sits on the Editorial Board of the Annals of Thoracic Surgery and gained
membership to the field's most prestigious association, the American Association for
Thoracic Surgery, as one of its youngest ever inductees.
He maintains a busy clinical practice in all aspects of General Thoracic Surgery, but
special interests include lung cancer and surgery for emphysema. His clinical
abilities have landed him at some point on all of the regional Philadelphia "Top Docs"
lists.
Dr. Shrager's well-published basic research program has focused on adaptation of the
Associate Professor diaphragm and other respiratory muscles to emphysema, lung volume reduction
Phone: 215-662-4767 surgery, and other conditions. This work has been supported by the American
Association for Thoracic Surgery's Churchill Research Scholarship as well as
joseph.shrager@ receiving continuous support from the VA Merit Review system.
uphs.upenn.edu
www.uphs.upenn.edu/
surgery/fac/jbs.html
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THE SOCIETY OF CLINICAL SURGERY
Dr. Stedman was the principal investigator on the world's first human trial investigating
gene therapy as a treatment for Muscular Dystrophy. Much of the scientific rationale for
this clinical investigation was detailed in landmark papers in Nature and Nature Medicine
from his laboratory, including the development of the first surgical method to achieve
limb-wide gene transfer in an animal model for muscular dystrophy. His laboratory has
continued this focus with a program that is currently expanding in scope to address the
most common and devastating childhood-onset form of this disease, Duchenne Muscular
Dystrophy. A major goal of this work, in the tradition of Jonathan Rhoads' development
of TPN, is the demonstration of an effective treatment in a naturally occurring canine
model for the disease.
Gastrointestinal Surgery A fascinating recent spin-off from this research was his laboratory's finding that all
humans have a mutant version of the gene for a critical muscle contractile protein. This
Associate Professor work was featured on the cover of Nature, and received world-wide press coverage
because of its implications for human evolution. He attributes the rare insight culminating
Phone: 215-898-1432
in this and other high-impact publications to his having had the privilege to combine forhstedman@ mal training in such disparate fields as general surgery and molecular genetics.
mail.med.upenn.edu
After earning undergraduate degrees in Biology and Chemistry from M.I.T. and his M.D.
www.uphs.upenn.edu/ from Harvard in 1984, Dr. Stedman trained in General Surgery and Human Genetics at the
surgery/fac/hhs.html University of Pennsylvania. In 1988, he was awarded the prestigious Robert Sampson
award for postdoctoral research on the genetics and pathobiology of Muscular Dystrophy.
He has been the principal investigator on numerous NIH grants and has offered a critical
component to the research portfolios of both the Department of Surgery and the School of
Medicine. He has served for over a decade as attending surgeon at HUP and the
Philadelphia VA hospital, and is one of the few members of the department clinically
active in both General and Vascular Surgery.
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FACULTY PROFILE
THE SOCIETY OF CLINICAL SURGERY
Joseph H. Gorman, III, MD
Kim M. Olthoff, MD
Joseph H. Gorman, III is an assistant professor of surgery at the University of
Pennsylvania. After graduating from Robert Wood Johnson Medical School in the
spring of 1991 he completed both his General and Thoracic surgical residences at the
University of Pennsylvania. During that time he spent two years as a post doctoral
research fellow in the laboratory of L. H. Edmunds, Jr., M.D.
Kim M. Olthoff, MD, is Associate Professor of Surgery in the Division of
Transplantatin at the University of Pennsylvania. She joined the surgical faculty at the
University of Pennsylvania in 1995 and is currently Director of the Liver Transplant
Program at the PENN Transplant Center and at the Children's Hospital of
Philadelphia. Dr. Olthoff received her medical degree from the University of Chicago
in 1986, and completed a residency in general surgery at UCLA followed by a fellowship in transplantation and hepatobiliary surgery at the Dumont - UCLA Transplant
Center. From there, she was recruited to help build the liver transplant programs at
Penn and CHOP. The Liver Transplant Program at Penn is currently one of the busiest
clinical programs in the country, transplanting over 120 patients per year. It was
recently named as the Top Performer for Transplant Benchmarking 2003 by the
University HealthSystem Consortium for patient outcomes, operative statistics,
resource utilization, and initiation of system pathways.
Dr. Gorman's Laboratory effort is funded by several NIH grants and several industrial
contracts. His research interests include:
1. Pathophysiology of heart failure
2. Novel pharmacologic and gene therapy for treating heart failure
3. Effect of left ventricular assist devices on ventricular remodeling and HF
4. Scientific evaluation of surgical procedures/devices in the treatment of heart failure
5. Cardiac Imaging: MRI & real time 3D echocardiography
Cardiothoracic Surgery 6. Mitral valve physiology
Assistant Professor 7. Design of novel annuloplasty rings
Phone: 215-615-0977 8. Percutaneous valve repair/replacement
9. Anorexigen induced valve disease
gormanj@
uphs.upenn.edu 10. Effect of selective ventricular pacing on heart failure
www.uphs.upenn.edu/ 11. Development of material/processes to limit prosthetic heart valve calcification
surgery/fac/jhg.html
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Transplant Surgery
Associate Professor
Phone: 215-662-6136
kim.olthoff@
uphs.upenn.edu
www.uphs.upenn.edu/
surgery/fac/kmo.html
Dr. Olthoff is active in numerous national surgical societies, having served as an officer or councilor for several, such as the AAS and SUS. She also participates in many
national and international transplant organizations. Dr. Olthoff is currently the regional councilor to United Network for Organ Sharing (UNOS) for Region 2, Chair of the
Awards committee for the American Society of Transplant Surgery, and Councilor for
the International Pediatric Transplantation Association. She recently chaired the Liver
and Intestinal Committee of the American Society of Transplantation, and co-chaired
the Membership and Professional Standards Committee for UNOS. She was recently
honored as the Thomas E. Starzl Invited Lecturer at the American Association for the
Study of Liver Diseases.
Dr. Olthoff has an active research laboratory in both basic and translational research
and is a recipient of NIH funding for studies in liver regeneration, living donor transplantation, and immunologic monitoring studies in transplant recipients. She has
authored or coauthored over 100 original papers and book chapters, serves on the editorial boards for Liver Transplantation, Pediatric Transplantation, and the Journal of
Surgical Research, and is an editor of Pediatric Solid Organ Transplantation, 2nd ed
(2005).
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FACULTY PROFILE
Ronald M. Fairman, MD
Ronald M. Fairman, M.D. is Associate Professor of Surgery and Radiology and serves
as Chief of the Division of Vascular Surgery at the Hospital of the University of
Pennsylvania. For the past several years his academic interests have centered on the
development and advancement of endovascular therapies for diseases of the thoracic
and abdominal aorta. He was a Principal Investigator (PI) for the Phase II FDA sponsored EVT and Talent Trials in 1996 and with that began a large collaborative aortic
endovascular program at Penn. Since then he has been National PI for a number of
aortic endovascular stent graft Trials and his Division now has one of the largest experiences internationally totaling well over 700 implants. In 2001, his endovascular interests expanded to include cerebrovascular angioplasty and stenting, and he has served
as PI for multiple industry-sponsored carotid stent with cerebral protection trials culminating in the first FDA approved device this year. He has been actively involved
with training other vascular surgeons regionally to acquire these new endovascular
skills.
After earning his M.D. from Jefferson Medical College in 1977, Dr. Fairman took his
Chief, Vascular Surgery intership and residency in general surgery at Penn. He served as Chief Resident in
General Surgery from 1982-83. He completed his training at Penn as the Vascular
Associate Professor
Surgery Fellow in 1984. Following his training he worked as an Attending on the vasPhone: 215-614-0308 cular surgical service at the Philadelphia VA Hospital and developed a busy vascular
surgery private practice at Jeanes Hospital which was an integrated hospital in the surron.fairman@
gical training program at Penn. He served as Chief of Surgery at Jeanes Hospital for
uphs.upenn.edu
several years before he returned to Penn full-time in 1996.
www.uphs.upenn.edu/
Dr. Fairman serves on the editorial boards of a number of professional journals includsurgery/fac/rmf.html
ing The Journal of Endovascular Therapy and Vascular. He publishes frequently in the
Journal of Vascular Surgery. He has been an invited lecturer throughout the United
States as well as internationally. He has not only been a featured speaker at vascular
surgical societal events, but over the past couple of years has delivered lectures to
interventional radiologists and invasive cardiologists at their forums. He has authored
or co-authored more than 100 original papers.
THE SOCIETY OF CLINICAL SURGERY
Omaida C. Velázquez, MD
Omaida C. Velazquez (B.S., Stevens Institute of Technology, 1987; M.D., University of
Medicine and Dentistry of New Jersey, New Jersey Medical School, Valedictorian,
1991) underwent her post-graduate training in General Surgery and subsequently in
Vascular Surgery at the University of Pennsylvania where she then joined the Faculty,
board certified in both General and Vascular Surgery. In addition to her clinical training she pursued additional years in research studies and was the recipient of the
Jonathan E. Rhoads Research Award (1997). Dr. Velazquez is the Principal
Investigator of an NIH-funded basic science laboratory that investigates endothelial
cell biology, angiogenesis, and vasculogenesis. She received the von Liebig
Foundation Award for Excellence in Vascular Surgical Research (2001), the University
of Pennsylvania Center of Excellence Faculty Scholar Award (2002), and the Joel J.
Roslyn Faculty Research Award (2003). Her current research focuses on further understanding and advancing new treatments in lower extremity arterial occlusive disease
and wound healing. In addition, Dr. Velazquez leads a very active clinical practice that
focuses on endovascular and other minimally invasive approaches in the surgical
treatment of vascular disease and has been listed in Who's Who in Medicine and
Vascular Surgery
Healthcare, 2004. She has been a co-investigator in multiple clinical trials that study
Assistant Professor endovascular approaches for aortic aneurysms and carotid stenosis.
Phone: 215-662-6451 Among other important professional societies, Dr. Velazquez is a fellow of the
American College of Surgeons, the American Society of Angiology and member of
omaida.velazquez@
Alpha Omega Alpha Honor Medical Society, the American Association for Vascular
uphs.upenn.edu
Surgery, the Association for Academic Surgery, the American Association for the
www.uphs.upenn.edu/ Advancement of Science, the International Society for Vascular Surgery, the New York
surgery/fac/ocv.html Academy of Science, Sigma Xi Scientific Research Society, the Society for Clinical
Vascular Surgery, and the Society of University Surgeons.
He is a member of numerous professional organizations including the Society for
Vascular Surgery, American Association for Vascular Surgery, the Society for Clinical
Vascular Surgery, Eastern Vascular Society, and the American College of Surgeons.
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FACULTY PROFILE
James F. Markmann, MD, PhD
Y. Joseph Woo, MD
James Markmann, MD, PhD is an Associated Professor of Surgery and multi organ
transplant surgeon with a focus on liver transplantation. He currently serves as
Director of the Pancreas Transplant program at the Hospital of the University of
Pennsylvania and is the director of the human islet isolation facility.
Joseph Woo, M.D. received an undergraduate degree from the Massachusetts Institute
of Technology in 1988. While there he conducted molecular biology research and his
senior thesis with Salvador E. Luria M.D. In 1992, Dr. Woo earned his M.D. from the
University of Pennsylvania where he was a member of the Alpha Omega Alpha Honor
Society and was awarded the I.S. Ravdin prize in Surgery. Dr. Woo then performed
his surgical residency training at the University of Pennsylvania which he completed
in 1999. During this time, Dr. Woo completed a two year post-doctoral basic science
research fellowship with H. Lee Sweeny, PhD. studying cardiac gene transfer and
developing novel strategies of attenuating myocardial ischemia. For his research, Dr.
Woo was awarded the American Heart Association, Vivien Thomas, Young
Investigator Award in 1997. During his general surgery training, Dr. Woo also won
several teaching awards. Dr. Woo then began his residency training in cardiothoracic
surgery at the University of Pennsylvania with Timothy J. Gardner, M.D. and Larry R.
Kaiser, M.D.
Dr. Markmann's academic pursuits include both basic research and translational clinical research. In the laboratory, two areas in which he has NIH funded research in
transplant immunobiology include: gene based strategies to improve graft survival
and strategies to induce transplantation tolerance induction. First we have constructed
viral vectors encoding immunosuppressive or immunomodulatory molecules to
impact the host response to islet allografts. Second, we have focused on characterization of a particular population of immunoregulatory T cells that are know to be critical
for self-tolerance as a means to induce tolerance to an allograft. In addition to basic
research, Dr. Markmann has been integral to the development and success of the
human islet transplant program at Penn. The Penn clinical islet trial that is funded by
the NIH and JDRF began 3 years ago and has become one of the most active and most
Transplant Surgery successful in the nation.
Associate Professor After earning his M.D. and PhD from the University of Pennsylvania School of
Medicine in 1989, Dr. Markmann completed his internship and residency in general
Phone: 215-662-7367
surgery at HUP. He served as Chief Resident in Surgery from 1995-96. In 1998, Dr.
james.markmann@ Markmann completed a fellowship in multi-organ Transplant Surgery at Dumontuphs.upenn.edu UCLA Transplant Center. Dr. Markmann then returned to join the faculty at the
University of Pennsylvania as Assistant Professor of Surgery, rising early to Associate
www.uphs.upenn.edu/
Professor with tenure in 2003.
surgery/fac/jfm.html
Dr. Markmann has authored or co-authored more than 150 original papers and chapters including manuscripts in to science journals such as Nature, Science, Diabetes
Journal of Immunology, Journal of Virology and Gene Therapy. He co-authored several Chapters in major books such as, Handbook of Organ Transplantation, Sabiston
Textbook of Surgery and Retransplantation. He performs editorial services for a number of professional journals, including Transplantation, Diabetes, Journal of
Immunology, Human Gene Therapy and American Journal of Transplantation. He
was recently selected to serve on the Juvenile Diabetes Research Foundation Science
Review Committee, the Immune Tolerance Network Strategic Planning Committee,
and the ASTS Joint Planning committee for the American Transplant Congress. He
has also served on a number of NIH grant review committees.
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THE SOCIETY OF CLINICAL SURGERY
He is a member of numerous professional organizations including the American
Association for the Advancement of Science, American College of Surgeons, American
Society of Transplant Surgeons, Association for Academic Surgery, International
Society of Pancreas and Islet Transplantation, Society of University Surgeons,
International Transplantation Society, Cell Transplant Society, and the Surgical Biology
Club II. He also currently is on numerous national professional committees including,
AST Patient Affairs Committee and the ASTS Cell Transplant Committee.
In 2002, Dr. Woo joined the faculty at the University of Pennsylvania and was appointCardiothoracic Surgery ed Assistant Professor of Surgery and Director of the Minimally Invasive and Robotic
Cardiac Surgery Program. Dr. Woo performed the first robotic cardiac surgical proceAssistant Professor
dure in the Delaware Valley as well as the world's first robotic aortic valve procedure.
Phone: 215-662-2956 He was the principal investigator of a clinical trial investigating totally endoscopic
coronary artery bypass grafting with the daVinci robotic system. He currently actively
[email protected]
utilizes the robotic system to perform mitral valve reconstruction, atrial septal defect
www.uphs.upenn.edu/ repair, as an adjunct to coronary artery bypass grafting, and several other cardiac prosurgery/fac/yjw.html cedures. Dr. Woo is also currently the principal investigator for a randomized clinical
trial investigating off-pump repair of the mitral valve.
Dr. Woo currently heads a basic science research laboratory funded by the National
Institutes of Health, Thoracic Surgery Foundation for Research and Education, and the
American Heart Association studying angiogenic, somatotrophic, and myocardial
regeneration strategies for the treatment of heart failure. His laboratory has published
several papers describing novel treatment strategies for myocardial ischemia and heart
failure.
Dr. Woo has served as reviewer for professional journals such as Circulation, The
Journal of Thoracic and Cardiovascular Surgery, The Annals of Thoracic Surgery, and
The Journal of Molecular Histology. Dr. Woo has co-authored textbook chapters on
myocardial re-vascularization and thoracic aortic disease. He is a member of several
professional organizations including the Society of Thoracic Surgeons, The American
College of Surgeons, The International Society for Minimally Invasive Cardiac Surgery,
The American College of Cardiology and The International Society for Heart Research.
Dr. Woo serves as a member of the leadership committee for the Council on
Cardiovascular Surgery and Anesthesia of the American Heart Association.
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