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Rudbeck Life Science Symposium 2nd Chiba-Uppsala Meeting February 16-17, 2012 Rudbeck Laboratory, Uppsala Program Thursday, February 16 Session 1 Chairpersons: Koutaro Yokote and Lars Larsson 9.00-9.10 Lena Claesson-Welsh, Welcome, introduction, 9.10-9.30 Olle Kämpe, Dept. Medical Sciences, Uppsala University, “Molecular mechanisms in autoimmune disease” 9.30-9.50 Kazuo Suzuki, Inflammation Program, Dept. Immunology, Chiba University Graduate School of Medicine. “Mechanism of vasculitis development” 9.50-10.10 Lars Larsson, Dept. Neurosciences, Uppsala University. “Molecular mechanisms for muscle waisting/sarcopenia in ageing" 10.10-10.30 Koutaro Yokote, Dept. Internal Medicine, Chiba University Graduate School of Medicine. “Progeric syndrome and its implication in age-related diseases” 10.30-10.50 Coffee Session 2 Chairpersons: Kotaro Suzuki and Birgitta Heyman 10.50-11.10 Birgitta Heyman, Dept. Medical Biochemistry and Microbiology, Uppsala University, “IgE in antigen transport and immune responses” 11.10-11.30 Gunnar Nilsson, Clinical Immunology and Allergy, Department of Medicine, Karolinska Institutet “Mast cells as regulators of skin inflammation and immunity.” 11.30-11.50 Kotaro Suzuki, Dept. Molecular Genetics. Chiba University Graduate School of Medicine. “Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation” 12.00-14.00 LUNCH Session 3 Chairpersons: Takashi Miki and Mikael Rehn 14.00-14.20 Leif Andersson, Dept. Medical Biochemistry and Microbiology, Uppsala University. "Novel animal models for genetic dissection of growth and appetite". 14.20-14.40 Takashi Miki, Dept Medical Physiology, Chiba University Graduate School of Medicine. “Metabolic consequences of high fat diet in insulin resistance” 14.40-15.00 Mikael Rhen, Dept. Microbiology, Tumor and Cell Biology, Karolinska Institutet “Genetic regulation of salmonella-host interactions” 15.00-15.20 Tomoko Yamamoto, Dept. Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sci., Chiba University Graduate School of Medicine. “Control of Salmonella pathogenicity island expression on the stress-induced regulatory loop within macrophages” 15.20-15.40 Akiko Takaya, Dept. Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Sci. Chiba University, ”Control of inflammatory response and macrophage cell death by Salmonella” Friday, February 17 Session 4 Chairpersons: Magnus Essand and Anna Dimberg 9.00-10.00 Jacques Pouyssegur, Institute of Developmental Biology and Cancer Research, University of Nice, “Tumor and metabolism” 10.00-10.30 Coffee 10.30-10.50 Magnus Essand, Dept of Immunology, Genetics and Pathology, Uppsala University, “Cancer Gene Therapy” 10.50-11.10 Anna Dimberg, Dept of Immunology, Genetics and Pathology, Uppsala University “Distinct gene expression signature of vessels in high grade human glioma” 11.10-11.30 Michael Welsh, Dept. of Medical Cell Biology, Uppsala University. “Role of the Shb adaptor protein in tumor angiogenesis”. 11.30-11.50 Lena Claesson-Welsh, Dept of Immunology, Genetics and Pathology, Uppsala University “Regulation of tumor inflammation” 11.50-12.00 Concluding remarks