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Stool testing for Gastrointestinal Pathogens Antibodies used in commercial stool antigen detection assays Meridian offers a range of antibodies to gastrointestinal pathogens, which have been validated in various types of immunoassays. These products are currently being used in commercial diagnostic assays to detect pathogens from stool samples. Common Gastro Pathogens Adenovirus Calprotectin Campylobacter jejuni Clostridium difficile Toxin A & B Cryptosporidium parvum E. coli O157 Giardia lamblia Helicobacter pylori Norovirus Rotavirus Salmonella species Shigella species Verotoxin Antibodies suitable for rapid testing Diagnostics for Acute Gastroenteritis Acute gastroenteritis is a common syndrome that is generally caused by a virus, parasite or food-borne bacteria. Diagnosis of the responsible intestinal pathogen requires the detection of the organism in the feces, duodenal fluid, or small intestine using biopsy specimens. Since fecal examination is labor intensive and requires a skilled microscopist, antigen detection tests have been developed as alternatives using direct fluorescent antibody (DFA), enzyme immunoassay (EIA), and rapid, dipstick-like tests. These immunoassays are quick to perform, do not require skilled personnel and are very specific. There are many commercially available diagnostics for a range of gastrointestinal pathogens, including panel assays that simultaneously test for a range of possible infectious agents using a single stool sample. Antibody Pairs Adenovirus Capture C01727M C66431M C66431M C65431M Calprotectin L1 K01373M C. jejuni C65727M C. difficile Toxin A C01678M C. difficile Toxin B C65423M E. coli O157 C01535M Giardia lamblia C65612M Norovirus GI Capsid C01872M C01871M Norovirus GII Capsid C01880M C01880M C01879M C01877M C01877M Rotavirus C65196M C65196M C01729M Detection C01728M C01554M C01256M C65604M K01376M C65727M C01677M C65426M C01533M C65361M C01871M C01875M C01878M C01880M C01877M C01878M C01877M C65194M C65197M C01730M ELISA & LF ELISA ELISA & LF ELISA & LF ELISA ELISA & LF ELISA LF ELISA ELISA LF ELISA LF LF LF ELISA ELISA ELISA, LF ELISA, LF ELISA, LF www.MeridianLifeScience.com ANTIBODIES for stool testing Adenovirus Hexon C11994M ELISA, LF C01727MELISA, LF, pair C01728MELISA, LF, pair C01554MELISA, IFA, pair C01256MELISA, LF, IFA, pair C65431MELISA, LF, IFA, pair C65604MELISA, LF, IFA, pair Adenovirus 40 & 41 C66431M ELISA Calprotectin L1 K01375MELISA K01374MELISA K01373MELISA, pair K01376MELISA, pair Campylobacter jejuni C66700MELISA C65727MELISA, LF, WB, pair Clostridium difficile Toxin A C70517MELISA C01677MELISA, pair C01678MELISA, pair Clostridium difficile Toxin B C65427M ELISA C65423M ELISA, LF, pair C65426M ELISA, LF, pair Cryptosporidium parvum Giardia lamblia C01597MELISA, IFA, WB C65361MELISA, IFA, WB, pair C65612MELISA, IFA, WB, pair Helicobacter pylori C65461MELISA, IFA, WB Norovirus GI Capsid C01871MELISA, LF, WB, pair C01872M ELISA, LF, WB, pair C01875M ELISA, WB, pair B65901RELISA, IFA (Rabbit PAb) Verotoxin I (Shiga-Like) B Subunit (SLT-1b, STX-1b) C01690MELISA Verotoxin II (Shiga-like) A subunit (SLT-2a, STX-2a) C65585MELISA, Neutralizing Norovirus GII Capsid C01877MELISA, LF, WB, pair C01878MELISA, pair C01879MELISA, LF, WB, pair C01880MELISA, LF, WB, pair Rotavirus C65194MELISA, LF, pair C65196MELISA, LF, pair C65197MELISA, LF, pair C01729MELISA, LF, pair C01730MELISA, LF, pair Rotavirus Group A Specific Antigen, VP6 C66130MELISA Salmonella species (A,B,C,D,E,F & G Groups) C65370MELISA, IFA, IHC C65957MELISA, IFA C01360MELISA, IFA E. coli O157 Salmonella typhi (LPS) C65160MELISA, IFA C01533MELISA, IFA, pair C01535MELISA, IFA, pair Shigella C01362MELISA, IFA Salmonella paratyphi A C01884MELISA, IFA Meridian Life Science Inc. 5171 Wilfong Road, Memphis, TN 38134 901-382-8716 • 800-327-6299 [email protected] www.MeridianLifeScience.com