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Connective Tissue Diseases Marfan Syndrome Affects connective tissue Makes them loose Aorta walls weaken and artery swells Long spidery fingers Sunken Chest Tall Lanky body Eye Lens out of place Scleroderma Connective tissue get hard or thick Hard tight Skin Major organs become hard Localized and Systemic Ehlers-Danlos Weak, fragile connective tissue Loose skin and joints Double Joints Fibromyalgia Controversy Psychological or physiological Cymbalta