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Wound edges drive strong currents toward the wound center. (A) Electrical currents at a corneal epithelial wound measured with a vibrating probe. The lower panel shows the direction and size of the currents represented with the length of the arrows. (B) The wound electrical currents are strongest at the wound edge. (From Reid, B, Song, B, McCaig, CD, et al: Wound healing in rat cornea: The role of electric currents. FASEB J 2005; 19:379–386.) (C) Lateral electric potentials in the vicinity of a wound made in the mammalian skin. Schematic graphs illustrate the transepithelial and lateral electric potentials and the corresponding measurement methods. Transepithelial potentials in the vicinity of the wound were measured as shown on the left. Data obtained from such a measurement are shown as the blue curve. (For actual data, see Barker et al, Am J Physiol Regul Integr Comp Physiol 1982; 11: Source: Endogenous and Exogenous Electrical Fields for Wound Healing, Wound Healing Evidence-Based Management, 4e R248.) The resistance at the wound decreased due to the short-circuitry at the wound. When the wound is kept moist, the current driven by the epidermal Citation: KlothtoLC. Healing Evidence-Based 4e; 2010 Available Accessed: May TEP flows toward theMcCulloch wound andJM, returns theWound "epithelial battery" via the route Management, between the dead cornified layer at: andhttp://mhmedical.com/ the live epithelial layers. The lateral 02, 2017 field in the vicinity of the wound, plotted as a function of distance from the wound edge, is shown as the red curve. As the currents return to the epidermal Copyright © 2017 McGraw-Hill All rights reserved battery, the lateral voltage potential drops Education. gradually (the red curve). (Modified from Vanable, JW Jr: Integumentary potentials and wound healing. In: Borgans, RB, Robinson, K, Vanable, J, McGinnis, M, et al (eds): Electric Fields in Vertebrate Repair. New York, Alan R. Liss, 1989, p 187.)