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M ORE CHOICES MORE ANSWERS MICROSCAN GRAM POSITIVE CONVENTIONAL MIC PANELS Combating antibiotic-resistant bacteria: the Microbiology lab answers the challenge There has been an alarming increase in antibiotic-resistant infections, both in the United States and worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) outbreaks have been reported by the media for more than a decade. In early 2015, a presidential task force released the National Action Plan for Combating Antibiotic Resistant Bacteria. The goals and strategies outlined in this document are intended to significantly reduce the incidence of urgent and serious threats, including MRSA, by 2020. New! Ceftaroline and Tigecycline now available MicroScan is the first to offer ceftaroline on an automated susceptibility panel. Unlike most previous cephems, ceftaroline† is able to bind to and inhibit altered penicillin-binding proteins associated with resistance to ß-lactam drugs, making it the first drug in its class approved for treatment of MRSA in acute bacterial skin and skin structure infections (ABSSSI). Tigecycline‡, a glycycline antibiotic, is not affected by the two major in-class resistance mechanisms, ribosomal protection and efflux, and has demonstrated activity against a broad spectrum of bacterial pathogens including MRSA. Including these advanced-generation antibiotics can augment your testing menu and help improve workflow efficiency in your laboratory by: » Expanding your capabilities for treating MRSA » Enhancing your microbiology testing menu » Reducing supplemental testing costs MicroScan MIC Panels For over 30 years, MicroScan panels have provided gold-standard bacterial identification and susceptibility products, confronting emerging resistance with first time results and accuracy. The first vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus isolates were detected during routine testing on MicroScan Systems.1, 2 Now with the adoption of MALDI technologies, there is even more interest in complementary MIC panel options. Integration of rapid MALDI-TOF identifications with the accuracy of MicroScan MIC results, provide best-in-class technologies to support antimicrobial stewardship programs and ultimately, patient care goals. Count on MicroScan for unmatched experience, expertise, and selection. Panel Name Pos MIC 29 Pos MIC 34 MICroSTREP plus 1 MICroSTREP plus 2 MicroScan Catalog Number B1017-212 B1017-216 B1027-201 B1027-202 Languages EN,ES,FR,PT EN,ES,FR,PT EN,ES,FR,PT EN,ES,FR,PT Antimicrobic Agent µg/mL µg/mL µg/mL µg/mL Abbr. Antimicrobial Agent Amoxicillin/K Clavulanate Ampicillin Ampicillin/Sulbactam Azithromycin Cefaclor Cefazolin Cefepime Cefotaxime Cefoxitin Screen Ceftaroline Ceftriaxone Cefuroxime Chloramphenicol Ciprofloxacin Clarithromycin Clindamycin Daptomycin Erythromycin Gatifloxacin Gentamicin Gentamicin Synergy Screen Imipenem Inducible Clindamycin Test Levofloxacin Linezolid Meropenem Moxifloxacin Nitrofurantoin Oxacillin Penicillin Rifampin Streptomycin Synergy Screen Synercid Tetracycline Tigecycline Trimethoprim/Sulfamethoxazole Vancomycin µg/mL 4/2 2-8 8/4-16/8 – – 4-16 – – 4 – 4-32 – 8-16 1-2 – 0.25-4 0.25-4 0.25-4 – 1-8 500 4-8 4/0.5 0.5-4 0.5-4 2-8 0.5-4 32-64 0.25-2 0.03-8 1-2 1000 0.25-2 1-8 – 0.5/9.5-2/38 0.25-16 µg/mL – 2-8 – – – 4-16 – – 4 0.5-4 4-32 – 8-16 1-2 – 0.25-4 0.25-4 0.25-4 – 1-8 500 – 4/0.5 0.5-4 0.5-4 – 0.25-4 32-64 0.25-2 0.03-8 1-2 1000 0.25-2 2-8 0.12-1 0.5/9.5-2/38 0.25-16 µg/mL 0.5/0.25-4/2 0.06-4 – 0.25-2 0.5-4 – 0.25-2 0.25-2 – – 0.25-2 0.25-2 1-16 – – 0.06-0.5 – 0.06-0.5 0.12-2 – – – – 0.25-4 – 0.06-0.5 – – – 0.03-4 – – – 0.5-4 – 0.25/4.75-2/38 0.12-1 µg/mL 0.5/0.25-4/2 0.06-4 – 0.5-2 0.5-4 – 0.25-2 0.25-2 – – 0.25-2 0.25-2 1-16 – 0.25-1 0.06-0.5 0.25-2 0.06-0.5 – – – – – 0.25-4 0.5-4 0.06-0.5 0.25-4 – – 0.03-4 – – – 0.5-4 – 0.25/4.75-2/38 0.12-4 Abbr. Aug Am A/S Azi Cfr Cfz Cpe Cft CfxS Cpt Cax Crm C Cp Cla Cd Dap E Gat Gm GmS Imp ICd Lvx Lzd Mer Mxf Fd Ox P Rif StS Syn Te Tgc T/S Va Total Antibiotic Tests/Panel 28 26 18 21 MicroScan Supplementary Identification Panels: Rapid Gram Positive B1017-166 Rapid Positive ID Type 3 Overnight Gram Positive B1017-221 Positive ID Type 3 †Ceftaroline fosamil is sold in the United States as Teflaro® by Forest Pharmaceuticals, Inc., an Allergan affiliate. ‡Tigecycline is sold under the trademark name TYGACIL® by Pfizer, Inc. 1CDC, 1997. Infect. Morbid. Mortal. Weekly Rep. 46:765-766. 2Chang et al., 2003. New Engl. J. Med. 348:1342-1347. Not all products available in all countries. Beckman Coulter, the stylized logo and MicroScan are trademarks of Beckman Coulter, Inc. and are registered in the USPTO. For Beckman Coulter’s worldwide office locations and phone numbers, please visit www.beckmancoulter.com/contact FL-50765 © 2015 Beckman Coulter, Inc. All Rights Reserved. www.beckmancoulter.com