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Assessing Cardiac Function Gusztav Belteki Rosie Hospital, Cambridge 20/10/2014 Summary of the talk 1. Transitional circulation 2. Ventricular function 3. Cardiac output Transitional circulation • Fetal circulation: - Right ventricular dominance - Fetal shunts • Postnatal circulation: - Left ventricular dominance - No shunts (“serially connected” circulation) Transitional circulation Tricuspid regurgitation Open ductus arteriosus These are normal findings in the first 72 hours and DO NOT mean PPHN or CHD in a newborn who is not hypoxic ! Ventricular function Cardiac output = Heart rate X Stroke volume Stroke volume is determined by: - Preload - Contractility - Afterload Ventricular function Left ventricular Right ventricular Systolic = Contractility Diastolic Left ventricular contractility • A useful method of assessing ventricular contractility is visual inspection of the apical four chamber view by a trained eye • Quantitative methods: - fractional shortening (FS) - ejection fraction (EF) - velocity of circumferential shortening (Vcf) M-mode of the left ventricle 1 2 2 1 Fractional shortening LVEDD - LVESD FS = X 100 25 – 41 % LVEDD Dependent on contractility AND preload Poor contractility • Ejection fraction (EF) LVEDD3 – LVESD3 FS = LVEDD3 X 100 (1.2)3 = 1.728 • Velocity of circumferential fiber shortening LVEDD – LVESD LVET X Vcfc = sqrtRR LVEDD LVET = left ventricular ejection time Right ventricular dominance S D - Dilated right ventricle - Paradoxical septal motion S D Right ventricular contractility Diastolic ventricular function • Hypertrophic cardiomyopathy: - Infants of diabetic mothers - Postnatal steroid course - Inborn errors of metabolism • Immature myocardium (prematurity) Hypertrophic obtructive cardiomyopathy Diastolic ventricular function Normal: E / A > 1 Abnormal: E / A < 0.7 E wave: passive filling A wave: atrial contraction Cardiac output Mean arterial pressure Cardiac output = Vascular resistance Cardiac output • No shunts: systemic and pulmonary circulations serially connected: Systemic CO = Pulmonary CO • Shunts (ASD, VSD, PDA): Systemic CO = Pulm. CO • VSD, PDA: Systemic CO = Left ventr. output Pulmonary CO = Right ventr. output How to measure left ventricular output Aortic stroke distance = aortic root velocity-time integral (VTI) AoSD normal (term newborn) 15 ± 3 cm How to measure left ventricular output Aortic root diameter (d) Aortic root cross sectional area (AoCSA) AoCSA = (d2 x π) / 4 (cm2) How to measure left ventricular output Left ventricular output (LVO) = AoSD (cm) x AoCSA (cm2) x HR (bpm) Body weight (ml / min / bwkg) Normal (term newborn): 160 – 320 mL/kg/min BUT: in case of PDA or VSD left ventricular output is not the same as systemic cardiac output !!) Right ventricular output Right ventricular output (RVO) = PSD (cm) x PCSA (cm2) x HR (bpm) Body weight