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The Nexus of HIV: How Mental Illness, Childhood Sexual Abuse, and Other Factors Make Individuals Vulnerable to HIV and Other Sexually Transmitted Infections M. Jann DeWitt, PhD Assistant Professor Department of Family and Preventive Medicine School of Medicine University of Utah Objectives To understand the role of mental illness in creating vulnerability to HIV/AIDS and other STD’s. To understand the mental health issues impacting individuals who have been diagnosed with HIV/AIDS. To be able to discuss the integration of treatment for HIV and mental illness. To identify major issues in psychotherapy with HIV+ patients. Risk Factors for HIV Infection and Transmission Mental Illness Drug Abuse Trauma Sexual Abuse Mental Health and HIV and STD’s HIV elevates mental health risk Mental health issues elevate HIV and STD risk – – – Increased risk for transmission Increased risk for nonadherence Possible increased risk for disease progression Substance abuse goes with both – – Mental health issues go with substance use Substance use complicates HIV treatment Reported Chlamydia Cases and Rates**(Per 100,000) for State of Utah 2004 2005 2006 2007* Cases Rates Cases Rates Cases Rates Cases Rates 3,859 156.28 4,602 181.97 5,092 197.18 5,721 211.92 * Provisional data as of 07/10/08 Utah Department of Health, Bureau of Communicable Disease Control, HIV/AIDS and STD Surveillance Program Reported Gonorrhea Cases and Rates**(Per 100,000) for State of Utah 2004 2005 2006 2007* Cases Rates Cases Rates Cases Rates Cases Rates 603 24.42 727 28.75 888 34.38 821 30.41 * Provisional data as of 07/10/08 Utah Department of Health, Bureau of Communicable Disease Control, HIV/AIDS and STD Surveillance Program Reported Primary and Secondary Syphilis Cases and Rates**(Per 100,000) for State of Utah 2004 2005 2006 2007* Cases Rates Cases Rates Cases Rates Cases Rates 13 0.53 10 0.39 21 0.81 20 0.74 * Provisional data as of 07/10/08 Utah Department of Health, Bureau of Communicable Disease Control, HIV/AIDS and STD Surveillance Program U.S. Trends in the HIV Epidemic Growing and persistent health threat to women, especially young women and women of color. Persons of minority races and ethnicities are disproportionately affected. More young MSM (men who have sex with men) are being impacted by HIV/AIDS. U.S. HIV/AIDS Statistics Transmission Categories AIDS Cases % HIV Positive % Men Having Sex with Men (MSM) 422,769 45% 74,150 31% Injection Drug Use 229,811 25% 33,434 14% MSM/IDU 61,080 6% 9,483 4% Hemophilia 5,737 1% 677 0% 117,063 12% 39,482 16% Transfusion/Tissue 9,780 1% 1,306 1% Other/Undetermined 94,042 10% 83,391 34% Subtotal for Adults 940,282 100% 241,923 100% 9,446 100% 5,028 100% Heterosexual Contact Subtotal for Children (under 13 years) Total Adults and Children 949,728 246,951 HIV/AIDS Reporting for Utah and United States February 29, 2008 U.S. HIV/AIDS Statistics Total Deaths AIDS Cases % 541,345 57% HIV/AIDS Reporting for Utah and United States February 29, 2008 Utah HIV/AIDS Statistics Transmission Categories AIDS Cases % HIV Positive % Men Having Sex with Men (MSM) 1,484 62% 551 56% Injection Drug Use 388 16% 106 11% MSM/IDU 237 10% 126 12% Hemophilia 48 2% 1 0% Heterosexual Contact 146 6% 87 9% Transfusion/Tissue 26 1% 2 0% Other/Undetermined 80 3% 118 13% 2,409 100% 991 100% 20 100% 13 100% Subtotal for Adults Subtotal for Children (under 13 years) Total Adults and Children 2,429 1,004 HIV/AIDS Reporting for Utah and United States February 29, 2008 Utah HIV/AIDS Statistics Total Deaths AIDS Cases % 1,168 48% HIV/AIDS Reporting for Utah and United States February 29, 2008 July 2008 e July 2008 e July 2008 e July 2008 e July 2008 e July 2008 e July 2008 e July 2008 e Mental Illness and Risk Factors for HIV/AIDS McKinnon et al (2001) interviewed 195 patients with severe mental illness. 51% were sexually active had a mean of 3.9 sexual partners in the previous 6 months with average of 27.5 sex episodes Mental Illness and Risk Factors for HIV/AIDS 49% had known high risk partners 34% used alcohol or drugs during sex 28% traded sex 59% never used condoms Mental Illness among HIV+ Individuals Occurs at very high rates among HIV+ individuals (Dr. Deborah Haller, Virginia Commonwealth University, in a multi-site study) Dual and Triple Diagnoses were common – – – – 94% of substance users had a co-occurring psychiatric disorder 88% had at least one non-substance use psychiatric disorder 43% of those with psychiatric diagnoses also had a substance use disorder. Mental Illness among HIV+ Individuals HIV and Mental Illness Study (11 sites around the U.S.). This CMHS study included 1,837 HIV+ male and female subjects, minorities, heterosexuals and homosexuals. Dr. Haller reported preliminary data for HIV+ men: Mental Illness among HIV+ Individuals Major Depression Drug Dependence Generalized Anxiety Disorder Panic Disorder Alcohol Dependence Dysthymia Agoraphobia 59% 48% 26% 25% 22% 22% 14% Mental Illness among HIV+ Individuals From Richmond Site, Dr. Haller reported these other Axis I, DSM IV diagnoses in HIV+ Men (N=150) and Women (N=41) based on the Millon-III: – – – – – – Anxiety Disorder Somatoform Disorder Post Traumatic Stress Disorder Thought Disorder Bipolar Disorder Delusional Disorder 82% 16% 19% 13% 11% 10% Mental Illness among HIV+ Individuals Dr. Haller also reported these Axis II, DSM IV diagnoses for HIV+ Men and Women from the Richmond Site based upon the Millon III: – – – – – – – – Dependent Passive Aggressive Avoidant Schizoid Borderline Paranoid Antisocial Schizotypal 45% 43% 39% 33% 32% 24% 22% 16% How does HIV Infection Impact Mental Health? CSF Viral Load Psychosocial manifestations of disease Impact of diagnosis, etc. With Asymptomatic Infection HIV invades the brain at initial infection Neither condition is rare and association may be due to chance Not known if HIV by itself increases biological vulnerability to certain mental illnesses. With Symptomatic Illness -Concern is differential diagnosis -Can be a complication of substance use/withdrawal, medical illness, metabolic disturbances, neuropsychiatric manifestations of HIV (e.g.,HAD, MCMD), side effects of HIV-related medications, etc. -Can occur at the initial presentation of symptomatic HIV illness. Personality Traits/States Associated with Sexual risk Behaviors for HIV exposure and Transmission Sensation seeking Impulsivity Conscientiousness (negatively associated) Neuroticism (weakly associated) Agreeableness ( negatively associated) *Hoyle, Fejfar, and Miller, Personality and sexual risk taking: A quantitative review. Journal of Personality,68;6: 1202-31 Common Treatment Dilemmas Provider counter transference reactions to “self- destructive” and “manipulative” patient behaviors. These patients are the most difficult to manage long term , the paradoxical help seeking chronically help rejecting patient. Sensible limit-setting. Personality Disorders Associated with HIV Risk Borderline Antisocial Histrionic Dependent Medical Management of Unstable PD Patients Reframe all consequence avoidance so this becomes a reward Appeal to the patients cognitive capacities in lieu of mandate or ultimatums which typically result in non productive power struggles and stalemates. Treatment plans should be written down clearly and agreed upon collaboratively setting firm limits and realistic goals based on provider resources and mandates . Social Discrimination and Mental Health Outcomes in Latino Gay Men Rafael M. Díaz Director, César Chávez Research Institute College of Ethnic Studies San Francisco State University A Sociocultural Model of Mental Health Psychological Symptoms Psychological Impact of Oppression Discrimination and Social Oppression Oppressive Sociocultural Factors Machismo / Homophobia Family Loyalty & Sexual Silence Poverty & Racism Violence & Sexual Abuse HIV/AIDS Stigma Psychosocial Impact of Oppression Loneliness / Social isolation Self esteem / Self respect Internalized homophobia and sexual discomfort Low perceptions of sexual control Hopelessness about HIV infection Psychological Symptoms Anxiety Depression Suicidal Ideation Sample Characteristics • 912 men recruited probabilistically in 35 Latino gay bars • 50% under age 30 • New York: n = 309 • Miami: n = 302 • Los Angeles: n = 301 • 27% unemployed • 84% self-identified gay or homosexual • 72% immigrant (including Puerto Rico) • 64% some college or more • 41% mostly Spanishspeaking (with friends) • 22% HIV-positive Physical & Psychological Symptoms last 6 months Felt sick 54% (49-59) Difficulty sleeping 61% (56-66) Scared for no reason 44% (39-49) Sad or depressed 80% (76-84) Suicidal ideation 17% (15-20) Impact of HIV/AIDS Stigma on HIV-Positive Men (N = 154) Prevalence Reported Impact More difficult to trust people 64% Harder to enjoy sex 66% More difficult to find sex 46% More difficult to find lover relationships 58% Worried that any physical symptom is a sign of AIDS 72% Expects sexual rejection after disclosure 82% Has to hide HIV status to find acceptance from family and friends 45% Treated unfairly for being HIV-positive 46% Testing the Impact of HIV/AIDS Stigma on the Mental Health of HIV-Positive Men Basic Model Resiliency Poverty Racism Homophobia Social Isolation Low SelfEsteem Psychological Symptoms D R2 ? Enhanced Model Resiliency Poverty Racism Homophobia HIV/AIDS Stigma Social Isolation Low SelfEsteem Psychological Symptoms Models of Oppression for Health Outcomes of HIV-Positive Men Predicted Outcome SCM + Stigma Sociocultural “Enhanced” Model “Basic” Model p R2 R2 DR2 Loneliness .30 .48 <.0001 Low Self-Esteem .28 .31 <.05 Psychological Symptoms .24 .35 <.001 Association Between Early Sexual Abuse and Adult HIV-Risky Sexual Behaviors among CommunityRecruited Women K. Parillo, R. Freeman, K. Collier, and P. Young Journal of Child Abuse & Neglect Volume 25, Issue 3, March 2001, Pages 335-346 Early Sexual Abuse & Adult HIV-Risky Sexual Behaviors in Women Methods – Recruitment in Boston, Los Angeles, & San Diego – Women recruited from neighborhoods characterized by high HIV seroprevalence rates – Eligibility requirements: Has not injected drugs in year prior to study Has had sexual intercourse with male IDU at least once in last 5 years Early Sexual Abuse & Adult HIV-Risky Sexual Behaviors in Women Results – – 34% of women had experienced sexual abuse with penetration 9% childhood only 17% adolescents only 7% both childhood & adolescents 49% had been raped in adulthood Early Sexual Abuse & Adult HIV-Risky Sexual Behaviors in Women Results – Women penetrated in childhood (<12 yrs old) were 2.4 times more likely to have traded sex for $ or drugs – Women penetrated in adolescence (12-18 yrs old) were 1.7 times more likely – Women penetrated in both childhood and adolescence were 3.4 times more likely to have engaged in such behavior – Women who had been raped in adulthood were 2.9 times more likely than women who had not been raped to have ever engaged in sex trading Early Sexual Abuse & Adult HIV-Risky Sexual Behaviors in Women Results – Sexual abuse in childhood was a predictor of # of recent sex partners (p=0.03) – Other predictors include: – Adulthood rape (p<0.01) Recent drug use (p<0.01) Recent IDU Sex Partner (p<0.01) Adulthood rape was a predictor of having unprotected vaginal or anal sex (p=0.05) Childhood Sexual Abuse and Risk Behaviors Among Men at High Risk for HIV Infection C. Dilorio, T. Hartwell, & N. Hansen American Journal of Public Health Volume 92, Number 2, Feb 2002, Pages 214-219 Childhood Sexual Abuse & Risk Behaviors Among Men Methods – Recruitment from STD clinics in 7 US sites – Eligibility requirements: Unprotected vaginal/anal intercourse in past 90 days At least one of the following during the past 90 days – An STD – Sex with a new partner – More than 1 sex partner – Sex with a partner known to have multiple partners – Sex with an IDU – Sex with an HIV+ partner Childhood Sexual Abuse & Risk Behaviors Among Men Results – 25.2% of men reported unwanted childhood sexual activity – Average number of unprotected sex acts (in past 90 days) – This was more common among Hispanic men 31.9 for men with unwanted childhood sexual activity 26.5 for men without childhood sexual activity Average number of sexual partners 6.4 for men with unwanted childhood sexual activity 5.0 for men without childhood sexual activity Childhood Sexual Abuse & Risk Behaviors Among Men Results – Risky behavior higher among men with unwanted childhood sexual activity – Men with childhood sexual abuse were 6.79 times more likely to report unwanted sexual activity as an adult – Bartering sex was more common among men who had unwanted sexual activity as a child OR 1.59 for buying sex OR 2.22 for selling sex OR 1.61 for bartering sex for food or a place to stay Childhood Sexual Abuse & Risk Behaviors Among Men Results – Alcohol and drug use was more common among men with unwanted childhood sexual activity OR 1.23 for alcohol use OR 1.64 for cocaine, heroine, injection drug use Longitudinal Analysis From the HIV Epidemiology Research Study Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women Ickovics JR, Hamburger ME, Vlahov D, et al. HIV Epidemiology Research Study Group (HERS) JAMA. 2001;285:1466-1474 Study Objectives To determine whether depressive symptoms were associated with mortality among women with HIV. To examine the association between depression and decline in CD4+ lymphocyte count among women with HIV. Primary Study Hypotheses Women with chronic depressive symptoms would have the highest mortality rate and most rapid CD4+ cell lymphocyte decline: – followed by those with intermittent depressive symptoms and limited/no depressive symptoms; – even after controlling for relevant clinical, substance use and demographic factors; – effects strongest for those with most advanced disease. HIV Epidemiologic Research Study Large, prospective cohort study of biological, social, and psychological manifestations of HIV in women from 4 US cities. Broad measurement framework enables control for confounding factors. Repeated assessments of depression – provide more reliable estimate – proximal to changes associated with illness Description of Study Cohort (N=765) Age: 19-55 (M = 35.5, SD = 6.7). Race/Ethnicity: – 62% Black, 21% White, 17% Latina Social Class: – 45% did not complete high school – 16% employed; 65% public assistance – 74% household income of <$12,000 Drug Use (study period): – 33% IDU; 41% non-injection crack/cocaine Summary of Study Results Compared to women with no/limited depressive symptoms, those with intermittent and chronic depressive symptoms: – 2.0 times more likely to die, controlling for potential confounding variables – More rapid decline in CD4+ lymphocyte count Those immunocompromised and with higher viral load were most vulnerable to the adverse consequences of depressive symptoms. Additional Complications Psychological – – Coping with sexual trauma Intimate partner violence (IPV) and domestic violence – Risky sexual behavior (RSB) (e.g., lower condom use, more number of partners) – Influence of partner substance abuse and HIV status Child sexual abuse and RSB Chronic abuse and RSB Possibly, partner HIV status IPV lower condom use Additional Complications Sexual/physical trauma more risky sexual behavior (more partners) greater number of STD’s Women experiencing both sexual and physical violence more likely to attempt suicide, use drugs to cope, and be threatened by their partner when asked that condoms be used Poor mental health tied to lower probability of use of HAART. Receiving mental health services increased HAART utilization Additional Complications Substance use – 30 to 75% of women in drug treatment programs have histories of child sexual abuse – Women who had traumatic childhood histories were five times more likely than those who did not to abuse drugs, and over twice as likely to abuse alcohol Familial responsibilities Therapeutic Model Psychological – Adaptive coping strategies in dealing with HIVrelated stressors – Problems of sexual and physical trauma faced by many women with HIV (e.g., PTSD, depression, relationship difficulties) – Maladaptive responses to abuse, including risk-taking behaviors – Substance abuse – Issues related to death and dying Therapeutic Model Social – Disclosure of status to family and children Biomedical – T-cell count, viral load, medication regimen, treatment for other medical conditions, nutrition and physical fitness Spiritual – Role of religion/spirituality: religion as a positive influence (e.g., meaning, spiritual growth) and religious struggles (e.g., feeling abandoned by the church, feelings of being punished by God) Coping & Secondary Prevention Research for HIV+ Women Remarkably limited # of evidence-based studies Ongoing intervention outcome research with HIV+ women – – – – Weiss Wyatt Sikkema NIMH Collaborative: Kelly, Chesney, Erhardt and Rotheram-Borus Primary focus – – – Stress management Cognitive behavioral Stress and coping Coping Intervention Model (Lazarus & Folkman, 1984) ADAPTIVE COPING Stress Appraisal Coping Outcome Changeable ProblemFocused Psychological Distress Unchangeable EmotionFocused Psychological Well-being HIV/traum astressors Coping Intervention Model (Lazarus & Folkman, 1984) MALADAPTIVE COPING Stress Appraisal Coping Changeable ProblemFocused Unchangeable EmotionFocused HIV/traum a stressors Outcome Psychological Distress Psychological Well-being Preliminary Study of HIV & Sexual Abuse (Kalichm an & Sikkema, 2002) Results: – 53% men, 76% women reported one lifetime unwanted sexual experience 86% reported repeat sexual victimization – Sexual abuse history among HIV+ men and women associated with: Depression and anxiety Use of drugs, including injection drugs Unprotected sex and exchange of sex for money or drugs General Goals Evaluate effectiveness of secondary prevention intervention for HIV+ women & men with history of sexual trauma to: – Reduce psychiatric distress, primarily trauma symptoms, depression, & anxiety – Reduce substance use and sexual risk behavior – Increase health protective behaviors, such as treatment adherence & medical service utilization Intervention Overview Trauma specific components – – – – Cognitive-behavioral components – – – – Exposure Connecting memory with narrative Connecting trauma with behavior Mindfulness/relaxation training Identifying and appraising specific stressors Identifying specific coping strategies Modeling/role-playing coping strategies Learning meta-cognitive skills Interpersonal components – – Sharing personal experiences Creating connections for support Therapy Themes “What gets me through? A good therapist!” Sexual Abuse Current abusive relationships HIV and health HIV and fears Losses Managing social services system Social support networks Family and child care Financial problems Substance Abuse Mental Illness Women with chronic depressive symptoms had the highest mortality rate and most rapid CD4 decline even after controlling for other variables (age, baseline CD4, viral load, presence of symptoms, antiretroviral use, and employment status). Mental Illness Women with chronic depressive symptoms were two times more likely to die than women with limited or no depressive symptoms. Those immunocompromised and with higher viral loads were most vulnerable to the adverse consequences of depressive symptoms. Additional Complications High levels of depressive symptoms and poor mental health quality of life is reportedly tied to lower probability of use of HAART. Receiving mental health services increased HAART utilization (Cook et al, 2002). Additional Complications A recent study (Douglas, 2002) found that service integration was an important mediating influence for all HIV+ patients with moderate to severe mental illness. University of Utah University of Utah HIV Clinic has approximately 1300 patients, including Patients who only speak Spanish, A refugee population from Africa, and Women as well as many MSM. University of Utah The Clinic Staff consists of: Four HIV specialists plus fellows in ID, A full-time clinical pharmacist (PharmD), Two Physician Assistants, A psychiatrist who spends 3 days a week in the clinic managing HIV+ psychiatric inpatients, University of Utah Five full-time case managers including two Spanishspeaking case manager, One nurse who work in the clinic, and A psychologist and other psychotherapists in the community. University of Utah The entire treatment team has a weekly 90 minute management meeting to coordinate care. Each team members can bring up cases to ask questions or to share information about patients. University of Utah Case managers visit patients at home in the community and routinely go looking for patients with mental illness and substance use problems who fail to appear for their appointments. They also help patients with housing, medications, insurance and disability applications. One patient described the clinic as “one stop shopping”. University of Utah In spite of these efforts at integration, more patients still died from substance use and suicide than from HIV in the past year in the clinic. Psychotherapy Strategies and Issues Existential Issues: What matters? How should I spend my time? How can I improve my relationships? Psychotherapy Strategies and Issues Empowerment and Control: Learning skills to deal with – health care, – insurance, – disability, and – social service systems. Psychotherapy Strategies and Issues Gathering information about Medical & alternative treatments, Legal issues, and Services. Psychotherapy Strategies and Issues Working through grief and loss: Loss of others, Loss of one’s sense of self as a person without health problems, and Anticipatory loss. Psychotherapy Strategies and Issues Managing pain and suffering and affective responses: Learning pain management skills. Learning cognitive strategies of managing depression, anxiety and fear. Psychotherapy Strategies and Issues Issues change across the course of the disease, but common milestones are: HIV testing, HIV diagnosis. Psychosocial issues of early disease. Accessing health care, Wondering, Psychotherapy Strategies and Issues Worrying and planning, Coping with early symptoms, Decline in T Cells, or Increase in Viral Load, and Preparing to die if treatments fail. Psychotherapy Strategies and Issues Problem-focused strategies for coping give a patient a sense of control. Emotion-focused strategies help to deal with situations that are uncontrollable. “METHAMPHETAMINE USE: REASONS, RISKS, AND PRACTICAL INTERVENTIONS” presented by: Neva Chauppette, Psy.D. P.O. Box 6234, Woodland Hills, CA 91365-6234 CA Psychologist License # PSY14524 (818) 680-0234 (voicemail/pager)- (818) 439-7080 (cell) - (818) 703-1854 (fax) [email protected] (E-Mail) Routes of Administration FIVE ROUTES LISTED IN DESCENDING ORDER: 1) Inhaling -- (7 to 10 seconds) 2) Injecting -- (15-30 secs.) intravenously (IV or slamming) (3-5 mins.) intramuscular (IM or muscling) (3-5 mins.) subcutaneously (skin popping) 3) Snorting -- (3-5 minutes) mucosal exposure 4) Contact -- (3-5 minutes) "dropping acid" (10-15 minutes) morphine suppositories 5) Oral -- (20-30 minutes) Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) Classification: Central Nervous System stimulant type: Synthetic Illegal. It is a freebase form of methamphetamine. It is odorless, colorless, resembles rock salt or a chip of ice or quartz rock. Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) Method of use: Inhaled by smoking Duration of action: 8 – 24 hours Detection in urine screening: 48-72 hours 2-3 days Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) At a low dose: – Increased alertness, wakefulness, elevation of mood, mild euphoria, increase in athletic performance, decrease in fatigue, increased energy, or may cause increased irritability, restlessness, insomnia, anxiety, panic Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) At a high dose: – Euphoria, can induce a pattern of psychosis marked by confused, disorganized behaviors, irritability, fear, paranoia, hallucinations, increased aggressiveness and antisocial behaviors. Note: Violence and hostility are more severe. Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) Physical symptoms: Puts body in “overdrive”, increased pulse, blood pressure, respiration, and temperature, and dilate pupils. Can cause a stroke, heart attack, or kidney failure. Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) Withdrawal symptoms: Disorientation, confusion, apathy, irritability, itching, depression that may be so severe that suicide occurs. Long periods of sleep and increased appetite occurs because while the user was on a “run” taking drugs for one or more days they did not sleep or eat. Ice (aka crystal, meth, ice, JIB, glass, Tina, P, etc.) In some cases more severe with hallucinations, paranoid ideation and toxic psychosis. Recovery from psychosis may be complete; for some, however, there has been no improvement after 2 years with medications. Overdose: Agitation, hostility, hallucinations, convulsions, high temperature, possible death. Powder (aka crank, speed, glass, hot ice, among other slang terms) Classification: Central Nervous System Stimulant Type: Synthetic Illegal - Methamphetamine is amphetamine to which 1 methyl group has been added thus it is more potent and can cross the blood brain barrier more rapidly than amphetamine. May be cut with toxic substances like cyanide or strychnine Powder (aka crank, speed, glass, hot ice, among other slang terms) Method of use: Intravenous, snorting Duration of Action: 4-6 hours Detection in Urine Screening: 48-72 hours after use (2-3 days) Powder (aka crank, speed, glass, hot ice, among other slang terms) At a low dose: – Increased alertness, wakefulness, elevation of mood, mild euphoria, increase in athletic performance, decrease in fatigue, increased energy, or may cause increased irritability, restlessness, insomnia, anxiety, panic. Powder (aka crank, speed, glass, hot ice, among other slang terms) At a high dose: – Euphoria, can induce a pattern of psychosis marked by confused, disorganized behaviors, irritability, fear, paranoia, hallucinations, increased aggressiveness and antisocial behaviors. Powder (aka crank, speed, glass, hot ice, among other slang terms) Physical symptoms: Puts body in “overdrive”, increased pulse, blood pressure, respiration, and temperature, and dilate pupils. Can cause a stroke, heart attack, or kidney failure. Powder (aka crank, speed, glass, hot ice, among other slang terms) Withdrawal symptoms: Disorientation, confusion, apathy, irritability, itching, depression that may be so severe that suicide occurs. Long periods of sleep and increased appetite occurs because while the user was on a “run” taking drugs for one or more days they did not sleep or eat. Overdose: Agitation, hostility, hallucinations, convulsions, high temperature, possible death. Powder (aka crank, speed, glass, hot ice, among other slang terms) Chronic methamphetamine abusers exhibit symptoms that can include violent behavior, anxiety, confusion, and insomnia. They also can display a number of psychotic features, including paranoia, auditory hallucinations, mood disturbances, and delusions (for example, the sensation of insects crawling/running on the skin – also known as formication). The paranoia can result in suicidal and homicidal thoughts. Three Neurotransmitters Play A Big Part In How Crystal Meth Affects The Mind & Body Dopamine Gives a sense of reward and pleasure Associated with body movement Too little dopamine causes paralysis or Parkinson’s-like tremors and rigidity. Too much dopamine and a person can become paranoid, hear voices, and have irrational, bizarre thinking Three Neurotransmitters Play A Big Part In How Crystal Meth Affects The Mind & Body Serotonin Plays a role in depression, sex, and regulating body temperature Involved with many emotional disorders like schizophrenia, phobias, super-aggressive states, and obsessive-compulsive behavior It is involved in sleep and sensory perception. Too much serotonin can make it difficult (or impossible) to have an orgasm Three Neurotransmitters Play A Big Part In How Crystal Meth Affects The Mind & Body Norepinephrine Increases alertness and concentration Helps kill pain and regulate blood pressure Basic instincts like hunger, thirst, and sex can be triggered by norepinephrine Too much contributes to “crystal dick” SEX ADDICTION Core Elements of Addiction Defined How Each if Manifested Obsession intrusive, ruminating thoughts, "preoccupation with" preoccupation with obtaining the drug/sex, using the drug/sex, and getting over withdrawal from drug/sex. Compulsion strong urge or drive to have to do something (i.e., use) "I have to do this, if for no other reason than to stop obsessing.” no ownership of a problem; at minimum the existence of (e.g., "I'm still functional") any problem is minimized or rationalized (e.g., "everyone is doing it") "My use is not a problem everyone gets STDs/uses drugs and/or uses something to change their mood." "I have done bad things during my use" (e.g., sex addict) "I'm engaging in types of sex that I consider against my morals." "As a result of doing bad things during my use, I am bad." "Because I'm engaging in types of sex that are morally wrong to me, I must be immoral or innately bad, evil, or defective." Denial Guilt Shame Ten Signs of Sexual Addiction 1. Out of control behavior a) escalating frequency b) escalating dangerousness Ten Signs of Sexual Addiction 2. Consequences - escalating and compounding consequences a) impaired or decreased job performance due to preoccupation, absenteeism b) STD, unwanted pregnancies c) possible arrests - lewd/lascivious conduct d) marital/monogamous relationships are jeopardized/lost Ten Signs of Sexual Addiction 3. Inability to stop - self perpetuation of behavior once guilt and shame are fused 4. Self-destructive or high risk - as frequency of "using" goes up, so too does the need for drama; danger to add to the "rush“ 5. Effort/desire to limit the sexual behavior - limit sexual behavior to only certain types, with certain partners, etc. Ten Signs of Sexual Addiction 6. Sexual obsession/fantasy - when things are uncomfortable or problematic, this is the mental place sex addicts go to 7. Increased amounts - it is equivalent to physiological need (tolerance) and the desire to achieve the same effect can only be reached with increasing frequency, intensity, etc. of acts 8. Mood swings - sex is used as a fix to alter "bad" mood states but ultimately is bad itself due to the guilt/shame Ten Signs of Sexual Addiction 9. Increased time - preoccupation with obtaining, using and recovering from sexual fix 10. Neglect - as disease progresses, so does the pervasiveness of the neglect