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Download Product Datasheet for ab18294
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www.abcam.com Product Datasheet for ab18294 Product Name Product type Description Immunogen Species Reactivity Tested applications Apc1 antibody Primary antibodies Rabbit polyclonal to Apc1 Recombinant full length protein (N terminal). Reacts with Human. Not yet tested in other species. Western blot Recommended dilutions WB: 1/500. Detects a band of approximately 220 kDa. Application notes Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Abcam's AbpromiseSM Quality is important to Abcam. If Apc1 antibody (ab18294) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund. Cellular localisation Research areas Relevance Database links Raised in Clonality Isotype Purity Secreted Cell Biology >> Proteasome / Ubiquitin >> APC/C APC1 is 1 of at least 11 subunits of the anaphase promoting complex (APC), which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle. Alternative names for Apc1 antibody (ab18294) Entrez Gene GeneCard Omim 64682 (Human) SwissProt GC02M112621 (Human) Unigene 608473 (Human) Rabbit Polyclonal IgG Immunogen affinity purified Preservative: 0.09% Sodium Azide Constituents: 50% Glycerol, PBS. pH 7.2 Q9H1A4 (Human) 436527 (Human) Storage buffer Form Storage instructions Material safety datasheets (MSDS) for this product: Glycerol MSDS Sodium Azide MSDS Liquid Aliquot and store at -20 ‹C. Avoid freeze / thaw cycles. At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Apc1 antibody is on this datasheet. But please do contact us if you would like any reassurance! References for Apc1 antibody (ab18294) General / background references: Hall MC et al. Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphasepromoting complex. J Biol Chem 278:16698-705 (2003). PubMed: 12609981 Golan A et al. The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J Biol Chem 277:15552-7 (2002). PubMed: 11859075 J rgensen PM et al. Characterisation of the human APC1, the largest subunit of the anaphasepromoting complex. Gene 262:51-9 (2001). PubMed: 11179667 Zachariae W & Nasmyth K Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13:2039-58 (1999). PubMed: 10465783 If you publish research using ab18294 please let us know so that we can cite the reference on this datasheet. Apc1 antibody - related products: Products for Western blot Loading controls Lysates Compatible Secondaries for Apc1 antibody ab2892 Goat polyclonal to mouse (AP) + rabbit (HRP) IgG double stain - predil ab6564 Cy5 antibody ab6717 FITC antibody ab6720 Biotin antibody ab6721 HRP antibody ab6722 Alkaline Phosphatase antibody ab6793 Texas Red antibody ab7007 Phycoerythrin antibody ab7019 Agarose antibody Other Apc1 Antibodies More Apc1 antibodies(5)... All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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