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TABLE 22–1 Blood Cells TYPE OF CELL MAIN FUNCTIONS TYPICAL CONCENTRATION IN HUMAN BLOOD (CELLS/LITER) Red blood cells transport O2 and CO2 5 ¥ 1012 (erythrocytes) White blood cells (leucocytes) Granulocytes Neutrophils phagocytose and destroy invading 5 ¥ 109 (polymorphonuclear bacteria leucocytes) Eosinophils destroy larger parasites and modulate 2 ¥ 108 allergic inflammatory responses Basophils release histamine (and in some species 4 ¥ 107 serotonin) in certain immune reactions Monocytes become tissue macrophages, which 4 ¥ 108 phagocytose and digest invading microorganisms and foreign bodies as well as damaged senescent cells Lymphocytes B cells make antibodies 2 ¥ 109 T cells kill virus-infected cells and regulate 1 ¥ 109 activities of other leucocytes Natural killer kill virus-infected cells and some 1 ¥ 108 (NK) cells tumor cells Platelets initiate blood clotting 3 ¥ 1011 (cell fragments arising from megakaryocytes in bone marrow) Humans contain about 5 liters of blood, accounting for 7% of body weight. Red blood cells constitute about 45% of this volume and white blood cells about 1%, the rest being the liquid blood plasma.