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January 2006 ALVARO MARTINEZ, M.D., F.A.C.R. Corporate Chairman Department of Radiation Oncology William Beaumont Hospital Royal Oak, Michigan PERSONAL DATA Date of Birth: Place of Birth: Marital Status: Citizenship: September 8, 1944 Girardot, Colombia, South America Married. Three Children USA EDUCATION Colegio Mayor del Rosario, Bogota, Colombia (*Certificate of Secondary School) Universidad Javeriana, School of Medicine, Bogota, Colombia (**University Study and Medical School combined) 1960 1968 POSTGRADUATE TRAINING AND EXPERIENCE Rotating Internship, Hospital Militar Central, Bogota, Colombia Rural Medicine, Hospital General de Villavicencio Villavicencio, Colombia Resident in Surgery, Hospital Universitario de la Universidad Javeriana, Medical School, Bogota, Colombia Instructor in Medical Physiology, Universidad del Rosario Medical School, Bogota, Colombia Rotating Internship, Jamaica Hospital, Jamaica, New York Resident, Radiation Therapy Department, Memorial Sloan Kettering Cancer Center, New York, New York Chief Resident, Radiation Therapy Department, Memorial Sloan Kettering Cancer Center, New York, New York Clinical Research Associate, Department of Radiology, Stanford School of Medicine, Stanford, California Acting Assistant Professor, Department of Radiology, Stanford School of Medicine, Stanford, California Staff Oncologist, Children's Hospital at Stanford, Stanford, CA Consultant Radiotherapist, Veterans Administration Hospital, Palo Alto, California Assistant Professor, Department of Radiology, Stanford School of Medicine, Stanford, California Assistant Professor of Oncology, Mayo Medical School, Rochester, MN Associate Professor of Oncology, Mayo Medical School, Rochester, MN Chairman, Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan 1 1966-1967 1967-1968 1968-1969 1969-1970 1970-1971 1971-1974 1973-1974 1974-1975 1975-1977 1975-1981 1975-1981 1977-1981 1981-1984 1984-1985 1985-Present Alvaro Martinez, M.D. DIPLOMATE Colombian Medical Association American Board of Radiology Therapeutic Radiology California Board of Medical Examiners State of California License #A030518 Minnesota Board of Medical Examiners State of Minnesota License #26,694 Michigan Board of Medical Examiners State of Michigan License #049192 1968 1974197619761981-1985 1981-1985 19851985- MEMBERSHIPS American College of Radiology (ACR) American Society of Therapeutic Radiologists (ASTRO) American Radium Society (ARS) American Society of Clinical Oncology (ASCO) American Brachytherapy Society (ABS) California Radiological Society (CRS) Circulo de Radioterapeutas Ibero-Latino-Americanos (CRILA) Colombian Medical Association (CMA) Inter-American College of Physicians and Surgeons (ICPS) Javeriana Medical Association (JMA) Michigan Radiological Society Michigan Society of Therapeutic Radiologists North Central Cancer Treatment Group (NCCTG) Northern California Oncology Group Northern California Radiotherapy Association (NCRA) Western Association of Gynecologic Oncology (WAGO) Southwest Oncology Group (SWOG) Radiation Therapy Oncology Group (RTOG) Associate Member National Surgical Adjuvant Breast Project (NSABP) 197719761979197819791977-1983 1979196719841978198719851983-1985 1976-1981 1976-1983 1979198819921999 HONORS Agnes Axtell Moule Faculty Scholar, Stanford University, CA Agnes Axtell Moule Faculty Scholar, Stanford University, CA President Michigan Society of Therapeutic Radiologist Fellow of the American College of Radiology President American Brachytherapy Society 2 1979-1980 1980-1981 1989-1990 19911991-1992 Alvaro Martinez, M.D. GRANT FUNDING PRINCIPAL INVESTIGATOR OR CO-INVESTIGATOR l. 2. 3. 4. 5. CA - 05838 NIH CA - 25862 NIH CA - 04542 NIH CA - 31224 NIH CA - 32972 NIH (Expired) (Expired) (Expired) (Expired) (Expired) 11. 12. 13. 14. 15. CA - 53167-01 NIH CA - 56620-03 NIH EY - 06289-06 NIH WBHRI - 91-24 WBHRI - 91-25 (Expired 1995) (Expired 1995) (Expired 1998) (Expired 1996) (Expired 1996) 6. 7. 8. 9. 10. CA - 19386 NIH (Expired) CA - 44550-03 NIH (Expired) CA - 53167-01 NIH (Expired) WBHRI - 91-24 (Expired) WBHRI - 91-25 (Expired) 16. 17. 18. 19. 20. WBHRI - 94-22 CA - 44550-03 NIH DAMD - 8495 DAMD – 8496 DAMD – 8497 (Expired 1996) (Expired 2001) (Expired 2001) (Expired 2002) (Expired 2002) 1. ROI-CA 66974-01A1, NIH. On-line Dual Beam Imaging for Treatment Verification. CoInvestigator; 5%, July 1999 - June 2004, $883,926. 2. Philips Medical systems North America: Conformal Radiation, Implementation and Verification of Conformal Radiation Therapy Using a SL-Series Accelerator. Co-Investigator; 2%, Oct 1992 to Dec 2004, $131,830, current year. 3. DAMD 0117 Army Prostate Cancer Research Program. $371,000.00. Co-Investigator; 5%, 2001-2004, 4. AG19381 High Precision Radiotherapy of the Prostate. $1,573,000.00 Co-Investigator, 5%, 2001-2005, 5. CA 91020 NIH Temporal Variation of Organ Dose Distribution in Radiation Treatment. CoInvestigator, 5%, 2003-2008, $960,000.00. 6. See Addendum #1. MEMBER OF SITE VISIT TEAM NATIONAL INSTITUTE OF HEALTH (NIH) Hyperthermia (NIH) Radiation Therapy Oncology Group (RTOG) Hyperthermia (NIH) Gynecology Oncology Group (GOG) Special Review Section (NIH) Special Review Section (NIH) NSABP (NIH) 1979 1983 1987 1987 1992 1998 1999 3 Alvaro Martinez, M.D. COMMITTEES AND PROFESSIONAL ACTIVITIES National Northern California Oncology Group (NCOG), Member of the following committees: Gynecology, Breast, Head & Neck, Soft Tissue Sarcoma Medical Education Committee of the Medical Board Children's Hospital, Stanford University Affirmative Action Task Force, Stanford University Isotope Committee (Human Use), Stanford University American Brachytherapy Society, Member of the Board of Directors, North-Western Chapter Western Association of Gynecologic Oncologists Member of the Executive Council Breast, Soft Tissue Sarcoma, Urology and Gynecologic Cancer Committees, Mayo Clinic Department of Oncology Research Committee, Mayo Clinic American College of Radiology (ACR) Committee on Professional Testing in Radiation Therapy North Central Cancer Treatment Group (NCCTG) Member of the Breast Committee American Brachytherapy Society, Treasurer American Brachytherapy Society, Member of the Board of Directors Medical Advisory Board of the Michigan Cancer Foundation American Brachytherapy Society, Chairman Scientific Program Committee for 1988 National Meeting, in Lake Tahoe Chairman of Training/Certification Committee, American Brachytherapy Society Michigan Society of Therapeutic Radiology and Oncology, President Michigan Department of Public Health, Member of the Task Force on Breast and Cervical Cancer American College of Radiology, Michigan Chapter, Member of the AD-HOC Committee on Professional Liability, and member of the Residents Award Committee American Brachytherapy Society, President American College of Radiology, Government Relations Committee, Federal Legislative Oversight Committee Member American Brachytherapy Society, Chairman of the Board American Brachytherapy Society, Board of Directors Member American Medical Association, Member of Minority Affairs Consortium 4 1976-1981 1976-1981 1979-1981 1979-1981 1982 1982-1984 1982-1985 1982-1983 1983-1985 1983-1985 1986-1987 1984-1986 1986-1989 1988 1987-1989 1988-1989 1988- 1990-1993 1991-1992 1992-1998 1992-1993 1994- Present 1998- Present Alvaro Martinez, M.D. INTERNATIONAL COMMITTEES Circulo de Radioterapeutas Ibero-Latino-Americano (CRILA) Coordinator for the Western U.S.A. Circulo de Radioterapeutas Ibero-Latino-Americano (CRILA) Member of Executive Council International Atomic Energy Agency (IAEA), Member of Radiation Oncology Advisory Board in Vienna for Mexico and Third World Countries EDITORIAL BOARD Associate Editor Endocurietherapy, Hyperthermia, Oncology An International Journal Associate Editor Cancer Journal from Scientific American Reviewer for International Journal Radiation Oncology Biology and Physics Reviewer for Cancer Journal Reviewer for American Journal of Clinical Oncology Reviewer for Journal of Clinical Oncology Reviewer for Journal of Gynecologic Oncology Reviewer for Journal Cancer Treatment Reports Reviewer for International Journal of Hyperthermia BIBLIOGRAPHY 1981-1983 1983-1985 1994-1995 1984 1995 1976 1980 1985 1985 1977 1980 1981 Published In Referee Journals 1. Rosen, G., Tefft, M., Martinez,A., Cham, W., Murphy, L.: Combination Chemotherapy and Radiation Therapy in the Treatment of Metastatic Osteogenic Sarcoma. Cancer S35: 622-630, 1975. 2. Cham, W., Tan, C.T., Martinez, A., Exelby, P., Tefft, M., Middleman, P., D'Angio, G.J.: Involved Field Radiation Therapy for Early Stage Hodgkin's Disease in Children. Cancer 37: 1625-1632, 1976. 3. Goffinet, D.R., Martinez, A., Palos, B., Fee, W., Bagshaw, M.A.: A Method of Interstitial Tonsillo-pallatine Implants. Int J Radiat Oncol Biol Phys. 22: 155-162, 1977. 4. Martinez, A., Donaldson, S.S., Bagshaw, M.A.: Special Set-up and Treatment Techniques for the Radiotherapy of Pediatric Malignancies. Int J Radiat Oncol Biol Phys. 2: 1007-1016, 1977. 5. Sandor, J., Palos, B., Goffinet, D.R., Martinez, A., Fessenden, P.: Dose Calculations for Planar Arrays of 192-Ir and 125-I Seeds for Brachytherapy. A Computer Preplanning Method. Applied Radiology 8: 41-47, May-June, 1979. 6. Good, R.L., Fee, W., Goffinet, D.R., Martinez, A.: Radioactive Suture in the Treatment of Head and Neck Cancer. The Laryngoscope 89: 349-354, March, 1979. 5 Alvaro Martinez, M.D. 7. Martinez, A., Goffinet, D.R., Palos, B., Pooler, D., Axnick, K.: Sterilization of 125- Iodine Seeds Encased in Ethicon Vicryl Sutures for Permanent Interstitial Implantation. Int J Radiat Oncol Bio Phys. 5: 411-413, 1979. 8. Palos, B., Pooler, D., Goffinet, D.R., Martinez, A.: A Method for Inserting I-125 Seeds Into the Absorbable Sutures for Permanent Implantation in Tissue. Int J Radiat Oncol Biol Phys. 6: 381-385, 1980. 9. Goffinet, D.R., Martinez, A., Freiha, F., Pooler, D., Pistenma, D.A., Cumes, C., Bagshaw, M.A.: 125-Iodine Prostrate Implants for Recurrent Carcinomas After External Beam Irradiation: Preliminary Results. Cancer 45: 2712-2724, 1980. 10. Hahn, G.M., Kernahan, P., Martinez, A., Pounds, D., Prionas, S., Anderson, T., Justice, G.: Some Heat Transfer Problems Associated with Heating by Ultrasound,Microwaves, or Radiofrequency. Annuals of the New York Academy of Sciences 335: 327-346, 1980. 11. Martinez, A., Goffinet, D.R.: Irradiation with External Beam and Interstitial Radioactive Implant as Primary Treatment for Early Breast Cancer. Surgery, Gynecology and Obstetrics 152: 285290, March, 1981. 12. Bush, S.E., Martinez, A., Bagshaw, M.A.: Primary Mediastinal Seminoma. Cancer 48: 18771882, 1981. 13. Cunes, D., Goffinet, D., Martinez, A., and Stamey, T.: Complication of 125-Iodine Implantation and Pelvic Lymphadenectomy for Prostate Cancer with Special Reference to Patients Who Had Failed External Beam Therapy as Their Initial Mode of Therapy. J Urology 126: 620-622. 1981. 14. Clarke, D., Martinez, A., Cox, R.S., Goffinet, D.R.: Breast Edema Following Staging Axillary Node Dissection in Patients with Breast Carcinoma Treated by Radical Radiotherapy. Cancer 49: 2295-2299, 1982. 15. Hendrickson, M., Rose, J., Eifel, P., Martinez, A., Kempson, R.: Uterine Papillary Serous Carcinomas: A Highly Malignant Form of Endometrial Adenocarcinoma. American Journal of Surgical Pathology 6: 93-108, 1982. 16. Eifel, P., Hendrickson, M., Ross, J., Ballon, S., Kempson, R. and Martinez, A.: Simultaneous Presentation of Carcinoma in the Ovary and Uterine Corpus. Cancer 50: 163-170, 1982. 17. Martinez, A., Faria, S.L. and Hahn, G.M.: The Effects of Heat on Wound Healing in Mice. Presented at the Third International Symposium: Cancer Therapy by Hyperthermia. Drugs and Radiation, Fort Collins, Colorado, June 22, 1980. National Cancer Institute. Monograph 61: 307-309, 1982. 18. Hendrickson, M., Ross, J., Eifel, P., Cox, R., Martinez, A., and Kempson, R.: Adenocarcinoma of the Endometrium: Analysis of 256 Cases with Carcinoma Limited to the Uterine Corpus I: Pathology Review and Analysis of Prognostic Variables. Gynecologic Oncology 13: 373-392, 1982. 6 Alvaro Martinez, M.D. 19. Martinez, A., and Goffinet, D.R.: Irradiation with External Beam and Interstitial Radioactive Implant as Primary Treatment for Early Carcinoma of the Breast. Current Surgery 39 (1): 52, 1982. 20. Goffinet, D., Martinez, A., Fee, W., and Levine, P.: Pterygoid-Base Skull 125-I Implants. Int J Radiat Oncol Biol Phys 9: 103-106, 1983. 21. Goffinet, D., Martinez, A., and Pooler, D.: 125-I Seed Implantation as a Surgical Adjuvant in Head and Neck Cancers. In Combined Surgical and Radiological Therapy of Malignant Tumors. In Kombinierte Chirurgiache und Radiologische Therapie Maligner Tumoreu. Urban and Schwarzenberg. Munich, 1981. pp. 46-49. 22. Cox, R.S., Howes, A.E. and Martinez, A.: A Computerized Technique for Optimizing the Loading of Gynecological Intracavitary Implants. Int J Radiat Oncol Biol Phys 9: (Suppl 1) 86-87, 1983. 23. Martinez, A., Herstin, P., and Portnuff, J.: Interstitial Therapy of Perineal and Gynecological Malignancies. Int J Radiat Oncol Biol Phys 9: 409-416, 198324. Martinez, A., Goffinet, D.R., Fee, W., Goode, R., and Cox, R.: 125-Iodine Implants as an Adjuvant to Surgery and External Beam Radiotherapy in the Management of Locally Advanced Head and Neck Cancer. Cancer 51: 973-979, 1983. 24. Meshorer, A., Prionas, S., Fajardo, L.F., Meyer, J., Hahn, G.M., and Martinez, A.: The Effects of Hyperthermia on Normal Mesenchymal Tissues. Archives of Pathology and Laboratory Medicine 107(6): 328-334, 1983. Martinez, A., Meshorer, A., Meyer, J., Hahn, G., Fajardo, L. and Prionas,S.: Thermal Sensitivity and Thermotolerance in Normal Porcine Tissues. Cancer Research 43 (1): 2072-2075, 1983. 25. 26. Schray, M., Cox, R., and Martinez, A.: Lower Abdominal Radiotherapy for Stages I-II and Selected III Epithelial Ovarian Cancer: 20 Years' Experience. Gynecologic Oncology Journal 15(1): 78-87, 1983. 27. Martinez, A., Clarke, D.: Irradiation as an Alternative to Mastectomy for Early Breast Cancer. The Western Journal of Medicine 138: 676-680, 1983. 28. Clarke, D., Curtis, J.L., Martinez, A., Fajardo, L.D., Goffinet, D.: Fat Necrosis of the Breast Simulating Recurrent Carcinoma Following Primary Radiotherapy in the Management of Early Stage Breast Carcinoma. Cancer 52: 442-445, 1983. 29. Johnson, D., Cox, R., Billingham, G., Ung, N., and Martinez, A.: Survival, Prognostic Factors and Relapse Patterns in Uterine Cervical Carcinoma. American J. Clin. Oncol. 6: 407-415, 1983. 30. Schray, M., Martinez, A., Cox, R. and Ballon, S.: Radiotherapy in Epithelial Ovarian Cancer: Analysis of Prognostic Factors Based on Long-Term Experience. Obstet-Gynecol. 62: 373382, 1983. 7 Alvaro Martinez, M.D. 31. Eifel, P.J., Ross, J., Hendrickson, M., Cox, R., Kempson, R. and Martinez, A.: Adenocarcinoma of the Endometrium: Analysis of 256 Cases With Disease Limited to the Uterine Corpus: Treatment Comparisons. Cancer 52: 1026-1032, 1983. 32. Johnson, D.W., Cox, R.S., Howes, A.E., Castallino, R.A., Martinez, A.: The Use of Para-Aortic Radiation Therapy Based on Lymphangiogram Interpretation in Uterine Cervical Carcinoma. Gynecologic Oncology 16: 326-333, 1983. 33. Clarke, D., Martinez, A., and Cox, R.S.: Analysis of Cosmetic Results and Treatment Complications in the Management of Breast Carcinoma by Excisional Biopsy and Radiation. Int J Radiat Oncol Biol Phys 9(12): 1807-1813, 1983. 34. Levine, J., Coleman, C.N., Cox, R.S., Ray, G., Rogoway, W., Martinez, A., and Stockdale, R.: The Effect of Postoperative an Primary Radiation Therapy on Delivered Dose of Adjuvant Cytoxan, Methotrexate and 5-FU (CMF) Chemotherapy in Breast Cancer. Cancer 53: 237-241, 1984. 35. Martinez, A., Cox, R.S. and Edmundson, G.K.: A Multiple-Site Perineal Applicator. MUPIT, for the Treatment of Prostatic, Anorectal, and Gynecological Malignancies. Int J Radiat Oncol Bio Phys 10(2): 297-305, 1984. 36. Coleman, C.N., Ballon, S.C., Howes, A.E., Martinez, A., Halsey, J. and Hirst, V.K.: The Current Status of Drug Development of Hypoxic Cell Radiosensitizers and Their Potential Role in Gynecological Oncology. Gynecol Oncol/Int J 18: 18-27, 1984. Gunderson, L.L., Martin, K., Earle, J.D., Byer, D., Voss, M., Fieck, J., Kvols, L., Rorie, D., Martinez, A., Nagorney, D.M., O'Connell, M.J. and Weber, F.: Intraoperative and External Beam Irradiation + Resection: Mayo Pilot Experience. Mayo Clinic Proceedings 59 (10): 691699, 1984. 37. 38. Martinez, A., Ahmann, D., O'Faddon, J.O., Payne, W., Scanlon, P., Hahn, R., Ingle, J., and Edmundson, J.: An Interim Analysis of the Randomized Surgical Adjuvant Trial for Patients with Unfavorable Breast Cancer. Int J Radiat Oncol Biol Phys 10(Suppl 2) 106, 1984. 39. Buskirk, S., Gunderson, L.L., Martinez, A., Adson, M.D., McIlrath, D.D., May, G.R., Bender, C.E., Edmundson, G.K., and Martin, K.: Analysis of Failure Following Curative Irradiation of Gallbladder and Extrahepatic Bile Duct Carcinoma. Int J Radiat Oncol Biol Phys 10 (11): 2013-2024, 1984. 40. Ballon, S.C., Martinez, A., Turbow, M.M., Koretz, M.M., and Carter, S.K.: Pelvic Irradiation Plus Adriamycin and Cyclophosphamide in Selected Patients with Epithelial Ovarian Cancer: A Phase II Study of the Northern California Oncology Group. Gynecol Oncol/Int J 19 (3): 278283, 1984. 41. Martinez, A., Goffinet, D.R., Donaldson, S.S., Bagshaw, M.A., and Kaplan, M.S.: Intra-Arterial Infusion of Radiosensitizer (BUDR) Combined with High-Dose Weekly Fractionation and Chemotherapy for Primary Treatment of Osteogenic Sarcoma. Int J Radiat Oncol Biol Phys 11(1): 123-128, 1985. 8 Alvaro Martinez, M.D. 42. Schray, M., McDougall, J.C., Martinez, A., Edmundson, G.K. and Cortese, D.A.: Management of Malignant Airway Obstruction: Clinical and Dosimetric Consideration Utilizing an Iridium192 Afterloading Technique in Conjunction with the Neodymimum-YAG Laser. Int J Radiat Oncol Biol Phys 11 (2): 403-410, 1985. 43. Goffinet, D.R., Martinez, A., and Fee, W.E.: 125-Iodine Vicryl Suture Implants as a Surgical Adjuvant in Cancer of the Head and Neck. Int J Radiat Oncol Bio Phys 11(2): 399-402, 1985. 44. Martinez, A., Edmundson, G.K., Cox, R.S., Gunderson, L.L. and Howes, A.: Combination of External Beam Irradiation and Multiple-site Perineal Applicator (MUPIT) for Treatment of Locally Advanced or Recurrent Prostatic, Anorectal and Gynecologic Malignancies. Int J Radiat Biol Phys 11(2): 391-398, 1985. 45. Brindle, J.S., Benson, R.C., Martinez, A., Edmundson, G.K., Zincke, H. and Utz, D.C.: Acute Toxicity and Preliminary Results of Pelvic Lymphadenectomy Combined with Transperineal Interstitial Implantation of 192-Iridium and External Beam Radiotherapy for Locally Advanced Prostatic Cancer. Urology 25 (3): 233-238, 1985. 46. Martinez, A., Benson, R.C., Edmundson, G.K., and Brindle, J.: Pelvic Lymphadenectomy Combined with Transperineal Interstitial Implantation of 192 Iridium and External Beam Radiotherapy for Locally Advanced Prostatic Carcinoma: Technical Description. Int J Radiat Onc Bio Phys 11(4): 841-847, 1985. 47. Martinez, A., Schray, M.F., Howes, A.E. and Bagshaw, M.A.: Postoperative Radiation Therapy for Epithelial Ovarian Cancer: The Curative Role Based on 24-year Experience. J Clin Oncol 3(7): 901-911, 1985. 48. Schray, M.F., Martinez, A., Howes, A., Podratz, K.C., Ballon, S.C., Malkasian, G.D. and Sikic, B.: Advanced Epithelial Ovarian Cancer: Salvage Whole Abdominal Irradiation for Patients with Recurrent or Persistent Disease Following Combination Chemotherapy. Cancer Clinical Trials 8: 12-13, 1985. 49. Harris, J.R., Hellman, J., Kinne, D.W., Martinez, A., et. al: Limited Surgery and Radiotherapy for Early Breast Cancer. N Engl J Med 313(21): 1365-1368, 1985. 50. Schray, M.F., Martinez, A., McDougall, J.C., Edmundson, G.K., Cortese, D.A. and Brutinel, W.M.: Malignant Airway Obstruction-Management with Temporary Intraluminal Brachytherapy and Laser Treatment. ECHO 1(4): 237-246. 1985. 51. Knight, C.D., Martin, K.S., Welch, J.S., Ingle, J.N., Gaffey, T.A. and Martinez, A.: Surgical Considerations After Chemotherapy and Radiation Therapy for Inflammatory Breast Cancer. Surgery 99 (4): 385-390, 1986. 52. Schray, M.F., Martinez, A., Howes, A.E., Ballon, S.C., Podratz, K.C., Sikic, B.I. and Malkasian, G.: Advanced Epithelial Ovarian Cancer: Toxicity of Whole Abdominal Irradiation After 9 Alvaro Martinez, M.D. Operation, Combination Chemotherapy and Re-Operation. Gynecol Oncol/Int J 24(1): 68-81, 1986. 53. Gunderson, L.L., Martin, J.K., Kvols, L.K., Nagorney, D.M., Fieck, J.M., Wieand, H.S., Martinez, A., O'Connell, M.J., Earle, J.D., McIlrath, D.C.: Intraoperative and External Beam Irradiation + 5-FU for Locally Advanced Pancreatic Cancer. Int J Radiat Oncol Biol Phys, 13:3, 319-329, March 1987. 54. Schray, M.F., McDougall, J.C., Martinez, A., Cortese, D.A., and Brutinel, M.W.: The Management of Malignant Airway Compromise with Laser and Low Dose Rate Brachytherapy: The Mayo Clinic Experience. Chest 93(2): 264-269, 1988. 55. Gunderson, L.L., Martin, J.K., Beart, R.W., Nagorney, D.M., Fiek, J.M., Wieand, H.S., Martinez, A., O'Connell, M.J., Martenson, J. and McIlrath, D.C.: Intraoperative and External Beam Irradiation for Locally Advanced Colorectal Cancer. Ann of Surg 207(1): 52-60, 1988. 56. Vicini, F., Decker, D., and Martinez, A.: The Role of External Beam Radiotherapy in the Treatment of Small Cell Lung Cancer. Hematology/Oncology Clinics of North America, 2, (3), 383-392, 1988. 57. Schray, M.F., Martinez, A., Howes, A.E., Podratz, K.C., Ballon, S.C., Malkasian, G.D. and Sikic, B.: Advanced Epithelial Ovarian Cancer: Salvage Whole Abdominal Irradiation for Patients with Recurrent or Persistent Disease Following Combination Chemotherapy. Journal of Clinical Oncology, 6, (9), 1433-1439, 1988. 58. Martinez, A., Podratz, K., Schray, M. and Malkasian, G.: Results of Whole Abdomino-Pelvic Irradiation with Nodal Boost for Patients with Endometrial Cancer at High Risk of Failure in the Peritoneal Cavity. A Prospective Clinical Trial at the Mayo Clinic. Hematology/Oncology Clinics of North America, 2, (3), 431-446, 1988. 59. Vicini, F.A.; Decker, D.; Martinez, A.A. The Feasibility of Performing Sequential Staging in Small Cell Lung Cancer. Proceedings of the American Society of Clinical Oncology. J. Clin. Oncol. Sept. 1988. 60. Clarke, D.H., Edmundson, G.K., Martinez, A., Matter, R.C., and Warmelink, C.: The Utilization of 125 Iodine Seeds as a Substitute for 192 Iridium Seeds in Temporary Implants. An Overview and a Description of the William Beaumont Hospital Technique. Int J Radiat Oncol Biol Phys 15(4), 1027-1034, 1988. 61. Schray, M.F., and Martinez, A.: The Role of Radiation Therapy Following Chemotherapy in Advanced Ovarian Cancer. Contemporary OB/GYN. Vol 32(5): 43-55, 1988. 62. Schray, M.F., Martinez, A., and Howes, A.E.: Toxicity of Open-Field Whole Abdominal Irradiation as Primary Postoperative Treatment in Gynecologic Malignancy. Int J Radiat Oncol Biol Phys 16(2): 397-403,1989. 63. Martinez, A., Schray, M., Podratz, K., Stanhope, R. and Malkasian, G.: Postoperative Whole Abdomino-pelvic Irradiation for Patients with High Risk Endometrial Cancer. Int J Radiat Oncol Biol Phys 17(4): 859-863, 1989. 10 Alvaro Martinez, M.D. 64. Clarke, D.H., Edmundson, G., Martinez, A., Matter, R.C., Vicini, F. and Sebastian, E.: The Clinical Advantages of 125 Iodine Seeds as a Substitute for 192 Iridium Seeds in Temporary Plastic Tube Implants. Int J Radiat Oncol Biol Phys 17(4):859-863, 1989. 65. Brindle, J., Martinez, A., Schray, M., Edmundson, G., Benson, R., Zincke, H., Diokno, A., and Gonzalez, J.: Pelvic Lymphadenectomy and Transperineal Interstitial Implantation (MUPIT) of 192 Ir Combined with External Beam Radiotherapy for Bulky Stage "C" Prostatic Carcinoma. Int J Radiat Oncol Biol Phys 17(5):1063-1066, 1989. 66. Banerian, K., Roberts, J., Borrego, C., Martinez, A.: CT-Guided Thermocouple Placement for Hyperthermia Treatment. Radiographics 10(3):499-506,1990. 67. Clarke, D., Martinez, A.: An Overview of Brachytherapy in Cancer Management. Oncology 4 (9): 39-46, 1990. 68. Martinez, A., Edmundson, G., Borrego, C., Brown, D., Kader, F., Clarke, D.: High Dose Rate Treatment of Ear Canal Carcinoma: A case report. Activity-Brachytherapy Journal 5:(1), 2-7, 1991. 69. Martinez, A., Edmundson, G.K. and Clarke, D.H.: The Role of Transperineal Template Implants in Gynecological Malignancies. Activity Brachytherapy Journal 5(2): 107-113, 1991. 70. Armour, E., Wang, Z., Corry, P., Martinez, A.: Sensitization of Rat 9L Gliosarcoma Cells to Low Dose Rate Irradiation by Long Duration 41 degrees C Hyperthermia. Cancer Research 51; 3088-3095, June 15, 1991. 71. Gibbons, S., Martinez, A., Schray, M., Podratz, K., Stanhope, R., Garton, G., Winer, S., Brabbins, D., Malkasian, G.: Adjuvant Whole Abdominopelvic Irradiation for High Risk Endometrial Carcinoma. Int J Radiat Oncol Biol Phys 21(4): 1019-1025, 1991. 72. Martinez, A., Schray, M.: Interstitial and Endobronchial Brachytherapy in Lung Cancer. Chest Surgery Clinics of North America I: 109-122, August 1991. 73. Armour, E., Wang, Z., Corry, P., Martinez, A.: Equivalence of Continuous and Fractionated Low Dose Rate Irradiation in 9L Gliosarcoma Cells at 37 degrees C and 41 degrees C. Int J Radiat Oncol Biol Phys 22(1): 109-114, 1992. 74. Clarke, D., Martinez,A.: Identification of Patients Who are at high Risk for Breast Recurrence Following Conservative Surgery and Radiotherapy -- A Review Article for the Surgeon, Pathologist, Radiation and Medical Oncology. The Journal of Clinical Oncology 10(3): 474483, 1992. 75. Wang, Z., Armour,, E., Corry, P., Martinez, A.: Elimination of Dose Rate Effects by Mild Hyperthermia. Int J Radiat Oncol Biol Phys 24:965-973, 1992. 11 Guided Alvaro Martinez, M.D. 76. Vicini, F. and Martinez, A.: The Role of Brachytherapy in Cancer Management. Contemporary Oncology 2 (9):17-29, 1992. 77. Vicini, F. and Martinez, A. The Impact of Time on Cosmetic Outcome Following Conservative Surgery and Radiation Therapy. J Clin Oncol 10(6), 1992. 78. Williamson, J., Anderson, L., Grigsby, P., Martinez, A., Nath, R., Neblett, D., Olch, A., and Weaver, K. American Endocurietherapy Society Recommendations for Specification of Brachytherapy Source Strength. ECHO 9(1): 1-8, 1993. 79. Gunderson, L.L., Nagorney, D.M., McIlrath, D. C., Fiek, J.M., Wieand, H.S., Martinez, A., Pritchard, D.S., Sim, F., Martenson, I., Edmonson, J.H., Donohue, J.H.: External Beam and Intraoperative Electron Irradiation for Locally Advanced Soft Tissue Sarcomas. Int J Radiat Oncol Biol Phys 25(4): 647-656, 1993. 80. Armour, E.P., McEachern, D., Corry, P., and Martinez, A.: Sensitivity of Human Cells to Mild Hyperthermia. Cancer Research 53:2740-2744, June 15, 1993. 81. Vicini, F., White, J., Gustafson, G., Matter, R.C., Clarke, D. H., Edmundson, G., Martinez, A.: The Use of Iodine Seeds as a Substitute for Iridium-192 Seeds in Temporary Interstitial Breast Implants. Int J Radiat Oncol Bio Phys 27(3): 561-566, 1993. 82. Edmundson, G., Rizzo, N., Teahan, M., Brabbins, D., Vicini, F., and Martinez, A.: Concurrent Treatment Planning for Outpatient High Dose Rate Prostate Template Implants. Int J Radiat Oncol Biol Phys Vol. 27(5): 1215-1223, 1993. 83. Nag, S.; Abitbol, A, Anderson, L., Blasko, J., Harrison, L., Hilaris, B., Martinez, A., Syed, A.M.,N., Mehta, M., Nori, D., Porter, A., Rossman, K., Speiser, B., Stitt, J.A., Vikram, B.: Consensus Guidelines for High Dose-Rate Remote Brachytherapy (HDR) in Cervical, Endometrial, and Endobronchial Tumors". Int J Rad Oncol Biol Phys 27(5): 1241-1244, 1993. 84. Stromberg, J., Martinez, A., Benson, R., Garton, Graciola, Diokno, A., Gonzalez, J., Zincke, H., Schray, M., Edmundson, G., Brabbins, D.: Improved Local Control and Survival for Surgically Staged Patients with Locally Advanced Prostate Cancer Treated with Low Dose Rate Iridium192 Prostate Implantation and External Beam Irradiation. Int J Radiat Oncol Biol Phys 28(1): 67-75, 1994. 85. Armour, E., Wang, Z., Corry, P., Chen, P., and Martinez. A.: Hyperthermic Enhancement of High Dose Rate Irradiation in 9L Gliosarcoma Cells. Int J Radiat Oncol Bio Phys 28(1): 171177, 1994. 86. White, J., Gustafson, G., Wimbish, K., Ingold, J., Lucas, E.J., Levine, A., Matter, R.C., Martinez, A. and Vicini, F.: Conservative Surgery and Radiation Therapy for Infiltrating Lobular Carcinoma of the Breast: The Role of Preoperative Mammograms in Guiding Treatment. Cancer 74(2): 640-647, 1994. 87. Du, M.N.; Yu, C.X.; Symons, M.; Yan, D.; Taylor, R.; Matter, R.C.; Gustafson, G.; Martinez, A. and Wong, J.: A Multi-Leaf Collimator Prescription Preparation System For Conventional Radiotherapy. Int Radiat Oncol Bio Phys 30 (3); 707-714, 1994. 12 Alvaro Martinez, M.D. 88. Armour, E.P., Wang, Z.W., Corry, P.M., and Martinez, A.: Thermotolerance and Radiation sensitizing Effects of Long duration and Mild Temperature Hyperthermia. Int J Hyperthermia 10(3):315-324, 1994. 89. Armour, E.; Wang, Z.; Corry, P and Martinez, A.: Thermotolerance and radiation sensitization effects of long duration mild temperature hyperthermia. Int J Hypert 10(3):315-334, 1994. 90. Nag, S.; Owen, J.B.; Farman, N.; Pajak, T.F.; Martinez, A.; Porter, A.; Blasko, J.; and Harrison, J.B.: Survey of Brachytherapy Practice in the United States: A Report of the Clinical Research Committee of The American Endocurietherapy Society. Int J Radiat Oncol Biol Phys 31(1);103-108;1995. 91. White, J., Levine, H., Gustafson, G., Wimbish, K., Ingold, J., Pettinga, J., Matter, R. C., Martinez, A. and Vicini, F.: Outcome and Prognostic Factors for Local Recurrence in Mammographically Detected Ductal Carcinoma In-Situ of the Breast Treated with Conservative Surgery and Radiation Therapy. Int J Radiat Oncol Bio Phys. 31(4); 791-797, 1995. 92. Yan, D., Wong, J., Gustafson, G., Martinez, A.: A Model for "Accept or Reject Strategies in Online and Off-Line Megavoltage Treatment Evaluation. Int J Radiat Oncol Bio Phys. 31(4); 943-952, 1995. Gustafson, G.; Vicini, F.; Freedman, L.; Johnston, E.; Edmundson, G.; Sherman, S.; Pursel, S.; Komic, M.; Chen, P.; Borrego, J.C.; Seidman, J. and Martinez, A.: High Dose Rate Endobronchial Brachytherapy in the Management of Primary and Recurrent Bronchogenic Malignancies. Cancer. 75(9); 2345-2350, 1995. 93. 94. Stromberg, J.S.; Lee, Y.J.; Armour, E.P.; Martinez, A. and Corry, P.: Lack of Radiosensitization After Paclitaxel Treatment of Three Human Carcinoma Cell Lines. Cancer. 75(9); 2262-2268, 1995. 95. White, J., Brown, D., Gustafson, S.G., Chen, P., Matter, R.C., Cook, C.A., Martinez, A. Vicini, F.: The role of total dose in conservative surgery and radiation therapy for early stage breast cancer: Is there a critical level? Int J Radiat Oncol Bio Phys. 32:257, 1995. 96. Martinez, A., Vicini, F.: The Role of Brachytherapy in the Management of Cancer. Advances in Oncology 11(4): 25-29, 1995. 97. Stromberg, J., Martinez, A., Gonzalez, J., Edmundson, G., Ohanian, N., Vicini, F., Hollander, J. Gustafson, G., Spencer, W., Yan, D., and Brabbins, D.: Ultrasound-guided High Dose Rate Conformal Brachytherapy Boost in Prostate Cancer: Treatment description and preliminary results of a dose-escalating clinical trial. Int J Radiat Oncol Bio Phys. 33(1): 161-171, 1995. 98. Yu, C.X.; Jaffray, D.A.; Wong, J.; Martinez, A., Intensity modulated arc therapy: a new method for delivering conformal treatments. Abstract/PDF (104K) 99. Frazier, A., Yan, D., Du, M., Wong, J., Vicini, F., Matter, R.C., Joyce, M., and Martinez, A.: Effects of Treatment Setup Variation on Beam's Eye View Dosimetry for Radiation Therapy 13 Alvaro Martinez, M.D. Using the Multileaf Collimator Versus the Cerrobend Block. Int J Radiat Oncol Biol Phys. 33(5): 1247-1256, 1995. 100. Martinez, A.; Gonzalez, J.; Stromberg, J.; Edmundson, G.; Plunkett, M.; Gustafson, G.; Brown, D.; Yan, D.; Vicini, F.; and Brabbins, D.: Conformal prostate Brachytherapy: Initial Experience of a Phase I/II Dose Escalating Trial. Int J Radiat Oncol Biol Phys. 33(5): 1019-1027, 1995. 101. Edmundson, G.K., Yan, D, and Martinez, A: Intraoperative optimization of needle placement and dwell times for conformal prostate brachytherapy. Int J Radiat Oncol Biol Phys. (33)5: 12571264, 1995. 102. Frazier, A., Du, M., Wong, J., Vicini, F., Taylor, R., Yu, C., Matter, R., Martinez, A., and Yan, D.: Dosimetric Evaluation of the Conformation of The Multileaf Collimator to Irregularly Shaped Fields. Int J Radial Oncol Biol Phys. (33)5: 1229-1238, 1995. 103. Yu, C. X., Symonds, M.J., Du, M.N., Martinez, A., and Wong, J.: A Method for Implementing Dynamic Photon Beam Intensity Modulation Using Independent Jaws and Multileaf Collimator. Phys Med and Biol 40: 769-787, 1995. 104. Armour, E.; White, J.; DeWitt, C.; Corry, P.; Martinez, A.: Effects of Continuous Low-DoseRate brachytherapy on the Rectum of the Rat. Radiation Research 145: 474-480, 1996. 105. Beron, P., Wimbish, K., Levine, A., Chen, P., Pettinga, J., Benitez, P., Martinez, A. and Vicini, F.: Mammographic and Pathologic Findings Predicting the adequacy of Tumor Excision Before Breast Conserving Treatment. Am Jr Radiol 167:1-6, 1996. 106. Horwitz, E., Vicini, F., Ziaja, E., Gonzalez, A., Dmuchowski, C., Stromberg, J., Brabbins, D., Hollander, J., Chen, P., and Martinez, A., etc.: Assessing the Variability of Outcome for Patients Treated with Localized Prostate Irradiation Using Different Definitions of Biochemical Control. Int J Radiat Oncol Biol Phys 36(3):565-572, 1996. 107. Horwitz, E., Frazier, A., Martinez, A., Keidan, R., Clarke, D., Lacerna, M., Gustafson, G., Heil, E., Dmuchowski, C., and Vicini, F.: Excellent Functional Outcome in Patients with Squamous Cell Carcinoma of the Base of Tongue Treated with External Irradiation and Interstitial Iodine 125 Boost. Cancer 78(5):948-957, 1996. 108. Lacerna, M.; Irwin, R.; Vicini, F.; Goldstein, N.; Gustafson, G.; Martinez, A.: Iodine 125 temporary interstitial implants and limb conserving surgery in the managements of extremity soft tissue sarcomas. Endocurietherapy/Hyperthermia Oncology 12(4): 191-198, 1996. 109. Armour, E.P.; White, J.R.; DeWitt, D.C.; Corry, P.M. and Martinez, A. Effects of Continuous Low-Dose-Rate Brachytherapy on the Rectum of the Rate. Radiat Res 145(4); 474-80, 1996. 110. White, J.R.; Armour, E.P.; Armin, A.R.; DeWitt, C.C.; Corry, P.M. and Martinez, A. Reproducible Rate Model for Comparing Late Rectal Toxicity From Different Brachytherapy Techniques. Int J Radiat Oncol Biol Phys. 37(5): 1155-61, 1997. 111. Yan, D., Vicini, F., Wong, J. and Martinez, A.: Adaptive Radiation Therapy. Phys Med and Biol. 2242: 123-132, 1997. 14 Alvaro Martinez, M.D. 112. Horwitz, E. M.; Frazier, A.; Vicini, F.; Clarke, D.; Edmundson, G.; Keidan, R.; Gustafson, G.; Dmuchowski, C.F. and Martinez, A.: The Impact of Iodine 125 Interstitial Implant Boost in the Primary Management of Squamous Cell Carcinoma of the Oropharynx. Head and Neck. 19:219-226, 1997. 113. Gupta, A.; Lee, Y.; Galofor, S.; Berns, C.; Martinez, A.; Corry, P.; Wu, X. and Guan, K.: Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells. Molecular and Cellular Biochemistry 170:23-30, 1997. 114. Vicini, F.A.; Horwitz, E.; Lacerna, M.; Dmuchowski, C.F.; Brown, D.M.; White, J.; Chen, P.Y.; Edmundson, G.K.; Gustafson, G.S.; Clarke, D.H.; Gustafson, G.S.; Matter, R.C. and Martinez, A.: Long term outcome with interstitial brachytherapy in the management of patients with early stage breast cancer treated with breast conserving therapy. Int J Radiat Oncol Biol Phys. 37(4):845-852, 1997. 115. Yan, D., Vicini, F., Wong, J., Michalski, J., Pan, C., Frazier, A., Horwitz, E., and Martinez, A.: Adaptive Modification of Treatment Planning to Minimize the Deleterious Effects of Treatment Setup Errors. Int J Radiat Oncol Biol Phys 38(1):197-206, 1997. 116. Vicini, F.A.; Fraile, M.; Chen, P.; Gustafson, G.; Edmundson, G.; Jaffray, D.; Benitez, P.; Pettinga, J.; Medrazo, B.; Ingold, J.; Goldstein, N.; Matter, R.C.; Martinez, A.: Low dose rate brachytherapy as a sole radiation modality in the management of patients with early stage breast cancer treatment with breast conserving therapy: Preliminary results of a pilot trial. Int J Radiat Oncol Biol Phys 38(2): 301-310, 1997. 117. DeBoise, D.A., Horwitz, E.M., Martinez, A., Edmundson, G.K., Chen, P.Y., Gustafson, G.S., Madrazo, B., Wimbish, K., Mele, E., Vicini, F.A.: The use of ultrasonography in the localization of the lumpectomy cavity for interstitial brachytherapy of the breast. Int J Radiat Bio Phys. 38(4):755-759, 1997. 118. Armour, E.P.; White, J.R.; Armin, A.R.; Corry, P.M.; Coffey, M.; DeWitt, C.; Martinez, A.: Pulsed low dose rate brachytherapy in a rat model: Dependence of late rectal injury on radiation pulse size. Int J Radiat Oncol Biol Phys. 38(4):825-834, 1997. 119. Vicini, F.A.; Horwitz, E.; Gonzalez, J.; Martinez, A.: Treatment options for localized prostate cancer based upon pretreatment serum prostate specific antigen levels. J Urol 158(2):319-325, 1997. 120. Stromberg, J.S., Martinez, A., Horwitz, E.M., Gustafson, G.S., Gonzalez, J., Spencer, W.F., Brabbins, D.S., Dmuchowski, C.F., Hollander, J.B., Vicini, F.A.: Conformal high dose rate iridium-192 boost brachytherapy in locally advanced prostate cancer: Superior prostate specific antigen response compared to external beam treatment. The Cancer Journal. 3(8):346-352, 1997. 15 Alvaro Martinez, M.D. 121. Vicini, F.; Horwitz, E.; Lacerna, M.; Brown, D.; White, J.; Dmuchowski, C.; Kini, V. J; and Martinez, A.: The role of regional nodal irradiation in the management of patients with early stage breast cancer treatment with breast conserving therapy. Int J Radiat Oncol Biol Phys. 39(5): 1069-1076, 1997. 122. Horwitz, E.M., Vicini, F.A., Ziaja, E.L., Dmuchowski, C.F., Stromberg, J.S., Gustafson, G.S., and Martinez, A.: An analysis of clinical and treatment related prognostic factors on outcome using biochemical control as an end-point in patients with prostate cancer treated with external beam irradiation. Radiotherapy and Oncology. 44:223-228, 1997. 123. Vicini, F.A., Kini, V.J., Martinez, A. Neoadjuvant adrogen deprivation for locally advanced prostate cancer. Letter to the Editor. N Eng J Med 337:1667-1674, 1997. 124. Vicini, F.; Lacerna, M.; Goldstein, N.; Horwitz, E.; Dmuchowski, C. F.; White, J. R.; Gustafson, G. S.; Ingold, J.; and Martinez, A.: Ductal carcinoma in situ detected in the mammographic ERA: An Analysis of clinical pathologic and treatment-related factors affecting outcome with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 39(3): 627-635, 1997. 125. Gupta, A., Galoforo, S., Berns, C., Martinez, A., Corry, P., Guan K., and Lee, Y.: Elevated Levels of ERK2 in Human Breast Carcinoma MCF-7 Cells Transfected with Protein Kinase C. Cell Proliferation.29: 655-663, 1997. 126. Vicini, F., Jaffray, D., Edmundson, G.K., Martinez, A.: Implementation of 3D virtual brachytherapy in the management of breast cancer: A description of a new method of interstitial brachytherapy. Int J Radiat Oncol Biol Phys. 40(3):629-635, 1998. 127. Huerta, J.; Martinez, A., Yan, D., Edmundson, G.; Mele, B.; Edmundson, G.K.; Brown, D.; Hardy, M.; Brabbins, D.; and Gustafson, G.: Spatial reproducibility of the ring and tandem high dose rate cervix applicator. Int J Radiat Oncol Biol Phys. 41(1):13-19, 1998. 128. Yan, D.; Ziaja, E.; Jaffray, D.; Wong, J.; Vicini, F.; Brabbins, D. and Martinez, A: The use of adaptive radiation therapy to reduce set-up error: A prospective clinical study. Int J Rad Oncol Biol Phys. 41(3): 715-720, 1998. 129. Vicini, F.A. and Martinez, A. One Step At A Time. Response to Letter to the Editor. Int J Radiat Oncol Biol Phys 40(4): 1008, 1998. 130. Vicini, F.A.; Horwitz, E.M.; Stromberg, J.S. and Martinez, A.. Radiotherapy Options for localized Prostate Cancer Based Upon Pretreatment serum Prostate Specific Antigen Levels and Biochemical Control: A Comprehensive Review of the Literature. Int J Radiat Oncol Biol Phys 40(5): 1101-1110, 1998. 131. Goldstein, N.S.; Stromberg, J.; Vicini, F.A. and Martinez, A.. The Histology of Radiation Therapy Effect on Prostate Adenocarcinoma as Assessed by Needle Biopsy After Brachytherapy Boost: Correlation with Biochemical Failure. Am J Clin Path 110(6): 765-775, 1998. 16 Alvaro Martinez, M.D. 132. Horwitz, E. M.; Vicini, F.A.; Ziaja, E.L.; Dmuchowski, C.F.; Stromberg, J.S. and Martinez, A. The Correlation Between the ASTRO Consensus Panel Definition of Biochemical Failure and Clinical Outcome for Patients with Prostate Cancer Treated with External Beam Irradiation. Int J Radiat Oncol Biol Phys 41(2): 267-272, 1998. 133. Schachat, A.P.; Hawkins, B.S.; Reynolds, S.M.; Dutton, J.J.; Earle, J.D.; Martinez, A.; McCormick, B.; McGowan, H. and Nerad, J.A. The Collaborative Ocular Melanoma Study (COMS) Randomized Trial of Pre-enucleation radiation of Large choroidal Melanoma III: Local Complications and Observations Following enucleation COMS Report No. 11. American Journal of Ophthalmology 126(3): 362-372, 1998. 134. Kini, V.J.; White, J.W.; Horwitz, E.M.; Dmuchowski, C.F.; Martinez, A. and Vicini, F.A. LongTerm Results with Breast Conserving Therapy for Early Stage Breast Cancer in a Community Hospital Setting. Cancer 82: 127-133, 1998. 135. Victor, S.; Brown, D.M.; Horwitz, E.M.; Martinez, A.; Kini, V.J.; Pettinga, J.E.; Shaheen, K.W., Chen, P.Y. and Vicini, F.A. Treatment Outcome with Radiation Therapy After Breast Augmentation or Reconstruction in Primary Breast Cancer. Cancer 82: 1303-1309, 1998. 136. Vicini, F.A.; Ziaja, E.; and Martinez, A. A Dose escalation with Three-Dimensional Conformal Radiation Therapy Affects Outcome in Prostate Cancer. Letter to the Editor. Int J Radiat Oncol Biol Phys. 43(1): 235-236, 1999. 137. Vicini, F.A.; Chen, P. Y.; Kini, V.J.; and Martinez, A. Irradiation of the Tumor Bed Alone After Lumpectomy in Selected Patients with Early Stage Breast Cancer Treated with Breast Conserving Therapy. J Surg Oncol 70: 33-40, 1999. 138. Vicini, F.A.; Ziaja, E.L.; Kestin, L.L.; Brabbins, D.B.; Stromberg, J.S.; Gonzalez, J.A. and Martinez, A. Treatment outcome with Adjuvant and Salvage irradiation Following Radical Prostatectomy for prostate Cancer. Urology 54(1): 111-117, 1999. 139. Vicini, F.A.; Kestin, L.; Stromberg, J. and Martinez, A. Brachytherapy Boost Techniques for locally Advanced prostate Cancer. ONCOL 13(4): 491-503, 1999. 140. Kini, V.J.; Vicini, F.A.; Martinez, A., et. al. Mammographic, Pathologic, and Treatment Related factors Affecting local Recurrence in patients with Early Stage Breast Cancer Treated with Breast Conserving Therapy. Int J Radiat Oncol Biol Phys 43(2): 341-346, 1999. 141. Kini, V.J.; Edmundson, G.K.; Vicini, V.A. and Martinez, A. Use of Three Dimensional Radiation Therapy Planning Tools and Intraoperative Ultrasound to Evaluate High Dose Rate Prostate Brachytherapy Implants. Int J Radiat Oncol Biol Phys 43(3): 571-578, 1999. 142. Vicini, F.A.; Kini, V.J.; Diokno, A.; Spencer, W. and Martinez, A. The Role of Androgen Deprivation in the Definitive management of Clinically Localized Prostate Cancer Treated with Radiation Therapy. Int J Radiat Oncol Biol Phys 43(4): 707-713, 1999. 143. Gupta, A., Vicini, F.A.; Frazier, A., Dmuschowski, C., Edmundson, G.K.; Mele, E. and Martinez, A.: Iridium-192 Transperineal Interstitial Brachytherapy for Locally Advanced Gynecological Malignancies. Int J Radiat Oncol Biol Phys 43(5): 1055-1060, 1999. 17 Alvaro Martinez, M.D. 144. Vicini, F.A.; Kini, V.J.; Edmundson, G.S.; Gustafson, G.S; Stromberg, J.S.; Martinez, A.: A comprehensive review of prostate cancer brachytherapy: Defining an optimal technique. Int J Radiat Oncol Biol Phys 44(3): 483-492, 1999. 145. Wong, J.W.; Sharpe, M.B.; Jaffray, D.A.; Kini, V.J.; Robertson, J.; Stromberg, J.S. and Martinez, A. The Use of Active Breathing Control to Reduce Margin From Breathing Motion. Int J Radiat Oncol Biol Phys 44(4): 911-919, 1999. 146. Vicini, F.A.; Kestin, L.L.; Goldstein, N.S.; and Martinez, A.A. Pathologic and technical Considerations in the Treatment of Ductal carcinoma-In-Situ of the Breast with Lumpectomy and Radiation Therapy. Annals Oncol. 10(8): 883-890, 1999. 147. Vicini, F.A.; Kestin, L.L.; Jaffray, D.A.; Edmundson, G.K.; Wong, J. W.; Kini, V.J.; Chen, P.Y. and Martinez, A. Dose-Volume Analysis for Quality Assurance of Interstitial Brachytherapy for Breast Carcinoma. Int J Radiat Oncol Biol Phys 45(3): 803-810, 1999. 148. Vicini, F.A.; Kestin, L.L.; Martinez, A.A.: The importance of adequate follow-up in defining treatment success after external beam irradiation for prostate cancer. Int J Radiat Oncol Biol Phys 45(3): 553-561, 1999. 149. Kini, V.J.; Vicini, F.A.; Victor, S.J.; Dmuchowski, C.F.; Wimbish, K. and Martinez, A. The impact of the Mode of Detection on outcome in Breast Cancer patients Treated with Breast Conserving Therapy. Am J Clin Oncol 22(5): 429-435, 1999. 150. Victor, S.; Vicini, F.A.; Decker, D.; Wilner, F. and Martinez, A. Clinical, Pathologic and Treatment Related Factors affecting Outcome in Patients with locally Advanced Breast Cancer Treated with Trimodality Therapy. Amer J Clin Oncol 22(2): 119-125, 1999. 151. Vicini, F.A.; Kestin, L.; Martinez, A.: Prostatectomy, external beam radiation therapy or brachytherapy for localized prostate cancer. Letter to the Editor. JAMA 281(17): 1583-1584, 1999. 152. Kestin, L.L.; Vicini, F.A.; Ziaja, E.L.; Stromberg, J.S.; Frazier, R.C. and Martinez, A. Defining Biochemical Cure for Prostate Cancer Treated with External Beam Radiation Therapy. Cancer 86(8): 1557-1566; 1999. 153. Jaffray, D., Drake, D., Morea, M., Martinez, A., et al. A Radiographic and Tomographic Imaging System Integrated into a Medical Linear Accelerator for Localization of Bone and SoftTissue Targets. Int J Radiat Oncol Biol Phys. 45: 773-789, 1999. 154. Vicini, F.A., Kestin, L.L., Martinez, A.A. The Importance of Adequate Follow-up in Defining Treatment Success After External Beam Irradiation for Prostate Cancer (letter). Int J Radiat Oncol Biol Phys. 45:1457-1458. 2000. 155. Kestin, L.L.; Goldstein, N.S.; Rebner, M.; Balasubramaniam, M.S.; Martinez, A.; Frazier, R.C.; Register, J.T.; Pettinga, J. and Vicini, F.A. Mammographically-Detected Ductal carcinoma in Situ Treated with Conservative Surgery with or without Radiation Therapy: Patterns of Failure and Ten-Year Results. Ann Surg 231(2): 2000. 18 Alvaro Martinez, M.D. 156. Frazier, R.C., Vicini, F.A., Sharpe, M.B., Fayad, J., Yan, D., Martinez, A.A., Wong, J.W. The Impact of Respiration on Whole Breast Radiotherapy: A Dosimetric Analysis Using Active Breathing Control. Int J Radiat Oncol Biol Phys. Jan 1; 48(3 Supp 1): 200, 2000. 157. Kestin, L.L.; Jaffray, D.A.; Edmundson, G.K.; Martinez, A.A.; Wong, J.W.; Kini, V.J.; Chen, P.Y. and Vicini, F. Improving Dosimetric Coverage of Interstitial High Dose Rate Breast Implants. Int J Radiat Oncol Biol Phys 46(1): 35-44, 2000. 158. Martinez, A., Gonzalez, J., Chung, A., Kestin, L.L., Balasubramaniam, M., Diokno, A., Ziaja, E., Brabbins, D., Vicini, F.A. A Comparison of External Beam Radiation Therapy versus Radical Prostatectomy for Patients with Low Risk Prostate Carcinoma Diagnosed, Staged and Treated at a Single Institution. Cancer 88(2): 425-432, 2000. 159. Vicini, F.A.; Kestin, L.L.; Goldstein, N.S., Chen, P., Pettinga, J., Frazier, R.C., Martinez, A.A.: The Impact of Young Age on Outcome in Patients with Ductal Carcinoma-in-situ of the Breast Treated with Breast Conserving Therapy. J Clin Oncol 18(2): 296-307, 2000. 160. Vicini, F.A., Kestin, L.L.; Martinez, A.A The Use of Conformal High Dose Rate Brachytherapy in the Management of patients with Localized Prostate Cancer: Optimizing dose escalation. Techniques Urol. 6(2): 135-145, 2000. 161. Kestin, L.L.; Vicini, F.A.; Goldstein, N.S.; Martinez, A.A.; et. al.: Factors associated with local recurrence of mammographically detected ductal carcinoma-in-situ treated with breast conserving therapy. Cancer 88(3): 596-607, 2000. 162. Martinez, A.A.; Kestin, L.L.; Vicini, F.A.: Interim report of image-guided high dose rate brachytherapy for patients with unfavorable prostate cancer: The William Beaumont Hospital phase II dose escalating trial. Int Radiat Oncol Biol Phys 47(2): 343-352, 2000 163. Vicini, F.A.; Kestin, L.L.; Martinez, A.A.: The correlation of serial prostate specific antigen measurements with clinical outcome following external beam radiotherapy for prostate cancer. Cancer 88(10): 2305-2318, 2000. 164. Vicini, F.A.; Kestin, L.L.; Martinez, A.A.: Letter to Editor. The influence of follow-up on biochemical outcome estimation. Int J Radiat Oncol Biol Phys 47(5): 1457-1458, 2000. 165. Pisani, L.; Lockman, D.; Jaffray, D.; Yan, D.; Martinez, A.; and Wong, J.: Setup error in radiotherapy: On-Line correction using electronic kilovoltage and megavoltage radiograph. Int Radiat Oncol Biol Phys 47(3): 825-839, 2000. 166. Stromberg, J.S.; Sharpe, M.; Kim, L.; Kini, V.J.; Jaffray, D.; Martinez, A. and Wong, J. Active Breathing Control (ABC) for Hodgkins Disease: Reduction in Normal Tissue Irradiation with Deep Inspiration and Implications for Treatment. Int J Radiat Oncol Phys 48(3): 797-806, 2000. 19 Alvaro Martinez, M.D. 167. Yan, D.; Lockman, D.; Brabbins, D. and Martinez, A. An Off-Line Strategy for Construction of a Patient Specific Planning Target Volume in Adaptive Treatment Process for Prostate Cancer. Int J Radiat Oncol Biol Phys 48(1): 284-302,2000. 168. Kestin, L.L.; Sharpe, M.B.; Frazier, R.C.; Vicini, F.A.; Matter, R.C.; Martinez, A.A.; Wong, J.W. Intensity Modulation to Improve Dose Uniformity with Tangential Breast Radiotherapy. Int J Radiat Oncol Biol Phys. 48(5): 1559-1568, 2000. 169. Martinez, A.A.: Permanent Prostate Brachytherapy: Lessons Learned, Lessons to learn, Oncology, July 2000. 170. Vicini, F.A., Baglan, K.L., Kestin, L.L., Mitchell, C., Chen, P.Y., Frazier, R.C., Edmundson, G., Martinez, A. Accelerated Treatment of Breast Cancer. Int J Radiat Oncol Biol Phys 1: 48(3 Suppl 1); 197-198, 2000. 171. Vicini, F.A., Kestin, L.L., Martinez A. Biochemical Outcomes of Treatment for Prostate Cancer (letter). JAMA Dec 13: 284(22): 2869, 2000. Kestin, L.L., Martinez, A.A.; Stromberg, J.S.; Edmundson, G.K.; Gustafson, G.G.; Brabbins, D.S.; Chen, P.Y.; Vicini, F.A. Matched-pair Analysis of Conformal High-Dose-Rate brachytherapy Boost Versus External-beam Radiation Therapy Alone for Locally Advanced Prostate Cancer. J Clin Oncol 18(15): 2869-2880, 2000. 172. 172. Vicini, F.A., Kestin, L.L., Goldstein, N.S., Pettinga, J.E., Martinez, A. The Relationship Between Excision Volume, Margin Status, and Tumor Size with the Development of Local Recurrence in Patients with Ductal-Carcinoma-Insitu Treated with Breast Conserving Therapy. J Surg Oncol. 76(4): 245-254, 2000 173. Kestin, L.L., Martinez, A.A. A Matched Pair Analysis of Conformal High Dose Rate Brachytherapy Versus External Beam Radiation Therapy Alone for Locally Advanced Prostate Cancer (letter). J of Clin Oncol 18:4005, 2000. 174. Vicini, F.A., Baglan, K.L., Kestin, L.L., Mitchell, C., Chen, P.Y., Frazier, R.C., Edmundson, G., Goldstein, N.S., Benitez, P., Huang, R.R., Martinez, A. Accelerated Treatment of Breast Cancer. J Clin Oncol April 1: 19(7): 1993-2001, 2001. 175. Martinez, A.; Pataki, I.; Edmundson, G.; Sebastian, E.; Brabbins, D.S.; Gustafson G.: Phase II prospective study of the use of conformal high dose rate brachytherapy as monotherapy for the treatment of favorable stage prostate cancer: A feasibility report. Int J Radiat Oncol Biol Phys 49(1): 61-69, 2001. 176. Frazier, R; Kestin, L; Kini, V; Martinez, A.; Chen, P; Baglan, K; and Vicini, F.: Impact of Boost Technique on Outcome in Early-Stage Breast Cancer Patients Treated with Breast-Conserving Therapy. Am J Clin Oncol 24(1): 26-32, 2001. 177. Baglan, K.L.; Martinez, A.; Frazier, R.C.; Kini, V.; Kestin, L.L.; Chen, P.Y.; Edmundson, G.; Mele, E.; Jaffray, D.; and Vicini, F.A.: The use of high-dose rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 50(4): 1003-1011, 2001. 20 Alvaro Martinez, M.D. 178. Martinez, A.A.; Yan, D.; Lockman, D.; Brabbins, D.; Kota, K.; Sharpe, M.; Jaffray, D.; Vicini, F.A.; and Wong, J.: Improvement in dose escalation using the process of adaptive radiotherapy combined with three dimensional conformal or intensity-modulated beams for prostate cancer. Int J Radiat Oncol Biol Phys. 50(5): 1226-1234, 2001. 179. Yan, D., Benhua, X., Lockman, D., Kota, K., Brabbins, D., Wong, J., Martinez, A. The influence of interpatient and intrapatient rectum variation on external beam treatment of prostate cancer. Int J Radiat Oncol Biol Phys. 51(4): 1111-1119, 2001. 180. Vicini, F.A., Abner, A., Baglan, K.L., Kestin, L.L., Martinez, A.A. Defining a dose-response relationship with radiotherapy for prostate cancer: Is more really better? Int J Radiat Oncol Biol Phys. 51(5): 1200-1208, 2001. 181. Nuyttens, J., Robertson, J., Yan D., Martinez, A. The position and volume of the small bowel during adjuvant radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys. 51(5): 12711280, 2001. Goldstein, N., Kestin, L.L., Vicini, F.A., Martinez, A.A. The Influence of Percentage of Preradiation Needle Biopsies with Adenocarcinoma and Total Radiation Dose on the Pathologic Response of Unfavorable Prostate Adenocarcinoma. Amer J of Clin Path 117: 927-934, 2002. 182. 183. Vicini, F.A, Kestin, L.L., Martinez, A.A.. The Correlation of Serial Prostate-Specific Antigen Measurements with Clinical Outcome in the Treatment of Prostate Cancer with External Beam Radiotherapy (letter). Cancer. 91:1064-1065; 2001. 184. Baglan, K., Frazier, R.C., Yan, D., Huang, R., Martinez, A., Robertson, J. The Dose-volume Relationship of Acute Small Bowel Toxicity from Concurrent 5-FU Based Chemotherapy and Radiation Therapy for Rectal Cancer. Int J. Radiat Oncol Biol Phys. 52(1): 176-183, 2002. 185. Brenner, D., Martinez, A., Edmundson, G., Mitchell, C., Thames, H., Armour, E. Direct Evidence that Prostate Tumors Show High Sensitivity to Fractionation (low аß ratio), Similar to Late-Responding Normal Tissue. Int J Radiat Oncol Biol Phys. 52(1): 6-13, 2002. 186. Nag, S., Chao, C., Erickson, B., Fowler, J., Gupta, N., Martinez, A., Thomadsen, B., for the American Brachytherapy Society. The American Brachytherapy Society Recommendations for Low-Dose Rate Brachytherapy for Carcinoma of the Cervix. Int J Radiat Oncol Biol Phys. 52(1): 33-48, 2002. 187. Vicini, F.A., Baglan, K., Kestin, L.L., Chen, P., Edmundson, G., Martinez, A.A. The Emerging Role of Brachytherapy in the Management of Patients with Breast Cancer. Seminars in Radiation Oncology 12(1); January 2002. 188. Edmundson, G., Vicini, F., Chen, P., Mitchell, C., Martinez, A. Dosimetric Characteristics of the Mammosite RTS, a New Breast Brachytherapy Applicator. Int J Radiat Oncol Biol Phys. 52(4): 1132-1139, 2002. 189. Kucway, R.; Vicini, F.A.; Huang, R.; Stromberg, J.; Martinez, A.A. Prostate Volume Reduction with Androgen Deprivation Therapy prior to Interstitial Brachytherapy. J Urology. 167: 24332447, 2002. 21 Alvaro Martinez, M.D. 190. Cumberlin, R., Coleman, N., and Workshops Participants: Martinez, A., et al: New Directions in Brachytherapy. Int J Radiat Oncol Biol Phys. 53(1): 6-11, 2002. 191. Devlin, P., Christina, R., Kazakin, J., Mitchell, R., Demanes, D., Edmundson, G., Gribble, M.,Gustafson, G., Kelly, D., Linares, L., Martinez, A., et al: An internet ready database for prospective randomized clinical trials of high-dose-rate brachytherapy for adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys. 53(1): 104-115, 2002. 192. Kestin, L., Vicini, F.A., Martinez, A.A.: Practical Application of Biochemical Failure Definition: what to do and when to do it. Int J Radiat Oncol Biol Phys. 53(2): 304-315, 2002. 193. Martinez, A..A., Gustafson, G., Gonzalez, J., Armour, E., Mitchell, C., Edmundson G, Spencer, W., Stromberg, J., Huang, R., Vicini, F.A.: Dose escalation using conformal high dose rate brachytherapy improves the outcome in unfavorable prostate cancer. Int J Radiat Oncol Biol Phys. 53(2): 316-327, 2002. 194. Jaffray, D., Siewerdsen, J.W., Wong, J.W., Martinez, A. Flat-Panel Cone-Beam Computer Tomography for Image-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 53(5): 13371349, 2002. 195. Vicini, F.A., Sharpe, M., Kestin, L., Martinez, A., Wong, J. Intensity Modulated Radiation Therapy for Breast Cancer: Improving Treatment Efficacy. Am J Cancer 1(4): 237-245, 2002. 196. Kestin, L., Goldstein, N.S., Vidal, F., Mitchell, C., Gustafson, G., Martinez, A.A, et al: Pathologic Evidence of Dose-response and Dose-volume Relationships for Prostate Cancer Treated with Combined External Radiotherapy and High-dose rate brachytherapy. Inter J Radiat Oncol Biol Phys. 54(1): 107-118, 2002. 197. Ghilezan, M.J., Jaffray, D., Siewedersen, J.H., Van Herk, M., Shetty, A., Sharpe, M.B., Jafri, S., Vicini, F.A., Matter, R.C., Brabbins, D.S., Martinez, A.A.: One Hour Intra-fraction Prostate Motion Assessed with Cine-Magnetic Resonance Imaging (cine-MRI). Int J Radiat Oncol Biol Phys. 54(Suppl): 182-183, 2002. 198. Stewart, K.D., Martinez, A.A., Weiner, S., Stromberg, J.S., Mitchell, C., Jennings, J., Sherman, A., Chen, P., Brabbins, D. Ten year outcome including patterns of failure and toxicity for adjuvant whole abdomino-pelvic irradiation in high risk and poor histology patients with endometrial cancer. Int J Radiat Oncol Biol Phys. 54(2): 527-535, 2002. 199. Kestin, L., Goldstein, N., Vicini, F.A., and Martinez, A.: Percentage of positive biopsy cores as a predictor of clinical outcome in prostate cancer treated with radiotherapy. J of Urol 168: 19941991, November 2002. 200. Kestin, L.L., Goldstein, N.S., Vicini, F.A., Yan, D., Korman, H., Martinez, A.A. Treatment of prostate cancer with radiotherapy: Should the entire seminal vesicles be included in the Clinical Target Volume. Int J Radiat Oncol Biol Phys 54(3): 686-697, 2002. 201. Vicini, F. A., Martinez, A., Hanks, G., et al. An Interinstitutional and Interspecialty Comparison 22 Alvaro Martinez, M.D. of Treatment Outcome Data for Patients with Prostate Carcinoma Based on Predefined Prognostic Categories and Minimum Follow-Up. Cancer Vol 95(10): 2126-2135, November 2002. 202. Nuyttens, J.J., Robertson, J., Yan, Di, Martinez, A., The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int Radiat Oncol Biol Phys. 53(2): 497-503, June 2002. 203. Brenner, D., Martinez, A., Edmundson, G., Mitchell, C., Armour, E., Thames, H., In response to Dr. Lee: Int J. Radiat Oncol Biol. 53(5) 1393, August, 2002. 204. Vicini, F.A., Sharpe, M., Kestin, L.L., Martinez, A.A., Mitchell, C.K., Wallace, M.F., Matter, R., and Wong, J.: Optimizing Breast Cancer Treatment Efficacy with Intensity-Modulated Radiotherapy. Int J Radiat Oncol Biol. 54(5): 1336-1344, 2003. 205. Vicini, F.A., Kestin, L., Huang, R., and Martinez, A.A.: Does Local Recurrence Affect the Rate of Distant Metastases and Survival in Patients with Early Stage Breast Carcinoma Treated with Breast Conserving Therapy? Cancer 97 (4): 910-919, 2003. Martinez, A.A.; Gonzalez, J.; Spencer, W., Gustafson, G.S., Kestin, L., Kearney, D., Vicini, F.A. Conformal high dose rate brachytherapy improves biochemical control and cause specific survival in patients with prostate cancer and poor prognostic factors. J of Urol. 169(3): 974-980, 2003. 206. 207. Baglan, K.L., Sharpe, M.B., Jaffray, D., Frazier, R.C., Fayad, J., Kestin, L.L., Remouchamps, V., Martinez, A.A., Wong, J., and Vicini, F.A.: Accelerated Partial Breast Irradiation Using 3D Conformal Radiation Therapy (3D-CRT). Int J Radiat Oncol Biol Phys. 55(2): 302-311, 2003. 208. Remouchamps, V.M., Vicini, F.A., Sharpe, M., Kestin, L., Martinez, A., and Wong, J. Significant Reductions in Heart and Lung Doses Using Deep Inspiration Breath Hold and Active Breathing Control and Intensity Modulated Radiation Therapy for Patients with Locoregional Breast Cancer Irradiation. Int J Radiat Oncol Biol Phys. 55(2): 392-406, 2003. 209. Grills, G.S., Kestin, L.L., Goldstein, N., Mitchell, C., Martinez, A.A., Ingold, J., Vicini, F.A. Risk Factors for Locoregional nodal failure after breast conserving therapy: Regional Nodal Reduces Rate of Axillary Failure in Patients with Four or More Positive Lymph Nodes. Int J Radiat Oncol Biol Phys. 56(3): 658-670, 2003. 210. Remouchamps, V.M., Letts, N., Vicini, F.A., Sharpe, M., Kestin, L.L., Chen, P., Martinez, A.A. and Wong, J.: Initial Clinical Experience with Moderate Deep Inspiration Breath Hold Using an Active Breathing Control Device in the Treatment of Patients with Left-Sided Breast Cancer Using External beam Radiation Therapy. Int J Radiat Oncol Biol Phys. 56(3): 704-715, 2003. 211. Vicini, F.A., Vargas, C., Edmundson, G., Kestin, L.L., Martinez, A.A.: The Role of High Dose Rate Brachytherapy in Locally Advanced Prostate Cancer. Seminars in Radiation Oncology. 13:98-108; 2003. 212. Vicini, F.A., Kestin, L., Chen, P., Benitez, P., Goldstein, N., Martinez, A.A.,: Limited-Field radiation Therapy in the Management of Early-Stage Breast Cancer. Journal of the National Cancer Institute, Vol., 95, No. 16, 1205-1211, 2003. 23 Alvaro Martinez, M.D. 213. Martinez, A.A., Weiner, S., Podratz, K., Armin, A.R., Stromberg, J., Stanhope, R., Sherman, A., Schray, M., Brabbins, D.: Improved Outcome at 10 years for Serous-Papillary/Clear Cell or High-Risk Endometrial Cancer Patients Treated by Adjuvant High-Dose Whole Abdominopelvis Irradiation. Gynecologic Oncology. 90, 537-546- 2003. 214. Grills, I., Di Yan D.Sc., Martinez, A.A., Vicini, F., Wong, J.W., Kestin, L.: Potential for Reduced Toxicity and Dose Escalation in the Treatment of Inoperable Non-small-cell Lung Cancer: A comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. Int J Radiat Oncol Biol Phys. 57(3): 875-890, 2003. 215. Kuban, D., Thames, H., Levy, L., Horwitz, E., Kupelian, P., Martinez, A.A., Michalski, J., Pisansky, T., Sandler, H., Shipley, W., Zelefsky, M., Zietman, A.: Long-Term Multi-Institutional Analysis of Stage T1-T2 Prostate Cancer Treated with Radiotherapy in the PSA ERA. Int J Radiat Oncol Biol Phys. 57(4): 915-928, 2003. 216. Thames, H., Kuban, D., Levy, L., Horwitz, E., Kupelian, P., Martinez, A.A., Michalski, J., Pisansky, T., Sandler, H., Shipley, W., Zelefsky, M., Zietman, A.: Comparison of Alternative Biochemical Failure Definitions Based on Clinical Outcome in 4839 Prostate Cancer Patients Treated by External Beam Radiotherapy Between 1986 and 1995. Int J Radiat Oncol Biol Phys. 57(4): 929-943, 2003. 217. Remouchamps, V., Letts, N., Di Yan D.Sc., Vicini, F., Moreau, M., Zielinski, J., Liang, J., Kestin, L., Martinez, A.A., Wong, J.: Three-Dimensional Evaluation of Intra-and Interfraction Immobilization of Lung and Chest Wall using active Breathing Control: A Reproducibility Study with Breast Cancer Patients. Int J Radiat Oncol Biol Phys.57(4): 968-978, 2003. 218. Martinez, A.A., Galalae, R., Gonzalez, J., Mitchell, C., Gustafson, G., Kovac, G., No Apparent Benefit at 5 Years from a Course of Neoadjuvant/concurrent Androgen Deprivation for Prostate Cancer Patients Treated to a High Total Radiation Dose. J of Urol. 170(6) 2296 – 2301, 2003. 219. Vicini, F.A., Kestin, L.L., Huang, R., Martinez, A.A. Does Local Recurrence Affect the Rates of Distant Metastases and Survival in Patients with Early Stage Breast Cancer Treatment with Breast Conserving Therapy? Cancer Feb 15; 97(4): 910-9 2003. 220. Vicini, F.A., Vargas, C., Gustafson, G., Edmundson, G., Martinez, A.A. High Dose Rate Brachytherapy in the Treatment of Prostate Cancer. World J Urol Sep 21(4): 220-228, 2003. 221. Galalae, R.M., Martinez, A.A., Mate, T., Mitchell, C., Edmundson, G. et al. Long-term Outcome by Risk Factors Using Conformal HDR Brachytherapy Boost with or without Neoadjuvant Androgen Deprivation Suppression for Localized Prostate Cancer. Int J Radiat Oncol Biol Phys. 58(4): 1048 – 1055, 2004 222. Grills, I., Martinez, A.A., Hollander, M., Huang, R., Goldman, K., Chen, P. and Gustafson, G.: High Dose Rate Brachytherapy as Prostate Cancer Monotherapy Reduces Toxicity Compared to Low Dose Rate Palladium Seeds. J. of Urol vol 171: 1098-1104, March 2004. 223. Kestin, L.L., Vicini, F.A., Martinez, A.A. Potential survival advantage with early androgen 24 Alvaro Martinez, M.D. Deprivation for Biochemical Failure after External Beam Radiotherapy: The importance of accurately defining biochemical disease status. Int J Radiat Oncol Biol Phys 60 (2):453-462, 2004 224. Frazier, R.C., Vicini, F.A., Sharpe, M., Yan, D., Fayad, J., Baglan, K.L., Kestin, L.L., Remouchamps, V.M. Martinez, A.A., Wong, J. Impact of Breathing Motion on Whole Breast Radiotherapy: A dosimetric analysis using active breathing control. Int J Radiat Oncol Biol Phys 58:1041-1047, 2004. 225. Vicini, Sharpe, M., Kestin, L.L., Remouchamps, V., Martinez, A.A. The Use of Intensity Modulated Radiation Therapy in the Treatment of Breast Cancer: evolving definition, misdirected criticism, and untoward effects. Int J Radiat Oncol Biol Phys 58:1642-1644, 2004. 226. Weed. D.W., Yan, D., Martinez, A.A., Vicini, F.A., Wilkinson, T.J., and Wong, J.: The Validity of Surgical Clips as a Radiographic Surrogate for the Lumpectomy Cavity in Image-guided Accelerated Partial Breast Radiation. Int J Radiat Oncol Biol Phys 60(2): 484-492, 2004. 227. Krauss, D.J., Kestin, L.L., Mitchell, C., Martinez, A.A., Vicini, F.A. Changes in Temporal patterns of Local Failure after Breast-Conserving Therapy and their Prognostic Implications. Int J Radiat Oncol Biol Phys. 60 (3): 731 – 758, 2004. 228. Black, G.C., Grills, I.S., Kestin, L.L., Wong, C-Y.O., Wong, J., Martinez, A.A., Yan, Di. Defining a Radiotherapy Target with Positron Emission Tomography. Int J. Radiat Oncol Biol Phys. 60 (4) 1272 – 1282, 2004. 229. Benitez, P.R., Chen, P.Y., Vicini, F.A., Wallace, M., Kestin, L.L., Edmundson, G., Martinez, A.A. Surgical Considerations in the Treatment of Early Stage Breast Cancer with Accelerated Partial Breast Irradiation (APBI) in Breast Conserving Therapy via Interstitial Brachytherapy. Amer J of Surg 188:355-364, 2004. 230. Nuyttens, J, Robertson, J., Yan, Di, Martinez, A., The influence of small bowel motion on both a conventional three-field and intensity modulated radiation therapy (IMRT) for rectal cancer. Cancer/Radiotherapie 8 (5): 297-304, Oct. 2004 231. Pass, H., Vicini, F.A., Kestin, L.L., Goldstein, N.S., Decker, D., Pettinga, J., Ingold, J., Benitez, P., Neumann, K., Rebner, M., Dekhne, N., Martinez, A.A. Changes in Management Techniques and Patterns of Disease Recurrence Over Time in Patients with Breast Carcinoma Treated with Breast Conserving Therapy at a Single Institution. Cancer 101:713-720, 2004. 232. Jolly, S., Kumar, T., Vargas, C., Weiner, S., Brabbins, D., Chen, P., Kestin, L., Floyd, W. Martinez, A.A. Vaginal Brachytherapy Alone: An alternative in whole pelvis radiation for early stage endometrial cancer. Int J Radiat Oncol Biol Phys. 60(1S): 212-213, 2004. 233. Brabbins, D., Jolly, S., Vargas, C., Kumar, T., Weiner, S., Chen, P., Kestin, L., Floyd, W., Martinez, A.A. The Impact of Age on Long Term Outcome in Endometrial Cancer Patients Treated with Post-operative Radiation Therapy. Int J Radiat Oncol Biol Phys 60(1S): 306-307, 2004. 25 Alvaro Martinez, M.D. 234. Harsolia, A., Vargas, C., Kestin, L.L., Yan, D., Brabbins, D.S., Lockman, D., Liang, J., Gustafson, G., Chen, P., Vicini, F.A., Martinez, A.A. Predictors for Chronic Urinary Toxicity Following Treatment of Prostate Cancer with 3D Conformal Radiotherapy: Dose-volume analysis of a Phase II dose escalation study. Int J Radiat Oncol Biol Phys 60(1S): 437-438, 2004. 235. Ghilezan, M., Vargas, C., Gustafson, G., Hollander, M., Balasubramanian, M., Chen, P., Brabbins, D., Korman,H., Sebastian, E., Edmundson, G., Gonzalez, J., Martinez, A.A. HDR vs. LDR (Pd102 permanent implants) Brachytherapy as Monotherapy for Prostate Cancer: timing to onset and predictors of erectile dysfunction. Int J Radiat Oncol Biol Phys 60(1S): 442-443, 2004. 236. Ghilezan, M., Yan, Di., Liang, J., Jaffray, D., Wong, J., Martinez, A.A. Online Image-Guided Intensity-Modulated Radiotherapy For Prostate Cancer: How much Improvement can we expect? A Theoretical Assessment of Clinical Benefits and Potential Dose Escalation by Improving Precision and Accuracy of Radiation Delivery. Int J Radiat Oncol Biol Phys 60(5): 1602-1610, 2004. 237. Kuban, D., Thames, H., Levy, L., Horwitz, E., Kupelian, P., Martinez, A., Michalski, J., Pisansky, T., Sandler, H., Shipley, W. Failure definition-dependent differences in Following radiation for localized prostate cancer: Can one size fit all? Int J. Radiat Oncol Biol Phys 61(2): 409-414, 2005. 238. Weed, D., Edmundson, G., Vicini, F., Chen, P., Martinez, A.. Accelerated partial breast irradiation: A dosimetric comparison of three different techniques. Brachytherapy 4(2): 121-129, 2005 239. Kupelian, P., Kuban, D., Thames, H., Levy, L., Horwitz, E., Martinez, A., Michalski, J. Pisansky, T., Sandler, H., Shipley, Wm. Improved biochemical relapse-free survival with Increased external radiation doses in patients with localized prostate cancer: The combined experience of nine Institutions in patients treated in 1994 and 1995. Int J. Radiat Oncol Biol Phys 61(2): 415 – 419, 2005. 240. Brabbins, D., Martinez, A.A., Yan, Di., Lockman, D., Wallace, M., Gustafson, G., Chen, P.,Vicini, F., Wong, J. A dose-escalation trial with the adaptive radiotherapy process as a Delivery system in localized prostate cancer: Analysis of chronic toxicity. Int J. Radiat Oncol Biol Phys 61 (2): 400 – 408, 2005. 241. Horwitz, E., Thames, H., Kuban, D., Levy, L.B., Kupelian, P., Martinez, A.A., Michalski, J., Pisansky, T., Sandler, H., Shipley, W., Zelefsky, M., Hanks, G., Zietman, A. Definitions of Biochemical Failure that best predict clinical failure in Patients with prostate cancer treated with external beam radiation alone: A multiInstitutional pooled analysis. J of Urol 173: 797-802 March 2005. 242. Vargas, C., Kestin, L., Weed, D., Krauss, D., Vicini, F., Martinez, A.A. Improved Biochemical Outcome with Adjuvant Radiotherapy after Radical 26 Alvaro Martinez, M.D. Prostatectomy for Prostate Cancer with Poor Pathologic Features. Int J Radiat Oncol Biol Phys. 61(3): 714-724, 2005 243. Krauss, D., Kestin, L.L., Raff, G., Yan, D., Wong, J., Gentry, R., Letts, N., Vargas, C., Martinez, A.A., Vicini, F.A. MRI based dosimetric Assessment of Cardiac anatomy and dose reduction via Active Breathing Control during irradiation for left sided breast cancer. Int J Radiat Oncol Biol Phys. 61(4):1243-1250 April 2005 244. Vicini, F.A., Vargas, C., Abner, A., Kestin, L.L., Horwitz, E., Martinez, A.A. Limitations in the use of Serum Prostate Specific Antigen Levels to Monitor Patients After Treatment for Prostate Cancer. J of Urol. 173(5):1456-1462, May 2005 245. Letourneau, D., Martinez, A.A., Lockman, D., Yan, Di., Vargas C., Ivaldi, G and Wong, J.: Assessment of residual error for online cone beam CT Guided Treatment of Prostate patients. Int. J. Radiation. Int. J. Radiat Oncol Biol. Phys. 62(4): 1239-1246, 2005. 246. Vargas, C., Kestin L., Yan, D., Grills, I., Brabbins, D., Lockman, D., Liang, J., Gustafson, G., Chen, P., Vicini, F.A., Wong, J., Martinez, A.A. Dose-Volume Analysis of Predictors for Chronic Rectal Toxicity Following Treatment of Prostate Cancer with Adaptive Image-Guided Radiotherapy. Int. J. Radiat Oncol Biol Phys. 62(5): 1297-1308, 2005. 247. Martinez, A.A., Demanes, J., Galalae, R., Vargas, C., Bertermann, H., Rodriguez, R., Gustafson, G., Altieri, G., and Gonzalez, J.: Lack of Benefit from a Short Course of Androgen Deprivation for Unfavorable Prostate Cancer Patients Treated with an Accelerated Hypofractionated Regime. Int J Radiat Oncol Biol Phys. 62(5): 1322-1331, 2005. 248. Letourneau, A., Wong, J., Oldham, M., Gulan, M., Watt, L., Jaffray, D. Siewerdsen, J., Martinez, A., Cone-beam-CT guided radiation therapy: technical implementation. Radiotherapy and Oncology, 75(3): 279-286, June 2005. 249. Vargas, C., Martinez A.A., Yan, d., et al.: A phase II dose escalation study of image guided adaptive radiotherapy for prostate cancer: Use of dose constraints to achieve rectal isotoxicity. Int J Radiat Oncol Biol Phys. 63(1): 141-149, 2005. 250. Oldham, M., Letourneau,D., Watt, L., Hugo, G., Yan, Di, Lockman, D., Kim, L., Chen, P., Martinez, A., Wong, J. Cone-beam-CT guided radiation therapy: A model for on-line Application. Radiotherapy and Oncology June 2005; 75(3): 271- 278 251. Ghilezan, M.J., Jaffray, D.A., Siewerdsen, J.H., Van Herk, M., Shetty, A., Sharpe, M.B., Jafri, S.Z., Vicini, F.A., Matter, R.C., Brabbins, D.S., Martinez, AA. Prostate Gland Motion Assessed with Cine-Magnetic Resonance Imaging (CINE-MRI). Int. J. Radiat Oncol. Biol Phys. June 05; 62(2): 406-417 252. Yan, Di, Lockman, D., Martinez, A., Wong, J., Brabbins, D., Vicini, F., Liang, J, Kestin, L., Computed Tomography Guided Management of Interfractional Patient Variation. Seminars in Radiation Oncology, July 2005; 15(3): 168-179. 253. Vargas C., Ghilezan M., Hollander M., Gustafson, G., Korman H., Gonzalz J., Martinez, A., 27 Alvaro Martinez, M.D. New Model Using Number of Needles and Androgen Deprivation to Predict Chronic Urinary Toxicity for Either High or Low Dose Rate Prostate Brachytherapy. Journal of Urol. Sept. 2005, 174(3): 882-887 254. Ray, M., Thames, H., Levy, L., Horwitz, E., Kupelian, P., Martinez, A., Michalski, J., Pisansky, T., Shipley, W., Zelefsky, M. PSA nadir predicts biochemical and distant failures After external beam radiotherapy for prostate cancer: A multi-institutional analysis. Int. Journal of Rad. Onc./Biol./Physics, Sept. 2005, 63(1) 255. Kupelian, P., Thames, H., Levy, L., Horwitz, E., Martinez, A.., Michalski, J., Pisansky, T., Sandler, H., Shipley, W., Zelefsky, M., et al. Year of treatment as independent predictor of Relapse-free survival in patients with localized prostate cancer treated with definitive Radiotherapy in the PSA era. Int. Journal of Rad. Onc./Biol./Physics, Nov. 2005 63(3): 795-799. 256. Vargas, C., Kestin, L., Go, N., Krauss, D., Chen, P., Goldstein, N., Martinez, A. Factors associated with local recurrence and cause-specific survival in patients with Ductal carcinoma in situ of the breast treated with breast-conserving therapy or mastectomy. Int. Journal of Rad. Onc./Biol./Physics, Dec. 2005 63(5): 1514 -1521 257. Vargas, C., Galalae, R., Demanes, J., Harsolia, A., Meldolesi, E., Nurnberg, N., Schour, L., Martinez, A. Lack of benefit of pelvic radiation in prostate cancer patients with a high risk of positive pelvic lymph nodes treated with high-dose radiation. Int. Journal of Rad. Onc./Biol/Physics, Dec. 2005 63(5): 1474-1482. 28 Alvaro Martinez, M.D. BIBLIOGRAPHY ACCEPTED/IN PRESS 1. Nag, S., Martinez, A.A., Orton, C., et al. High dose rate brachytherapy for prostate cancer: Assessment of current clinical practice and recommendations of the American Brachytherapy Society. Brachy J. In Press 2. Robertson, J., Nuyttens, J.J., Martinez, A.A., et al: The variability of the clinical target volume for rectal cancer due to internal organ motion during adjuvant treatment. Int J Radiat Oncol Biol Phys. In Press. 3. Chen, P.Y., Vicini, F.A., Kestin, L.L., Wallace, M., Mitchell, C., Benitez, P., Pettinga, J., Martinez, A.A. Long-term Cosmetic Results and Toxicity with Accelerated Partial Breast Irradiation (APBI) Utilizing Interstitial Brachytherapy. Cancer. In Press. 4. Kuban, D.A., Thames, H.D., Levy, L.B., Horwitz, E.M., Kupelian, P.A., Martinez, A.A., Michalski, J.M., Pisansky, T.M., Sandler, H.M., Shipley, W.U., Zelefsky, M.J., Zietman, A.L. Predicting Outcome after PSA Failure in Prostate Cancer Patients Treated by Radiation. Who Needs Salvage Therapy? Journal of Clinical Oncology. In Press. 29 Alvaro Martinez, M.D. SUBMITTED FOR PUBLICATION 1. Krauss, D.J., Martinez, A., Weiner, S., Stromberg, J., Mitchell, C., Jennings, J., Sherman, A., Chen, P., Brabbins, D. Long-term outcome of adjuvant whole abdominopelvic irradiation for patients with stages I/II endometrial cancer harboring poor histological subtypes including serous papillary and clear cell. 2.. Martinez, A.A., Demanes, J., Vargas, C., Armour, E., DiYan, DSc., Schour, L., Rodriguez, R., Altieri, G., Edmundson, G., Gustafson, G. High Dose Rate “HDR” Prostate brachytherapy: an excellent accelerated-Hypofractionated Treatment for Prostate Cancer. 3. Letts, N., Martinez, A., Remouchamps, V., DiYan, D.Sc., Vicini, F., Wong, J., Set-up Inaccuracies in Breast Irradiation: A comparison of Free Breathing and Active Breathing Control (ABC) treatment using Electronic Portal Images (EPI). 4. Galalae, R., Martinez, A., Kovacs, G., Mitchell, C., Nuernberg, N., Bertermann, H., Edmundson, G., Kohr, P., Gustafson, G., Gonzalez, J., Kimmig, B. Significant Benefit From Prostatic Local Dose Escalation Using Conformal Modulated High Dose Rate Brachytherapy in Hormone Naïve Men with Localized Prostate Cancer. 5. Martinez, A.A., Vargas, C., Gonzalez, J., Hollander M., Korman, H., Grills, I.S., Gustafson, G.: Cost analysis of treatment and related toxicity between “high dose rate” and “low dose rate” brachytherapy for favorable prostate cancer patients. 6. Harsolia, A., Vargas, C., Yan, Di, Brabbins, D., Lockman, D., Liang, J., Gustafson, G., Vicini, F., Martinez, A., Kestin, L. Predictors for Chronic Urinary Toxicity Following the Treatment of Prostate Cancer with 3-D Conformal Radiotherapy Using the Adaptive Radiotherapy Process: Dose-Volume Analysis of a Phase II Dose Escalation Study. 7. Prada, P., Juan, G., Fernandez, J., Martinez, A. Conformal Prostate Brachytherapy Guided by Real-Time Dynamic dose calculation in permanent 125 I Implants: Technical Description and Preliminary experience. 8. Wu, Q., Ivaldi, G., Liang, J., Lockman, D., Yan, Di, Martinez, A.A. Geometric and Dosimetric Evaluations of An Online Image-Guided 3D Conformal Radiation Therapy of Prostate Cancer. 30 Alvaro Martinez, M.D. PUBLISHED IN BOOK CHAPTER 1. Goffinet, D.R., Martinez, A., Palos, B.: Perineal Brachytherapy. Front. Rad. Ther. & Onc. #12, Renaissance of Interstitial Brachytherapy. Editor Jerome M. Vaeth, San Francisco, CA, S. Karger, Basel Medical and Scientific Publishers, New York, 1978. 2. Martinez, A., Goffinet, D.R., Donaldson, S.S., Palos, B.: The Use of Interstitial Therapy in Pediatric Malignancies. Front. Rad. Ther. & Onc. #12, Renaissance of Interstitial Brachytherapy. Editor Jerome M. Vaeth, San Francisco, CA, S. Karger, Basel Medical and Scientific Publishers, New York, 1978. 3. Goffinet, D.R., Martinez, A., Pooler, D., Palso, B., Cox, R.: Brachytherapy Renaissance. A chapter for the book entitled: Frontiers of Radiation Therapy and Oncology: Editor J.M. Vaeth, San Francisco, CA. Vol. 15: 43-57, Karger, Basel, 1981. 4. Goffinet, D.R., Martinez, A., Pooler, D., Palos, B., Donaldson, S.S.: Pediatric Brachytherapy, Chapter 7 for the book entitled: Modern Interstitial and Intracavitary Radiation Cancer Management, Editor Frederick George, III, Los Angeles, CA, 57-69, 1981. 5. Martinez, A.: The Role of Radiation Therapy in the Treatment of Epithelial Ovarian Cancer. Chapter 12 for the book entitled: Controversies in Gynecologic Oncology, Editor Samuel C. Ballon, Chief of Gynecologic Oncology, Stanford University School of Medicine. Stanford, CA. Publishers, G.K. Hall and Co., 1981, pp. 300-310. 6. Goffinet, D., Martinez, A., and Pooler, D.: I-125 Seed Implantation As A Surgical Adjuvant in Head and Neck Cancers., Kombinierte Chirugiache and Radioloschetherapie Maligner Tumoren. pp. 46-49, Urban & Schwargenberg, 1981. 7. Martinez, A.: Radical Irradiation Without a Mastectomy as an Alternative to Radical Surgery for the Treatment of Early Breast Cancer. Chapter 5, Recent Advances in Clinical Oncology. Editors C.J. Williams and Michael Whitehouse. First Edition. Churchill-Livingstone Publishers, pp, 353-362, 1982. 8. Martinez, A. and Coleman, C.N.: Radiation Therapy in the Treatment of Epithelial Ovarian Cancer. Chapter 2, Recent Advance in Clinical Oncology. Editors C.H. Williams and Michael Whitehouse. First Edition. Churchill-Livingstone Publishers, pp. 155-164, 1982. 9. Martinez, A.: Bone Tumors. Principles of Radiotherapy. Chapter 6, Diagnosis and Treatment of Bone Tumors: A Team Approach (A Mayo Clinic Monograph). Edited by Dr. Frank Sim. First Edition, Slack, Inc. Publishers. Edited by Dr. Frank Sim. First Edition, Slack, Inc. Publishers. 10. Fajardo, L.F., Meyer, J.L., Meshorer, A., Prionas, S.D., Martinez, A., and Hahn, G.M.: Thermal Injury and Thermotolerance in Mesenchymal Tissues. In Frontiers of Radiation Therapy and Oncology. J.M. Vaeth, ed. 18: 144-152, 1984. 11. Martinez, A.: The Role of Interstitial Implants in the Management of Pediatric Solid Tumors. Monograph from the Third Annual Endocurietherapy Symposium. Edited by K.M. Sheikh, Endocurietherapy Research Foundation. pp. 231-233, 1984. 31 Alvaro Martinez, M.D. 12. Martinez, A.: Indications for the Vycril Suture Containing Radioactive 125-Iodine Seeds. Technique for Permanent Implantation of Malignant Tumors. Monograph from the Third Annual Endocurietherapy Workshop. Edited by K.M. Sheikh, Endocurietherapy Research Foundation. pp. 195-198, 1984. 13. Martinez, A., and Clarke, D.: Treatment Results, Cosmesis and Complications in Stages I and II Breast Cancer Patients Treated by Excisional Biopsy and Irradiation. In "Current Controversies in Breast Cancer". Edited by F.C. Ames, G.R. Blumenschein, and E.D. Montaque. University of Texas Press, Austin, Texas. pp. 369-381, 1984. 14. Martinez, A., Goffinet, D., Fee, W., Good, R., and Cox, R.S.: 125-Iodine Implants as an Adjuvant to Surgery and External Beam Radiotherapy in the Management of Locally Advanced Head and Neck Cancer. The 1984 Year Book of Otolaryngology, Section Head and Neck Oncology, Edited by Byron J. Bailey, M.D., Published by Year Book Medical Publishers, Inc., Chicago, IL. pp. 282-284, 1984. 15. Martinez, A. and Gunderson, L.L.: Intraoperative Radiation Therapy for Bladder Cancer. A chapter in Symposium on Recent Advances in the Diagnosis and Treatment of Urothelial Cancer. Urologic Clinics of North America. Editor H. Zincke. W.B. Saunders Company, Publishers, Philadelphia, PA. pp. 693-698, 1984. 16. Martinez, A.: Futuro de la Radioterapia en la Enfermedad Maligna. Presented at the XXVII Annual Congress, American College of Surgeons, Chilean Chapter. Monograph from the Conference, 1985, Santiago, Chile. 17. Martinez, A., and Schray, M.F.: Template and Other Extended Techniques for Pelvic and Perineal Implants. Refresher Course Syllabus of the XXVII Annual Meeting of the American Society of Therapeutic Radiology and Oncology, Miami Beach, Florida, September 25, 1985. 18. Martinez, A., and Schray, M.F.: Template and Other Extended Techniques for Pelvic and Perineal Implants. Refresher Course Syllabus of the XXVIII Annual Meeting of the American Meeting of the American Society of Therapeutic Radiologists and Oncology. Los Angeles November 6, 1987. 19. Corry, P.M., Martinez, A., Frazier, H.O.: Hyperthermia with Chronically Implanted Electrodes for Tumors in the Thorax, Abdomen and Pelvis. Hyperthermia Oncology Vol. 2, Special Plenary Lectures, Plenary Lectures and Symposium and Workshop Summaries: Proceedings of the 5th International Symposium of Hyperthermia Oncology, Kyoto, Japan. (Eds) Tsutomu Sugahara and Masao Saito. Publisher - Taylor 7 Francis, pp. 658-661, 1988. 20. Martinez, A.: Interstitial and External Beam Therapy for the Treatment of Locally Advanced Cancers of the Female Genital Tract. Changes in Brachytherapy. Prof. Dr. Med. K. Rotte and J.D. Kiffer, M.B.B.S. (Editors). Wachholz - Printed in Germany, 1989, pp. 154-163. 21. Gunderson, L.L., Martin, J.K., Nagorney, D.M., Fieck, J., Martinez, A., and Earle, J.D.: Mayo Clinic Experience with Intraoperative and External Beam Irradiation with or without Resection. Intraoperative Radiation Therapy. Edited by R.R. Dobelbower, JR. and M. Abe. Published by CRC Press, 1989. 32 Alvaro Martinez, M.D. 22. Martinez, A., Edmundson, G., Littles, F., Benson, R., Diokno, A., Gonzalez, J., Brabbins, D., Kader, F., and Clarke, D.H.: Use of a Remote Afterloading Continuous Low Dose Rate Apparatus for Patients Undergoing Interstitial Implantation of the Prostate with Iridium 192 Combined with External Beam Irradiation. Brachytherapy HDR and LDR. Remote Afterloading: State-of-the-Art. Edited: Martinez, A., Orton, C., Mould, R. Publisher: Nucletron International B.V. The Netherlands, 304-318, 1990. 23. Corry, P.M., Martinez, A., Armour, E.P., Edmundson, G.: Simultaneous Hyperthermia and Brachytherapy with Remote Afterloading. Brachytherapy HDR and LDR. Remote Afterloading: State-of-the-Art. (Eds.) Martinez, A., Orton, C., Mould, R. Publisher: Nucletron International B.V., The Netherlands, 193-204, 1990. 24. Martinez, A.: Radioterapia -- La Radioterapia En El Tratamiento Del Cancer De Mama. Chapter of the Book: Tratamiento del cancer de mama. Edited by Prof. J. Garcia-Conde. Publisher - Ediciones Doyma, Spain, pp. 45-56, 1991. 25. Robertson,J., Clarke,D. and Martinez,A.: The Role of Radiotherapy in High Risk Breast Cancer. High-Risk Breast Cancer. Eds. Joseph Ragaz and I. M. Ariel, Springer-Verleg Publishing Company, Hiedelberg, New York, pp. 141-159, l99l. 26. Martinez, A.; Gersten, D. and Corry, P.: Clinical Rationale for Interstitial Thermoradiotherapy of Gynecological Tumors: Review of Clinical Results and own Experiences with Continuous Mild Hyperthermia. Interstitial and Intracavitary Thermoradiotherapy Eds. M. H.Seegenschmiedt and R. Sauer. Publisher: Springer-Verlag Publishing Company, Hiedelberg Germany, pp.179-186, 1993. 27. Corry, P.M.; Gersten, D.; Langer, S. and Martinez, A.: Thermobrachytherapy: Requirements for the Future. Interstitial and Intracavitary Thermoradiotherapy. Eds: M. H. Seegenschmiedt and R. Sauer. Publisher: Springer-Verlag Publishing Company, Hiedelberg Germany, pp. 373-380, 1993. 28. Martinez, A., Edmundson, G.K., Gonzalez, J., Hollander, J., Brabbins, D., Stromberg, J., Spencer, W. and Vicini, F.: Combined External Beam radiation and Conformal HDR Real-Time Ir-192 Brachytherapy Dosimetry for locally Advanced Adenocarcinoma of the Prostate. Brachytherapy from radium to Optimization. Eds: Mould RF, Batterman J.J., Martinez, A. A. and Speiser, B. Publisher: Nucletron Int. B.V., Veenendaal, The Netherlands, 1994. 29. Martinez, A., White, J., Armour, E., Armin, A.R., Edmundson, G.K. and Corry, Pl: Continuous versus Pulsed LDR: Preliminary Analysis of Rat Rectal Toxicity. Brachytherapy from Radium to Optimization. Eds: Mould, R.F., Battermann, J.J., Martinez, A.A. and Speiser, B. Publisher: Nucletron Int. B.V., Veenendaal, The Netherlands, 1994. 30. Mate, T.P., Kovacs, G. and Martinez, A. High Dose Rate Brachytherapy of the Prostate. High Dose Rate Brachytherapy: A Textbook. Eds: Nag, S. Publisher Futura Publishing Company, Inc., Armonk, NY, l994. 31. Nag, S., Martinez, A., Porter, A.T., and Hilaris, B.S. The Future of High Dose Rate Brachytherapy. High Dose Rate Brachytherapy: A Textbook. Eds. Nag, S. Publisher: futura Publishing Company, Inc. Armonk, NY l994. 33 Alvaro Martinez, M.D. 32. Martinez, A., Stitt, J., Speiser, B., Perez, C.A.: Chapter 18. Clinical applications of brachytherapy II: High dose rate. Principles and Practice of Radiation Oncology. Third Edition. Eds. Perez, C.A. and Brady, L.W. Publisher: Lippincott-Raven, Philadelphia, 1997. 33. Vicini, F.A.; Jaffray, D.; Edmundson, G.; DeBoise, D.; and Martinez, A.A. Virtual Reality Imaging for Interstitial Breast Implants. In: New Developments in Interstitial Remote Controlled Brachytherapy: Textbook Ed. N. Zambaglou, 1997. 34. Vicini, F.A.; Clarke, D.H.; Martinez, A.A. Clinical Body Sites – Breast. In: Principles and Practice of Brachytherapy: A Textbook Ed. Nag, S., 1997. 35. Vicini, F.A.; Kini, V.J.; Chen, P.Y.; Gustafson, G.G., Edmundson, G.K.; Martinez, A.A. Brachytherapy Alone in the Treatment of Selected Patients with early Stage Breast Cancer treated with breast Conserving therapy. In: Brachytherapy for the 21 st Century. Ed: Speiser, B., and Mould, R.F. Nucletron B.V., Veenedaal, The Netherlands, p. 299-311, 1998. 36. Martinez, A.A. and Edmundson, G.K. Chapter 9 Brachytherapy. In: Oncology. Ed: Gunderson, L. and Tepper, J., Churchill Livingstone, 2000. 37. Martinez, A.A. and Gunderson, L.L. Overview. In: Clinical Radiation Oncology. Ed: Gunderson, L. and Tepper, J., Churchill Livingstone, pp. 879-885, 2000. 38. Martinez, A.A. Chapter 47 Ovarian Cancer. In: Clinical Radiation Oncology. Gunderson, L. and Tepper J., Churchill Livingstone, 2000. 39. Corry, P.M.; Armour, E.P.; Gersten, D., Borelli, M., Martinez, A. Hyperthermia and Brachytherapy. In: Principles and Practice of brachytherapy, Chapter 30: 400-409, Joslin, Hall and Flynn (Eds.), Publisher, Arnold, London, U.K., 2001. 40. Yan, D., Dipt, M., Liang J., Nusslin F., Lockman D., Wong, J., Martinez, A. Strategies for Offline and On-line Image Feedback Adaptive Radiotherapy. In: Biological & Physical Basis of IMRT & Tomotherapy, pp. 139-150, Paliwal, Herbert, Fowler, Mehta (Eds.), Publisher: Medical Physics Publishing, Madison, Wisconsin, 2002. 41. Vicini FA, Kestin L, Ingold J, Martinez AA. The impact of young age on outcome in patients with ductal carcinoma in situ: the William Beaumont Hospital experience. In: Ductal carcinoma in situ of the breast, 2nd ed., Silverstein MJ, editor, Philadelphia, Lippincott Williams and Wilkins, 2002, pp. 381-393. 42. Vicini, F.A., Kestin, L., Martinez, A. Radiotherapy and Ductal Carcinoma In Situ. In: The Breast: Comprehensive Management of Benign and Malignant Disorders 3rd Edition, Bland KI, Copeland, EM, editors, Chapter 58, pp.1151-1157, 2004. 43. Wong, J., Yan, Di., Lockman, D., Brabbins, D., Vicini, F., Martinez, A.A., Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, U.S.A. External Beam Adaptive Radiation Therapy (ART) on a Conventional Medical Accelerator. Book Chapter on IMRT. Editor T. Bortfield., 2004. 34 Clinical Radiation Ed: Alvaro Martinez, M.D. 44. Martinez, A.A., Demanes, J., Galalae, R., Korman, J., Berterman, H., Vargas, C., Gonzalez, J., And Gustafson, G.: High dose rate afterloading 192 Ir prostate brachytherapy. Chapter 35: 311 – 326. Edits: Dicker, Merrick, Waterman, Valicenty & Gomella. Taylor and Francis Group, London, New York, 2005. WORKSHOPS 1. Martinez, A., Goffinet, D.R., Pooler, D., and Palos, B.: Twelfth Annual San Francisco Cancer Symposium (West Coast Cancer Foundation), "A Renaissance of Interstitial Brachytherapy": Indications, Techniques and Results in Management of Cancers of: 1) Colon/Rectal and Gynecological Tract, 2) Pediatric Soft Tissue Sarcomas, March 4-5, 1977. 2. Martinez, A., Goffinet, D.R., Pooler, D., Palos, B.: Exhibit of the American Society of Therapeutic Radiologists, 19th Annual Meeting "Treatment Techniques for 125-Iodine and 192Iridium in Brachytherapy", November 1-5, 1977. 3. Martinez, A., Goffinet, D.R., Pooler, D., Palos, B.: Exploratorium Exhibit. San Francisco, CA. "The Use of Interstitial Radioactive Sources in Cancer Therapy". 4. Hahn, G.M., Pounds, D., Martinez, A.: Exploratorium Exhibit. San Francisco, CA. "Clinical Use of Hyperthermia Induced by an Ultrasound Transducer", May 1-1979. 5. Steed, P., Martinez, A.: A Technique for External Breast Irradiation With Cerrobend Blocks and Compensators. Exhibit of the American Society of Therapeutic Radiology Oncology (ASTRO) Miami Beach, Florida, October 13, 1981. 6. Martinez, A., Cox, R., Schultz, M.J. and Chin, B.: Martinez Universal Perineal Interstitial Template Technique (MUPIT). Exhibit of the American Society of Therapeutic Radiology Oncology (ASTRO). Miami Beach, Florida, October 13, 1981. 7. Martinez, A., Kisrow, K., Edmundson, G., Weber, F., Earle, J.: The Mayo Clinic Breast Cancer Treatment Technique. Exhibit of the American Society of Therapeutic Radiology Oncology (ASTRO). Orlando, Florida, October 12, 1982. 8. Martinez, A.: The Technique of Transperineal Interstitial Template Implant for Prostate Cancer. Exhibit at the First Biennial Brachytherapy and Remote Afterloading Symposium at Mallinckrodt Institute of Radiology. St. Louis, Missouri, September 14-16,1987. 9. Brown, D., Gregory, C., Edmundson, G., Clarke, D. and Martinez, A.: High Dose-Rate Brachytherapy Techniques for the Treatment of A) Malignant Airway Obstruction, B) Malignant Biliary Tract Infection, C) External Ear Canal, and D) Postoperative Endometrial Cancer. Brachytherapy -Remote Afterloading State -of-the-Art. Dearborn, Michigan, May 4-5-6, 1989. 35 Alvaro Martinez, M.D. INVITED PRESENTATIONS 1. "Cancer" Postgraduate Medical Education Course, Stanford University School of Medicine: The Role of Irradiation in the Treatment of Breast Cancer -March, 1976. 2. "Cancer" Postgraduate Medical Education Course, Stanford University School of Medicine: Radical Irradiation Without a Mastectomy: An Alternative to Radical Surgery in the Treatment of Early Breast Cancer-February, 1977. 3. Twelfth Annual San Francisco Cancer Symposium (West Coast Cancer Foundation), "A Renaissance of Interstitial Brachytherapy": Indications, Techniques and Results in Management of Cancers of: 1) Colon/Rectum and Gynecological Tract, 2) Pediatric Soft Tissue Sarcoma -March 4-5, 1977. 4. ENT - Peninsula Association: The Use of Interstitial Therapy in Head and Neck Cancer. San Francisco, California-March, 1977. 5. Continuing Medical Education Conference, Doctor's Hospital, Modesto, CA: Radical Irradiation Without a Mastectomy: An Alternative Approach to Managing Breast Cancer-May, 1977. 6. American Cancer Society, Alameda County Unit: Role of Radiation Therapy as the Primary Management of Breast Cancer-December, 1977. 7. Continuing Medical Education Conference, Mills Memorial Hospital, San Mateo, CA: Radical Irradiation Without a Mastectomy: An Alternative to Radical Surgery in the Treatment of Early Breast Cancer-January, 1978. 8. Continuing Medical Education Conference, Santa Clara Valley Medical Center, San Jose, CA: Current Concepts in the Treatment of Cancer of the Cervix -March 1978. 9. "Cancer" Postgraduate Medical Education Course, Stanford University School of Medicine: Radiotherapeutic Approach to Breast Cancer-March, 1978. 10. "Cancer" Postgraduate Medical Education Course, Stanford University School of Medicine: 1) Head and Neck Cancer, Primary Sites and Radiotherapy, 2) Combined Approach: Surgery, Radiotherapy and Chemotherapy-March 1978. 11. Continuing Medical Education Conference, El Camino Hospital, Mountain View, CA: Radical Irradiation for Primary Breast Cancer, an Alternative to Radical Surgery-April, 1978. 12. Continuing Medical Education Conference, Mary's Help Hospital, Daly City, CA: Radiotherapeutic Approach to Breast Carcinoma-April 1978. 13. American Cancer Society, Science Writers Seminar, Houston, TX: The Price of the Cure, New Avenues in Cancer Treatments-April 1978. 14. Tenth Annual Radiation Therapy Symposium for Technologist, Denver, CO: 1) Iridium Implants in the Oral Cavity, 2) Radiation Side Effects-April 1978. 36 Alvaro Martinez, M.D. 15. California Radiological Society 1978 Annual Meeting: "The Current Status of Hyperthermia: Radiology, Technology and Clinical Application". Monterey, California-May 1978. 16. The Inter hospital Tumor Conference. The Good Samaritan Hospital of Santa Clara Valley, San Jose, CA: Alternatives to Mastectomy in the Management of Early Breast Cancer- August 1978. 17. University of Southern California, School of Medicine, Radiation Medicine Division, Los Angeles, CA: Current Concepts in Radiation Oncology, "Endocurietherapy in Pediatric Cancer- August 1978. 18. "Current Concepts on Cancer Therapy". Series of Lectures at the Hospital do Cancer do Sao Paulo, Brazil. Topics: 1) The Role of Radiotherapy on Gastrointestinal Malignancies; 2) Therapeutic Options on Prostate Cancer; 3) New Approaches to Head and Neck Cancer; 4) Hodgkin's and non-Hodgkin's Lymphomas. The Stanford Experience; 5) Alternative to Radical Mastectomy in Breast Cancer; 6) Controversial Issues in Gynecological Malignancies; 7) The Renaissance of Brachytherapy, New Techniques and Computerized Dosimetry; 8) Radiotherapy in Pediatric Malignancies; 9) Hyperthermia Present Status and Future, in Anti-Cancer Therapy; 10) The increasing Importance of the Multidisciplinary Approach in Cancer Therapy -November 1978. 19. Hospital do Cancer do Sao Paulo, Brazil. Surgical Grand Rounds: Combined Limited Surgery and Radiotherapy in the Management of Localized Breast Cancer. Sao Paulo, Brazil-November 1978 20. San Francisco Regional Cancer Foundation, Letterman Army Medical Center, Presidio of San Francisco, CA: "Radiation Therapy of Gynecol Cancer-January, 1979. 21. Continuing Medical Education Conference, Doctor's Hospital, Modesto, CA: The Increasing Role of Radiotherapy in Vulvar and Ovarian Cancer-March, 1979. 22. The College of San Mateo, Health Science #48 - Multidisciplinary Inquiry into the Biological, Clinical and Psychological Nature of CANCER, San Mateo, CA: "Childhood Cancers"-May 1979. 23. Northern California Tumor Registrar's Association, Stanford University School of Medicine, Stanford, CA: "Current Techniques in the Treatment of Childhood Malignancies". -August 1979. 24. Oregon Society of Clinical Oncologists, St. Vincent Hospital and Medical Center, Department of Radiation Oncology, Portland, OR: "Cancer of the Ovary"-September 1979. 25. Office of Continuing Education, St. John's Hospital, Oxnard, CA: "Radiation Therapy as a Primary Treatment for Breast Cancer"-September 1979. 26. "Cancer in Children" Postgraduate Medical Education Course, Stanford University School of Medicine, Department of Pediatrics and Children's Hospital at Stanford, CA: "Acute and Chronic Sequelae of Radiotherapy" and "Radioactive Implants in the Treatment of Soft Tissue Sarcomas"-October 1979. 37 Alvaro Martinez, M.D. 27. "XIV Argentinian Congress in Gastroenterology". Series of Lectures at Cultural Center of General San Martin, Buenos Aires, Argentina. Topics: 1) The Role of Radiotherapy in Abdominal Lymphomas; 2) The Role of Radiotherapy in GI Malignancies-October 1979. 28. "IX Congresso Brasileiro de Cancerologia"., Series of lectures at the Brazilian Cancer Congress in the Hotel Nacional in Rio de Janeiro, Brazil. 1) Conference on the Stanford Protocols for Hodgkin's and Non-Hodgkin's Lymphomas; 2) Round table on Breast Cancer; 3) A Week Long Course in Radiotherapy; 4) Two Courses in Pediatric Malignancies-November 1979. 29. City of Hope Medical Center, Duarte, CA: "Treatment Alternative for Early Breast Cancer February 1980 30. Seminar on Prostate Cancer, Orlando, FL: Treatment of Prostate Cancer”-March 1980. 31. Northern California Oncology Group (NCOG): April 1980 Group Meeting, Plaza Airport Inn Millbrae, CA. Scientific Session Epithelial Ovarian Carcinoma: "The Role of Radiation Therapy In Ovarian Carcinoma"-April 1980. "The Application of 125-Iodine Seeds in the 32. Canadian Gynecological Fellowship Club, 31st Annual Meeting at Stanford, April 25, 1980, Stanford, CA: "Newer Concepts in the Management of Carcinoma of the Breast"-April 1980. 33. Seminar on Prostate Cancer, San Francisco, CA: "The Application of 125-Iodine Seeds in the Treatment of Prostate Cancer”-May 1980. 34. Mayo Clinic, Curie Pavilion, Rochester, MN: "Overview of Interstitial Implants. Present and Future-May 1980. 35. McGill University School of Medicine, Montreal, Canada: Radiotherapy Grand Rounds - "Past, Present and Future of Brachytherapy" -June 1980. 36. Seminar on Prostate Cancer, Chicago, IL: Treatment of Prostate Cancer”-June 1980. 37. Hematology Grand Rounds, Stanford University School of Medicine, Stanford, CA: "Breast Cancer"-August 1980. 38. Hospital General, Pabellon de Oncologic, Buenos Aires, Argentina: "Results of Stanford's Clinical Trials in Hodgkin's and Non-Hodgkin's Lymphomas-August, 1980. 39. The Radiological Society of North America (RSNA) Annual Meeting, Dallas, TX. RSNA Refresher Course Program, Course #618: "Brachytherapy for Head and Neck Tumor”-November 1980. 40. National Institute of Health (NIH), Bethesda, MD. Workshop on "Role of Radiotherapy in the Treatment of Ovarian Carcinoma"-November 1980. 41. Eden Hospital, Castro Valley, CA: Radiation Therapy"-February 1981. "The Application of 125-Iodine Seeds in the "Primary Treatment of Carcinoma of the Breast with 38 Alvaro Martinez, M.D. 42. Valley Memorial Hospital, Livermore, CA: "Radiation Therapy for Minimal Breast Cancer" March 1981. 43. Northern California Oncology Group (NCOG): April 1981 Group Meeting, Plaza Airport Inn, Millbrae, CA, Scientific Session - Primary Treatment of Stages I and II Carcinoma of the Breast with Radiation Therapy: Stanford Results and Complications-April 1981. 44. Daniel Morton Society, University of California, Department of Obstetrics and Gynecology, Los Angeles, CA, Early Breast Cancer: Is Radiation Therapy a Substitute for Total Mastectomy?May 1981. 45. Fifth Argentinean Medical Oncology Congress. Buenos Aires, Argentina: Lectures in 1) The Role of Radiotherapy in Soft Tissue Sarcoma; 2) Current Therapeutic Concepts in Cancer of the Cervix; 3) Radiotherapeutic Approach to Ovarian Cancer, Panel Participation in: Psychological Aspects of the Cancer Patient-September 1981. 46. 67th Annual Meeting of the Radiological Society of North America (RSNA) Chicago, IL. Principles of Brachytherapy and Treatment Results in Head and Neck Cancer-November 1981. 47. Oncology Society, Mayo Clinic, Rochester, MN: Radiotherapy in epithelial Ovarian Cancer: Pretreatment Prognostic Factors and 20 Years' Experience with Linear Accelerator-October 1981 48. The Radiological Society of North America (RSNA) Annual Meeting, Chicago, IL. RSNA Refresher Course Program, Course #218, Principles of Brachytherapy-November 1981. 49. Area Medicine Grand Rounds, Mayo Clinic, Rochester, MN: Radiotherapy As Primary Treatment for Stage I and Stage II Carcinoma of the Breast-November 1981. 50. Gynecological Surgery Conference, Mayo Clinic, Rochester, MN. Complications of Radiation Therapy-November 1981. 51. Oncology Society, Mayo Clinic, Rochester, MN. Is There an Alternative to Mastectomy?December 1981 52. The American Endocurietherapy Society (AES) Annual Meeting, Hawaii. Chairman of the Gynecologic Session-December 1981. 53. Oncology Society, Mayo Clinic, Rochester, MN: Newer Options in the Management of Patients with Advanced Head and Neck Cancer (with Drs. Creagan and Pearson)-March 1982. 54. Minnesota Society of Radiologic Technologists, District V Spring Symposium, Rochester, MN. Radiation Therapy: Present & Future-May 1982 55. Approaches to Management of Patients with Common Malignancies, Mayo Medical School, Rochester, MN: Is Radiation an Alternative to Mastectomy for Patients with Early Breast Cancer? -May 1982. 56. Practice of Internal Medicine, 1982, Mayo Medical School, Rochester, MN. Breast Carcinoma: Surgery and/or Radiation Treatment (with Dr. Martin)-May 1982. 39 Alvaro Martinez, M.D. 57. Core Curriculum for Residents, Mayo Clinic, Rochester, MN. Radiation Therapy of Cervix and Ovarian Cancer-June 1982. 58. The American Society of Therapeutic Radiologists (ASTRO) Annual Meeting, Orlando, FL. Chairman of the Gynecological Session-October 1982. 59. First MEDICANCER Congress, Medellin, Colombia. Lectures in 1) The Role of Interstitial Implants in Head/Neck Cancer; 2) Current Trends in Ovarian Endometrial Cancer; 3) Preop or Postop Radiotherapy in Soft Tissue Sarcomas; 4) Conservative Approach in Early Breast CancerNovember 1982. 60. The Radiological Society of North America (RSNA) Annual Meeting, Chicago, IL. RSNA Refresher Course Program, Course #719, Brachytherapy for Head and Neck Tumors-November 1982. 61. American Endocurietherapy Society, Midwest Chapter, Chicago, IL: Treatment of Advanced Gynecological and Perineal Malignancies with Interstitial Radiation Therapy-November 1982. 62. Colombian National Cancer Institute, Bogota, Colombia, Surgical Grand Rounds: Therapeutic Alternatives to Radical Mastectomy in Operable Breast Cancer-December 1982. 63. Northwest Community Hospital Arlington Heights, IL: The Role of Hyperthermia and Intraoperative Radiation in Malignant Diseases-February 1983. 64. Memorial Hospital Medical Center, Long Beach, CA: Pediatric Grand Rounds on: Present Role of Interstitial Implants in Pediatric Oncology-March 1983. 65. IV Congress of the Association of Ibero-Latin-Americano Radiotherapists (CRILA), Buenos Aires, Argentina. Lectures: 1) Present Role of Radiotherapy in Ovarian Cancer; 2) Complication of Lumpectomy, Axillary Dissection and External Beam Irradiation in patients with Early Breast Cancer; 3) Treatment of Locally Advanced Cancer of the Cervix with the "MUPIT" Applicator; 4) New Horizons in Interstitial Therapy-April 1983. 66. XXVII Annual Meeting of the American College of Surgeons, Chilean Chapter. Santiago, Chile. Lectures: 1) The Future of Radiotherapy on Malignant Diseases; 2) Present and Future of Interstitial Radiotherapy; 3) Intraoperative Radiotherapy; 4) Panelist in A) Breast Cancer, Future Perspectives: B) Genitourinary Cancer Round Table -April 1983. 67. The American Society of Clinical Oncologists (ASCO) Annual Meeting, San Diego, CA. Chairman of the Non-Ovarian Gynecological Session-May 1983. 68. MEDICANCER Congress, Cali, Colombia. Lectures: 1) Results and Complications from Primary Irradiation for Patients with Early Breast Cancer; 2) Adjuvant Implants in Cancer Therapy-July 1983. 69. V Colombia Cancer Congress, Cartagena, Colombia. Lecture: Radiotherapy In Lung Cancer. Round Table Panelist A) Breast Cancer, B) Hodgkin's Disease-July 1983. 40 Alvaro Martinez, M.D. 70. Fourth Annual Meeting, Alabama Society of clinical Oncology, Birmingham, AL. Radiation As the Primary Therapy for Breast Cancer-August 1983. 71. St. Francis Medical Center, La Crosse, WI. Cancer of the Breast: Excision and Radiation Therapy-August 1983. 72. V European Congress of Radiology, II Congress of the European Society of Therapeutic Radiology and Oncology. Bordeaux, France. 1) Panelist in Staging and Future Directions in Cancer of the Cervix, 2) Lecture: The Use of the Martinez Universal Perineal Interstitial Template (MUPIT) in Locally Advanced Cancer of the Cervix-September 1983. 73. Institute Gustave-Roussy, Villejuif, France. 1) Radiotherapy Grand Rounds: Results and Complications of the Martinez Universal Perineal Interstitial Template (MUPIT) in the Treatment of Prostatic, Perineal and Gynecological Malignancies, 2) The Use of 125 Iodine Implants as a Surgical Adjuvant-September 1983. 74. U of Michigan Medical School, Ann Arbor, MI. Combined ENT/Radiotherapy Grand Rounds: Interstitial Therapy of Head/Neck Cancer-December 1983. 75. American Endocurietherapy Society (AES) 6th Annual Meeting, Lake Tahoe, Nevada. Chairman of the Permanent Implants Session-January 1984. 76. Spring Symposium in Radiation Oncology: 3rd Annual Conference, University of Michigan Medical School, Ann Arbor, MI. 1) Brachytherapy for Head and Neck Cancer, 2) Interstitial Radiation Therapy for Gynecologic Cancers, 3) Role of Interstitial Irradiation in Pediatric Malignancies-April 1984. 77. 3rd Annual Endocurietherapy Workshop and Symposium, Memorial Medical Center of Long Beach and University of California Irvine, Long Beach, CA. 1) Techniques and Indications for Permanent Iodine 125 Vicryl Suture Implants. 2) Interstitial Irradiation in Pediatric Cancer-May 1984. 78. American Academy of Orthopedic Surgeons: Bone and Soft Tissue Tumors, Rochester, MN. The Role of Radiation Therapy for Soft Tissue Tumors-May, 1984. 79. Western Association of Gynecologic Oncology (WAGO) Annual Meeting, Sun River, OR. Chairman of the Endometrial Cancer Session-June 1984. 80. Internal Medicine Grand Rounds. William Beaumont Hospital, Royal Oak, MI. Alternatives to Mastectomy in Early Breast Cancer-September 1984. 81. Third Annual Cancer Symposium: Update on Breast Cancer. Sutter Community Cancer Center. Sacramento, CA. Radiation Therapy for Breast Cancer-November 1984. 82. American Endocurietherapy Symposium (AES) 7th Annual Meeting, Maui: The Use of Permanent Implants with Vycril Continuing 125 Iodine Seeds in Abdominal, Pelvic and Perineal Malignancies-December 1984. 41 Alvaro Martinez, M.D. 83. American Urological Association Allied, Upper Midwest Chapter. Brachytherapy with 192 Iridium Interstitial Implants for Locally Advanced Prostate Cancer. Holiday Inn-South, Rochester, Minnesota-March 1985. 84. Circulo de Radioterapeuta Ibero-Latino-Americano (CRILA) Meeting of the V Congress, Miami, FL. 1) Treatment of Locally Advanced Cancer of the Cervix. 2) Indications and Rationale for Radiotherapy in Soft Tissue Sarcomas-April 1985. 85. Northwestern University Medical School. Radiation Oncology Grand Rounds. Chicago, IL. The Role of Radiotherapy in Soft Tissue Sarcomas, Mayo Clinic Experience-April 1985. 86. Western Association of Gynecologic Oncology (WAGO) Annual Meeting, San Diego, CA. Panelist Advanced Vulvar Cancer-June 1985. 87. Breast Preservation: Workshop on the Technique of Conservative Surgery and Radiotherapy for Early Breast Cancer. Sponsored by Memorial Sloan-Kettering Cancer Center and Harvard Medical School, New York, NY-June 1985. 88. Community Health Education Series, William Beaumont Hospital, Royal Oak, MI. Approaches to Breast Cancer-September 1985. 89. XXVII Annual Meeting of the American Society for Therapeutic Radiology and Oncology. 1) Moderator of the Scientific Session on Gynecologic Tumors. 2) Refresher Course on: Template and Other Extended Techniques for Pelvic and Perineal Implants. Miami Beach, FL.September 1985. 90. XX Brasilian Congress of Radiology: Lectures: 1) Treatment of Locally Advanced Carcinoma of the Cervix, 2) Carcinoma of the Colon and Rectum, Past and Present, 3) Hodgkin's Disease Update and Review of Literature, 4) Conservative Management of Patients with Early Breast Cancer, 5) Carcinoma of the Prostate, Present Directions, 6) Multi-Disciplinary Approach to Soft Tissue Sarcomas. In Bello Horizonte, Brasil - South America-September 1985. 91. VI Colombian Cancer Congress. Lectures: 1) Conservative Management of Patients with Early Breast Cancer, 2) Treatment of Locally Advanced Cervix Cancer, 3) Pre-or Postoperative Radiotherapy for Soft Tissue Sarcomas. 4) Interstitial Implant in Head/Neck Cancer, 5) Locally Advanced Cancer of the Prostate; The Role of Interstitial Implants. In Cali, Colombia, South America-September 1985. 92. Northwest Community Hospital, Medical Staff Grand Rounds: Intraoperative Radiation Therapy. Arlington Heights, Illinois-October 1985. 93. Henry Ford Hospital, Medical Staff Grand Rounds: The Management of Patients with Malignant Airway Obstructions with Laser Therapy and Endobronchial Brachytherapy. In Detroit, Michigan-October 1985. 94. Wayne State University, Harper-Grace Hospital, Medical Oncology Staff Grand Rounds: Ovarian Cancer; Myths, Biases and Results of Treatment. In Detroit, Michigan-November 1985. 42 New Alvaro Martinez, M.D. 95. AERALTS, The First Annual Endobronchial Radiation and Laser Therapy Symposium: Rational for Adopting a High Dose Rate System After Historical Experience with Low Dose Rate Approaches. In Houston, Texas-April 1986. 96. Second Annual Oncology Symposium Shawnee County Medical Foundation and St. Francis Hospital. Lectures: 1) Radiation Therapy of Cervical Carcinoma: Indications and Techniques. 2) Radiation Therapy of Uterine Cancer as an Adjuvant to Surgery or in Indications and Techniques. In Topeka, Kansas-May 1986. 97. Western Association of Gynecologic Oncologists (WAGO). Fourteenth Annual Meeting, Second Scientific Session: Uncommon Clinical Dilemma in Gynecologic Oncology. Discussant In Monterey, California-May 1986. 98. III Medicancer Congress on New Horizons in Cancer Treatment. Lectures; 1) Radiation Therapy in the Treatment of Early Breast Cancer. 2) New Radiotherapeutic Techniques in Urogenital Cancer. Panelist in Round Table on a) The Treatment of Locally Advanced Breast Cancer and b) The Treatment of Locally Advanced Prostate Cancer. Medellin, Colombia, South America-June 1986. 99. International Selectron Users Meeting: Vancouver, Canada-September 1986. 100. Chiefs Executive Organization, C.E.O. Fall Forum: Breast Preservation in Patients with Breast Cancer. Laguna Niguel, California-September 1986. 101. Urology Update in Prostate Cancer. Annual William Beaumont Hospital Urology Course. 1) Role of Radiotherapy in the Treatment of Early Prostate Cancer. 2) Role of Interstitial Therapy in Locally Advanced Prostate Cancer. Dearborn, Michigan-October 1986. 102. Mercy-Memorial Medical Center Annual Cancer Symposium: The Role of Radiation Therapy in Gynecologic Cancer. Benton Harbor, Michigan-October 1986. 103. XXVIII Annual Meeting of the American Society for Therapeutic Radiology and Oncology. Refresher Course on: Template and Other Extended Techniques for Pelvic and Perineal Implants. Los Angeles, California-November 1986. 104. British Colombia Cancer Control Agency, Radiotherapy Grand Rounds: 1) Rationale for Boost Therapy in the Management of Early Breast Cancer Treated with Limited Surgery and Radiotherapy. 2) American System of Brachytherapy; Present and Future. Vancouver, CanadaNovember 1986. 105. William Beaumont Hospital, Gynecology and Obstetrics Grand Rounds. The Role of Radiotherapy in Gynecologic Malignancies. Royal Oak, Michigan-January 1987. 106. Cross Cancer Institute, Radiation Oncology Rounds: Treatment Options and New Trends in the Management of Locally Advanced Prostate Cancer. Edmonton, Canada-February 1987. 107. VI Congress of CRILA - Circulo de Radioterapia Ibero-Latino-Americano: 1) Current Concepts in the Treatment of Esophageal Cancer, 2) Local Failure and Complications in the Treatment of Rationale for Transperineal Interstitial Implants. 43 Alvaro Martinez, M.D. Early Breast Cancer, 3) Interstitial Therapy in the Treatment of Prostate Cancer, 4) Salvage Whole Abdomino-Pelvic Irradiation for Patients with Either Recurrent or Persistent Ovarian Cancer After Surgery and Chemotherapy. Punta del Este, Uruguay, South America-March 1987. 108. VII Annual Current Approaches to Radiation Oncology, Biology and Physics. University of California San Francisco, School of Medicine. 1) The Use of the Martinez Universal Transperineal Interstitial Template "MUPIT" in the Treatment of Carcinoma of the EsophagusIndications, Techniques and Results. San Francisco, California-March 1987. 109. The Second Annual Endobronchial Radiation and Laser Therapy Symposium: AERALTS II. St. Patrick Hospital, Lake Charles, Louisiana. "Radiobiologic Considerations of High and Low Dose-Rate Brachytherapy as It Applies to Malignant Airway Obstruction". New Orleans, LOMay 1987. 110. Fifteenth Annual Meeting of The Western Association of Gynecologic Oncologists (WAGO). 1) "Advanced Epithelial Ovarian Cancer: Salvage Whole Abdominal Irradiation for Patients with Recurrent of Persistent Disease After Combination Chemotherapy". 2) "Postoperative Whole Abdomino-Pelvic Irradiation for Patients with High Risk Endometrial Cancer". Tucson, Arizona-May 1987. 111. American Endocurietherapy Symposium (AES) 8th Annual Meeting. 1) The use of 125 Iodine Seeds as a Substitute for 192 Iridium Seeds for Temporary Plastic Tube Implants. 2) Intraluminal Brachytherapy in the Treatment of Malignant Airway Obstruction. 3) Intraoperative Electron Beam and/or Permanent Interstitial Implantation for Pancreatic Cancer. Orlando, Florida-June 1987. 112. First Biennial Brachytherapy and Remote Afterloading Symposium and Workshop. Radiation Oncology Center, Mallinkrodt Institute of Radiology: The Use of Templates for Treatment of Gynecological and Prostate Tumors. St. Louis, Missouri-September 1987. 113. XXIX Annual Meeting of the American Society for Therapeutic Radiology and Oncology. Refresher course on: Template and Other Extended Techniques for Pelvic and Perineal Implants. Boston, MA-October 1987. 114. IV Course of the Instituto Valencio de Oncologia. 1) The Role of Radiotherapy in Early Cancer of the Ovary. 2) Roundtable Radiotherapy Multidisciplinary Approach to Early Ovarian Cancer. 3) What is the Role of Radiotherapy for Advanced Ovarian Cancer. 4) Roundtable Multidisciplinary Approach to Advanced Ovarian Cancer. Valencia, Spain-December 1987. 115. The Future of Brachytherapy, Humana Hospital, Phoenix, AZ. 1) Combined MUPIT Implants with Hyperthermia. 2) Iodine 125 Seeds in Plastic Tube as a Substitute for Iridium in Temporary Implants. Phoenix-February 1988. 116. First users Meeting of Lab thermics Hyperthermia Equipment. Implants Combined with Hyperthermia. Bahamas-February 1988. 117. 75th Annual Meeting of the Texas Radiological Society. The Role of Whole Abdomino-Pelvic Irradiation for Patients with High Risk Endometrial Cancer. Arlington, Texas-April 1988. 44 1) The Role of Interstitial Alvaro Martinez, M.D. 118. 5th International Selectron Users Meeting. Moderator of the Session "Innovative Approaches". Also, a presentation on "Preliminary Experience of Combining Interstitial Hyperthermia with the Micro-selectron Unit". The Hague, Netherlands-September 1988. 119. 7th Annual Meeting of the European Society for Therapeutic Radiology and Oncology ESTRO. 1) Pelvic Lymphadenectomy and Transperineal Interstitial Implantation of 192 Ir Combined with External Beam Radiotherapy for Patients with Bulky Prostatic Carcinoma. 2) Experience with Pre or Postoperative Irradiation for Limb Preservation in Sarcomas of the Extremities. The Hague, Netherlands-September 1988. 120. 7th Brachytherapy Update 1988 - Memorial Sloan-Kettering Cancer Center. Moderator of the Session on Brachytherapy on Lung Cancer and Brain Tumors. Memorial Hospital, New York, New York-September 1988. 121. Brachytherapy in Wandel Mit Internationaler Beteiligung-Universitats-Frouenklinik-Interstitial Therapy in Gynecologic Tumors, Wurzburg, West Germany-October 1988. 122. Harper-Grace Hospitals, Wayne State University, Head/Neck Conference. The Role of Interstitial Implants in Head/Neck Cancer. Harper Hospital, Detroit, Michigan-November 1988. 123. Remote Afterloading: State of the Art Brachytherapy Meeting -- "Low Dose Rate Interstitial Implants in Head/Neck Cancer. Harper Hospital, Detroit, Michigan-May 1989. 124. International Course In Interstitial Brachytherapy, Medical College of Wisconsin. "Transperineal MUPIT Template Implants in Gynecologic Malignancies". Milwaukee, Wisconsin -June 1989. 125. Fifteenth Regional Congress of the International College of Surgeons -- Update in Medicine and Surgery. "Use of Radiation Therapy as an Adjuvant in Lung Cancer". Detroit, Michigan-August 1989. 126. VII Congress of the CRILA Society (Circulo de Radioterapeutas Ibero Latino Americanos). 1) Management of Anal Carcinoma/RT; 2) Role or R.T. in Ovarian Malignancy; and 3) Management of Advanced Cervical Carcinoma". Caracas, Venezuela-October 1989. 127. Urology Update: 1989 -- Bladder Cancer Update. 1) Indications for Radiation Therapy: Interstitial, External, Combined; 2) When and how of radiation therapy; 3) New Developments. Dearborn, Michigan-October 1989. 128. 22nd Brazilian Congress of Radiology. 1) Brachytherapy Clinical Implications of High Dose Rate and Low Dose Rate. 2) Present and Future Prospectives in the Treatment of Epithelial Ovarian Carcinoma. Rio de Janeiro, Brazil-November 1989. 129. Meeting of the Academy of Medicine in Toledo: 1) Increase Local Control and Survival for Patients with Bulky Stage "C" Prostate Cancer Treated with PLA and Implant and External Beam. 2) Current Status of Brachytherapy Techniques LDR and HDR. The Medical College of Ohio. Toledo, Ohio-February 1990. 130. Radiation Oncology Grand Rounds: The Management of Locally Advanced Prostatic Carcinoma, Henry Ford Hospital, Detroit, MI-March 1990. 45 Alvaro Martinez, M.D. 131. Primer Seminario Internacional de Actualizacion en Braquiterapia: 1) Treatment of Locally Advanced Gynecologic Cancer. 2) Breast Preservation Treatment. 3) Role of Brachytherapy in Head/Neck Cancer. 4) Treatment of Locally Advanced Prostate Cancer. Argentinian Society of Radiology. Buenos Aires, Argentina-March 1990. 132. First International Brachytherapy Meeting, Sociedad Chilena de Braquiterapia. 1) Remote Afterloading in Bulky Cancer of the Cervix. 2) Indications for Breast Preservation in Early Breast Cancer. Santiago, Chile-March 1990. 133. Second International Brachytherapy and Remote Afterloading Symposium and Workshop. Interstitial and External Beam Therapy for the Treatment of Locally Advanced Cancers of the Female Genital Tract. Washington University and Medical Center, St. Louis, Missouri-April 1990. 134. Thirteenth Varian Users Meeting: Remote Afterloading, Current Status and Future Prospects. Orlando, Florida-May 1990. 135. Brachytherapy Working Conference, First P.R. China Meeting: 1). Implications of Utilizing Continuous LDR or Fractionated HDR: The Physician's Point of View. 2). Brachytherapy in Gynecologic Cancer; 3). Brachytherapy in Soft Tissue Sarcomas. Chinese Academy of Medical Sciences. Beiging, China-May 1990. 136. Thirty-Second Meeting of the American Association of Physicists in Medicine: Clinical Considerations in Dose Specifications of Interstitial Brachytherapy. Cervantes Convention Center, St. Louis, Missouri-July 1990. 137. XII Pan-American-VIII Colombian Pediatric Surgery Congress: Implants in Pediatric Tumors. Bogota, Colombia-August, 1990. 138. Brachytherapy Working Conference. Sixth International Selectron users Meeting: 1) Increase Local Control-Survival for Bulky Prostate Cancer Patients Treated with Remote Afterloading LDR and External Beam. 2) A New Electronic Template for Remote Afterloading Interstitial Thermoradiotherapy in Pelvic Malignancies. 3) The Role of Transperineal Template Implant in Gynecologic Malignancies. Florence, Italy-September, 1990. 139. International Symposium on Remote Afterloading and Brachytherapy: 1) Interstitial and External Beam Therapy for the Treatment of Locally Advanced Cancers of the Female Genital Tract. 2) Improve Survival for Bulky Prostate Cancer patients Treated with Micro-Selectron and External Beam. Booth Memorial Medical Center. Flushing, New York-September 1990. 140. Third Annual Japanese Society for Therapeutic Radiology and Oncology: 1). Interstitial Rectum Implants; 2). Implications of Utilizing Continuous LDR or Fractionated HDR: The Physician's Point of View. 2). Brachytherapy in Gynecologic Cancer. The Japan Education Hall, Chiyodaku, Tokyo, Japan-October l990. 141. Hyperthermia Clinical Conference: Interstitial Thermoradiotherapy for the Treatment of Locally Advanced and Recurrent Cancers of the Female Tract: The William Beaumont Hospital Experience. White Plains, New York-October l990. 46 The Role of Radioactive Alvaro Martinez, M.D. 142. Society of Mexican Radiotherapists: l). Radioterapia En Cancer De La Mama; 2). Braquiterapia En Tumores ano Rectales; 3). Braquiterapia En cancer De Prostata; 4). Radioterapia En La Enfermedad De Hodgkin. Monterrey, Nuevo Leon, Mexico-November l990. 143. Vail Mid-Winter Cancer Conference of the American Cancer Society: 1). Radiation Therapy for Esophageal Cancer; 2). Primary X-Ray Therapy in Ovarian Cancer; 3). Salvage X-Ray Therapy in Ovarian Cancer; 4). New Frontiers in Cancer Management; and 5). A Panel Discussion. Vail, Colorado-January 1991. 144. Mid-Michigan Regional Medical Center--Medical Staff Presentation: State of the Art External Beam Radiation Therapy in Cancer Treatment. Midland, Michigan-February 1991. 145. Mid-Winter Symposium Radiation Oncology: Old Disease, New Modalities: l) Role of Brachytherapy in Early and Advanced Head/Neck Cancer; 2). Different Treatment Options in Recurrent Cancer of the Head/Neck Area; 3). Postoperative Whole Abdomen Irradiation in High Risk Endometrial Carcinoma; 4). Conventional Brachytherapy for Gynecologic Malignancies. Lake Buena Vista, Florida-February 1991. 146. Sparrow Hospital: High Dose Rate Brachytherapy. Lansing, Michigan-February 1991. 147. Cancer Conference at Northern Virginia Cancer Center--New Advances in Oncology: Role of Interstitial Templates in Gynecologic & Urologic Neoplasms. Alexandria, Virginia -March 1991. 148. OB/GYN Grand Rounds, William Beaumont Hospital: l) Radiotherapeutic Treatment of Gynecologic Cancer. Royal Oak, Michigan-March 1991. 149. Brachytherapy Congress Hospital Padre Machado: l). Intracavitary HDR for Cancer of the Cervix; 2). Brachytherapy Treatment of the Prostate. Caracas, Venezuela-April 1991. 150. Associacao Brasileira de Fisicos em Medicinia: l) The Radiobiology of High Dose Rate Remote Afterloading; 2) Intracavitary HDR for Cancer of the Cervix. Sao Paulo, Brazil-April 1991. 151. Radiation Therapy Congress - Bracuiterapia Comalta Taxa De Dose-High Dose Rate Brachytherapy: l). The Radiobiology of High Dose Rate Remote Afterloading -- The Clinicians Point of View; 2). Approved Protocols from the High Dose Rate Brachytherapy Working Group "HIBWOG"; 3). Brachytherapy with HDR in Prostate Cancer; 4). Intracavitary HDR for Cancer of the Cervix. Sao Paulo, Brazil-April 1991. 152. Brachytherapy Past, Present and Future: Co-Chairman of Meeting and Presenter: l). Current Practices in Brachytherapy; 2). Physics-Clinician's Perspective; 3). Prostate Implants-Iridium192. Scottsdale, Arizona-May 1991. 153. Pacific Northwest Cancer Foundation-Prostate Cancer-The Role of Interstitial Implantation: Continuous Low Dose Rate Interstitial Implantation with Ir-192 and External Irradiation. Seattle, Washington-June 1991. 154. Prostate Cancer in the 90's: l). Ir-192 and External Beam: The William Beaumont Experience. Valhalla, New York-October 1991. 47 Alvaro Martinez, M.D. 155. United States-Japan Radiation Oncology Meeting: l) I-125 in Afterloading Temporary Implants. University of Michigan, Ann Arbor, Michigan-November 1991. 156. American Endocurietherapy Society: l) Template Techniques in Brachytherapy: Perspective. Las Vegas, Nevada-December 1991. 157. Radiation Oncology Conference, McAuley Health System: Past and Present Research Activities in Ovarian Cancer. Ann Arbor, Michigan-February 1992. 158. New York Medical College Third Annual Cancer Symposium -- Cancer of the Uterus and Ovary: New Dimensions in Diagnosis and Therapy: l) Abdominal Irradiation in High Risk Endometrial Cancer Patients; 2) HDR for Early Cervical Cancer; LDR perineal Template Brachytherapy for Advanced Cancer of the Cervix. White Plains, New York-April 1992. 159. Sixth International Congress on Hyperthermic Oncology: Clinical Implications of Continuous Mild Hyperthermia and Remote Afterloading Brachytherapy. Tucson, Arizona-May 1992. 160. VIII Congress Crila 92: l) High Dose Rate vs Low Dose Rate Brachytherapy in Cancer of Cervix; 2) Limb Conservation in Bone and Soft Tissue Tumors. San Juan, Puerto Rico-May 1992. 161. Advances in Brachytherapy: An International Conference: Is There a Role for High Dose Rate Brachytherapy in Prostate Cancer? East Elmhurst, New York-June 1992. 162. Prostate Cancer-The Role of Transperineal Implantation: Brachytherapy in Prostate Cancer: LDR vs HDR. Seattle, Washington-June 1992. 163. Clinical Considerations of Pulsed Brachytherapy: Animal Trials. Working PDR Group, University of California. San Francisco, California-July 1992. 164. Nursing Issues for Cancer Care-William Beaumont Hospital: Treatment Modalities in Radiation Oncology. Detroit, Michigan-September 1992. 165. XII Congreso Argentino De Radiologia Diagnostico por Imagenes y Terapia Radinate: l) Identification of High Risk Factors for Local Failures for patients Treated with Conservative Surgery and Radiotherapy; 2) Radiotherapeutic Options in Prostate Cancer; 3) Present and Future Brachytherapy. 4) High Dose Rate in Cancer of the Cervix. Buenos Aires, ArgentinaSeptember 1992. 166. Sociedad Mexicana De Radioterapeutas A.C.: l) HDR Brachytherapy in Breast Cancer; 2) HDR Brachytherapy en lung Cancer; 3) HDR Brachytherapy Using Template Transperineal in Prostate Cancer. Tijuana, Mexico-October 1992. 167. 1992 Michigan State Medical Society Annual Scientific Meeting: Indications and Results of Radiation Therapy on patients with Prostate Carcinoma. Dearborn, Michigan-November 1992. 168. 15th Annual Midwinter Meeting of the American Endocurietherapy Society: Chairman of this Program: Presidential Address: Economics and Brachytherapy. Beaver Creek, ColoradoDecember 1992. 48 Clinical Alvaro Martinez, M.D. 169. Medical Grand Rounds-Western Reserve Care System-Southside Medical Center: Update in Brachytherapy, Primary Cancer Management. Youngstown, Ohio-March 1993. 170. Radiation Research Society/41st Annual Meeting North American Hyperthermia Society/13th Annual Meeting: Clinical Experience with Continuous Mild Hyperthermia and Continuous Brachytherapy. The WBH Experience. Dallas, Texas-March 1993. 171. Albert Einstein Hospital, Sao Paulo. Advances in Radiation Therapy: l) Advances in Brachytherapy; 2) Brachytherapy of Prostate Cancer; 3) HDR Experience in Gynecological Malignancies. Sao Paulo, Brazil-March 1993. 172. Prostate Cancer -- Detection, Diagnosis and the Role of 3D Conformal Radiation Therapy: Role of Low & Conformal High dose Rate Temporary Implants in the Treatment of Prostate Cancer. Booth Memorial Hospital, Flushing, New York-April 1993. 173. The Pan American Health Organization: Brachytherapy Treatments in Gynecological Malignancies. Managua, Nicaragua-May 1993. 174. The Role of Transperineal Implantation -- Fourth Annual Symposium. Experience with LDR and Conformal HDR Brachytherapy for Locally advanced Prostate cancer. The Stouffer Madison Hotel, Seattle, Washington-April 1993. 175. XIII Congreso Peruano de Cancerologia at the Instituto de Enfermedades Neoplasicas in Lima, Peru. l) Role of Radiation Oncology in Carcinoma of the Rectum; 2) Treatment of Cancer of the Pancreas; 3) Brachytherapy in the Treatment of Endobronchial Malignancies; 4) Brachytherapy for Treatment of Cancer of the Prostate; and 5) Preservation and Treatment of Carcinoma of the Breast-November 1993. 176. Segunda Conferencia Internacional de Hematologia Y Oncologia. 1) Avances en fisica y radiobiologia practicas, para el oncologo; 2) Cancer de Esofago; 3) Cancer de prostat. Uso de la radioterapia. 3) Radioterapia en cancer de mama. 4) Radioterapia paliativa en cancer de mama. Cali, Colombia, South America- March 1994. 177. Conformal HDR Prostatic Brachytherapy - Brachytherapy Today and The Future Hyatt RegencyGainey Ranch, Scottsdale, Arizona-May, 1994. 178. 30th Annual Meeting of the American Society of Clinical Oncology. Developments in Radiation Oncology. Dallas, Texas-May 1994. 179. Prostate Cancer: Horizons in Transperineal Therapy, 5th Annual Symposium. Brachytherapy: HDR vs LDR Boost in Prostate Cancer. Seattle, Washington- June 1994. 180. Training of local medical physics staff in Quality Control in Radiotherapy. I was invited by the International Atomic Energy Commission to be a project teacher for Mexico City. Mexico City, Mexico-August 1994. 181. Congreso de la Liga de la lucha contra el Cancer. l) Indicaciones de radioterapia en cancer de mama; 2) Radioterapia adyuvante en cancer de colon y recto; 3) Cancer de prostata -Generalidades y radioterapia. Barranquilla, Colombia, South America-September 1994. 49 1. New Clinical Alvaro Martinez, M.D. 182. Carcinoma of the Prostate: An Update for the Primary Care Physician. Carcinoma of the Prostate at William Beaumont Hospital. Royal Oak, Michigan-October 1994. 183. Intraoperative Optimization of needle Placement and Dwell times for Conformal Prostate Brachytherapy. Presented at the annual Meeting of the American Society for Therapeutic Radiology and Oncology, San Francisco, California-October 1994. 184. North Central Section, American Urological Association, Inc. Annual Meeting: 3rd Annual Heavyweight Fight. Boca Raton, Florida-November 1994. 185. GU/Oncology Research Conference at Harper Hospital. Investigational Study with brachytherapy for prostate cancer. Detroit, Michigan-November 1994. 186. Annual Society of Gynecologic Oncology Nursing Meeting. Collaborative Management of the Patient Receiving High Dose Rate Brachytherapy in Gynecological and Breast Cancers. San Francisco, CA-February 1995. 187. The 17th annual Oncology Update, Cedars Medical Center -- New Diagnostic Treatments and Techniques for Cancer and Treatment of Early Diagnosed Cancer. 1) Latest Therapy of Prostate Cancer; 2) Radiation Therapy of Minimal Breast Cancer. Miami, Florida-February 1995. 188. San Francisco Cancer Symposium. 1) Clinical Contributions of High Dose Rate Brachytherapy; 2) Conformal HDR Prostate Brachytherapy. San Francisco, CA-March 1995. 189. Philips International Radiotherapy User's Meeting. Beam Intensity Modulation Using a Computer Controlled Multileaf Collimator: Transition from the Design to the Clinic. London, England (UK) -March 1995 190. Brachytherapy and Conservative Treatments an International Brachytherapy Working Conference. 1) Advances in the Treatment of Prostate Cancer-Brachytherapy; 2) Advances in the Treatment of the Anal Canal Cancer 3) The Role of Brachytherapy in Esophageal Cancer. Naples, Italy -April 1995 191. 4TH International Brachytherapy & Remote Afterloading Symposium & Workshop. 1) Moderator of Clinical Session; 2) Presenter -- Role of LDR and HDR in Breast Brachytherapy. Palm Beach, FL -May 1995 192. Implementation of Emergent Technology in Radiation Oncology. 1) Moderator - Treatment Planning: Input Data; 2) Presenter - Treatment Uncertainty in HDR Treatment; 3) Presenter Conformal HDR brachytherapy for Prostate Cancer; 4) Moderator - New Horizon; 5) Closing Remarks. Indian Wells, CA - June 1995 193. IX Congreso LatinoAmericano De Mastologia. 1) Radioterapia en Cancer de Mama; Radioterapia Exclusiva Como Tratamiento en Cancer de Mama. Bogota, Colombia, S.A. -July 1995 50 Alvaro Martinez, M.D. 194. Carcinoma of the Breast: An Update for Physicians. 1) A Comprehensive Review of Radiation Therapy Treatment for Breast Cancer; 2) Round Table Discussions. Royal Oak, MI-October 1995. 195. XI Congreso Nacional de Cancerologia. 1) Braquiterapia en Ca de Cervix; 2) Radioterapia en Ca de Laringe; 3) Braquiterapia; Alta tasa v.s. baja tasa de dosis; 4) Papel de la Radioterapia en Cancer de Pulmon; 5) Round Table Discussions. Cali, Colombia, S.A.-November 1995. 196. 3RD Annual Radiotherapy Teaching Course/Israel Cancer Association. 1) Treatment of Prostatic Carcinoma - External Irradiation or Brachytherapy; 2) External Beam Irradiation and Brachytherapy in the Management of Gynecological Malignancies; 3) Round Table/Case Presentations on Head and Neck; 4) The Management of Recurrent GYN Malignancies; 5) Low vs High dose BT in GYN Malignancies; and 6) Round Table on GYN. Tel Aviv, Israel November 1995. 197. 8TH International Brachytherapy Conference. 1) Keynote Presentation -- The Influence of Conformal Brachytherapy on Local Control and Normal Tissue Damage. Nice, FranceNovember 1995. 198. Proceedings of the 18th Annual Mid-Winter Meeting of the American Brachytherapy Society. 1) Conformal Dose Escalation Trial in Prostate. Scottsdale, AZ-December 1995. 199. III Curso Internacional Cancer Urologico. 1) RDT Externa - Carcinoma Prostatico; 2) Indicaciones de Braquiterapia de Alta dosis en Cancer de Prostata Inicial. Bogota, Colombia, S.A.-February 1996. 200. X Congreso CRILA 96. Braquiterapia en Cancer de Cabeza Y Cuello. Panama-March 1996. 201. 1er Seminario Chileno de Braquiterapia. 1) Bronquios y Esofago; 2) Intersticial, Mama y Prostata; and 3) Round Table Discussion. Santiago, Chile-March 1996. 202. 78th Annual Meeting of the American Radium Society. Brachytherapy. San Francisco, CA-March 1996. 203. 1996 Annual Meeting of the Texas Radiological Society. 1) Implementation of the Multileaf Collimator into a Radiation Oncology Department. Houston, Texas-April 1996. 204. II International 3D Radiation Treatment Planning and Conformal Therapy Symposium. Advances in 3D Brachytherapy. St. Louis, Missouri-April 1996. 205. American Radium Society--Technological Innovations Symposium. 1) Interactive and Virtual Brachytherapy-April 1996. 206. First International Brachytherapy Meeting GEC/ESTRO-ABS-GLAC. 1) On-Line Conformal HDR Dose Escalation Trial in Prostate Cancer. Tours, France-May 1996. 207. New Developments in Interstitial Remote Controlled Brachytherapy. 1) Moderator of HDR Panel; 2) Ultrasound Based Interstitial Brachytherapy. Santorini, Greece-May 1996. 51 1) Interactive and Virtual 1) Alvaro Martinez, M.D. 208. I Congreso Internacional de Braquiterapia. 1) Braquiterapia Con Cancer de Prostata, 2) Braquiterapia H.D.R. Cancer de Mama. Mexico City, Mexico-September 1996. 209. 2nd Annual Conference of The West Michigan Cancer Center. 1) Gynecological Cancer and Radiation Therapy-September 1996. 210. 7th Annual Oncology Symposium. 1) Salvage Management for recurrent Rectal Cancer, Round Table-October 1996. 211. UROK 96 II Ulusal Radyasyon Onkolojisi Kongresi. 1) Radiotherapy in the Management of Prostate Cancer, 2) Brachytherapy in Head and Neck Cancers, 3) Brachytherapy in Gynecological Cancers. Ankara, Turkey-October 1996. 212. VII Congreso Chileno de Radioterapia Oncologica. 1) Braquiterapia en Tumores esofagicos, 2) Braquiterapia de Mediana y Alta Tasa de Dosis (MDR/HDR), 3) Tema Alternativo, a su Eleccion. Santago, Chile-November 1996. 213. VII Congreso Nacional de Radioterapia Oncologica. Mexico City, Mexico-November 1996. 214. III Congreso Peruano De Mastologia. 1) Present and Future of radiotherapy in Treatment of Breast Carcinoma, 2) Multidisciplinary Treatment of Breast Carcinoma. Lima, Peru-November 1996. 215. First Annual Oncology Seminar, Mercy Hospital, The Division of Hematology/Oncology. 1) Miami, Florida-February 1997. 216. Tratamento Multidisciplinar em Oncologia Desafio do Seculo XXI. 1) Intraoperative Brachytherapy - Clinical Indications and Results Gastrointestinal Tumors, 2) The Role of Brachytherapy in Esophageal Tumors. Porto, Portugal-April 1997. 217. Brachytherapy in the Next Millennium. 1) Virtual Brachytherapy: Understanding Uncertainties & Decreasing their Impact on Local Control, 2) Brachytherapy as the Sole Treatment Modality for patients with Early Stage Breast Cancer, 3) Prostate Cancer: Superiority of Conformal HD Brachytherapy Boost over External Beam Boost. New York City, New York-April 1997. 218. American Brachytherapy Society 19th Annual Meeting. 1) Irradiation of the Tumor Bed Alone After Lumpectomy with High Dose Rate (HDR) Brachytherapy in Early Stage Breast Cancer Patients with Breast Conserving Therapy (BCT). Palm Beach, Florida-May 1997. 219. National Cancer Institute Workshop on "Clinical QA in Brachytherapy with an emphasis on Prostate Implants": 1) Interstitial Prostate; 2) Clinical Comments on Physics QA; 3) What Methods are used to Analyze the Implants. Reston, VA- June 1997. 220. National Cancer Institute Workshop on "Oncologic Imaging in Treatment Planning": 1) Imaging Correlation in the Pelvis. Reston, VA- Sept 1997. 221. 9th International Brachytherapy Conference. 1) Welcome (Co-Chairman of Conference); 2) Intravascular brachytherapy -- Moderator; 3) Virtual brachytherapy - Moderator; 4) Radiotherapy Options for localized Prostate Cancer Based upon Pretreatment Serum Prostate Specific Levels 52 Alvaro Martinez, M.D. and Biochemical Control: A Comprehensive Review of the Literature; 5) Conformal Prostate Implants: Initial Experience of a Phase I/II Dose-Escalating Trail; 6) Conformal High Dose Rate Iridium-192 Boost Brachytherapy in Locally Advanced Prostate Cancer: Superior prostate Specific Antigen Response Compared to External Beam Treatment; 7) Prostate Workshop. Palm Springs, CA-Sept 1997. 222. Nordstrom/Town & Country Event -- Panel Discussion. 1) How Effective is Lumpectomy with Radiation Treatment, Compared with Mastectomy, as a Treatment for Women with Breast Cancer. Troy, MI-Oct 1997. 223. 39th American Society of Therapeutic Radiology and Oncology Annual Meeting. 1) Brachytherapy Boost Techniques for Locally Advanced Prostate Cancer. Orlando, FL -Oct 1997 224. National Regulatory Commission Workshop. 1) American College of Radiology Policy on Training and Experience. Chicago, IL-Nov 1997. 225. Seminario Internacional de Braquiterapia con Alta Tasa de Dosis: 1) Principios Generales de la Braquiterapia; 2) Braquiterapia de Alta Tasa en Cancer de Pulmon y Esofago; 3) Braquiterapia de Alta Tasa en Cancer Ginecologico; 4) tratamientos con Alta Tasa de Dosis en Cancer de Prostata, Sarcoma de Partes Blandas, Braquiterapia Intraoperatoria. Lima, Peru-Feb, 1998. 226. The Optima 1998 Radiation Oncology Symposium. 1) The Process of Adaptive Radiotherapy (ART) to Correct for Inter-fraction Treatment Variations using the Philips Equipment; 2) Advantages of the Active Breathing Control (ABC) Technique to Decrease Intrafraction Organ Motion. New Delhi, India- April 1998. 227. 80th American Radium Society Annual Meeting. 1) Biochemical Control Following High Dose Rate Conformal Boost Brachytherapy for Locally Advanced Prostate Cancer: Correlation with Post-Radiation prostate Biopsy Results. Monte Carlo, Monaco- May 1998. 228. Elekta User's Conference: Moderator for the Conference Regarding IMRT, Gamma Knife Radiosurgery. Palm Springs, CA-June 1998. 229. Jornada Sobre Radioterapia Intersticial en Cancer de Prostata. 1) Aplicacion de implanted intersticia ecodirigida; 2) Experiencia e indicaciones de la Radioterapia intersticial en el cancer de prostata. Spain - July 1998 230. Cancer Center at Washington University Seminar Series. Millenium. St. Louis, MO-Sept 1998. 231. National Gynecological Oncology Meeting. 1) Cervical Carcinoma Panel; 2) Endometrial Carcinoma Panel; 3) Ovarian Cancer Panel. Ankara, Turkey -Oct 1998. 232. 40th Annual American Society of Therapeutic Radiology and Oncology. 1) Brachytherapy Boost techniques for Locally Advanced Prostate Cancer. Phoenix, AZ-Oct 1998. 233. 6th Annual American Society of Therapeutic Radiology and Oncology Refresher Course Program. 1) Brachytherapy Boost techniques for Locally Advanced Prostate Cancer. New Orleans, LA-March 1999. 53 1) Radiotherapy for the Next Alvaro Martinez, M.D. 234. Great Lakes Urology Seminar. 1) Postoperative Radiation Therapy for Rising PSA. Troy, MIApril 1999. 235. American Radium Society 1999 Annual Meeting. 1) Co-moderator on Gynecological Tumors. Hawaii, April 1999. 236. New York Roentgen Society. 1) HDR - Brachytherapy for Early Breast Carcinoma; 2) HDR US Guided Brachytherapy for Prostate Cancer. New York, NY-April 1999. 237. XII CRILA 2000 Huatulco Oaxaca, Mexico – Gynecological Cancer –Treatment of Endometrial Carcinoma with Radiation Therapy –April 2000. 238. 4th National Oncology Congress- Brachytherapy Applications HDR in Gynecological Oncology Malignancies, Ankara, Turkey, March 2000. 239. 4th National Oncology Congress –Brachytherapy in Head and Neck Cancer- Ankara, Turkey, March 2000. 240. ABS2nd Joint International Meeting: Results of HDR prostate brachytherapy. Crystal City, Virginia, May 2000. 241. Grand Rounds, Radiotherapy of the Next Millennium, University of Pennsylvania, Cancer Center, July 2000. 242. Annual meeting of the Florida Radiological Society (FRS): High dose rate prostate brachy therapy. Lake Buena Vista, Florida. July, 2000. 243. The 10th International Brachytherapy Conference: l) Image Guided Brachytherapy 2) Interstitial Accelerated Partial Breast Brachytherapy. Madrid, Spain. Nov. 2000. 244. 20th Mexican Annual Radiotherapy meeting: l) Radiotherapy of the next Millennium 2) Radiotherapy WAPI for Endometrial Cancer. Guanajuato, Mexico. Nov. 2000. 245. University of Ghent. Annual IMRT course: Planning for Breast and Prostatic Cancer IMRT. Ghent, Belgium. March 2001. 246. NIH – Translational Research in Brachytherapy workshop: Biologic considerations and therapeutic response in prostate brachytherapy. Bethesda, Maryland. March 2001. 247. Seattle Prostate Institute 4th Annual Advanced Prostate Brachytherapy conference: HDR Prostate Brachytherapy outcome results and Toxicity. Seattle, Washington. April 2001. 248. Cleveland Clinic Foundation Radiotherapy Grand Rounds: Radiotherapy of the New Millennium. Cleveland, Ohio. April 2001. 249. ESTRO/GEC Annual Meeting: l) Accelerated Partial breast Irradiation. 2) IMRT Breast Irradiation. Stresse, Italy. June 2001. 54 Alvaro Martinez, M.D. 250. Oncology Symposium – Congreso de Invesigation: l) Hormones and radiotherapy in prostate cancer. 2) Prostate brachytherapy. Monterrey, Mexico. Sept. 2001. 251. lst China conference in Radiation Oncology: Clinical applications of IMRT. Jinan, China. Sept. 2001. 252. Hong Kong College of Radiologists: External beam and HDR with or without hormones in prostate cancer. Hong Kong, China. Nov. 2001. 253. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: Practical Application of Biochemical Failure Definitions: What to Do and When to Do It. Boston, MA- Nov 2001. 254. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: A Dose Selection –Escalation Trial Using the Adaptive Radiotherapy Process (ART) in Localized Prostate Cancer. San Francisco, CA- Nov 2001. 255. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: Percentage of Positive Biopsy Cores as a Predictor for Clinical Outcome in Prostate Cancer. San Francisco, CA - Nov 2001. 256. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: A Dose Selection –Escalation Trial Using the Adaptive Radiotherapy Process (ART) in Localized Prostate Cancer. San Francisco, CA-Nov 2001. 257. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: The Impact of Radiation Modality and Poor Prognostic Factors on Clinical Outcome in Prostate Cancer. San Francisco, CA - Nov 2001. 258. 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology: No Benefit at 5 Years from a Brief Course of Neoadjuvant Androgen Deprivation for Prostate Cancer Patients Treated with A Conformal High Dose Rate Brachytherapy Boost. San Francisco, CA - Nov 2001. 259. Japanese Association of Radiation Oncologists JASTRO: l) Breast IMRT 2) Accelerated partial breast irradiation. Osaka, Japan. Dec. 2001. 260. Indiana University School of Medicine. Radiation Oncology Conference: l) Dose escalation results of HDR prostate brachytherapy boost for unfavorable prostate cancer. 2) IMRT of prostate cancer using the Adaptive Radiotherapy Process (ART). Kona, Hawaii. Feb. 2002 261. Christie Hospital Cancer Center. Cancer Meeting: 1) The William Beaumont Hospital experience with IMRT and the Adaptive Radiotherapy Process (ART) in Prostate Cancer Treatment. Manchester, England. March 2002. 262. Society of Gynecologic Oncology, 33rd Annual Meeting Plenary Session: 1) Ten-year outcome for poor histology or high risk endometrial cancer patients treated by whole abdominopelvic irradiation. Miami, Florida. March 2002. 55 Alvaro Martinez, M.D. 263. Mayo Clinic, Comprehensive Cancer Center: 1) The role of IMRT in the Treatment of breast cancer, 2) Toxicity results of ART in prostate cancer. A dose escalation trial. Jacksonville, Florida. April 2002. 264. 5th Annual Advanced Prostate Brachytherapy Conference. 1) HDR Monotherapy Review 2) Quality of Life after prostate brachy therapy. 3) HDR Brachytherapy as a Boost Long term results. Seattle, WA. May 2002. 265. Turkish National Gynecologic Oncology Meeting: 1) HDR brachytherapy in cancer of the cervix in Endometrium. 2) Long term results of whole abdominopelvic irradiation in high risk endometrial cancer patients. Ankara, Turkey. May 2002. 266. American Radiation Society 84th Annual Meeting. 1) Ten year outcome for poor histology and high risk endometrial cancer patients treated by whole abdominopelvic irradiation. 2) Dose escalation using conformal high dose rate brachytherapy improves the outcome in unfavorable prostate cancer. San Juan, Puerto Rico. May 2002. 267. 4th Shanghai International Conference on Radiation Oncology. 1) The increasing role of HDR brachytherapy in the clinic 2) IMRT in Breast and Prostate Cancer. Shanghai, P.R. China, May 2002. 268. 23rd American Brachytherapy Society meeting. 1) HDR brachytherapy school. Techniques for HDR brachytherapy as mono and as a boost. 2) Long term results of HDR brachytherapy boost. 3) Collaborative HDR data report. Orlando, Florida. June 2002. 269. 11th International Brachytherapy Conference. 1) Chair of the Session on Prostate Cancer. 2) Results of HDR Boost. 3) Results of HDR vs. Monotherapy in prostate cancer. Sante Fe, N.M. June 2002 270. The Queens Medical Center, Honolulu. 1) Advanced Treatments in Prostate Cancer 2) IMRT and Adaptive radiotherapy in prostate cancer. 3) IMRT on breast cancer. Honolulu, Hawaii August, 2002. 271. 44th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, Louisiana, Refresher course on LDR and HDR brachytherapy in Gynecologic malignancies. Multiple oral presentations. October 2002. 272. North Shore Long Island Jewish Health System. Radiotherapy Grand Rounds:1) HDR Boost and EBRT for locally advanced Prostate Cancer, 2) Breast IMRT current status. Long Island, N.Y. November 2002. 273. 24th National Conference of the Association of Radiation Oncologists in India. 1) Role of external beam in the new millennium. 2) The role of whole abdominopelvic irradiation in Endometrial cancer. Mumbai, India. November, 2002 274. 55th Annual Midwinter Radiation Oncology Conference Los Angeles Radiological Society: Image guided external radiotherapy in prostate cancer; today’s limits and tomorrow’s dreams. Los Angeles, California. February 2003. 56 Alvaro Martinez, M.D. 275. 2003 Mammosite Physician Conference. 1) Preliminary experience with the Mammosite applicator for accelerated partial breast treatment in breast cancer. Miami, Florida. Feb. 2003. 276. Synergy Consortium Annual meeting. 1) William Beaumont Hospital preliminary experience with synergy in prostate cancer. 2) New directions in Image Guided Radiotherapy. Crawley, England. March 2003. 277. First International Symposium on extracranial radiosurgery. 1) Experience at Beaumont and future directions. 2) Image Guidance and organ motion management. Dearborn, Michigan. April 2003. 278. 24th American Brachytherapy Society, HDR brachytherapy school for prostate cancer and gynecologic malignancies. 1) The Beaumont experience and approach for HDR prostate brachytherapy. New York, N.Y. May 2003. 279. National Cancer Institute Annual meeting, Lima, Peru: 1) Accelerated partial breast radiation in early breast cancer. 2) HDR monotherapy in favorable prostate Cancer. 3) HDR boost and EBRT dose escalation trial for locally advanced prostate cancer. Lima, Peru July 2003. 280. Turkish Oncology Association Annual Meeting: 1) Radiotherapy of the new millennium. 2) Advances in prostate brachytherapy. Istanbul, Turkey. Aug. 2003. 281. Panama Radiotherapy Association – National Meeting: 1) HDR brachytherapy in Cancer of the cervix. 2) IMRT in breast cancer, a new horizon. Sept. 2003. 282. 7th Hong-Kong International conference on Oncology: Image Guided Radiotherapy, present and future. 2) The role of HDR brachytherapy, present and future. 2) The role of HDR brachytherapy in prostate cancer. 3) Brachytherapy in breast Cancer. Hong-Kong Nov. 2003. 283. American College of Radiology, Semi-Annual meeting: 1) Image guided radiotherapy; Today’s limits, tomorrow’s dreams. 2) Panel discussion on partial breast irradiation. New Orleans, LA. Jan. 2004. 284. 21st Annual Miami Breast Cancer Conference: Session on Innovation in radiotherapy: accelerated partial breast irradiation within breast conserving therapy. Miami, Florida. Feb. 2004. 285. 14th Annual Meeting American College of Radiation Oncology: 1) Plenary session: HDR prostate brachytherapy as a boost or as monotherapy for prostate cancer patients. Orlando, Florida. Feb. 2004. 286. Texas Radiological Society, 91st Annual meeting: 1) Breast IMRT, current status. 2) Long term experience with HDR prostate brachytherapy. 3) Prostate IMRT, organ motion challenges. Irving, Texas. April 2004. 57 Alvaro Martinez, M.D. 287. Doctors’ Medical Center of Modesto Oncology Symposium: 1) Whole abdominal radiotherapy in endometrial cancer. 2) Breast brachytherapy with emphasis on the MammoSite applicator. Monterrey, CA. April 2004. 288. American Brachytherapy Society: HDR brachytherapy School: 1) Long Term outcome of HDR prostate brachytherapy, the combined Kiel, Detroit, Seattle experience, Chicago, Illinois. June 2004. 289. 34th Spanish National Urology Conference: 1) Long-term results of HDR dose escalation trial for locally advanced disease. 2) HDR prostate monotherapy, rationale and results. Oviedo, Spain. July 2004. 290 4th International Prostate Cancer Congress: Advances in brachytherapy session. Novel techniques, combining EBRT with high dose rate brachytherapy in high risk disease. Bahamas. July 2004. 291. Colombian Annual Cancer Congress, “Cancer 2004”: 1) Session on New Technology: Image Guided radiotherapy. 2) The role of HDR brachytherapy in Prostate Cancer. 3) Panelist on treatment of early breast cancer. Medellin, Colombia. August 2004. 292. Advances in breast Cancer care and diagnosis. 1) Accelerated partial breast irradiation. A new approach to radiation treatment for breast conservation. Creighton University Medical Center, Omaha, Nebraska. August 2004. 293. 46th Annual Conference of the American Society for therapeutic Radiology and Oncology. 1) Refresher course on Techniques and results of Gynecologic Brachytherapy. 2) Multiple oral presentations. Atlanta, Georgia. Oct. 2004. 294. XI Conference of Indian Society of Oncology: 1) New radiotherapeutic approaches for breast conservation. 2) Radiotherapy on prostate cancer, new frontiers. Bangalore, India. Oct. 2004. 295. Karolinska Cancer Institute Annual Meeting: 1) Image guided radiotherapy, present and future. 2) Radiotherapeutic advances in prostate cancer with IMRT, and HDR. Stockholm, Sweden. Nov. 2004. 296. Helsinki Medical School, Radiotherapy Grand Rounds: Technological advances with Image Guided Radiotherapy. Helsinki, Finland. Nov. 2004. 297. Radiation Therapy Oncology Group, Semi-Annual Meeting: GU Committee – HDR. Phoenix, Arizona. Jan. 2005. 297. Multidisciplinary Prostate Cancer Symposium. ASCO-ASTRO-SUO-PCF. Treatment of localized disease-Advances and outcomes: High dose rate prostate brachytherapy. Orlando, Florida. Feb. 2005. 298. 4th International Conference of Rajiv Gandhi Cancer Institute & Research Centre: “HDR Brachytherapy in Carcinoma Prostate. New Delhi, India. March 2005. 58 Alvaro Martinez, M.D. 298. Fourth International Conference of the International Society of Intraoperative Radiation Therapy. Co-moderate the Prostate Tumor Section – HDR topic presentation. Miami, Florida. March 2005. 299. XIV Congreso Circulo De Radioterapeutas Ibero LatinoAmericano: Radioterapia externa guiada por imagines Cone Beam Cone Beam image guidance Radiotherapy. Crila, Peru. March 2005 300. LOS PROXIMOS 10 ANOS DE LA ONCOLOGIA RADIOTERAPICA. “Conferencia: “Experiencia con Radioterapia adaptativa dirigida por imagines volumetricas” and Indicaciones de BT. Segovia, Spain. April 2005. 301. 26th Annual American Brachy Society Meeting (ABS): The Ulrich Henschke Memorial Lecture and Award Presentation San Francisco, California June 2005 302. Visiting Professorship at Montefiore Medical Center: “Image Guided Brachytherapy for Prostate & Breast Cancers”. Bronx, New York. June 2005. 303. Mercoledi 22 Giugno 20005 Corso Monotematico: HDR Prostate Brachytherapy and Adaptive Radiotherapy in Clinical Treatments. Lecco, Italy. June 2005. 304. Segundas Jornadas de Oncologia del Sureste. Puebla, Mexico. August 2005. 305. National Cancer Institute Conference. Bogota, Colombia. August 2005. 306. Probstein Oncology Lecture and receipt of Probstein Award. Washington University School of Medicine. St. Louis, MO Sept. 2005 59